Irritable Bowel Syndrome

About the Disease
Irritable Bowel Syndrome, also known as irritable colon, is related to fibromyalgia and lactose intolerance, and has symptoms including abdominal pain, constipation and diarrhea. An important gene associated with Irritable Bowel Syndrome is SLC6A4 (Solute Carrier Family 6 Member 4), and among its related pathways/superpathways are Signal Transduction and GPCR downstream signalling. The drugs Clarithromycin and Simethicone have been mentioned in the context of this disorder. Affiliated tissues include colon, brain and kidney, and related phenotypes are homeostasis/metabolism and nervous system

Common Targets
5-Hydroxytryptamine Receptor 3 (5-HT3 receptor) (nonspecified subtype) | PROKR2 | TACR3 | Protein Phosphatase 2A | Prostanoid Receptor (nonspecified subtype) | P2X2/3 Receptor Complex | SCN10A | Phosphodiesterase IV (PDE4) (nonspecified subtype) | TFRC | F2RL1 | Corticotropin-Releasing Factor (CRF) Receptor (nonspecified subtype) | ELANE | Tyrosine-Protein Kinases Src (nonspecified subtype) | TACR2 | OPRK1 | OPRM1 | CNR2 | PPARA | GRM5 | L-type voltage-dependent calcium channel complex | IL2RA | Metabotropic glutamate (mGluR) receptor (nonspecified subtype) | Phosphatidylinositol 3-kinase (PI3K) (nonspecified subtype) | CCDC6 | G4780 | KLK8 | ST14 | HP | CHRM4 | DRD2 | PDGFRB | Tachykinin Receptor (nonspecified subtype) | LTA | Calcium channel (nonspecified subtype) | Gamma-Aminobutyric acid type B receptor | GNB3 | G7124 | IL6-AS1 | PRKCA | TRPV4 | Alpha-2 Adrenergic receptors (nonspecified subtype) | Somatostatin receptor (nonspecified subtype) | Lipoxygenase (nonspecified subtype) | TSPAN8 | SCN3A | BRD4 | TRPM8 | GH1 | COMT | HTR1A | GABRG2 | DHODH | GABRB2 | CNR1 | PPARG | CHRM1 | ALDH3A2 | CASR | DGAT2 | KEAP1 | PPP3R2 | Mucin (nonspecified subtype) | SLC6A2 | CCKBR | CACNA1G | ICAM1 | ANKK1 | ADORA1 | FPR1 | PPP3CC | HTR2B | P2RX3 | Small Conductance Calcium-Activated Potassium Channel (SK) (nonspecified subtype) | PPID | HTR4 | SCN8A | TRPV1 | GABA(A) receptor | TRPV2 | MAP3K8 | Opioid receptor (nonspecified subtype) | NXPH1 | SLC9A3 | NTRK3 | NAT1 | CCR2 | NR1I2 | SYK | CHRNA7 | NR3C1 | PGAM5-KEAP1-NRF2 Complex | DIPK1A | ACHE | VCAM1 | ADRA2A | ADRB3 | Guanylate cyclase (nonspecified subtype) | Nicotinic alpha4beta2 receptor | CRHBP | NTRK1 | Voltage-Gated Sodium Channel Complex | G3630 | VSIG4 | XDH | OXT | SLC15A4 | G5743 | FFAR2 | OPRL1 | OPRD1 | KLK4 | Interferon (nonspecified subtype) | Platelet-Derived Growth Factor Receptor (nonspecified subtype) | ADORA3 | Sodium channel (nonspecified subtype) | K(ATP) Channel (nonspecified subtype) | PRKCD | PTGDR | IL1R1 | GABRA1 | BCL2A1 | GNRHR | PTGDR2 | KDR | CHRM3 | TPH2 | Immunoproteasome | FAAH | Elastase (nonspecified subtype) | beta-Adrenoceptor (nonspecified subtype) | SST | ABCC8 | CALCRL | IL10 | SLC6A4 | LINC02210-CRHR1 | MMP13 | RET | COL6A1 | CTSC | CRHR1 | ADRA1D | Glycine receptor | TLR9 | HTR6 | SCN1A | PDGFRA | SCN9A | L-Type calcium channel (nonspecified subtype) | TPH1 | Tryptase (nonspecified subtype) | CXCR2 | ITPA | MYLK | NOS2 | HTR2A | TRPA1 | PROKR1 | MLNR | VHL | SLC26A2 | GABRA5 | GRM1 | CCKAR | IL1B | Cyclooxygenase (COX) (nonspecified subtype) | ADRB2 | TACR1 | CHRM5 | PPP3CB | SSTR5 | AGTR1 | PLAU | ASIC1 | ICMT | Proteasome Complex | G3569 | PPP3R1 | PRKCQ | Muscarinic Acetylcholine Receptor (mAChR) (nonspecified subtype) | CYP19A1 | GLP2R | IL4 | P2RX2 | TNFSF15 | AGTR2 | GUCY2C | P2RX7 | GABRA2 | HTR2C | 5-Hydroxytryptamine Receptor (nonspecified subtype) | Nitric oxide synthase (NOS) (nonspecified subtype) | JAK3 | OTUB1 | JAK2 | NAAA | PRLHR | alpha-6 beta-2 Nicotinic receptor | JAK1 | PPARGC1B | KRR1 | MRGPRX2 | DRD3 | CTNNB1 | ASIC3 | Tryptophan 5-Monooxygenase (nonspecified subtype) | Imidazoline I2 receptor (I2) | GLP1R | G3576 | IL13 | KAT5 | VASN | Potassium Channels (nonspecified subtype) | LPA | RIPK1 | GRPR | ABL1 | GPR55 | Voltage-Gated Calcium Channel alpha-2/delta (nonspecified subtype) | OXTR | NF-kappaB (NFkB) | LTA4H | CHRNB2 | IL23R | CRHR2 | CHRM2 | PI3 | KIT | NTRK2 | PTAFR | Mitogen-activated protein kinase p38 (MAPK p38) (nonspecified subtype) | MPO | RPL5 | ADRA2C | MIR4761 | GABRA3 | RORC | PPIA | HTR7 | MC1R | FAP | HRH3 | SCN2A | BTK | Protein Phosphatase 2B | G7099 | CCK receptor (nonspecified subtype) | CCR3 | GPBAR1

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