Disease

Retinitis Pigmentosa

About the Disease
Cone-Rod Dystrophy 2, also known as cone-rod dystrophy, is related to cone-rod dystrophy 3 and cone-rod dystrophy 16. An important gene associated with Cone-Rod Dystrophy 2 is CRX (Cone-Rod Homeobox), and among its related pathways/superpathways are Bardet-Biedl syndrome and Ciliopathies. The drugs Tocopherol and Acetylcysteine have been mentioned in the context of this disorder. Affiliated tissues include Eye, and related phenotypes are abnormality of retinal pigmentation and photophobia

Common Targets
ZBED1 | HDAC1 | SPATA7 | Alpha-2 Adrenergic receptors (nonspecified subtype) | Folate Receptor (nonspecified subtype) | RARA | CNGA3 | NGFR | PEX26 | F13A1 | HGSNAT | REEP6 | MYO7B | SYNJ1 | POMGNT1 | FLG | RPGRIP1L | FAM161A | GUCY2D | G23411 | SIGMAR1 | TRIP13 | G842 | GON4L | BSG | MPDZ | CA1 | F2 | CDC73 | PKD2 | CHM | ZDHHC24 | TRIP12 | PRPH2 | NPHP4 | CFAP418 | SAG | SNU13 | PDE10A | SNRNP200 | ZEB2 | NEUROD1 | CLCC1 | Integrin Receptor (nonspecified subtype) | SCLT1 | CYP4V2 | ALG12 | CEP250 | BBS2 | Serine palmitoyltransferase | PDE6A | ABHD12 | THEGL | NTRK1 | ESX1 | EML4 | G7422 | CLN3 | SERPINE1 | AVPR2 | SHOX | UNC119 | TEX15 | ATP10B | RET | RHO | OAT | CLK4 | MUC1 | ABHD16A | CRX | RAX2 | ATP7A | TUBGCP6 | RPGRIP1 | CERKL | KIF3B | LCA5 | FTSJ1 | ZNF513 | MAK | RBP4 | PDE5A | Integrin alphavbeta5 receptor | GP5 | ROM1 | Chaperone (nonspecified subtype) | ARL3 | GRK1 | PRPF8 | IMPDH1 | ATXN7L1 | TOPORS | CA7 | PCDH15 | FLVCR1 | GUCA1A | CEP290 | CFAP20 | CHRM3 | TEKT4 | DZIP1L | MVK | TET1 | ABCA4 | CWC27 | NF-kappaB (NFkB) | IQCB1 | AAR2 | MERTK | TBP | ADGRV1 | TULP1 | BBS7 | NMDA receptor | HRNR | NOS2 | PDE6B | FSCN2 | RDH5 | PRPF6 | PRPF31 | F5 | FGB | Amyloid beta A4 precursor protein-binding family (APP-BP) (nonspecified subtype) | ERBB4 | SLC4A7 | RLBP1 | PDE4DIP | FASLG | ATP6V1F | GNL3 | ROCK2 | GUCA1B | UBR2 | NRL | EYS | NLRP3 Inflammasome | SCN9A | DHX38 | MTREX | ALMS1 | DHDDS | CAPN1 | TEX13C | SEC24A | G114548 | SPANXD | G196 | ADIPOR1 | FGF10 | MAGI3 | HMCN1 | SIRPB1 | WDR19 | RP9 | ARMS2 | CSF2 | CA2 | RP1 | CLDN5 | NPHP3 | PRPF4B | MST1L | FGF10-AS1 | PKM | PROM1 | IMPG1 | POC5 | SEMA4A | HK1 | USH2A | PDZD7 | GRID2 | PITPNM3 | LTN1 | B3GALT2 | RORB | CYP26A1 | GGCX | CA9 | IMPG2 | DYNC2H1 | CLK1 | ATP6 | VCP | MDN1 | CFH | APP | TDRD6 | PRKAR2A | ACACB | ALPK3 | PRDM13 | MUC3A | PTBP2 | RBP3 | RP2 | SI | Potassium Channels (nonspecified subtype) | TRAIP | ABCC1 | ARL6 | HTT-AS | CDHR1 | RDH12 | ERN1 | RPGR | BEST1 | SCAPER | ADAM9 | HPSE | C1QTNF5 | AKR1B10 | KRR1 | CNGB1 | IDH3A | DHFR | TTC8 | LRP2 | HTT | PCDHB14 | SDCCAG8 | DLX6 | ESRRG | PCARE | TTLL5 | CRB1 | RIPK1 | COL11A1 | CRB2 | Rho kinase (ROCK) (nonspecified subtype) | Integrin alphavbeta1 | DMBT1 | OPA1 | WHRN | CLRN1 | RHBDD2 | COL2A1 | EMC1 | PANK2 | PEX1 | KLHL7 | RPL14 | CNGA1 | TRIM32 | TREX1 | Mitogen-activated protein kinase p38 (MAPK p38) (nonspecified subtype) | ZNF408 | RDH11 | ATP8 | PALS2 | COL6A3 | FLG-AS1 | CYP4A11 | CFAP410 | FRG1 | PDE6G | G5347 | ABCC3 | MFRP | USH1C | WDPCP | KIZ | SYTL3 | G8878 | CR1L | RPE65 | G4780 | LRAT | Integrin alpha2beta1 (VLA-2) receptor | CDH23 | MFSD8 | MC1R | PRCD | MKKS | EFTUD2 | CLK2 | CNOT3 | IFT140 | VCAN | Melanocortin receptor (nonspecified subtype) | HKDC1 | PRPF4 | RP1L1 | SCN2A | AGBL5 | CACNA1F | BBS1 | BRD9 | PDHA2 | mu-Calpain (calpain 1) | UBR1 | PPARA | SOS1 | PRPF3 | NOP56 | SF3B2 | APEH | ADAR | COL6A6 | Integrin alphavbeta3 (vitronectin) receptor | NPHP1 | BBS10 | TTC26 | SLC7A14 | G1956 | MTHFR | CTSD | AIPL1 | NR2E3 | NEK2 | CA4 | PRPS1 | TGFBI | FFAR4 | CEP78 | AHI1 | ABCA13 | ARL2BP | CNGB3 | IFT172 | TJP2 | OTX2 | MXRA5 | TNFRSF1B | FAM110C | OFD1 | MYO7A | PPP1R15A | CFAP74

疾病靶点研报
Retinitis Pigmentosa

Note: If you'd like to get a target analysis report for Retinitis Pigmentosa, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Retinitis Pigmentosa at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Spondylocostal Dysostosis | Light Chain Amyloidosis | Hypersensitivity | Hereditary Inclusion Body Myopathy | Trismus-pseudocamptodactyly Syndrome | Ehlers-Danlos Syndrome With Progressive Kyphoscoliosis, Myopathy, And Hearing Loss | Schamberg Disease | Uremia | Binge Eating Disorder | Thyroiditis | Endometrial Hyperplasia | Arteriosclerosis | Carney Triad | Schizotypal Personality Disorder | Hyperthyroidism | Pneumococcal Meningitis | Periodontitis | Epidermolytic Hyperkeratosis | Nicotine Addiction | McLeod Syndrome | Congenital Sodium Diarrhea | Leber Congenital Amaurosis | Astrocytoma | Non-small Cell Lung Cancer | Eiken Syndrome | Esthesioneuroblastoma | Exotropia | Urticaria | Cerebellar Ataxia, Cayman Type | Arthrogryposis | Primary Hyperoxaluria | Thin Basement Membrane Disease | Hypoproteinemia, Hypercatabolic | Craniofacial Dysostosis | Tylosis With Esophageal Cancer | Occipital Neuralgia | Dermatomyositis | Familial Hemiplegic Migraine | Budd-Chiari Syndrome | Hypohidrotic Ectodermal Dysplasia, X-linked | Bone Marrow Necrosis | Charcot-Marie-Tooth Disease Type 4E | ADNP Syndrome | Chanarin-Dorfman Syndrome | HUPRA Syndrome | Primary Biliary Cholangitis | Sensory Ataxic Neuropathy, Dysarthria, And Ophthalmoparesis | Nephrotic Syndrome Type 1 | Heart Failure | Sialoadenitis | Spinocerebellar Ataxia Type 10 | Hydrolethalus Syndrome | Glycogen Storage Disease Type 0, Muscle | Diamond-Blackfan Anemia | Burn-McKeown Syndrome | Influenza | Osteoporosis | Basal Ganglia Cerebrovascular Disease | Gnathodiaphyseal Dysplasia | Hyperferritinemia-cataract Syndrome | Neurocysticercosis | Pseudohypoparathyroidism Type 2 | Bartter Syndrome | Distal Myopathy 2 | Herpes Genitalis | Argininosuccinic Aciduria | Neurofibromatosis Type 2 | Hepatic Veno-occlusive Disease | Tricho-hepato-enteric Syndrome | Sotos Syndrome | Cholera | Pseudomyxoma Peritonei | Dystonia Musculorum Deformans | Neurodegeneration Due To Cerebral Folate Transport Deficiency | Botulism | Hypothalamic Obesity | Epithelial-myoepithelial Carcinoma | Antiphospholipid Syndrome | Inflammatory Bowel Disease | Dentinogenesis Imperfecta | Hypogammaglobulinemia | Papillon-Lefevre Syndrome | Polyomavirus Nephropathy | Hereditary Hemorrhagic Telangiectasia Type 2 | Thanatophoric Dysplasia Type 1 | Proteasome-associated Autoinflammatory Syndrome 2 | Specific Granule Deficiency | Crimean-Congo Hemorrhagic Fever | Gingivitis | Vascular Cognitive Impairment | Thyrotoxic Periodic Paralysis | Iron Metabolism Disorders | Papilledema | Adenoma, Villous | Incontinentia Pigmenti | Sporadic Inclusion Body Myositis | Schistosomiasis Mansoni | Jalili Syndrome | Lymphangiomatosis | Spinocerebellar Ataxia Type 17 | Choroideremia | Coronary Heart Disease | Corneal Neovascularization | Bartsocas-Papas Syndrome | VACTERL/VATER Association | Kearns-Sayre Syndrome | Uterine Leiomyoma | Blepharospasm | McKusick Type Metaphyseal Chondrodysplasia | Avian Influenza | Fibromyalgia | Macrodactyly | Hyperekplexia | Pernicious Anemia | Fanconi Syndrome | Angiodysplasia | Cancer, Colon | Schnyder Crystalline Corneal Dystrophy | Basan Syndrome | Cystinosis | Hyperbilirubinemia | Twin-to-twin Transfusion Syndrome | GNE Myopathy | Very Long-chain Acyl-CoA Dehydrogenase Deficiency | Camurati-Engelmann Disease | Pierpont Syndrome | Atherosclerosis | Cardiomyopathy, Dilated, 1L | Bronchitis | Pyoderma Gangrenosum | Ocular Albinism Type 1 | T-cell Lymphoma, Subcutaneous Panniculitis-like | Hepatitis B, Chronic | Leigh Syndrome | Pulmonary Alveolar Proteinosis | Melnick-Needles Syndrome | Tonsillitis | Multicystic Renal Dysplasia | Colon Adenoma | Johanson-Blizzard Syndrome | Sengers Syndrome | Liddle Syndrome | Pierre Robin Syndrome | Pfeiffer Syndrome | Mitochondrial Myopathy | Hyperparathyroidism, Secondary | Leukodystrophies | Long QT Syndrome Type 2 | Leukocyte Adhesion Deficiency | Weill-Marchesani Syndrome | Gangliosidosis | Diabetic Macular Edema | Varices | Majeed Syndrome | Pierson Syndrome | Discoid Lupus Erythematosus | TARP Syndrome | Asphyxia Neonatorum | Intestinal Obstruction | Tatton-Brown-Rahman Syndrome | Subcortical Band Heterotopia | Fibrosis | Guttate Psoriasis | Stiff-man Syndrome | Milk Allergy | Spinocerebellar Ataxia Type 27 | Fatty Aldehyde Dehydrogenase Deficiency | Rhizomelic Chondrodysplasia Punctata | Waardenburg Syndrome Type 2E | Goldenhar Syndrome | Sclerosteosis 2 | Androgenic Alopecia | Waldenstrom Macroglobulinemia | Ameloblastoma | Guillain-Barre Syndrome | Glucagonoma | Asperger Syndrome | Retinal Dystrophy, Early-onset Severe | Cardiac Sarcoidosis | Spasticity | Pheochromocytoma | Neurotoxicity | Schnitzler Syndrome | Benign Familial Pemphigus | Histiocytic Sarcoma | Thalassemia, Beta | Auriculocondylar Syndrome | Chromosome 17q21.31 Deletion Syndrome | Anorectal Fistula | Glioma | Japanese Encephalitis | Gastroenteritis | Delirium | Osteopathia Striata With Cranial Sclerosis | Cancer, Kidney | Optic Neuropathy | Osteochondrosis | Mucormycosis | Ophthalmoplegia | Spondylo-ocular Syndrome | Methemoglobinemia Type IV | Early Infantile Epileptic Encephalopathy 28 | Hypermetropia | Spinal Cord Diseases | Malonyl-CoA Decarboxylase Deficiency | Melanocytic Nevus | Hypokalemic Periodic Paralysis | Retinal Telangiectasia | Noonan Syndrome | Strabismus | Keratoacanthoma | Myositis, Focal | Persistent Mullerian Duct Syndrome | Facioscapulohumeral Muscular Dystrophy | Neuropathy | Brugada Syndrome 1 | Autism Spectrum Disorders | Focal Dermal Hypoplasia | Erectile Dysfunction | Myoclonus | Hemoglobinopathies | Xeroderma Pigmentosum | Pityriasis Rubra Pilaris | Retinopathy Of Prematurity | McCune-Albright Syndrome | Calcium Pyrophosphate Deposition Disease | Impulse Control Disorder | Thyroiditis, Autoimmune | Hamartoma | Histoplasmosis | Joubert Syndrome | Sickle Cell Anemia | Chronic Myeloid Leukemia | Primary Carnitine Deficiency | Infantile Nephropathic Cystinosis | Tetraplegia | Hyperuricemia | Sulfite Oxidase Deficiency | Cousin Syndrome | Asplenia | Glycogen Storage Disease Type 5 | Anodontia | Rift Valley Fever | Sclerocornea | Epithelioid Hemangioma | Chylothorax, Congenital | Osteogenesis Imperfecta Type II | Rett Syndrome | Familial Mediterranean Fever | Hepatitis, Autoimmune | Conn Syndrome | Rheumatoid Arthritis | Atrial Septal Defect | Glaucoma, Congenital | Monilethrix | Congenital Stationary Night Blindness | Alcoholism | Bullous Pemphigoid | Dyslexia | Metaphyseal Chondrodysplasia, Schmid Type | Angioedema, Acquired | Pontocerebellar Hypoplasia | Spondyloepimetaphyseal Dysplasia With Joint Laxity, Type 3 | Scleroderma | Glycogen Storage Disease Type 9 | Long QT Syndrome Type 3 | Lipid Storage Myopathy | Spondylolisthesis | Cutaneous T-cell Lymphoma | Familial Digital Arthropathy-brachydactyly | Meningioma | Babesiosis | Farber Disease | Trichotillomania | Nicotine Dependence | Angioedema, Hereditary | B-cell Prolymphocytic Leukemia | Bronchiolitis | Schwartz-Jampel-Aberfeld Syndrome | Cardiac Arrest | Fibromuscular Dysplasia | Noonan Syndrome-like Disorder With Loose Anagen Hair | Duane Retraction Syndrome | Superficial Spreading Melanoma | Leiomyosarcoma | Enterocolitis, Necrotizing | Lactose Intolerance | Tuberculosis | Esophageal Adenocarcinoma | Lymphoma | Limb Girdle Muscular Dystrophy | Congenital Hypofibrinogenemia | Congenital Bile Acid Synthesis Defect | Focal Cortical Dysplasia Type 2 | Hemophilia | Cancer, Prostate | Premature Ejaculation | Pulverulent Zonular Cataract | Keratosis | Lupus Erythematosus | Giant Axonal Neuropathy | Myocarditis | Multiple Sclerosis | Mohr-Tranebjaerg Syndrome | Cataplexy | Angiosarcoma Of The Breast | Acute Lymphocytic Leukemia | Genee-Wiedemann Syndrome | Iron Overload | Stickler Syndrome | AIDS Dementia Complex | Congenital Dyserythropoietic Anemia | Genitopatellar Syndrome | Large Granular Lymphocytic Leukemia | Cardiomyopathy, Peripartum | Reye Syndrome | Pterygium | Combined Deficiency Of Factor V And Factor VIII | Renal Medullary Carcinoma | Intestinal Tuberculosis | Bleeding Disorder Due To CalDAG-GEFI Deficiency | Hydrocephalus | Multiple Myeloma | Pleomorphic Xanthoastrocytoma | Diabetes Insipidus | Withdrawal Syndrome | Pycnodysostosis | Seasonal Mood Disorder | Hyperinsulinemia | Polymyositis | Neurodermatitis | Proopiomelanocortin Deficiency | Takotsubo Cardiomyopathy | Primary Hyperoxaluria Type 3 | Osteogenesis Imperfecta | Amyotrophic Lateral Sclerosis, Juvenile | Congestive Heart Failure | Anti-NMDA Receptor Encephalitis | Acute Chest Syndrome | Guanidinoacetate Methyltransferase Deficiency | Pulmonary Stenosis | CEDNIK Syndrome | Silver-Russell Syndrome | Gastritis, Atrophic | Keratocystic Odontogenic Tumor | Autonomic Neuropathy | Pleurisy | Autoimmune Autonomic Ganglionopathy | Amelanotic Melanoma | Nanophthalmos | Yellow Fever | Hypotrichosis, Congenital, With Juvenile Macular Dystrophy | Oligoastrocytoma | Pouchitis | Hypophosphatemic Rickets With Hypercalciuria, Hereditary | Hemolytic Uremic Syndrome | Tularemia | Osteopetrosis | Pemphigus | Torticollis | Chondrodysplasia Punctata | Urethritis | Schwannoma | Rubeosis Iridis | Leishmaniasis, Visceral | Alopecia | Thrombasthenia | CDKL5 Deficiency Disorder | Liver Failure, Acute Infantile | Hyperlipidemia, Familial Combined | Idiopathic Pulmonary Fibrosis | Reticular Dysgenesis | Glycogen Storage Disease Type 1b | Molybdenum Cofactor Deficiency | Retinal Degeneration | Amyotrophic Lateral Sclerosis | Niemann-Pick Disease | Familial Glucocorticoid Deficiency | AIDS | Myositis | Crouzon Syndrome With Acanthosis Nigricans | Dysthymia | Thromboembolism | Liver Diseases | Primary Torsion Dystonia | Peutz-Jeghers Syndrome | Swine Influenza | Nephroblastoma | Birt-Hogg-Dube Syndrome | Neovascular Glaucoma | Arteriovenous Malformations | Addison Disease | Cherubism | Craniometaphyseal Dysplasia | Globozoospermia | Cyst | Thyroid Dysgenesis | Erysipelas | Neurocutaneous Syndromes | Glycogen Storage Disease Type 1