Disease

Hypercholesterolemia

About the Disease
Hypercholesterolemia, Familial, 3, also known as hypercholesterolemia, autosomal dominant, 3, is related to hyperaldosteronism, familial, type iii and strabismus. An important gene associated with Hypercholesterolemia, Familial, 3 is PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9). The drugs Probucol and Cilostazol have been mentioned in the context of this disorder. Affiliated tissues include heart, endothelial and skin, and related phenotypes are hypercholesterolemia and xanthelasma

Common Targets
APOE | GLP1R | G5743 | Monoamine oxidase (MAO) (nonspecified subtype) | GCGR | SREBF1 | ASGR1 | Asialoglycoprotein Receptor (ASGPR) (nonspecified subtype) | NADPH Oxidase (nonspecified subtype) | CYP19A1 | APOA2 | CETP | SPP1 | LPL | G7422 | Prolyl 4-hydroxylase | HSD17B2 | FFAR4 | Proteasome Complex | CYP3A4 | G5243 | CCN1 | SNCA | RLN3 | TRIB1 | APOA4 | LDLR | CYP7A1 | PREP | APOA5 | KDR | FFAR1 | G3576 | G1956 | THRB | P4HA3 | NPC1L1 | SLCO2B1 | NR1H2 | FDFT1 | G7015 | ANGPTL3 | DGAT2 | HDAC2 | Chymotrypsin (nonspecified subtype) | AGT | G7124 | ADIPOQ | HDAC6 | AMP-activated protein kinase (AMPK) | G595 | G3620 | Phospholipase A2 (nonspecified subtype) | Cholesterol esterase (nonspecified subtype) | CYP17A1 | SLC15A1 | SCARB1 | HIF1A | SORT1 | NR1H3 | RPS6KB1 | Liver Bile Transporters (LBAT) (nonspecified subtype) | ELANE | GPR146 | ACE | MIR122 | LIPA | S1PR4 | LTA | PPARA | Calcium channel (nonspecified subtype) | IL1B | Lipoxygenase (nonspecified subtype) | LDLRAP1 | APOC3 | Oxysterols receptor LXR (nonspecified subtype) | Acetylcholine Receptors (Nicotinic) (nAChR) (nonspecified subtype) | Peroxisome Proliferator-Activated Receptors (PPAR) (nonspecified subtype) | ESR2 | PCSK9 | HMGCR | NPPA | G4780 | NPPA-AS1 | G4137 | GIPR | NR1I2 | ABCA1 | CELSR2 | S1PR3 | ABCG5 | Histone acetyltransferase (HAT) (nonspecified subtype) | NF-kappaB (NFkB) | DYRK1A | ABCC2 | NPY | Estrogen receptor (nonspecified subtype) | CES1 | HSD11B1 | P4HB | PPARD | SLC10A1 | DPP4 | Reverse transcriptase (Telomerase) | G7099 | MTTP | ATP7B | ABCG8 | P2RY12 | HDAC1 | AKR1B1 | Trypsin (nonspecified subtype) | Voltage-Gated Sodium Channel Complex | CASP8 | G3605 | ADORA3 | Triacylglycerol Lipase (TG Lipase) (nonspecified subtype) | SOAT1 | G6PC1 | LIPC | LSS | XDH | OSBP | GSK3B | APOC1 | PTGS1 | PTPN1 | G9429 | NR1H4 | ACHE | SQLE | PPARG | RXRA | CYP3A5 | HNF1A | G3480 | Sterol O-acyltransferase (ACAT) (nonspecified subtype) | FAAH | STK25 | Platelet-Derived Growth Factor Receptor (nonspecified subtype) | TXNRD1 | FGFR4 | ACACB | G2099 | G3630 | Sodium channel (nonspecified subtype) | HCAR3 | SLC10A2 | APOA1 | FASN | G836 | Poly [ADP-ribose] polymerase (nonspecified subtype) | Mitogen-Activated Protein Kinase (nonspecified subtype) | SLC5A1 | AP-1 Transcription Factor Complex | ACLY | FASLG | HSD17B1 | Sterol Regulatory Element-Binding Protein (nonspecified subtype) | SOAT2 | ADRB2 | MRAS | FMO3 | LIPE | G1786 | SLCO1B1 | LPA | ERP44 | PNLIP | HCAR2 | NOX3 | APOB | MBOAT4 | UGT1A1 | THRA | FSHB | P4HA2 | G367 | NADPH Oxidase Complex | SIK3 | GLA | ENOX2 | TRPM3 | LIPG | S1PR1

疾病靶点研报
Hypercholesterolemia

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