Heterotopic Ossification

About the Disease
Osseous Heteroplasia, Progressive, also known as progressive osseous heteroplasia, is related to myositis ossificans and ossification of the posterior longitudinal ligament of spine, and has symptoms including polydipsia and muscle weakness. An important gene associated with Osseous Heteroplasia, Progressive is GNAS (GNAS Complex Locus), and among its related pathways/superpathways are Signal Transduction and Akt Signaling. The drugs Etoricoxib and Cyclooxygenase 2 Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and skeletal muscle, and related phenotypes are subcutaneous nodule and limitation of joint mobility

Common Targets
CASC20 | ACVR1 | TGFB1 | ACVRL1 | TGFB2 | Vascular endothelial growth factors (VEGF) (nonspecified subtype) | CTH | BMPR1A | TGFB3 | BMPR1B

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