Frontotemporal Dementia

About the Disease
Frontotemporal Dementia, also known as frontotemporal lobar degeneration, is related to inclusion body myopathy with paget disease of bone and frontotemporal dementia and frontotemporal dementia and/or amyotrophic lateral sclerosis 1, and has symptoms including myoclonus and personality changes. An important gene associated with Frontotemporal Dementia is PSEN1 (Presenilin 1), and among its related pathways/superpathways are Cytoskeletal Signaling and Neuroscience. The drugs Memantine and Citalopram have been mentioned in the context of this disorder. Affiliated tissues include brain, amygdala and bone marrow, and related phenotypes are brain atrophy and visual agnosia

Common Targets
HDAC8 | TMEM106B | CCNF | SPG11 | DYRK1A | KIF13A | C9orf72 | CDK5 | CDK13 | CHRNA7 | HTR2A | IFNL2 | FAM171A2 | GSK3B | PALM2 | SP4 | Neurotrophic Factor (nonspecified subtype) | PSEN2 | COL28A1 | CACNA1C | BTNL2 | ARRB2 | SLC13A4 | JAK2 | LOC107987057 | HNRNPA2B1 | SORT1 | TNIK | G4137 | ZNF532 | LGMN | MOBP | CHCHD10 | CLU | GPR3 | CFAP54 | NDUFS1 | RCOR1 | JAK1 | TSPO | TAF15 | TIA1 | TUBA4A | CRBN | ARRB1 | UNC13A | PRKAG2 | Histone deacetylase (nonspecified subtype) | DAPK1 | USP14 | Amyloid beta A4 precursor protein-binding family (APP-BP) (nonspecified subtype) | MOB3B | MARCHF4 | FOXP2 | ABCC8 | PIKFYVE | APOE | CHMP2B | MMP13 | HAS1 | ABCC9 | TREM2 | BACE1 | GFRA2 | LINC02210-CRHR1 | OPTN | YLPM1 | APP | ALS2 | MAOB | OGA | RAB38 | NUAK1 | GABRA5 | CCDC144NL | G2475 | VCP | PRB1 | RGS6 | Cyclooxygenase (COX) (nonspecified subtype) | PFN1 | ATP9B | CSF1R | ACTN3 | Vacuolar H+ ATPase | G3146 | SCARB2 | FUS | ANG | TNK2 | SMPD3 | DYRK1B | G7124 | HDAC2 | PLEKHH1 | Rho kinase (ROCK) (nonspecified subtype) | HTT | SETX | PRR5L | G6647 | SQLE | ST18 | KCNJ8 | BDNF | FIG4 | HRH3 | NR4A2 | PPARGC1A | GLDN | GRN | CSNK1D | TBK1 | NECTIN2 | SORL1 | ACHE | CDK12 | UBQLN2 | G8878 | TSGA13 | LRRK2 | SNCA | ATXN2 | VPS13C | HDAC1 | WASHC5 | TTBK1 | SMCHD1 | RRBP1 | TRNC | WAKMAR1 | LHFPL3 | LINC01170 | PRNP | L3MBTL1 | SLIT3 | KCNJ11 | RYR1 | WNT3 | TFRC | PLCG2 | GRB2 | SIGMAR1 | Eukaryotic translation initiation factor 2B | MARK2 | CDC7 | LOC105379117 | CHRM1 | EWSR1 | NOS1 | PSEN1 | NF-kappaB (NFkB) | TARDBP | mTOR complex 1 | HDAC3 | Chromosome 16 open reading frame 47 | FLT3 | LRP10

Note: If you'd like to get a target analysis report for Frontotemporal Dementia, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Frontotemporal Dementia at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Oculocutaneous Albinism Type 1 | Overactive Bladder | Pfeiffer Syndrome | Bartter Syndrome | Colitis | Mountain Sickness | Primary Pigmented Nodular Adrenocortical Disease | Retinitis | Mitochondrial DNA Depletion Syndrome, Hepatocerebral Form | Autoimmune Polyendocrinopathy Syndrome Type I | Antisocial Personality Disorder | Renal Hypomagnesemia 3 | Neurofibroma, Plexiform | Splenomegaly | Demyelinating Diseases | Spondyloarthritis | Familial Thoracic Aortic Aneurysm | Spermatocele | T-cell Chronic Lymphocytic Leukemia | Cystitis | Anovulation | Charcot-Marie-Tooth Disease, Type 1A | Hereditary Xerocytosis | Charcot-Marie-Tooth Disease | Orotic Aciduria | Thyrotoxic Periodic Paralysis | Cardiac Sarcoidosis | Systemic Mastocytosis | Acrocallosal Syndrome | Epidermolysis Bullosa Simplex, Dowling-Meara Type | Arterial Tortuosity Syndrome | Atopy | Stuve-Wiedemann Syndrome | Synpolydactyly | POEMS Syndrome | Leber Hereditary Optic Neuropathy | Toxoplasmosis | X-linked Sideroblastic Anemia | Sturge-Weber Syndrome | Amyotrophic Lateral Sclerosis-parkinsonism-dementia Complex | Localized Scleroderma | Jawad Syndrome | Cervicitis | Cancer, Prostate | Greenberg Dysplasia | Bruck Syndrome | Neurocutaneous Syndromes | Twin-to-twin Transfusion Syndrome | Gestational Trophoblastic Disease | Persistent Truncus Arteriosus | Vitreoretinal Degeneration, Snowflake Type | Double Outlet Right Ventricle | Chondrodysplasia Punctata | Adams-Oliver Syndrome | Cholestasis | Waardenburg Syndrome | Pituitary Stalk Interruption Syndrome | Kaposi Sarcoma | Parkinson Disease 6, Autosomal Recessive Early-onset | Meningioma, Benign | Stevens-Johnson Syndrome | Colitis, Collagenous | Lung Diseases | Takotsubo Cardiomyopathy | Acne Vulgaris | Waardenburg Syndrome Type 4 | Rett Syndrome | Antley-Bixler Syndrome | Supravalvular Aortic Stenosis | Cardiofaciocutaneous Syndrome | Osteochondroma | Charcot-Marie-Tooth Disease Type 2D | Pregnancy, Ectopic | Congenital Torticollis | Endometriosis | Familial Advanced Sleep Phase Syndrome | Basal Ganglia Cerebrovascular Disease | Gastritis, Atrophic | Autosomal Recessive Spastic Paraplegia Type 35 | Diabetic Nephropathy | Major Depression | Noonan Syndrome | Spinocerebellar Ataxia Type 13 | Urea Cycle Disorder | Ichthyosis, X-linked | Sarcoidosis | Neurodevelopmental Disorders | Familial Dysautonomia | Blepharoconjunctivitis | Oligoastrocytoma | Microphthalmia, Syndromic 7 | CREST Syndrome | Smith-Magenis Syndrome | Myositis, Focal | Anorexia Nervosa | MELAS Syndrome | Optic Neuritis | Keratosis | Compartment Syndrome | Camptocormia | Systemic Lupus Erythematosus | Sickle Cell Disease | Congestive Heart Failure | 5-oxoprolinase Deficiency | Pouchitis | Obsessive-compulsive Disorder | Larsen Syndrome | Herpes Simplex Dermatitis | Spinocerebellar Ataxia Type 14 | Ocular Hypertension | X-linked Acrogigantism | Pericarditis | Aplastic Anemia | Proximal Symphalangism | Mesial Temporal Lobe Epilepsy With Hippocampal Sclerosis | Stomatitis | Benign Familial Infantile Seizures | Roberts Syndrome | Myocardial Infarction | Mucolipidosis Type IV | Polycythemia Vera | Fanconi Syndrome | Hepatic Veno-occlusive Disease | Miyoshi Myopathy | Lichen Planus | Brachial Plexus Neuropathy | Neural Tube Defect | Pernicious Anemia | Mandibuloacral Dysplasia With Type A Lipodystrophy | Analgesia | Uveitis | Hyperbilirubinemia | Hyperammonemia | Neuroectodermal Tumors, Primitive | T-cell Prolymphocytic Leukemia | Ameloblastic Carcinoma | Craniolenticulosutural Dysplasia | Congenital Generalized Lipodystrophy | Zellweger Syndrome | Currarino Syndrome | Carbamoyl Phosphate Synthetase I Deficiency | Paronychia | NGLY1 Deficiency | Heart Block | Papulopustular Rosacea | Pituitary Disorders | Arteriovenous Malformations | Binge Eating Disorder | Sialidosis Type I | Metaphyseal Chondrodysplasia, Schmid Type | Nager Acrofacial Dysostosis | Fatty Aldehyde Dehydrogenase Deficiency | Esthesioneuroblastoma | Acrodermatitis Enteropathica | Primary Ovarian Insufficiency | Hemochromatosis Type 1 | Molybdenum Cofactor Deficiency | Cryptosporidiosis | Bronchiolitis | Sarcoma, Endometrial Stromal | Eosinophilic Asthma | Carpal Tunnel Syndrome | Alstrom Syndrome | Pompe Disease | Fibromuscular Dysplasia | Spinal And Bulbar Muscular Atrophy | Tinea | Haim-Munk Syndrome | Progressive Familial Intrahepatic Cholestasis Type 2 | Schnyder Crystalline Corneal Dystrophy | Autism Spectrum Disorders | Lymphoma, AIDS-related | Infectious Diarrhea | Parvovirus B19 Infection | Hemochromatosis Type 2 | Multiple Hamartoma Syndrome | Superficial Spreading Melanoma | Scabies | CHARGE Syndrome | Walker-Warburg Syndrome | Congenital Hereditary Endothelial Dystrophy Type I | Diabetic Macular Edema | Azoospermia | Best Macular Dystrophy | Leiomyoma | Argininosuccinic Aciduria | Glycogen Storage Disease Type 6 | Alcoholism | Aldosterone Deficiency | Ocular Albinism Type 1 | Marshall-Smith Syndrome | Infertility, Male | Charcot-Marie-Tooth Disease, Type 2A | Schizophrenia | Spinocerebellar Ataxia Type 21 | IgA Deficiency | Duodenal Atresia | Progressive Myoclonic Epilepsy | Trismus-pseudocamptodactyly Syndrome | Follicular Dendritic Cell Sarcoma | Retinoschisis | Osteogenesis Imperfecta Type V | Achromatopsia | Renal Oncocytoma | LMNA-related Congenital Muscular Dystrophy | Retinitis Pigmentosa | Primary Sclerosing Cholangitis | REM Sleep Behavior Disorder | Beta-Propeller Protein-associated Neurodegeneration | Schizoaffective Disorder | AIDS | IMAGe Syndrome | Niemann-Pick Disease, Type B | Peters-plus Syndrome | Delayed Sleep Phase Syndrome | Temtamy Preaxial Brachydactyly Syndrome | WAGR Syndrome | Metatropic Dysplasia | Blastomycosis | Combined Malonic And Methylmalonic Acidemia | Waardenburg Syndrome Type 2E | Paroxysmal Kinesigenic Dyskinesia | Coloboma | Partington Syndrome | Glanzmann Thrombasthenia | LEOPARD Syndrome | Impetigo | Hypothyroidism | Histoplasmosis | Learning Disability | Endometrial Hyperplasia | Non-bullous Congenital Ichthyosiform Erythroderma | Common Cold | Tumoral Calcinosis | Familial Hypobetalipoproteinemia | 3-hydroxyacyl-CoA Dehydrogenase Deficiency | Xeroderma Pigmentosum | Hyperparathyroidism-jaw Tumor Syndrome | Dermatofibrosarcoma | Ghosal Syndrome | Guanidinoacetate Methyltransferase Deficiency | Cholecystitis | Diffuse Intrinsic Pontine Glioma | Blepharophimosis Syndrome | Hemorrhagic Disorders | Lipid Metabolism Disorders | Okihiro Syndrome | Snyder-Robinson Syndrome | Dysthymia | Erythropoietic Protoporphyria | Vitamin K Deficiency | Peyronie's Disease | Hypertelorism | Gliosarcoma | Heavy Chain Disease | Neurodegeneration Due To Cerebral Folate Transport Deficiency | Hereditary Hemorrhagic Telangiectasia | Sweet Syndrome | Congenital Dyserythropoietic Anemia | Gynecomastia | Blepharo-cheilo-odontic Syndrome | Achondrogenesis | Autosomal Recessive Spastic Paraplegia Type 75 | Neovascular Glaucoma | Acute Lymphocytic Leukemia | Rash | Congenital Primary Aphakia | Sorsby Fundus Dystrophy | Relapsing Polychondritis | Robinow Syndrome | Arthritis, Gouty | Chediak-Higashi Syndrome | Nutrition Disorders | Angioimmunoblastic T-cell Lymphoma | Nemaline Myopathy 10 | Anal Fissure | Influenza | Lipoma | Rubinstein-Taybi Syndrome | Optic Atrophy 2 | Angioedema, Hereditary | Bacterial Meningitis | Becker Muscular Dystrophy | Leri-Weill Dyschondrosteosis | Glaucoma, Congenital | Bulimia Nervosa | Diamond-Blackfan Anemia | Inflammatory Myofibroblastic Tumor | Porphyria Cutanea Tarda | Hepatoblastoma | Leishmaniasis, Visceral | Headache | Meningioma | Measles | Dengue Hemorrhagic Fever | Stickler Syndrome | Spinocerebellar Ataxia Type 6 | Albinism | Gastroenteritis | Nicotine Dependence | Antisynthetase Syndrome | X-linked Creatine Transporter Deficiency | Angiodysplasia | Epicondylitis | Borderline Personality Disorder | Urolithiasis | Spinocerebellar Ataxia Type 7 | Sclerocornea | Esophageal Motility Disorders | Hypertriglyceridemia | Swine Influenza | HIBCH Deficiency | Patent Ductus Arteriosus | Charcot-Marie-Tooth Disease Type 2E | Macrodactyly | Essential Fructosuria | Barrett Esophagus | Connective Tissue Disorders | Cri-du-chat Syndrome | Cryoglobulinemia | Delirium | Weill-Marchesani Syndrome | Blue Rubber Bleb Nevus Syndrome | B-cell Prolymphocytic Leukemia | Dysgerminoma | Heterotopic Ossification | Coenzyme Q10 Deficiency | DICER1 Syndrome | Primary Erythromelalgia | Hyperparathyroidism, Secondary | Stiff-man Syndrome | Heart Failure | Mitochondrial Disease | Holoprosencephaly | Cerebrotendinous Xanthomatosis | Knobloch Syndrome | NDH Syndrome | Primary Torsion Dystonia | Juvenile Xanthogranuloma | Portal Vein Thrombosis | Primary Lateral Sclerosis | 3-methylcrotonyl-CoA Carboxylase Deficiency | Heimler Syndrome | Onchocerciasis | Necrotizing Autoimmune Myopathy | Lysosomal Acid Lipase Deficiency | Hemolytic Uremic Syndrome, Atypical | Large Granular Lymphocytic Leukemia | Cataplexy | Hereditary Multiple Exostoses | PASLI Disease | Melnick-Needles Syndrome | Postpoliomyelitis Syndrome | Epidermolysis Bullosa Simplex With Mottled Pigmentation | Adenomyosis | Chanarin-Dorfman Syndrome | Diarrhea | Cardiomyopathy, Hypertrophic | Pelvic Inflammatory Disease | Granular Corneal Dystrophy | Ameloblastoma | Nicotine Addiction | Nephritis, Interstitial | Intestinal Tuberculosis | Hereditary Hemorrhagic Telangiectasia Type 2 | Canavan Disease | Spinocerebellar Ataxia | Autoimmune Autonomic Ganglionopathy | Unverricht-Lundborg Syndrome | Sialoadenitis | Graves Disease | Vici Syndrome | Spinal Muscular Atrophy Type 2 | Perivascular Epithelioid Cell Tumor | Early Infantile Epileptic Encephalopathy 13 | Hyperacusis | Lymphoma, Mantle Cell | Hypertrophy | Mitochondrial Cytopathy | Esophageal Carcinoma | Malnutrition | Hashimoto Thyroiditis | Microvillus Inclusion Disease | CDKL5 Deficiency Disorder | Irritable Bowel Syndrome | Autosomal Recessive Congenital Ichthyosis | Arthritis | Genee-Wiedemann Syndrome | Hemophagocytic Lymphohistiocytosis | Skin Carcinoma | Von Hippel-Lindau Disease | Dupuytren Disease | Hemolytic Uremic Syndrome | Prediabetes | Glycogen Storage Disease Type 3 | Palmoplantar Keratoderma | Spinocerebellar Ataxia Type 16 | Echinococcosis | Mixed Connective Tissue Disease | 3-hydroxy-3-methylglutaryl-CoA Synthase Deficiency