Alpha-mannosidosis

About the Disease
Mannosidosis, Alpha B, Lysosomal, also known as alpha-mannosidosis, is related to mannosidosis, beta a, lysosomal and angiokeratoma, and has symptoms including muscle spasticity and gait ataxia. An important gene associated with Mannosidosis, Alpha B, Lysosomal is MAN2B1 (Mannosidase Alpha Class 2B Member 1), and among its related pathways/superpathways are Metabolism and Diseases of glycosylation. The drugs Sorbitol and Glycine have been mentioned in the context of this disorder. Affiliated tissues include bone, eye and tongue, and related phenotypes are intellectual disability and macroglossia

Common Targets
Chaperone (nonspecified subtype) | MAN2B1 | alpha-Mannosidase (nonspecified subtype)

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