Neuroleptic Malignant Syndrome

About the Disease
Neuroleptic Malignant Syndrome is related to metabolic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration and acute kidney failure. An important gene associated with Neuroleptic Malignant Syndrome is CYP2D6 (Cytochrome P450 Family 2 Subfamily D Member 6), and among its related pathways/superpathways are Sudden infant death syndrome (SIDS) susceptibility pathways and "Ca, cAMP and Lipid Signaling". The drugs Creatine and Clofibric Acid have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and subthalamic nucleus, and related phenotypes are hyperhidrosis and fever

Common Targets
CYP2D6

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