Atrial Fibrillation

About the Disease
Atrial Fibrillation, also known as a fib - [atrial fibrillation], is related to stroke, ischemic and mitral valve stenosis, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Atrial Fibrillation is SCN5A (Sodium Voltage-Gated Channel Alpha Subunit 5), and among its related pathways/superpathways are Neuropathic Pain-Signaling in Dorsal Horn Neurons and G-Beta Gamma Signaling. The drugs Hydroxychloroquine and Isoprenaline have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and atrioventricular node, and related phenotypes are no effect and no effect

Common Targets
IKBKB | XPO7 | G5243 | KCNN3 | G59272 | MAOA | ADCY7 | NUCKS1 | ELOA2 | AGT | Alpha-2 Adrenergic receptors (nonspecified subtype) | MIR31 | GATA4 | HDAC1 | KNL1 | HCN4 | THRB | FRMD4B | KCNAB2 | TTYH2 | HMGCR | Tubulin | KCND3 | LINC02576 | G9429 | ACHE | GABA(A) receptor | Voltage-gated K(v) channel (nonspecified subtype) | WNT8A | G23411 | LINC01426 | ADAMTS13 | ADORA1 | SYNE2 | LINC01629 | NFKB2 | G4318 | EFHD1 | GTF2I | Voltage-Gated Sodium Channel Complex | CDC42BPG | ASB13 | CYP21A2 | TRPC5 | VKORC1 | LRMDA | MYO18B | KIF7 | TNFSF13 | CTC1 | ADAT1 | NMNAT3 | RyR2/FKBP12.6 Complex | TNFSF11 | MCM10 | F2 | HTR4 | Sodium channel (nonspecified subtype) | CSPG4 | AKAP6 | KCNK1 | NOS3 | ABCA1 | FBRSL1 | DPP4 | Kir 3.1/3.4 | SYNPO2L | CD44 | ASAH1 | F10 | PALLD | CD96 | G3480 | SLC18A3 | TNFSF12 | CTDSP2 | REEP3 | Small Conductance Calcium-Activated Potassium Channel (SK) (nonspecified subtype) | alpha-Adrenoceptor (nonspecified subtype) | Glutamate Transporter (nonspecified subtype) | MGAT5 | XDH | CASQ2 | LOC101927942 | HNRNPC | CACNA1C | SERPINE1 | GMCL1 | GJA5 | KCNK2 | CACNB2 | GYPC | G protein-Coupled Inwardly-Rectifying Potassium Channel (GIRK) (nonspecified subtype) | JMJD1C | G836 | TNFSF12-TNFSF13 | FLT3 | ALPK1 | MEX3C | Gap junction Connexin ( (nonspecified subtype) | SHOX2 | KLF17 | KIF15 | PIEZO1 | ZFHX3 | XXYLT1 | SMAD7 | Mitogen-Activated Protein Kinase (nonspecified subtype) | WDR27 | HTR2A | SLAMF7 | GCOM1 | PRKAG2 | RYR2 | IMPDH1 | GATA2 | CUL4A | NAV2 | ADRB1 | EPHA3 | TTN-AS1 | LOC105377979 | KIF3C | PRRX1 | SNX19 | NPPA | FANCL | KCNA5 | IL27 | MFSD1 | KCNE1 | VPS13D | CAV1 | FCMR | KCNC3 | ADGRV1 | AGTR1 | KCNJ3 | SPATC1L | ANXA4 | NPPA-AS1 | CTSA | beta-Adrenoceptor (nonspecified subtype) | SLC22A25 | ABCC8 | LHX3 | P2RY12 | SOX5 | USP32 | LOC105369698 | ARHGAP8 | PPFIA4 | ABCC9 | GATA5 | CMYA5 | PDE4DIP | FOXN3 | FASLG | GTF2I-AS1 | G5747 | ZNF25 | ERBB4 | SCN9A | KCNK3 | NACA | LINC01681 | CEP152 | RTKN2 | NLRP3 Inflammasome | KCNJ5 | TBX5 | MYL4 | TMX4 | KCNQ1 | TTN | G114548 | CYP2C9 | SOAT1 | MIR146A | Heat shock protein 70 (nonspecified subtype) | TUBA8 | APOE | KLHL3 | PGP | DNAH17 | RBM20 | HERC1 | NEURL1 | STEAP1B | KCNE3 | ARHGAP10 | PLA2G4E | LMNA | TEX41 | MYOCD | SYNPO2L-AS1 | CAMK2D | RORB | SCN3B | KCNE4 | BRWD1 | KCNK9 | GRK5 | CRYAB | ENPEP | MDN1 | F11 | TGFB1 | USP34 | IL6R | FTO | AOPEP | Serine-aspartate repeat-containing protein I-like | KLKB1 | MYH6 | CYTH1 | Potassium Channels (nonspecified subtype) | SLC4A4 | NUP155 | ABHD17C | HIP1R | FAF1 | NPR1 | SALL4 | Adrenoceptor (nonspecified subtype) | KCNE2 | DSC2 | HELZ | CYP4F2 | BAHD1 | TP53INP1 | SLC6A3 | CYP11B2 | SNAPC1 | Gap Junction Protein (nonspecified subtype) | OPN1SW | HMOX1 | PLCXD2 | ATXN1 | KCNS3 | SCN5A | SPATS2L | PPP2R3A | SDHA | CRP | KCNH1 | MAOB | ITPK1 | CRAMP1 | FBXO32 | KCNA1 | GJD2 | PKD2L2 | CCDC71 | LOC105374778 | DGKB | ACE | CAND2 | ALPK2 | TENM4 | CREB5 | MYZAP | NFKB1 | PKP2 | UTP4 | GML | NLRX1 | NEXN | Calcium/calmodulin-dependent protein kinase type II (CaMK-II) | MPO | SLC35F1 | SCMH1 | MicroRNA 4532 | EPN1 | KCNN1 | LOC102723321 | BEST3 | DPF3 | NGF | CCDC168 | CUX2 | ZPBP2 | LY96 | TMEM245 | KCNIP1 | N4BP2 | CAV3 | FREM2 | SLIT3 | F8 | CDK6 | CP | Na+/Ca2+ Exchanger (NCX) (nonspecified subtype) | RPL3L | SLC5A2 | KCNN2 | KDM1B | WNT3 | DES | APEH | LRIG1 | SCN10A | NR3C2 | NTF3 | PPARA | Calcium channel (nonspecified subtype) | PITX2 | AGBL4 | NEBL | KCNH2 | LOC107986203 | CTBP2 | SSPOP | DNAAF3 | SLC9B1 | DLGAP1 | SETD7 | CASZ1 | TUBB3 | L-type voltage-dependent calcium channel complex | URB2 | SH3PXD2A | XIRP2 | PRIMPOL | ADRA1A | TTR | G1026 | CEP68 | OR4X2 | KCNA3 | HAND2 | EPHX2

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