DOCK8 Immunodeficiency Syndrome

About the Disease
Dock8 Immunodeficiency Syndrome, also known as combined immunodeficiency due to dock8 deficiency, is related to hyper-ige recurrent infection syndrome 2, autosomal recessive and immunodeficiency 35. An important gene associated with Dock8 Immunodeficiency Syndrome is DOCK8 (Dedicator Of Cytokinesis 8). The drugs Cyclophosphamide and Fludarabine have been mentioned in the context of this disorder. Affiliated tissues include skin, brain and t cells, and related phenotypes are chronic otitis media and skin ulcer

Common Targets
CARD9 | AIRE | DOCK8

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Camptocormia | Carcinoid Syndrome | Ichthyosis Bullosa Of Siemens | NGLY1 Deficiency | Alzheimer Disease, Late Onset | Giant Cell Arteritis | Beare-Stevenson Syndrome | Familial Hemiplegic Migraine | Atopic Dermatitis | Frank-ter Haar Syndrome | Congenital Adrenal Hyperplasia | GAPO Syndrome | Corneal Neovascularization | Thrombophlebitis | Common Variable Immunodeficiency | Nutrition Disorders | Gastritis | Sclerocornea | Hyperparathyroidism-jaw Tumor Syndrome | Axenfeld-Rieger Syndrome | Paraganglioma | Nicotine Addiction | Congenital Bilateral Absence Of Vas Deferens | Kaposiform Hemangioendothelioma | Kashin-Beck Disease | Gitelman Syndrome | Osteosclerosis | Disseminated Intravascular Coagulation | Very Long-chain Acyl-CoA Dehydrogenase Deficiency | Pathological Gambling | Costello Syndrome | Follicular Dendritic Cell Sarcoma | Lassa Fever | Hepatitis A | Hartsfield Syndrome | Mixed Connective Tissue Disease | Riboflavin Transporter Deficiency Neuronopathy | Blepharospasm | Ichthyosis | Multifocal Motor Neuropathy | Photosensitivity | Transthyretin-related Amyloidosis | H Syndrome | Syphilis | Centronuclear Myopathy | Porphyria | Exocrine Pancreatic Insufficiency | Presbycusis | Lung Diseases | Larsen Syndrome | Pierpont Syndrome | Pyloric Stenosis, Infantile Hypertrophic | Heimler Syndrome | Pituitary Dwarfism | Muscle Wasting | Tuberculous Meningitis | Spinocerebellar Ataxia Type 8 | Absence Epilepsy | Hypercholesterolemia | Osteochondrosis | Focal Segmental Glomerulosclerosis | Leishmaniasis, Visceral | Angina Pectoris | Epidermal Nevus Syndrome | Parkinsonism | Hepatitis | Ectrodactyly | Sleep Disorder | Sialidosis Type I | Trachoma | Inflammatory Bowel Disease | Frontotemporal Dementia With Amyotrophic Lateral Sclerosis | Cramp Fasciculation Syndrome | Glaucoma | Bronchitis, Chronic | Congenital Aniridia | Hypophosphatemic Rickets, Autosomal Recessive, 1 | Multiple Epiphyseal Dysplasia | Choriocarcinoma | Antithrombin III Deficiency | Frontotemporal Dementia | Peritonitis | Danon Disease | Lymphangioma | Thrombosis | Ocular Albinism Type 1 | Orotic Aciduria | Angioedema, Acquired | TARP Syndrome | Mitochondrial DNA Depletion Syndrome, Hepatocerebral Form | Patent Foramen Ovale | FG Syndrome | Triphalangeal Thumb-polysyndactyly Syndrome | Rubinstein-Taybi Syndrome | Duane Retraction Syndrome | Intermittent Explosive Disorder | Anorchia | Lymphoma | Epicondylitis | Polycystic Ovary Syndrome | Chronic Inflammatory Demyelinating Polyneuropathy | Hemophagocytic Lymphohistiocytosis | Autoimmune Hemolytic Anemia | Familial Isolated Hyperparathyroidism | Central Retinal Artery Occlusion | Budd-Chiari Syndrome | Mitochondrial DNA Depletion Syndrome | Mandibuloacral Dysplasia With Type A Lipodystrophy | Stargardt Disease | Early Infantile Epileptic Encephalopathy 4 | Spinocerebellar Ataxia Type 16 | Antley-Bixler Syndrome | Lafora Disease | Jaundice, Obstructive | Alcoholism | Esophageal Adenocarcinoma | Brugada Syndrome 1 | Specific Granule Deficiency | Overactive Bladder | Autism | Focal Dermal Hypoplasia | Psoriasis | Hamartoma | Acromesomelic Dysplasia | Gestational Trophoblastic Disease | Guttate Psoriasis | Chiari Malformation Type I | Rhizomelic Chondrodysplasia Punctata | Dermatitis | Proteasome-associated Autoinflammatory Syndrome 2 | Campomelic Dysplasia | Ulcerative Colitis | Adenoma, Villous | Frontometaphyseal Dysplasia | Sporadic Inclusion Body Myositis | Amyotrophic Lateral Sclerosis, Juvenile | Trismus-pseudocamptodactyly Syndrome | Atelosteogenesis Type 2 | Ameloblastoma | VEXAS Syndrome | Hydrocephalus | Coloboma | Dermatitis Herpetiformis | Palmoplantar Keratoderma | Crohn's Disease | Chronic Enteropathy Associated With SLCO2A1 Gene | Hyperinsulinemia | Ganglioglioma | Pleomorphic Xanthoastrocytoma | Carcinoma, Transitional Cell | Dystrophy, Cone-rod | Cardiofaciocutaneous Syndrome | Primary Aldosteronism | Splenomegaly | Familial Hypobetalipoproteinemia | Lissencephaly 2 | LRBA Deficiency | Evans Syndrome | Dysequilibrium Syndrome | Postpoliomyelitis Syndrome | Craniofacial Dysostosis | Subcortical Band Heterotopia | Thyroid Dysgenesis | Netherton Syndrome | Silver-Russell Syndrome | Schistosomiasis | Macrodactyly | Familial Cerebral Amyloid Angiopathy | Chorea | Lipid Storage Diseases | T-cell Chronic Lymphocytic Leukemia | Pneumococcal Meningitis | Bipolar Disorder | Duodenal Atresia | Guanidinoacetate Methyltransferase Deficiency | Hypopituitarism | Neuronal Ceroid Lipofuscinosis | Osteogenesis Imperfecta Type I | Otopalatodigital Syndrome Type 2 | 3-methylglutaconic Aciduria Type I | Snyder-Robinson Syndrome | Hyperhomocysteinemia | Compartment Syndrome | Multiple System Atrophy | Melanoma | Neuromyotonia | Tic Disorder | Hemorrhage | Angiosarcoma | Pleurisy | Hereditary Pyropoikilocytosis | Motor Neuron Diseases | Micro Syndrome | Pleural Tuberculosis | Epilepsy Of Infancy With Migrating Focal Seizures | Glioblastoma Multiforme | DOCK8 Immunodeficiency Syndrome | 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Type 1 | Blastomycosis | Paronychia | Alopecia Areata | Rift Valley Fever | Granular Corneal Dystrophy | Osteopetrosis | Hypertension, Pulmonary | Sialoadenitis | Polymyositis | Facioscapulohumeral Muscular Dystrophy Type 2 | Pontocerebellar Hypoplasia | Congenital Stromal Corneal Dystrophy | Alazami Syndrome | Vici Syndrome | Sepiapterin Reductase Deficiency | Antiphospholipid Syndrome | Non-epidermolytic Palmoplantar Keratoderma | Sarcoma | Autosomal Recessive Bestrophinopathy | Hepatitis, Alcoholic | Usher Syndrome Type III | Blepharo-cheilo-odontic Syndrome | Hyper IgE Syndrome | Optic Neuropathy, Anterior Ischemic | Mosaic Variegated Aneuploidy Syndrome 2 | Veno-occlusive Disease | Retinal Dystrophy | Hypophosphatasia | Genitopatellar Syndrome | Conn Syndrome | Adult Polyglucosan Body Disease | MELAS Syndrome | Lymphangiomatosis | Epidermolysis Bullosa Dystrophica | Hyperuricemic Nephropathy, Familial Juvenile | Malaria, Cerebral | Hypodontia | Trimethylaminuria | Androgen 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