Cornelia De Lange Syndrome

About the Disease
Cornelia De Lange Syndrome, also known as de lange syndrome, is related to cornelia de lange syndrome 3 with or without midline brain defects and cornelia de lange syndrome 1. An important gene associated with Cornelia De Lange Syndrome is NIPBL (NIPBL Cohesin Loading Factor), and among its related pathways/superpathways are "Cell Cycle, Mitotic" and EML4 and NUDC in mitotic spindle formation. The drugs Acetylcysteine and Cysteine have been mentioned in the context of this disorder. Affiliated tissues include eye, bone and heart, and related phenotypes are high palate and short neck

Common Targets
MED13L | AFF4 | CFAP57 | ARID1B | BRD4 | HDAC8 | SMARCA2 | ZMYND11 | CPLANE1 | TAF1 | KPRP | EHMT1 | SMC1A | SETD5 | RAD21 | TAF6 | SUZ12 | FREM1 | NAA10 | G2033 | NAA50 | NSMCE2 | KMT2A | NIPBL | ANKRD11 | POU3F3 | SMARCB1 | MAU2 | SMC3 | PHIP | F8 | HDAC2 | SPEN

Note: If you'd like to get a target analysis report for Cornelia De Lange Syndrome, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Cornelia De Lange Syndrome at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

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