Disease

Crigler-Najjar Syndrome

About the Disease
Crigler-Najjar Syndrome, Type I, also known as crigler-najjar syndrome, is related to crigler-najjar syndrome, type ii and cardiomyopathy, dilated, with hypergonadotropic hypogonadism. An important gene associated with Crigler-Najjar Syndrome, Type I is UGT1A1 (UDP Glucuronosyltransferase Family 1 Member A1), and among its related pathways/superpathways are Metabolism and Metapathway biotransformation Phase I and II. The drugs Diazepam and Gastrointestinal Agents have been mentioned in the context of this disorder. Affiliated tissues include Liver, brain and skin, and related phenotypes are jaundice and prolonged neonatal jaundice

Common Targets
Heme Oxygenase (HO) (nonspecified subtype) | UGT1A1 | HMOX1

疾病靶点研报
Crigler-Najjar Syndrome

Note: If you'd like to get a target analysis report for Crigler-Najjar Syndrome, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Crigler-Najjar Syndrome at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Primary Biliary Cholangitis | Charcot-Marie-Tooth Disease, Type 2A | Thrombotic Microangiopathy | Vaginitis | Trichothiodystrophy | Gastric Atrophy | Pterygium | Arthritis, Psoriatic | Sotos Syndrome | 3-M Syndrome | Peyronie's Disease | Nephrotic Syndrome Type 1 | Acrocallosal Syndrome | Hyperkeratosis | Obesity, Morbid | Spinocerebellar Ataxia Type 15 | Miyoshi Myopathy | Migraine | Hypopituitarism | Polyomavirus Nephropathy | Autosomal Recessive Spastic Paraplegia Type 75 | Blepharospasm | Keratosis | Spastic Paraplegia Type 7 | Peripheral T-cell Lymphoma | Lennox-Gastaut Syndrome | Fetal Alcohol Syndrome | Chronic Inflammatory Demyelinating Polyneuropathy | Meningococcal Meningitis | Diffuse Mesangial Sclerosis | Hepatitis | Benign Familial Pemphigus | Hemophagocytic Lymphohistiocytosis | Binge Eating Disorder | Retinal Diseases | Mitochondrial DNA Depletion Syndrome, Encephalomyopathic Form | Spinocerebellar Ataxia Type 13 | Bone Giant Cell Tumor | Isobutyryl-CoA Dehydrogenase Deficiency | Hypertrophy | Thrombocytopenia | Stomatitis | Reye Syndrome | Geleophysic Dysplasia | GM2-gangliosidosis AB Variant | Glutaric Aciduria Type 3 | Schizencephaly | Tendinopathy | Pseudohypoparathyroidism Type 1B | Spondylolisthesis | Adrenoleukodystrophy, X-linked | Distal Spinal Muscular Atrophy | Arrhythmogenic Right Ventricular Cardiomyopathy | Cardiospondylocarpofacial Syndrome | Mucolipidosis Type IV | Spinocerebellar Ataxia Type 12 | FG Syndrome | LEOPARD Syndrome | Paget's Disease Of The Breast | Paraganglioma | Acute Coronary Syndrome | Atopic Dermatitis | Swine Influenza | Noonan Syndrome-like Disorder With Loose Anagen Hair | Epiphyseal Chondrodysplasia, Miura Type | Overactive Bladder | Syndactyly | Gastroenteritis | Chronic Mucocutaneous Candidiasis | GAPO Syndrome | Harlequin Ichthyosis | Xeroderma Pigmentosum Variant Type | Hereditary Multiple Exostoses | Pyruvate Decarboxylase Deficiency | Fetal Akinesia Deformation Sequence | Otitis Media | Amyloidosis | McCune-Albright Syndrome | Urofacial Syndrome | Acne | Bainbridge-Ropers Syndrome | Dermatomyositis | Vascular Cognitive Impairment | Wagner Disease | Mitochondrial Myopathy | Systemic Lupus Erythematosus | Situs Inversus | Muir-Torre Syndrome | Allergic Contact Dermatitis | Multiple Sclerosis, Chronic Progressive | ADNP Syndrome | Pulmonary Capillary Hemangiomatosis | Bartsocas-Papas Syndrome | Peeling Skin Syndrome, Acral Type | Disseminated Intravascular Coagulation | Retinoschisis | Osteogenesis Imperfecta | Pelizaeus-Merzbacher Disease | Keratocystic Odontogenic Tumor | Follicular Dendritic Cell Sarcoma | Castleman Disease | Carotid Artery Disease | Anorexia Nervosa | Idiopathic Pulmonary Fibrosis | D-2-Hydroxyglutaric Aciduria | Dementia | Hypertension, Pulmonary | Alazami Syndrome | Crouzon Syndrome With Acanthosis Nigricans | Endophthalmitis | Hepatitis, Autoimmune | Charcot-Marie-Tooth Disease Type 4B1 | Muscular Dystrophy | Leber Congenital Amaurosis | Diabetes Mellitus, Transient Neonatal | Achondrogenesis | Peripheral Neuropathy | Fuchs Dystrophy | Hydrops Fetalis | Hemolytic Anemia | Fahr Disease | Pfeiffer Syndrome | Lesch-Nyhan Syndrome | Acute Anterior Uveitis | Hyperthyroidism | Megacystis-microcolon-intestinal Hypoperistalsis Syndrome | Demyelinating Diseases | Hyperphosphatasia With Intellectual Disability Syndrome 4 | Melanoma | Osmotic Demyelination Syndrome | Porphyria, Variegate | Lupus Erythematosus | Pseudohypoaldosteronism | Liver Failure, Acute Infantile | Myofibromatosis | Hemolytic Uremic Syndrome, Atypical | Schnitzler Syndrome | Cholestasis, Intrahepatic | Obesity | Congenital Tufting Enteropathy | Polycystic Ovary Syndrome | Glioblastoma Multiforme | Progressive Familial Intrahepatic Cholestasis Type 1 | Diabetes Insipidus, Neurogenic | Angelman Syndrome | Diffuse Intrinsic Pontine Glioma | Lymphoma, Primary Cutaneous Anaplastic Large Cell | Pulmonary Veno-occlusive Disease | Otopalatodigital Syndrome Type 2 | Rubeosis Iridis | Portal Vein Thrombosis | Uremia | Spondyloepimetaphyseal Dysplasia With Joint Laxity, Type 3 | Angiosarcoma | Fibrillation, Atrial | Platyspondylic Lethal Skeletal Dysplasia, Torrance Type | Parapsoriasis | Reflex Epilepsy | Congenital Fiber-type Disproportion Myopathy | Kabuki Syndrome | Cherubism | Leigh Syndrome | GATA2 Deficiency | Calcium Pyrophosphate Deposition Disease | Bulimia Nervosa | Takotsubo Cardiomyopathy | Tietze Syndrome | Renal Hypomagnesemia 3 | Kohlschutter-Tonz Syndrome | Pseudomyxoma Peritonei | Hypokalemia | Porphyria | Adenomyosis | Coma | Acrodermatitis | Renal-hepatic-pancreatic Dysplasia | Chronic Lymphocytic Leukemia | Urea Cycle Disorder | Cranial Nerve Disease | Charcot-Marie-Tooth Disease, Type 2 | Hyperglycemia | Bursitis | Pulmonary Vein Stenosis | Spina Bifida | Common Variable Immunodeficiency | Intellectual Disability, Autosomal Dominant 5 | Acquired Partial Lipodystrophy | Familial Glucocorticoid Deficiency | Carcinoma, Small Cell | 3-hydroxy-3-methylglutaryl-CoA Synthase Deficiency | Basan Syndrome | Cavitary Optic Disc Anomalies | Keratosis, Actinic | Hypotrichosis | Gitelman Syndrome | Microvillus Inclusion Disease | Beare-Stevenson Syndrome | Kleine-Levin Syndrome | Nestor-Guillermo Progeria Syndrome | Leukoplakia, Oral | Glycogen Storage Disease Type 3 | Lymphoproliferative Disease, X-linked | Familial Cerebral Amyloid Angiopathy | Bronchitis | Schizophrenia, Paranoid | Takenouchi-Kosaki Syndrome | Aspartylglycosaminuria | Gliosarcoma | Panuveitis | Chylomicron Retention Disease | IgA Deficiency | Interstitial Lung Diseases | DICER1 Syndrome | Epidermolysis Bullosa Simplex | Phenylketonuria | Hepatitis A | Meier-Gorlin Syndrome | Cabezas Syndrome | Polycythemia Vera | Hypersomnia | Alcoholism | Osteomalacia | Primary Cutaneous Amyloidosis | Olmsted Syndrome | Hemorrhagic Disorders | Familial Thoracic Aortic Aneurysm | Keratoconus | Congenital Hereditary Endothelial Dystrophy Type II | Congenital Lipoid Adrenal Hyperplasia | Encephalitis | Primary Erythromelalgia | Mycosis Fungoides | Palsy, Cerebral | Chromosome 5q Deletion Syndrome | Pseudohypoparathyroidism Type 1A | Holoprosencephaly | Ovarian Sex Cord-stromal Tumor | Angiodysplasia | Meningioma, Benign | Temtamy Preaxial Brachydactyly Syndrome | Loeys-Dietz Syndrome | Adenoid Cystic Carcinoma | Erysipelas | Liver Diseases | Spinocerebellar Ataxia Type 6 | Intestinal Obstruction | Muckle-Wells Syndrome | Sorsby Fundus Dystrophy | Neuroma | Dyggve-Melchior-Clausen Disease | Glutaric Aciduria Type 1 | Hyperuricemia | Down Syndrome | Nijmegen Breakage Syndrome | Hemangioendothelioma | Neurodegeneration Due To Cerebral Folate Transport Deficiency | Schuurs-Hoeijmakers Syndrome | Multiple Mitochondrial Dysfunctions Syndrome Type 1 | Uveitis, Anterior | Ichthyosis Hystrix, Curth-Macklin Type | Seizures | Carcinoid Syndrome | Hydrocephalus | Oligoasthenoteratozoospermia | Hyperinsulinemia | Epicondylitis | Periodic Limb Movement Disorder | Language Disorders | Rolandic Epilepsy | Encephalopathy, Ethylmalonic | Currarino Syndrome | Thrombocythemia, Essential | Takayasu's Arteritis | Cancer, Colon | Gerstmann-Straussler-Scheinker Syndrome | Pemphigus Vulgaris | Sialoadenitis | Familial Dysautonomia | Microcephalic Primordial Dwarfism | Cutaneous T-cell Lymphoma | Sickle Cell Anemia | Subacute Sclerosing Panencephalitis | Spinocerebellar Ataxia Type 10 | Anencephaly | Hyperinsulinemic Hypoglycemia | Diabetic Nephropathy | Urethritis | Trichotillomania | Hemangioma | Mannosidase Deficiency Diseases | Keratoacanthoma | Pulmonary Alveolar Proteinosis | Osteochondrosis | 3-hydroxy-3-methylglutaric Aciduria | Galactosialidosis | Diamond-Blackfan Anemia | Lymphoma Lymphoblastic | Fibromyalgia | Primary Progressive Aphasia | Uremic Pruritus | Neurocutaneous Syndromes | Lymphedema | Saethre-Chotzen Syndrome | Rotor Syndrome | Intracranial Hypertension | Neuropathy | Megalencephaly | Chondrodysplasia Punctata 2, X-linked Dominant | Analgesia | Infantile Refsum Disease | Dentinogenesis Imperfecta | Transient Bullous Dermolysis Of The Newborn | X-linked Sideroblastic Anemia | Eosinophilic Asthma | Sclerosteosis | Hypertensive Retinopathy | Thrombophlebitis | N-acetylglutamate Synthase Deficiency | Graves Disease | Wieacker-Wolff Syndrome | Proteus Syndrome | Fuchs Heterochromic Iridocyclitis | Peters-plus Syndrome | Multiple Myeloma | Spinocerebellar Ataxia Type 31 | Craniofacial Dysostosis | Brugada Syndrome 1 | Peeling Skin Syndrome Type B | Microcephaly | Schistosomiasis Mansoni | Hypertension | Otitis Externa | Mumps | Renal Failure | Parkinson Disease 6, Autosomal Recessive Early-onset | Amebiasis | Localized Scleroderma | Esophageal Adenocarcinoma | Adenosine Deaminase Deficiency | Rhabdomyosarcoma, Alveolar | Autonomic Nervous System Disorders | Hypoglycemia | Acute Lymphocytic Leukemia | Multiple Sclerosis, Relapsing-remitting | Noonan Syndrome | Kearns-Sayre Syndrome | Spinocerebellar Ataxia Type 7 | Ataxia-ocular Apraxia 2 | Hyperhomocysteinemia | Shock, Cardiogenic | Pulmonary Alveolar Microlithiasis | Thromboembolism | Cleidocranial Dysplasia | Erythematotelangiectatic Rosacea | Acute Lung Injury | Dominant Optic Atrophy | Poretti-Boltshauser Syndrome | Multicentric Carpotarsal Osteolysis Syndrome | Adrenal Insufficiency | Cervicitis | Myopia | Sertoli Cell-only Syndrome | Hyperbilirubinemia, Neonatal | Chorioretinitis | Benign Familial Infantile Seizures | Joubert Syndrome | Osteogenesis Imperfecta Type III | Barrett Esophagus | Congenital Torticollis | Microtia | Hodgkin Lymphoma | Diffuse Palmoplantar Keratoderma | Still Disease | Meckel-Gruber Syndrome | Exostoses | Perivascular Epithelioid Cell Tumor | Metatropic Dysplasia | Walker-Warburg Syndrome | Sialidosis Type I | Charcot-Marie-Tooth Disease Type 2D | Schnyder Crystalline Corneal Dystrophy | Polymicrogyria | Sporadic Hemiplegic Migraine | Diabetic Encephalopathy | Motion Sickness | Pilomatrix Carcinoma | VACTERL Association | Blepharophimosis Syndrome | Neovascular Glaucoma | Cryptococcal Meningitis | Protein S Deficiency | Uterine Leiomyoma | Glioma | Zollinger-Ellison Syndrome | Short-chain Acyl-CoA Dehydrogenase Deficiency | Learning Disability | Avian Influenza | Odonto-onycho-dermal Dysplasia | Oculocutaneous Albinism | Lipid Storage Diseases