Holt-Oram Syndrome

About the Disease
Holt-Oram Syndrome, also known as hos, is related to interatrial communication and aortic valve disease 2. An important gene associated with Holt-Oram Syndrome is TBX5 (T-Box Transcription Factor 5), and among its related pathways/superpathways are Cardiac conduction and Human Embryonic Stem Cell Pluripotency. Affiliated tissues include heart, upper limb and bone, and related phenotypes are joint stiffness and split hand

Common Targets
RYR2 | TBX5 | LMNA | Transcriptional Enhancer Factor (TEAD) (nonspecified subype) | G10413

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