Frontotemporal Dementia

About the Disease
Frontotemporal Dementia, also known as frontotemporal lobar degeneration, is related to inclusion body myopathy with paget disease of bone and frontotemporal dementia and frontotemporal dementia and/or amyotrophic lateral sclerosis 1, and has symptoms including myoclonus and personality changes. An important gene associated with Frontotemporal Dementia is PSEN1 (Presenilin 1), and among its related pathways/superpathways are Cytoskeletal Signaling and Neuroscience. The drugs Memantine and Citalopram have been mentioned in the context of this disorder. Affiliated tissues include brain, amygdala and bone marrow, and related phenotypes are brain atrophy and visual agnosia

Common Targets
HDAC8 | TMEM106B | CCNF | SPG11 | DYRK1A | KIF13A | C9orf72 | CDK5 | CDK13 | CHRNA7 | HTR2A | IFNL2 | FAM171A2 | GSK3B | PALM2 | SP4 | Neurotrophic Factor (nonspecified subtype) | PSEN2 | COL28A1 | CACNA1C | BTNL2 | ARRB2 | SLC13A4 | JAK2 | LOC107987057 | HNRNPA2B1 | SORT1 | TNIK | G4137 | ZNF532 | LGMN | MOBP | CHCHD10 | CLU | GPR3 | CFAP54 | NDUFS1 | RCOR1 | JAK1 | TSPO | TAF15 | TIA1 | TUBA4A | CRBN | ARRB1 | UNC13A | PRKAG2 | Histone deacetylase (nonspecified subtype) | DAPK1 | USP14 | Amyloid beta A4 precursor protein-binding family (APP-BP) (nonspecified subtype) | MOB3B | MARCHF4 | FOXP2 | ABCC8 | PIKFYVE | APOE | CHMP2B | MMP13 | HAS1 | ABCC9 | TREM2 | BACE1 | GFRA2 | LINC02210-CRHR1 | OPTN | YLPM1 | APP | ALS2 | MAOB | OGA | RAB38 | NUAK1 | GABRA5 | CCDC144NL | G2475 | VCP | PRB1 | RGS6 | Cyclooxygenase (COX) (nonspecified subtype) | PFN1 | ATP9B | CSF1R | ACTN3 | Vacuolar H+ ATPase | G3146 | SCARB2 | FUS | ANG | TNK2 | SMPD3 | DYRK1B | G7124 | HDAC2 | PLEKHH1 | Rho kinase (ROCK) (nonspecified subtype) | HTT | SETX | PRR5L | G6647 | SQLE | ST18 | KCNJ8 | BDNF | FIG4 | HRH3 | NR4A2 | PPARGC1A | GLDN | GRN | CSNK1D | TBK1 | NECTIN2 | SORL1 | ACHE | CDK12 | UBQLN2 | G8878 | TSGA13 | LRRK2 | SNCA | ATXN2 | VPS13C | HDAC1 | WASHC5 | TTBK1 | SMCHD1 | RRBP1 | TRNC | WAKMAR1 | LHFPL3 | LINC01170 | PRNP | L3MBTL1 | SLIT3 | KCNJ11 | RYR1 | WNT3 | TFRC | PLCG2 | GRB2 | SIGMAR1 | Eukaryotic translation initiation factor 2B | MARK2 | CDC7 | LOC105379117 | CHRM1 | EWSR1 | NOS1 | PSEN1 | NF-kappaB (NFkB) | TARDBP | mTOR complex 1 | HDAC3 | Chromosome 16 open reading frame 47 | FLT3 | LRP10

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