DOCK8 Immunodeficiency Syndrome

About the Disease
Dock8 Immunodeficiency Syndrome, also known as combined immunodeficiency due to dock8 deficiency, is related to hyper-ige recurrent infection syndrome 2, autosomal recessive and immunodeficiency 35. An important gene associated with Dock8 Immunodeficiency Syndrome is DOCK8 (Dedicator Of Cytokinesis 8). The drugs Cyclophosphamide and Fludarabine have been mentioned in the context of this disorder. Affiliated tissues include skin, brain and t cells, and related phenotypes are chronic otitis media and skin ulcer

Common Targets
CARD9 | AIRE | DOCK8

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Cutaneous Mastocytosis | Paroxysmal Kinesigenic Dyskinesia | Spinocerebellar Ataxia Type 10 | Multisystemic Smooth Muscle Dysfunction Syndrome | Syncope | Mountain Sickness | Papilledema | Keloid | Autism Spectrum Disorders | Paronychia | Polymicrogyria | Goiter, Nodular | Gastroschisis | Urticaria | Pontocerebellar Hypoplasia Type 7 | Priapism | Hypotonia-cystinuria Syndrome | HANAC Syndrome | Gastrointestinal Disorders | Pulmonary Alveolar Proteinosis | Hereditary Folate Malabsorption | Brachydactyly | Ichthyosis Bullosa Of Siemens | Corneal Neovascularization | Succinic Semialdehyde Dehydrogenase Deficiency | Pancreatitis | Frontotemporal Dementia | Congenital Dyserythropoietic Anemia Type 4 | Kearns-Sayre Syndrome | Autonomic Nervous System Disorders | Epilepsy | Erythrokeratodermia Variabilis | Heterotaxy | Antiphospholipid Syndrome | CDKL5 Deficiency Disorder | Hemolytic Anemia | REM Sleep Behavior Disorder | Synovitis | Arterial Tortuosity Syndrome | Sclerocornea | Takenouchi-Kosaki Syndrome | Cheilitis | Pitt-Hopkins Syndrome | Tardive Dyskinesia | Compartment Syndrome | Acromesomelic Dysplasia | Venous Insufficiency | Neuroendocrine Cancer | Antithrombin III Deficiency | Cold Agglutinin Disease | Oligospermia | Orthostatic Intolerance | Spinocerebellar Ataxia Type 15 | Headache | Takotsubo Cardiomyopathy | Autosomal Recessive Spastic Paraplegia Type 75 | Trichotillomania | Primrose Syndrome | Dyslexia | Meckel-Gruber Syndrome | Pancytopenia | Gastritis | H Syndrome | Tinea | Niemann-Pick Disease, Type C | Iron Deficiency Anemia | Renal Tubular Acidosis | Chorea-acanthocytosis | Glanzmann Thrombasthenia | Chudley-McCullough Syndrome | Leri-Weill Dyschondrosteosis | Neurofibroma, Plexiform | Keratosis, Seborrheic | Chediak-Higashi Syndrome | Steel Syndrome | Primary Progressive Aphasia | Fowler's Syndrome | Leiomyosarcoma | Osmotic Demyelination Syndrome | Hyperammonemia | Ophthalmia, Sympathetic | Hypertrophy | Nanophthalmos | 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Progressive Myoclonic Epilepsy