Disease

Idiopathic Pulmonary Fibrosis

About the Disease
Acute Interstitial Pneumonia, also known as acute interstitial pneumonitis, is related to mikulicz disease and pulmonary fibrosis, and has symptoms including dyspnea on exertion and dry cough. An important gene associated with Acute Interstitial Pneumonia is SFTPD (Surfactant Protein D), and among its related pathways/superpathways are Disease and Innate Immune System. The drugs Nintedanib and Protein Kinase Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include lung, bone marrow and bone, and related phenotypes are dyspnea and respiratory failure

Common Targets
STN1 | KANSL1 | GSR | P2X2/3 Receptor Complex | DRD2 | H4C16 | CSF3 | ZKSCAN1 | PREP | TYK2 | MAD1L1 | G1026 | LPAR2 | Phosphatidylinositol 3-kinase (PI3K) (nonspecified subtype) | CDK4 | C-C chemokine receptor (nonspecified subtype) | NPRL3 | Protein Kinase B (PKB/Akt) (nonspecified subtype) | EPHB2 | CYSLTR1 | PDGFRB | KNL1 | TNFSF14 | POLR1HASP | m-Calpain | FKBP1A | PDK1 | LGALS3 | FGFR3 | G2475 | ORAI1 | ST14 | DRD4 | MIR33A | FFAR1 | HTR1A | G1950 | PPARG | G1432 | CNR1 | CYP17A1 | LPAR1 | IFNGR1 | ROCK1 | STAT6 | BRD4 | AMFR | DEPTOR | G7852 | Lipoxygenase (nonspecified subtype) | VIM | DDR2 | GH1 | G142 | PIK3CD | IKZF1 | CHEK1 | KIAA1143 | G598 | CERT1 | MYOM2 | IQCH | Somatostatin receptor (nonspecified subtype) | P2RY2 | mTOR complex 1 | CDKN2B | PMEPA1 | HRH2 | IVD | DKC1 | MAP3K5 | Hedgehog Protein (nonspecified subtype) | G4851 | FAM13A | LEF1 | HDAC1 | HMOX2 | Calcium release-activated channel (CRAC) | PIK3CB | APLNR | CCR4 | G23411 | BCR | SCD | G9429 | HTR2B | IL-1 Receptor (nonspecified subtype) | MIR564 | ACHE | GLI3 | Integrin alpha-8/beta-1 receptor | P2RX3 | PDE1C | ADORA2B | Integrin Receptor (nonspecified subtype) | DYRK1A | MMP12 | STMN3 | alpha-Adrenoceptor (nonspecified subtype) | TNIK | FLT4 | TOLLIP | CHIT1 | PIK3CA | CCN2 | NOX4 | PPARD | SYK | FGFR1 | G5243 | G3630 | NTRK1 | FLT1 | IQCH-AS1 | ANGPT2 | CXCR1 | TGFBR1 | ATG16L1 | Tyrosine Kinase (nonspecified subtype) | Reverse transcriptase (Telomerase) | S1PR2 | HPGD | AKAP13 | PTCH1 | Peroxisome Proliferator-Activated Receptors (PPAR) (nonspecified subtype) | KIF15 | G4318 | DSP-AS1 | GSK3B | CARD10 | G1956 | TGM2 | NADH dehydrogenase (Complex I) | G4233 | EDNRB | G3480 | NR1H4 | Protein Kinase D (PKD) (nonspecified subtype) | SFTPC | TTK | Integrin alphavbeta5 receptor | SERPINB1 | VIPR1 | GIPR | Epithelial Sodium Channel (ENaC) | G581 | RXFP1 | HECTD2 | MAPT-AS1 | IL11 | SLC16A1 | MARCKS | COL1A2 | EIF3I | MAPKAPK2 | Platelet-Derived Growth Factor Receptor (nonspecified subtype) | STAT5 (nonspecified subtype) | KDR | ENO1 | DDAH1 | Interferon (nonspecified subtype) | MMP7 | MS4A1 | MAPK9 | MUC5B | G4193 | ACTRT3 | CHRM3 | DCX (DDB1-CUL4-X-box) E3 protein ligase complex | MAP4K4 | TSPO | ARHGEF4 | MAP3K19 | MMP2 | DRD1 | Heme Oxygenase (HO) (nonspecified subtype) | DSP | SMYD3 | G2033 | FLT3 | STAT4 | Interferon alpha/beta Receptor (nonspecified subtype) | mTOR complex 2 | PDE5A | CXCR3 | CCND3 | IL1B | Glycogen synthase kinase 3 (GSK-3) (nonspecified subtype) | BCL2A1 | RTEL1 | G3569 | SST | ACVRL1 | CD70 | RET | DUSP10 | GPR84 | CPB2 | MAP3K7 | APCS | TRIM71 | Prostanoid TP receptor (nonspecified subtype) | CAPN1 | TLR9 | DDR1 | CHIA | CHUK | TGFB2 | TRPA1 | IRF5 | NMDA receptor | NOS2 | CLDN5 | Transforming growth factor beta (nonspecified subtype) | FASLG | SRPK1 | ZNF467 | MMP13 | LRRC34 | PDGFRA | SFTPA2 | PDE1B | HBB | CYP2C9 | CDK2/Cyclin A | ROCK2 | HTR6 | ACVR1B | AGTR1 | CFTR | TACR1 | LRP12 | CR1 | G672 | G7015 | LOXL2 | NOX3 | JAK2 | TPH1 | CXCR2 | MGMT | CHI3L1 | LDHA | ADRB2 | BCL2L2 | Integrin alphavbeta6 receptor | G1786 | SERPINH1 | Histone deacetylase (nonspecified subtype) | OXER1 | Ikzf1 | ELDR | TNFRSF13C | CREBBP | JAK3 | NF-kappaB (NFkB) | ADH5 | JAK1 | ERN1 | NOX1 | MIF | NQO2 | PLAU | IL4 | G3576 | LRRC15 | DRD3 | STING1 | NPAS2 | NT5E | OSM | MDGA2 | TP53INP1 | PDE4A | SLC16A3 | CYSLTR2 | P2RX2 | CRBN | AGTR2 | C5AR1 | ALOX5 | NADPH Oxidase Complex | MMP8 | HLA-DQB1 | Focal Adhesion Kinases (FAK) (nonspecified subtype) | CDK6/Cyclin D3 | CCL2 | IKZF2 | FYN | Cyclin A (nonspecified subtype) | IL13 | G596 | LDHB | GLP1R | Integrin alphavbeta1 | FBXO32 | KCNMB1 | CAPN9 | Vascular endothelial growth factors (VEGF) (nonspecified subtype) | KIT | Voltage-Gated Calcium Channel alpha-2/delta (nonspecified subtype) | TMEM42 | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3 (PDE3) (nonspecified subtype) | ABL1 | EPRS1 | PIK3CG | TGFB1 | G7124 | HMOX1 | NADPH Oxidase (nonspecified subtype) | Rho kinase (ROCK) (nonspecified subtype) | Integrin alphavbeta8 Receptor | ABCA3 | TENT4B | SLC35F3 | GRIN2B | CCL24 | PORCN | LTA4H | TGFBR2 | TGFB3 | FGF2 | Mitogen-activated protein kinase (JNK) (nonspecified subtype) | G6774 | DPP9 | Collagen (nonspecified subtype) | FBXW7 | FCGR3B | PTGFR | Mitogen-activated protein kinase p38 (MAPK p38) (nonspecified subtype) | PDE4D | G6647 | Superoxide dismutase (SOD) (nonspecified subtype) | G7157 | TERC | FGFR2 | LPAR3 | Phosphodiesterase (nonspecified subtype) | HDAC6 | RORC | AMP-activated protein kinase (AMPK) | BTK | BCAR3 | HTR7 | F12 | ZC3H12A | IL17RB | DNA-Directed DNA Polymerase Complex | EDNRA | ENPP2 | GCGR | mu-Calpain (calpain 1) | XBP1 | Transforming growth factor (TGF)-beta receptor (nonspecified subtype) | CAPN2 | CDK4/Cyclin D3 | FAP | ATP11A | CGAS | Phosphodiesterase IV (PDE4) (nonspecified subtype) | IL1RN | TLR3 | GPBAR1 | HLA-DRB1 | SETD7 | MAP2K5 | CSF1R | RPTOR | CDK2 | GPR35 | G4780 | SERPINF1 | CASZ1 | G5599 | Protein Phosphatase 2A | SOX7 | Na+/H+ Exchanger (NHE) (nonspecified subtype) | SMO | PDE4B | Integrin alphavbeta3 (vitronectin) receptor | HFE

疾病靶点研报
Idiopathic Pulmonary Fibrosis

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