Progressive Multifocal Leukoencephalopathy

About the Disease
Progressive Multifocal Leukoencephalopathy, also known as leukoencephalopathy, progressive multifocal, is related to acquired immunodeficiency syndrome and demyelinating disease. An important gene associated with Progressive Multifocal Leukoencephalopathy is ITGA4 (Integrin Subunit Alpha 4), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. The drugs Teriflunomide and Natalizumab have been mentioned in the context of this disorder. Affiliated tissues include brain, t cells and bone marrow, and related phenotypes are immunodeficiency and functional motor deficit

Common Targets
G9429 | BCR | NDUFV2 | G6772 | HTR2A | PDGFRA | CCR5 | KIT | ABL1 | CSF1R | PDGFRB

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