Chronic Kidney Disease

About the Disease
Chronic Kidney Disease, also known as chronic renal disease, is related to kidney disease and end stage renal disease, and has symptoms including cloudy (hemodialysis) (peritoneal) dialysis effluent An important gene associated with Chronic Kidney Disease is COL4A4 (Collagen Type IV Alpha 4 Chain), and among its related pathways/superpathways are Signal Transduction and Primary focal segmental glomerulosclerosis (FSGS). The drugs Chlorhexidine and Fosinopril have been mentioned in the context of this disorder. Affiliated tissues include Bone and Adipose, and related phenotypes are homeostasis/metabolism and renal/urinary system

Common Targets
SLC6A16 | G9429 | HAMP | FLT1 | HTR1F | NOS1 | UMODL1 | KIAA1549L | SLC7A9 | KEAP1 | BMP4 | PNPLA3 | G3569 | ALOX5AP | GH1 | G23411 | CASR | IREB2 | LPAR1 | FFAR1 | G3630 | TBX1 | mTOR complex 1 | HDAC8 | FAM78B | DAZAP1 | HLA-A | CLCNKB | MAP3K5 | RNF121 | Phosphodiesterase 1 (PDE1) (nonspecified subtype) | SOS2 | PRKCA | VARS1 | COL4A1 | TTC21B | UBE2Q2 | COL4A5 | APLNR | G7124 | LINC02511 | CHRNB4 | ILF3 | BRD2 | CYP1A1 | TRPC5 | Integrin-linked kinase (nonspecified subtype) | CTSS | TGFBR1 | NOS3 | CERT1 | VKORC1 | PAX2 | IL1B | BANP | G367 | INHBA-AS1 | HMOX2 | ADORA2A | GSTT1 | VPS52 | SCNN1A | MMP12 | TNFSF11 | NPHP4 | HSD11B1 | DAB2 | CCR2 | SOST | GCK | CDKAL1 | JARID2 | XDH | NPHS2 | SLC22A12 | NUP93 | SYNPO2 | GLI3 | ZFP36L1 | ITGA8 | CTSL | CCN2 | AKR1B1 | PPARD | KLB | PDE1C | PDE9A | CEP83 | PDK2 | PCSK9 | FAN1 | ILK | PARVA | SALL1 | EYA1 | EGFEM1P | ANKS6 | SLC9A3 | NCAM2 | KCNJ1 | DCUN1D2 | LARP4B | ELMO3 | AQP11 | PGAM5-KEAP1-NRF2 Complex | WDR37 | G7015 | MUC1 | TP63 | PIP5K1B | NR1H4 | TMPRSS6 | KITLG | ALPK1 | NAT1 | RAMP2 | ITGB2 | UBE2Z | TGM2 | TGFA | SHROOM3 | CYP24A1 | UPK3A | CLU | DACH1 | PLCE1 | GALNT2 | Histone acetyltransferase (HAT) (nonspecified subtype) | NF-kappaB (NFkB) | CARS2 | PRKAG2 | FAM81A | GCKR | WNK4 | LOC105371097 | PRPF8 | ADD1 | ATXN7L1 | TLR9 | GIPR | IDI2 | RAMP1 | PKHD1 | AGTR1 | RNF128 | IQSEC1 | RXFP1 | MME | HYKK | TBX3 | CYP3A5 | FKBP5 | TRPC6 | DOK6 | NOS2 | DDAH1 | JAG1 | MT2A | RAMP3 | PRKCD | ELMO1 | DDR1 | GSTM1 | COL4A2 | Heme Oxygenase (HO) (nonspecified subtype) | ROCK2 | POSTN | WFS1 | CALCA | NLRP3 Inflammasome | AQP2 | CYP1A2 | NFKBIB | CHIA | QPCTL | CALCRL | JAZF1 | PEX11G | G114548 | TYSND1 | LOC101928219 | G196 | FABP5 | ANKRD11 | LOC100130587 | CAPN1 | PTP4A3 | HNF1A | GPR84 | APOE | SLC6A19 | PRKCB | CHRNA3 | VNN1 | BTN2A1 | CHUK | MAP2K2 | WT1 | FANCI | CYP2C9 | LOC105378178 | LTBP1 | CDKN1B | FGF23 | CSRNP1 | G7099 | PHACTR3 | PDE1B | LOXL2 | TGFB1 | EPOR | Integrin alphavbeta6 receptor | RNF186 | C3 | PTH | BMP6 | LINC01081 | LDHA | LSS | AGER | PTPRN2 | LMNTD1 | HIPK2 | G596 | CUX1 | TONSL | FTO | IL6R | CELA1 | DYNC2H1 | Nitric oxide synthase (NOS) (nonspecified subtype) | AGTR2 | CFAP298 | MCM2 | LINC01241 | SLC34A1 | UMOD | FIGN | PTH1R | GLP1R | C2CD3 | KL | APOL1 | IL1RL2 | KLF15 | Hypoxia-Inducible Factor Prolyl Hydroxylase (nonspecified subtype) | CRISPLD2 | EGLN1 | TFDP2 | CYP11B2 | C10orf105 | HMOX1 | COL4A3 | NQO1 | NLRP1 | CLCN5 | Voltage-Gated Calcium Channel alpha-2/delta (nonspecified subtype) | Soluble guanylyl cyclase | C21orf58 | G2069 | CRP | NAT8 | SEMA3A | LOC105372178 | Endothelin receptor (nonspecified subtype) | HLA-DRB1 | ZSCAN29 | ACE | TCF7L2 | MYCN | HNF1B | SLC34A2 | AMP-activated protein kinase (AMPK) | ABCB11 | CISD1 | USP40 | CHRNA4 | OCRL | REN | EPAS1 | PDILT | TNRC18 | LDB2 | G2475 | G4780 | CHRNB2 | PRKCE | Integrin alphavbeta8 Receptor | DDAH2 | SLC30A8 | TGFB3 | FABP4 | CHRNA6 | EDNRA | AGXT | KDM4B | PPARGC1A | CMA1 | LGALS1 | AHSG | GATM | GRK2 | TUBGCP4 | LRRFIP1 | CRHR2 | CDH23 | LRP8 | Phosphodiesterase (nonspecified subtype) | NGF | LOC101928462 | ATXN2 | NPR2 | PDE1A | HLA-B | EGLN2 | COL4A4 | NNMT | GALNT9 | EXOC3 | LDLR | G207 | FRMD1 | SLC8A1 | ACER1 | ENPP2 | IFT140 | TERC | PPARG | DNA Methyltransferase (DNMT) (nonspecified subtype) | TFCP2L1 | INF2 | CYBA | PPARA | CCDC186 | FREM2 | SLC5A2 | SLC47A1 | MTHFR | ZIK1 | CPM | ITGAM | AVPR1A | mu-Calpain (calpain 1) | GLA | BSND | SEC61A1 | NR3C2 | RASAL1 | RIPK2 | WDR46 | CHRNA5 | FGFR3 | G5243 | HCK | CNEP1R1 | NALF1 | NPHP1 | NR3C1 | TNFRSF11B | IBSP | EGLN3 | LHPP | CNR1 | FBN1 | DNMT3A | C5 | TP53BP2 | MYH9 | EXOC4 | GSR | TTR | NPHS1 | STK24 | PROKR2 | EPHX2 | BRD4 | CNTN5 | BBS9 | G1026 | ITGB8 | PLCB4 | SLC3A1 | CRADD | Integrin alphaMbeta2 (MAC-1) Receptor | AGT | ACHE | SLC25A45 | BAHCC1 | CHRNB3 | LGALS3 | TCF3

Note: If you'd like to get a target analysis report for Chronic Kidney Disease, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Chronic Kidney Disease at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

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