Colitis

About the Disease
Colitis is related to ulcerative colitis and inflammatory bowel disease 1. An important gene associated with Colitis is SYK (Spleen Associated Tyrosine Kinase), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Magnesium citrate and Doxycycline have been mentioned in the context of this disorder. Affiliated tissues include colon, bone marrow and t cells, and related phenotypes are no effect and no effect

Common Targets
CSF1R | Integrin alpha4beta1 (VLA-4) receptor | F2RL1 | CNR2 | Integrin alphavbeta3 (vitronectin) receptor | PADI4 | MYD88 | SLIT2 | Protein Kinase B (PKB/Akt) (nonspecified subtype) | CCR6 | G7124 | TYK2 | FKBP1A | CYSLTR1 | Folate Receptor (nonspecified subtype) | Integrin-linked kinase (nonspecified subtype) | G7295 | TYR | TRPM8 | Lipoxygenase (nonspecified subtype) | MAOA | SLC7A5 | BRD4 | SOST | PPARG | DHODH | DNA Topoisomerase II (nonspecified subtype) | C-X-C Chemokine Receptor CXCR1/CXCR2 (IL-8 Receptor) (nonspecified subtype) | PPP3R2 | TRPC5 | IL-1 Receptor (nonspecified subtype) | SLC3A2 | ILK | TRPV1 | G23411 | Integrin alpha4beta7 (LPAM-1) receptor | PTGS1 | FPR1 | PPP3CC | SSTR3 | CD14 | CD44 | TRPV2 | DYRK1A | PIM3 | IL34 | Glutamate Transporter (nonspecified subtype) | NEUROG1 | NR1I2 | KCNN4 | NAT1 | CD2 | G999 | SOD2 | CCR2 | NR3C1 | HPGD | Voltage-Gated Sodium Channel Complex | GPR4 | MOSPD2 | G5743 | G3630 | XDH | KLRK1 | FLNA | SELP | Interleukin-12 (IL-12) | TLR2 | PDPK1 | MIR124-1 | G5243 | NR1H4 | Mitogen-Activated Protein Kinase (nonspecified subtype) | SSTR4 | Sodium channel (nonspecified subtype) | ACVR1 | CCR8 | IL10 | FDPS | FAAH | MIR124-2 | CALCRL | GPIHBP1 | TGFB2 | KLRC4-KLRK1 | PIM1 | G196 | GPR151 | NMDA receptor | TLR9 | NLRC4 | TRPA1 | Janus Kinase (nonspecified subtype) | MIR124-3 | IL1B | PROKR1 | GAA | TACR1 | MIR214 | MEP1A | APOA1 | G3569 | HAVCR2 | Glutaminase (nonspecified subtype) | AGTR1 | SSTR5 | PPP3CB | NAMPT | CDX1 | MEP1B | NT5E | PPP3R1 | CYP19A1 | MIF | TNFSF15 | NLRP3 Inflammasome | STING1 | Hypoxia-Inducible Factor Prolyl Hydroxylase (nonspecified subtype) | AGER | JAK3 | JAK2 | CMKLR1 | JAK1 | GAD1 | G3576 | CTNNB1 | KRR1 | G114548 | BMPR1A | MADCAM1 | G596 | NF-kappaB (NFkB) | RIPK1 | S1PR1 | LTA4H | IL18 | IL23R | PRKCE | HRH4 | SCN5A | MCHR1 | IL22RA1 | FBXW7 | MIR1247 | EGLN2 | LY96 | LTB4R | MIR148A | IL-23 receptor complex | PDE4D | GAD2 | RORC | HDAC6 | TGFB1 | FAP | AMP-activated protein kinase (AMPK) | G7099 | Protein Phosphatase 2B | ITGB7 | CDH13 | GPBAR1 | CEACAM5 | Protein farnesyltransferase | IL1RN | Protein Phosphatase 2A | PROKR2

Note: If you'd like to get a target analysis report for Colitis, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Colitis at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

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