Antisynthetase Syndrome

About the Disease
Antisynthetase Syndrome, also known as anti-jo1 syndrome, is related to raynaud disease and nonspecific interstitial pneumonia. An important gene associated with Antisynthetase Syndrome is EPRS1 (Glutamyl-Prolyl-TRNA Synthetase 1), and among its related pathways/superpathways are Metabolism of proteins and tRNA Aminoacylation. The drugs Prednisone and Prednisolone phosphate have been mentioned in the context of this disorder. Affiliated tissues include lung, bone and skin, and related phenotypes are muscle weakness and respiratory insufficiency

Common Targets
HLA-DRB1

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