Dermatomyositis

About the Disease
Dermatomyositis, also known as amyopathic dermatomyositis, is related to inclusion body myositis and interstitial lung disease, and has symptoms including exanthema and pruritus. An important gene associated with Dermatomyositis is RN7SL1 (RNA Component Of Signal Recognition Particle 7SL1), and among its related pathways/superpathways are miRNAs involvement in the immune response in sepsis and miRNAs involved in DNA damage response. The drugs Pirfenidone and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include muscle, skin where a skin rash is often seen prior to the onset of muscle weakness and skin, and related phenotypes are autoimmunity and emg abnormality

Common Targets
Lipoxygenase (nonspecified subtype) | IL1B | ERBB3 | IL17RA | IFNB1 | GLIS3 | IL10 | PSMB9 | SYK | G3605 | G7015 | MC2R | RASGRP3 | ATG16L1 | CD86 | TLR9 | JAK2 | MS4A1 | Interleukin-12 (IL-12) | CTSG | CXCL12 | STAT4 | LILRA4 | SLC15A4 | JAK1 | TNFAIP3 | JAK3 | MBL2 | BLK | MIR146A | PRTN3 | IRF5 | ANKRD55 | HLA-DQB1 | CD80 | Immunoproteasome | HLA-DPB1 | S1PR5 | IL12A | IFIH1 | STING1 | GLP1R | ALB | S1PR1 | TLR7 | HLA-DRB1 | PSMB8 | ELANE | CNR2 | ARHGAP31 | RORC | Phosphodiesterase IV (PDE4) (nonspecified subtype) | IL12B | TLR8 | Interleukin 23 complex (IL-23) | TYK2 | G2099 | G5743 | C5 | G3569 | IL2RA | G7852 | G7124

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