Acute Intermittent Porphyria

About the Disease
Porphyria, Acute Intermittent, also known as acute intermittent porphyria, is related to photoparoxysmal response 1 and porphyria, and has symptoms including abdominal pain, constipation and diarrhea. An important gene associated with Porphyria, Acute Intermittent is HMBS (Hydroxymethylbilane Synthase), and among its related pathways/superpathways are Metabolism and superpathway of b heme biosynthesis from glycine. The drugs Caffeine and Losartan have been mentioned in the context of this disorder. Affiliated tissues include liver, skin and brain, and related phenotypes are abdominal pain and abnormal enzyme/coenzyme activity

Common Targets
CYP2C19 | CYP2D6 | HMBS | CYP3A5 | CYP2C9 | ALAS1 | CYP3A4

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