Crigler-Najjar Syndrome

About the Disease
Crigler-Najjar Syndrome, Type I, also known as crigler-najjar syndrome, is related to crigler-najjar syndrome, type ii and cardiomyopathy, dilated, with hypergonadotropic hypogonadism. An important gene associated with Crigler-Najjar Syndrome, Type I is UGT1A1 (UDP Glucuronosyltransferase Family 1 Member A1), and among its related pathways/superpathways are Metabolism and Metapathway biotransformation Phase I and II. The drugs Diazepam and Gastrointestinal Agents have been mentioned in the context of this disorder. Affiliated tissues include Liver, brain and skin, and related phenotypes are jaundice and prolonged neonatal jaundice

Common Targets
Heme Oxygenase (HO) (nonspecified subtype) | UGT1A1 | HMOX1

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