Acute Leukemia

About the Disease
Acute Leukemia, also known as stem cell leukaemia, is related to acute biphenotypic leukemia and leukemia, acute lymphoblastic. An important gene associated with Acute Leukemia is KMT2A (Lysine Methyltransferase 2A), and among its related pathways/superpathways are Nervous system development and PI3K-Akt signaling pathway. The drugs Busulfan and Rasburicase have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, myeloid and t cells, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Common Targets
XRCC1 | CDC7 | NCOR1 | AURKA | SULT1A1 | DNA-Directed DNA Polymerase Complex | ABL1 | G1956 | JAK2 | WDR5 | EZR | ASXL2 | HLA-E | G3569 | ASXL1 | EPCAM | IL1RN | LATS1 | SMO | BTG1 | FAT4 | HOXA9 | DNMT3A | KMT2C | KALRN | MLL1/MLL Complex | CHEK1 | Protein Kinase B (PKB/Akt) (nonspecified subtype) | AURKB | AXL | Hedgehog Protein (nonspecified subtype) | Ribonucleoside-diphosphate reductase | G598 | CD3 Complex (T Cell Receptor Complex) | MYH11 | GSTA1 | RRM2 | KIT | IKZF1 | IL3RA | ZNF557 | IDH1 | CDK9/Cyclin T1 | G7852 | PLAA | HOXA11 | BCR | ATXN7L1 | TIRAP | FAT2 | BRD4 | DNA Topoisomerase II (nonspecified subtype) | CDK9 | PTPN13 | PRRX1 | CD52 | CD22 | G1029 | ITK | CEACAM8 | TET2 | CCNT1 | GSTO2 | G4609 | PTCH1 | HLA-A | GSK3B | KIAA1958 | G999 | KHDRBS2 | MEN1 | G2475 | Toll-Like Receptor (nonspecified subtype) | GSTT1 | TNFAIP3 | MERTK | SETD2 | KMT2A | G2033 | Platelet-Derived Growth Factor Receptor (nonspecified subtype) | MLL/SET1 Complex | KDM1A | MPL | EEF1A2 | G7157 | SAV1 | SFRP5 | NUMA1 | MDN1 | TNFRSF17 | DOT1L | CDH10 | RB1 | Glutaminase (nonspecified subtype) | MSI2 | SRSF2 | CXCR2 | Tubulin | MEIS1 | TTN | ZMYM3 | MAGEF1 | G6776 | RUNX1 | NF1 | CTLA4 | WT1 | NOTCH2 | G7124 | G672 | BOC | KMT2D | FLT3 | GNAS | CREBBP | PTPN11 | GSTM1 | IL10 | MTHFR | RET | G2146 | Histone deacetylase (nonspecified subtype) | TOP2A | G5243 | IL4 | CD19 | U2AF1 | IGFBP7 | ASRGL1 | JAK3 | JAK1 | GSTP1 | G596 | Fibroblast Growth Factor Receptor (FGFR) (nonspecified subtype) | MSH2

Note: If you'd like to get a target analysis report for Acute Leukemia, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Acute Leukemia at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

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