Antisynthetase Syndrome

About the Disease
Antisynthetase Syndrome, also known as anti-jo1 syndrome, is related to raynaud disease and nonspecific interstitial pneumonia. An important gene associated with Antisynthetase Syndrome is EPRS1 (Glutamyl-Prolyl-TRNA Synthetase 1), and among its related pathways/superpathways are Metabolism of proteins and tRNA Aminoacylation. The drugs Prednisone and Prednisolone phosphate have been mentioned in the context of this disorder. Affiliated tissues include lung, bone and skin, and related phenotypes are muscle weakness and respiratory insufficiency

Common Targets
HLA-DRB1

Note: If you'd like to get a target analysis report for Antisynthetase Syndrome, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Antisynthetase Syndrome at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Nevus | Allan-Herndon-Dudley Syndrome | Multiple Mitochondrial Dysfunctions Syndrome Type 1 | Adenomyosis | Pre-eclampsia | Thanatophoric Dysplasia | Angioedema | Shwachman-Bodian-Diamond Syndrome | Spitzoid Melanoma | Mitochondrial DNA Depletion Syndrome, Hepatocerebral Form | Adenylosuccinate Lyase Deficiency | Impetigo | Congenital Adrenal Hyperplasia 1 | Weill-Marchesani Syndrome | Charcot-Marie-Tooth Disease, Type 2C | GLUT1 Deficiency Syndrome | Martsolf Syndrome | Chromosome 8q21.11 Deletion Syndrome | Neuromuscular Disorders | Specific Granule Deficiency | Porokeratosis | Pityriasis Rubra Pilaris | Vaginitis | Distal Myopathy 2 | Rhizomelic Chondrodysplasia Punctata | Neurofibroma | Mitochondrial Cytopathy | Spinal Muscular Atrophy Type 2 | Cryptorchidism | Botulism | Perry Syndrome | Genitopatellar Syndrome | Rolandic Epilepsy | Encephalitis, Tick-borne | Antley-Bixler Syndrome | Pulmonary Alveolar Microlithiasis | Hypervalinemia | Duodenal Atresia | Dyskeratosis Congenita | Van Der Knaap Disease | Cutaneous T-cell Lymphoma | Paraplegia | Birt-Hogg-Dube Syndrome | Gaze Palsy, Familial Horizontal, With Progressive Scoliosis, 2 | Androgen Insensitivity | Osteopathia Striata With Cranial Sclerosis | Alazami Syndrome | Meningococcal Infections | Fragile X Syndrome | Muir-Torre Syndrome | Lipodystrophy | Myositis, Focal | Fibrodysplasia Ossificans Progressiva | Avellino Corneal Dystrophy | Interstitial Lung Diseases | Chorea | Twin-to-twin Transfusion Syndrome | Idiopathic Multicentric Castleman Disease | Hypogammaglobulinemia | Polyarteritis Nodosa | Dystonia-parkinsonism, X-linked | Papillorenal Syndrome | Focal Dermal Hypoplasia | Alstrom Syndrome | Pterygium | Antenatal Bartter Syndrome Type 1 | Postpoliomyelitis Syndrome | Hepatitis, Autoimmune | Lymphoproliferative Disorders | Neuropathy | Hemorrhage | Cabezas Syndrome | Hyperferritinemia-cataract Syndrome | Nestor-Guillermo Progeria Syndrome | Craniopharyngioma | Bruck Syndrome | Chondrosarcoma | Rickets | Microcephalic Osteodysplastic Primordial Dwarfism, Type I | Cardiomyopathy, Hypertrophic | Focal Facial Dermal Dysplasia | Prolymphocytic Leukemia | HANAC Syndrome | Nemaline Myopathy 8 | Non-epidermolytic Palmoplantar Keratoderma | Creutzfeldt-Jakob Disease | Delayed Sleep Phase Syndrome | Aromatic L-amino Acid Decarboxylase Deficiency | Echinococcosis | Eclampsia | Azoospermia | Disseminated Intravascular Coagulation | Cystitis, Interstitial | Adrenoleukodystrophy, X-linked | Esophageal Carcinoma | Osteogenesis Imperfecta Type VI | Coronary Heart Disease | Costello Syndrome | Basan Syndrome | Charcot-Marie-Tooth Disease, Type 2A | GNE Myopathy | Absence Epilepsy | Cardiofaciocutaneous Syndrome | Leukoencephalopathy, Progressive Multifocal | Autonomic Nervous System Disorders | Spondylo-megaepiphyseal-metaphyseal Dysplasia | Seasonal Mood Disorder | Anodontia | Narcolepsy | Corneal Dystrophies, Hereditary | Papulopustular Rosacea | Spinocerebellar Ataxia Type 23 | Bainbridge-Ropers Syndrome | Sclerocornea | Congenital Afibrinogenemia | Kohlschutter-Tonz Syndrome | Oculopharyngeal Muscular Dystrophy | Amebiasis | Cerebrotendinous Xanthomatosis | Presbyopia | Bipolar Disorder | Creatine Deficiency Syndrome | NDH Syndrome | Gout | Vici Syndrome | Hepatitis A | Cataplexy | Precocious Puberty | Osteopetrosis | Lactose Intolerance | Angelman Syndrome | Gliosarcoma | Rhabdomyosarcoma, Alveolar | Robinow Syndrome | Nephritis, Interstitial | Thymoma, Malignant | Von Hippel-Lindau Disease | Beare-Stevenson Syndrome | Epidermodysplasia Verruciformis | MIRAGE Syndrome | Polyneuropathy | Frontotemporal Dementia With Amyotrophic Lateral Sclerosis | Microcephalic Primordial Dwarfism | Hereditary Coproporphyria | Glutathione Synthetase Deficiency | Neutrophilia | Prostatitis | Long QT Syndrome Type 3 | Ileitis | Charcot-Marie-Tooth Disease Type 2D | Asthma, Nocturnal | Benign Familial Pemphigus | Erythema Multiforme | Multiple Sclerosis, Secondary Progressive | Epicondylitis | REM Sleep Behavior Disorder | Congenital Heart Block | Nemaline Myopathy 10 | Hyperkalemic Periodic Paralysis | Familial Thoracic Aortic Aneurysm | Osteitis | Myotonia | Osteosarcoma | Trachoma | Hernia, Inguinal | Fibromyalgia | Tetraplegia | Imerslund-Grasbeck Syndrome | Glomerulonephritis, Membranous | Keratitis | Hypolipoproteinemia | Hypocalcemia | Primary Hyperoxaluria | Amish Infantile Epilepsy Syndrome | Arrhythmogenic Right Ventricular Cardiomyopathy | Cold-induced Sweating Syndrome | Familial Hypobetalipoproteinemia | Chronic Kidney Disease | Fibromuscular Dysplasia | Autoimmune Autonomic Ganglionopathy | Pancreatitis | Renal Dysplasia | Ovarian Hyperstimulation Syndrome | Abetalipoproteinemia | Postaxial Polydactyly | Bloom Syndrome | Blastoma, Pleuropulmonary | Raynaud Phenomenon | Schaaf-Yang Syndrome | Reye Syndrome | Alkaptonuria | Placenta Previa | Macular Corneal Dystrophy Type 1 | Microcephaly | Kearns-Sayre Syndrome | Brachial Plexus Neuropathy | Ornithine Transcarbamylase Deficiency | Hemorrhoids | Lymphoma, Follicular | Myotonic Disorders | Congenital Dyserythropoietic Anemia | Cancer, Kidney | Headache | NGLY1 Deficiency | Paronychia | Metachondromatosis | Pathological Gambling | Malonyl-CoA Decarboxylase Deficiency | Erdheim-Chester Disease | Arteriovenous Malformations | Pulverulent Zonular Cataract | Infantile Liver Failure Syndrome 1 | Pure Red Cell Aplasia | Prediabetes | Myelofibrosis | Common Variable Immunodeficiency | Micropenis | Adenomatoid Tumor | Adrenomyeloneuropathy | Camurati-Engelmann Disease | Gangliosidosis | Progressive Familial Intrahepatic Cholestasis Type 2 | Keratoconjunctivitis | Focal Segmental Glomerulosclerosis | Corneal Edema | Polycystic Kidney, Autosomal Dominant | Autoimmune Polyendocrine Syndrome | Lichen Planus | Progressive Osseous Heteroplasia | Spinal And Bulbar Muscular Atrophy | Asphyxia Neonatorum | Hydrops Fetalis | Congenital Mirror Movements | Schizophrenia | Anovulation | Peroxisomal Disorder | Infantile Refsum Disease | X-linked Creatine Transporter Deficiency | Diarrhea | Renal Oncocytoma | Light Chain Amyloidosis | Nail-Patella Syndrome | Cholestasis | Esophageal Motility Disorders | Camptocormia | Greenberg Dysplasia | Blepharospasm | Schistosomiasis | Early Infantile Epileptic Encephalopathy 13 | Disseminated Superficial Actinic Porokeratosis | Glioblastoma Multiforme | Chronic Periodontitis | Apert Syndrome | Hypoproteinemia, Hypercatabolic | Brachydactyly | Reticular Dysgenesis | Barakat Syndrome | Fetal Alcohol Syndrome | Hepatitis B, Chronic | Aplastic Anemia | Neuromyotonia | Gastric Atrophy | Sepiapterin Reductase Deficiency | Atrial Septal Defect | Esthesioneuroblastoma | Hereditary Spastic Paraplegia | Fibronectin Glomerulopathy | Hypothyroidism | Neurogenic Bladder | Neuroectodermal Tumors, Primitive | Osteoporosis | MELAS Syndrome | Diffuse Intrinsic Pontine Glioma | Acrocallosal Syndrome | Myeloid Leukemia | Pleurisy | Eiken Syndrome | Diabetic Encephalopathy | Pemphigoid | Aneurysm, Abdominal Aortic | Pericarditis | Autosomal Recessive Bestrophinopathy | Hamartoma | Pycnodysostosis | Aceruloplasminemia | Christianson Syndrome | Beckwith-Wiedemann Syndrome | Charcot-Marie-Tooth Disease Type 3 | Inborn Errors Of Metabolism | Hyper IgE Syndrome | Myelomeningocele | Spondylosis | Ocular Hypertension | Skin Carcinoma | Superficial Spreading Melanoma | Alpers Syndrome | Argininosuccinic Aciduria | Congenital Generalized Lipodystrophy | Onchocerciasis | TARP Syndrome | Rift Valley Fever | Bacterial Meningitis | Gestational Trophoblastic Disease | Thin Basement Membrane Disease | Rhabdomyosarcoma, Embryonal | Glaucomatocyclitic Crisis | Autosomal Recessive Spastic Paraplegia Type 35 | Sporadic Hemiplegic Migraine | Leukocyte Adhesion Deficiency Type 1 | Tricho-hepato-enteric Syndrome | T-cell Lymphoma, Subcutaneous Panniculitis-like | Paracoccidioidomycosis | Hemosiderosis | Hereditary Hemorrhagic Telangiectasia Type 2 | Pseudohermaphroditism | Cerebellar Ataxia, Cayman Type | Spinocerebellar Ataxia Type 8 | Acrodysostosis | Urolithiasis | Odonto-onycho-dermal Dysplasia | Amyotrophic Lateral Sclerosis | Lysosomal Acid Lipase Deficiency | Keloid | Mycosis Fungoides | Spondylolisthesis | Congenital Lipoid Adrenal Hyperplasia | Congenital Disorders Of Glycosylation Type II | Gastritis | Crimean-Congo Hemorrhagic Fever | Language Disorders | Congenital Dysfibrinogenemia | Congenital Primary Aphakia | Lymphomatoid Granulomatosis | Lymphoma | Pemphigus | H Syndrome | Cervicitis | Neurofibromatosis-Noonan Syndrome | Stuttering | Retinitis Pigmentosa 3 | Sandhoff Disease | Tonsillitis | Trismus-pseudocamptodactyly Syndrome | Mastitis | Borderline Personality Disorder | McLeod Syndrome | Loeys-Dietz Syndrome | Danon Disease | Photosensitivity | Alpha-thalassemia Myelodysplasia Syndrome | Chromosome 9q34.3 Deletion Syndrome | Chordoid Glioma | Lesch-Nyhan Syndrome | Epilepsy | Thrombophilia | Atrioventricular Septal Defect | Glycogen Storage Disease Type 0, Muscle | Constipation | Tremor | Uremic Pruritus | VACTERL Association | Varices | Porphyria, Variegate | Myasthenia Gravis | Macrodactyly | Hypertensive Nephropathy | Dystrophy, Cone-rod | Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia | Panuveitis | CDKL5 Deficiency Disorder | Lattice Corneal Dystrophy Type 1 | Creatine Deficiency Syndrome Due To AGAT Deficiency | Bulimia Nervosa | Spinocerebellar Ataxia Type 13 | Woodhouse-Sakati Syndrome | Pyruvate Dehydrogenase Deficiency | Veno-occlusive Disease | Nance-Horan Syndrome | Thyroid Hormone Resistance | Hemolytic Anemia | Renal Tubular Dysgenesis | Adenoma, Pituitary | Plasma Cell Leukemia | Hyperlipidemia, Familial Combined | Oligodendroglioma | Babesiosis | Holoprosencephaly | Enterocolitis, Necrotizing | Retinal Diseases | Cardiac Arrest | Hereditary Spherocytosis | Hemorrhagic Disorders | Bartter Syndrome | Osteoglophonic Dysplasia | Vogt-Koyanagi-Harada Syndrome | Plasmacytoma | Sickle Cell Disease | Enlarged Vestibular Aqueduct | Hyperostosis | Shprintzen-Goldberg Syndrome