Polycystic Kidney, Autosomal Dominant
Polycystic Kidney, Autosomal Dominant
About the Disease
Autosomal Dominant Polycystic Kidney Disease, also known as polycystic kidney disease, adult type, is related to polycystic kidney disease and polycystic kidney disease 1 with or without polycystic liver disease. An important gene associated with Autosomal Dominant Polycystic Kidney Disease is PKD1 (Polycystin 1, Transient Receptor Potential Channel Interacting), and among its related pathways/superpathways are MicroRNAs in cardiomyocyte hypertrophy and mTOR Signaling. The drugs Candesartan cilexetil and Curcumin have been mentioned in the context of this disorder. Affiliated tissues include kidney, liver and pancreas, and related phenotypes are renal cyst and decreased glomerular filtration rate
Common Targets
FLT4 | PTBP1 | HMGCR | KDR | EEIG1 | PKD1 | G3630 | GH1 | G4609 | PDK1 | mTOR complex 1 | Serine/Threonine Kinase (nonspecified subtype) | ZNF343 | BCR | TTC21B | G2064 | NOS3 | ALG5 | CDK5/p25 | NEK8 | Somatostatin receptor (nonspecified subtype) | CDK5 | PKD2 | HMOX2 | DYRK1A | G1/S-specific cyclin-E (nonspecified subtype) | SYK | XDH | LRP5 | UGCG | G7422 | LOC102724428 | CDK9/Cyclin T1 | CCNE2 | AGRN | CDK9 | TSC2 | ANGPT2 | AVPR2 | COQ8B | Casein kinase I (nonspecified subtype) | APCDD1 | TMPRSS6 | EPHB4 | Raf kinase (nonspecified subtype) | Chaperone (nonspecified subtype) | KDELR2 | RAF1 | NF-kappaB (NFkB) | CCNT1 | TMEM18 | PTGER4 | MIR17 | AGTR1 | PKHD1 | FREM1 | STAT5 (nonspecified subtype) | G673 | FASN | ADAM21 | Heme Oxygenase (HO) (nonspecified subtype) | Proteasome Complex | CFTR | SST | CCNE1 | CCR5 | CDK1/Cyclin B | CHUK | WT1 | ARAF | SIK2 | PKM | CDK2/Cyclin A | NAGLU | MEFV | GANAB | HEATR5A | G596 | CFH | ABL1 | ACMSD | G6774 | SIK1 | TRIM21 | CD19 | PAPPA | HMOX1 | COL4A3 | Cyclin A (nonspecified subtype) | CDK1 | CDK2/Cyclin E | ACE | AMP-activated protein kinase (AMPK) | HNF1B | CDHR5 | ALG8 | HDAC6 | G4780 | G2475 | G6714 | CDK7 | DCLRE1C | ACOT13 | CRACR2A | PTGER2 | CPLX1 | Phosphodiesterase IV (PDE4) (nonspecified subtype) | COL4A4 | PPARG | DAGLB | PPARA | G1956 | CDK2 | GET4 | PRKCSH | DNAJB11 | Heat shock protein 90 (nonspecified subtype) | CSK | GSR | Cyclin B (nonspecified subtype) | Tyrosine-Protein Kinases Src (nonspecified subtype) | TMEM237
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