Myhre Syndrome

About the Disease
Myhre Syndrome, also known as laryngotracheal stenosis, arthropathy, prognathism, and short stature, is related to ruvalcaba churesigaew myhre syndrome and cowden syndrome 1, and has symptoms including thick skin An important gene associated with Myhre Syndrome is SMAD4 (SMAD Family Member 4). Affiliated tissues include heart, skin and small intestine, and related phenotypes are intellectual disability and hearing impairment

Common Targets
G4089 | POLE | PMS2

Note: If you'd like to get a target analysis report for Myhre Syndrome, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Myhre Syndrome at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Beta-Propeller Protein-associated Neurodegeneration | Acute Myeloid Leukemia | Hyperkeratosis | Leukemia | Chromosome 8q21.11 Deletion Syndrome | Antenatal Bartter Syndrome Type 1 | Zollinger-Ellison Syndrome | Amebiasis | Fibrosis | 3-hydroxy-3-methylglutaryl-CoA Synthase Deficiency | Micropenis | Charcot-Marie-Tooth Disease Type 2D | Cherubism | Tinea | Homocystinuria | Benign Familial Pemphigus | Pregnancy, Ectopic | GATA2 Deficiency | Pompe Disease | Hypokalemic Periodic Paralysis | Cutaneous Angiosarcoma | Anorectal Malformations | Chordoma | Leber Hereditary Optic Neuropathy | Cri-du-chat Syndrome | Pityriasis Rubra Pilaris | Myelofibrosis | DICER1 Syndrome | Heavy Chain Disease | Esophagitis | Unverricht-Lundborg Syndrome | Lymphoma Lymphoblastic | Waardenburg Syndrome | Osteonecrosis Of The Jaw | ADNP Syndrome | Ischemia | Autonomic Nervous System Disorders | Lymphedema-distichiasis Syndrome | Major Depression | Werner's Syndrome | Malignant Fibrous Histiocytoma | Albinism | Netherton Syndrome | Angioedema | Aneurysm, Abdominal Aortic | Bleeding Disorder Due To CalDAG-GEFI Deficiency | Brooke-Spiegler Syndrome | Rhabdomyosarcoma, Embryonal | Familial Male-limited Precocious Puberty | Meningococcal Meningitis | Bartsocas-Papas Syndrome | Sturge-Weber Syndrome | Mastitis | Combined Malonic And Methylmalonic Acidemia | Hypothyroidism | Hypoglycemia | Leukoplakia | MIRAGE Syndrome | Hyperinsulinemia | Nail Disorder, Nonsyndromic Congenital | Arts Syndrome | Stroke, Hemorrhagic | Pulverulent Zonular Cataract | Neurotoxicity | Carcinoma In Situ | Alazami Syndrome | Amblyopia | Ehlers-Danlos Syndrome | Corneal Dystrophies, Hereditary | Guanidinoacetate Methyltransferase Deficiency | Rash | Coronary Restenosis | Polycystic Ovary Syndrome | Eczema | Usher Syndrome Type II | Gigantism | Hyperlipidemia Type V | Down Syndrome | Seborrheic Dermatitis | Oligoasthenoteratozoospermia | Xeroderma Pigmentosum | Leri-Weill Dyschondrosteosis | Brugada Syndrome 1 | Carcinoma, Small Cell | Alpha-1 Antitrypsin Deficiency | Oguchi Disease-2 | Paraplegia | Hypertension, Essential | Glycogen Storage Disease Type 1b | Niemann-Pick Disease | Congenital Lipoid Adrenal Hyperplasia | Gangliosidosis, GM1 | Corneal Edema | Pterygium | Hypomyelination With Atrophy Of Basal Ganglia And Cerebellum | Meleda Disease | Angina Pectoris | Necrotizing Autoimmune Myopathy | Reflex Epilepsy | Warsaw Breakage Syndrome | Non-Langerhans Cell Histiocytosis | Sleep Disorder | Lymphoma, Mantle Cell | Waardenburg Syndrome Type 2A | Oculocutaneous Albinism Type 4 | Spinocerebellar Ataxia Type 12 | Chronic Kidney Disease | Crohn's Disease | Cysticercosis | Inflammatory Linear Verrucous Epidermal Nevus | Tumoral Calcinosis | Best Macular Dystrophy | Prolactinoma | Facioscapulohumeral Muscular Dystrophy Type 2 | Basal Ganglia Disease, Biotin-responsive | Turner's Syndrome | Intestinal Hypomagnesemia 1 | Sleep Apnea | Metabolic Syndrome | Gastric Atrophy | Blue Rubber Bleb Nevus Syndrome | Aspergillosis | Kearns-Sayre Syndrome | Castleman Disease | Chronic Granulomatous Disease, X-linked | Congenital Stromal Corneal Dystrophy | Lymphomatoid Granulomatosis | Miyoshi Myopathy | Nephrotic Syndrome | Prediabetes | Myhre Syndrome | Microcephaly, Seizures, And Developmental Delay | Peeling Skin Syndrome, Acral Type | Hemochromatosis Type 2 | Hypercholesterolemia | Apparent Mineralocorticoid Excess Syndrome | Primary Cutaneous Amyloidosis | Usher Syndrome Type III | Erectile Dysfunction | Amyotrophic Lateral Sclerosis-parkinsonism-dementia Complex | Congenital Heart Block | Botulism | Polycythemia | Treacher Collins Syndrome | Sjogren Syndrome | Malignant Peripheral Nerve Sheath Tumor | Hypertension, Renal | Bladder Exstrophy | Inflammatory Bowel Disease | Pancytopenia | Hernia, Inguinal | Charcot-Marie-Tooth Disease Type 2T | Charcot-Marie-Tooth Disease Type 4B1 | Polyarteritis Nodosa | Hemochromatosis | Smith-Magenis Syndrome | Reye Syndrome | Thalassemia, Beta | Potocki-Shaffer Syndrome | Influenza | Sarcoma, Alveolar Soft Part | Impetigo | Spasticity | Asthma, Nocturnal | Gallstones | Eclampsia | Osteosclerosis | VACTERL Association | Long QT Syndrome Type 2 | X-linked Charcot-Marie-Tooth Disease | Heterotopic Ossification | Infantile Neuroaxonal Dystrophy | Endocarditis | Celiac Disease | Priapism | Sorsby Fundus Dystrophy | Necrobiosis Lipoidica | Obsessive-compulsive Disorder | Tricho-hepato-enteric Syndrome | Hydronephrosis | Chorioretinitis | Platyspondylic Lethal Skeletal Dysplasia, Torrance Type | Coffin-Siris Syndrome | Fetal Alcohol Syndrome | Acromicric Dysplasia | Conjunctivitis | Anti-NMDA Receptor Encephalitis | Paroxysmal Kinesigenic Dyskinesia | PHARC Syndrome | Demyelinating Diseases | Porphyria, Variegate | Azoospermia | Congenital Afibrinogenemia | Mabry Syndrome | T-cell Prolymphocytic Leukemia | Lipid Metabolism Disorders | Hypercalcemia | Herpes Genitalis | Ependymoma | Proximal Symphalangism | Myoclonus-dystonia Syndrome | Xeroderma Pigmentosum Variant Type | Pulmonary Veno-occlusive Disease | Dwarfism | Hepatitis, Autoimmune | Charcot-Marie-Tooth Disease Type 3 | Relapsing Polychondritis | Long QT Syndrome Type 3 | Alkaptonuria | Macular Corneal Dystrophy | Pontocerebellar Hypoplasia Type 7 | Hereditary Folate Malabsorption | Myeloid Leukemia | Glaucoma, Congenital | Cholecystitis | Speech Disorders | Rheumatic Heart Disease | Chorea-acanthocytosis | Transthyretin-related Amyloidosis | Sezary Syndrome | Progressive Familial Intrahepatic Cholestasis | Pseudoachondroplasia | Sensory Ataxic Neuropathy, Dysarthria, And Ophthalmoparesis | Beckwith-Wiedemann Syndrome | Otopalatodigital Syndrome Type 2 | MELAS Syndrome | Granular Corneal Dystrophy Type 1 | Spinocerebellar Ataxia Type 10 | Irritable Bowel Syndrome | Intestinal Obstruction | Fibrillation, Atrial | Aromatic L-amino Acid Decarboxylase Deficiency | Cryopyrin-associated Periodic Syndromes | Pericarditis | Purpura, Thrombotic Thrombocytopenic | Birk-Barel Syndrome | Pyoderma Gangrenosum | Myelitis, Transverse | Autosomal Recessive Spastic Paraplegia Type 35 | Adenosine Deaminase 2 Deficiency | CREST Syndrome | Cancer, Brain | Chronic Beryllium Disease | Insulinoma | Poirier-Bienvenu Neurodevelopmental Syndrome | Schwartz-Jampel-Aberfeld Syndrome | Adenocarcinoma | Kaposiform Hemangioendothelioma | Pilomatrix Carcinoma | Craniopharyngioma | Low Phospholipid Associated Cholelithiasis | Congenital Nephrotic Syndrome | Noonan Syndrome | Canavan Disease | Antithrombin III Deficiency | Pseudohypoaldosteronism | Nail-Patella Syndrome | Pneumonia, Mycoplasma | Tularemia | Primrose Syndrome | Short-chain Acyl-CoA Dehydrogenase Deficiency | Spinocerebellar Ataxia Type 20 | Cellulitis | Monilethrix | Pulmonary Stenosis | Osteogenesis Imperfecta | Inborn Errors Of Metabolism | Premature Ejaculation | Insulin Resistance | Spinocerebellar Ataxia Type 17 | Babesiosis | Lamellar Ichthyosis | Coronary Artery Disease | Cystinosis | Walker-Warburg Syndrome | Metaphyseal Chondrodysplasia, Schmid Type | Diabetes Insipidus, Nephrogenic | Hemangioma | Chylomicron Retention Disease | Cavitary Optic Disc Anomalies | X-linked Myotubular Myopathy | Kallmann Syndrome | Polyradiculopathy | Spinocerebellar Ataxia Type 38 | CHOPS Syndrome | Familial Retinal Arterial Macroaneurysm | Anovulation | Hemosiderosis | Hypophosphatasia | Osteogenesis Imperfecta Type II | Open-angle Glaucoma | Nemaline Myopathy 8 | Meningioma | Chronic Thromboembolic Pulmonary Hypertension | Muscle Wasting | Saethre-Chotzen Syndrome | Essential Fructosuria | Gerodermia Osteodysplastica | Rickets | Motor Neuron Diseases | Tardive Dyskinesia | WAGR Syndrome | Congenital Torticollis | Dystonia-parkinsonism, X-linked | Hyperthyroidism | Ameloblastoma | Depression | Acrodermatitis | Spondyloepiphyseal Dysplasia Tarda, X-linked | Meier-Gorlin Syndrome | Diamond-Blackfan Anemia | Diverticulitis | Dengue Shock Syndrome | Non-Hodgkin Lymphoma | Muckle-Wells Syndrome | Rotor Syndrome | Vascular Cognitive Impairment | Gastroenteritis | Hyperphenylalaninemia | Angiosarcoma | Polyneuropathy | Coffin-Lowry Syndrome | Autism Spectrum Disorders | Schnyder Crystalline Corneal Dystrophy | Feingold Syndrome | Schindler Disease | Tic Disorder | Porencephaly | Achondrogenesis | Fatty Aldehyde Dehydrogenase Deficiency | Oligoastrocytoma | Mevalonate Kinase Deficiency | Myopia | Schwannomatosis | Kawasaki Disease | Pitt-Hopkins Syndrome | Diastrophic Dysplasia | Creutzfeldt-Jakob Disease | Jaundice, Obstructive | Cramp Fasciculation Syndrome | Thromboembolism | Hypotension, Orthostatic | Spitzoid Melanoma | Glycogen Storage Disease Type 4 | Eosinophilic Asthma | Non-small Cell Lung Cancer | Encephalocele | Retinal Coloboma | Lysosomal Acid Lipase Deficiency | Duane Retraction Syndrome | Multiple Sclerosis, Secondary Progressive | Stomatitis | Prostatitis | Beare-Stevenson Syndrome | Idiopathic Multicentric Castleman Disease | Persistent Hyperplastic Primary Vitreous | Localized Scleroderma | Macrodactyly | Gnathodiaphyseal Dysplasia | Impulse Control Disorder | Toxic Epidermal Necrolysis | Focal Segmental Glomerulosclerosis | Progressive Encephalopathy-optic Atrophy Syndrome | Cutaneous Lupus Erythematosus | Odonto-onycho-dermal Dysplasia | Cataplexy | Dubin-Johnson Syndrome | Hypogammaglobulinemia | Neutropenia | Early Infantile Epileptic Encephalopathy 4 | Exocrine Pancreatic Insufficiency | Sleep Apnea, Obstructive | Cold Agglutinin Disease | Chudley-McCullough Syndrome | Dyggve-Melchior-Clausen Disease | Gingivitis | Nevus | Persistent Fetal Circulation | Lewy Body Dementia | Sialoadenitis | T-cell Chronic Lymphocytic Leukemia | Cluster Headache | Hypospadias | Hereditary Spastic Paraplegia | Cutaneous Mastocytosis | Acute Motor Axonal Neuropathy | Fibronectin Glomerulopathy | Neurodegeneration Due To Cerebral Folate Transport Deficiency | Hodgkin Lymphoma | Polycystic Kidney, Autosomal Dominant | Microphthalmia | Proopiomelanocortin Deficiency | Nicolaides-Baraitser Syndrome | Diabetic Neuropathy | Wolfram Syndrome 2 | Urticaria | Neurocutaneous Melanocytosis | Lymphoma, Primary Cutaneous Anaplastic Large Cell | Glutathione Synthetase Deficiency | Hypertension, Pulmonary