Progressive Familial Intrahepatic Cholestasis Type 1

About the Disease
Cholestasis, Progressive Familial Intrahepatic, 1, also known as byler disease, is related to cholestasis, progressive familial intrahepatic, 3 and cholestasis, progressive familial intrahepatic, 4, and has symptoms including diarrhea, icterus and pruritus. An important gene associated with Cholestasis, Progressive Familial Intrahepatic, 1 is ATP8B1 (ATPase Phospholipid Transporting 8B1), and among its related pathways/superpathways are Transport of inorganic cations/anions and amino acids/oligopeptides and Cardiac conduction. The drugs Bile Acids and Salts and Liver Extracts have been mentioned in the context of this disorder. Affiliated tissues include liver, appendix and lung, and related phenotypes are osteopenia and hepatomegaly

Common Targets
PKD1 | PLEC | ABCB4 | ATP8B1 | AKR1D1 | ABCC2 | HLA-DRA | CCL13 | JAG1 | NR1H4 | ABCG8 | SLC10A2 | NOTCH2 | G6PD | SLCO1B1 | ABCB11 | TJP2

Note: If you'd like to get a target analysis report for Progressive Familial Intrahepatic Cholestasis Type 1, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Progressive Familial Intrahepatic Cholestasis Type 1 at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Pouchitis | Teratozoospermia | Glioblastoma | Constipation | Cerebral Cavernous Malformations | Aldosteronism | Chondromyxoid Fibroma | Angioedema, Hereditary | Papillorenal Syndrome | Giant Cell Glioblastoma | Rubeosis Iridis | Granular Corneal Dystrophy | Blood Protein Disorders | Diamond-Blackfan Anemia | Tangier Disease | Prediabetes | Antley-Bixler Syndrome | Oral Lichen Planus | Cole-Carpenter Syndrome | Chronic Neutrophilic Leukemia | Shprintzen-Goldberg Syndrome | Long QT Syndrome Type 3 | Arteriovenous Malformations | Carcinoma In Situ | Primary Hyperoxaluria Type 3 | Trichothiodystrophy | Optic Nerve Diseases | Primary Lateral Sclerosis | Chorea | Metabolic Diseases | Non-Hodgkin Lymphoma | Nephrotic Syndrome | Barrett Esophagus | Infertility | Encephalopathy, Hepatic | Cousin Syndrome | Coloboma | Otitis Externa | Familial Dysautonomia | Ornithine Transcarbamylase Deficiency | Urea Cycle Disorder | Cranial Nerve Disease | Posterior Polar Cataract | Low Phospholipid Associated Cholelithiasis | Ehlers-Danlos Syndrome | Dysferlinopathy | Renal Hypomagnesemia 3 | Pierson Syndrome | Early Infantile Epileptic Encephalopathy 13 | Waardenburg Syndrome | Proteus Syndrome | Epidermodysplasia Verruciformis | Prostatitis | Protein C Deficiency | Auriculocondylar Syndrome | Placenta Previa | Waardenburg Syndrome Type 4A | IgA Deficiency | Angiosarcoma Of The Breast | Celiac Disease | Learning Disability | Hyperparathyroidism, Secondary | Hypertension, Essential | Cryptorchidism | Benign Recurrent Intrahepatic Cholestasis 1 | Bone Marrow Necrosis | Myopathy | Tay-Sachs Disease | Persistent Hyperplastic Primary Vitreous | Gyrate Atrophy Of The Choroid And Retina | Episodic Ataxia Type 2 | Hyperoxaluria | Aplastic Anemia | Carcinoid Syndrome | Hereditary Elliptocytosis | Chronic Leukemia | Glioma | Priapism | Atelosteogenesis Type 1 | Primary Ovarian Insufficiency | Purpura | Cholecystitis | Lymphoma, Mantle Cell | Isovaleric Acidemia | Rhabdoid Tumor | Spinocerebellar Ataxia Type 38 | Hypopituitarism | Withdrawal Syndrome | DRESS Syndrome | Cyclic Vomiting Syndrome | Lymphoproliferative Disorders | Hypogonadism | Cockayne Syndrome | Sclerosing Cholangitis | Charcot-Marie-Tooth Disease Type 4D | Hepatopulmonary Syndrome | Bone Giant Cell Tumor | Porphyria Cutanea Tarda | Niemann-Pick Disease, Type A | Kearns-Sayre Syndrome | T-cell Leukemia | Corticobasal Syndrome | Meckel-Gruber Syndrome | Tyrosinemia Type 2 | Endometritis | Mitochondrial DNA Depletion Syndrome | Infectious Diarrhea | Inflammatory Myofibroblastic Tumor | Epidermolysis Bullosa Simplex, Localized | Huntington's Disease-like 2 | Gigantism | Toxoplasmosis | Cancer, Colon | Occipital Neuralgia | Waardenburg Syndrome Type 4 | Porencephaly | Anosmia, Congenital | Congenital Muscular Dystrophy | Multiple Epiphyseal Dysplasia | Spinocerebellar Ataxia Type 42 | Rickets | Dystonia-parkinsonism, X-linked | Skin Fragility-woolly Hair Syndrome | Hyperparathyroidism-jaw Tumor Syndrome | Liebenberg Syndrome | Multiple Congenital Anomalies-hypotonia-seizures Syndrome 2 | Sandhoff Disease | Down Syndrome | Nestor-Guillermo Progeria Syndrome | Seizures | Alstrom Syndrome | Schamberg Disease | Duane Retraction Syndrome | 3-hydroxyacyl-CoA Dehydrogenase Deficiency | Congenital Heart Block | Nicolaides-Baraitser Syndrome | Protein S Deficiency | Scoliosis | Spinocerebellar Ataxia | Rheumatic Heart Disease | Progressive Familial Intrahepatic Cholestasis Type 2 | Parapsoriasis | Split Hand-foot Malformation | Atelosteogenesis Type 2 | Meningococcal Infections | Purpura, Thrombotic Thrombocytopenic | Cholelithiasis | Hairy Cell Leukemia | Cerebral Amyloid Angiopathy | Sturge-Weber Syndrome | Ehlers-Danlos Syndrome With Progressive Kyphoscoliosis, Myopathy, And Hearing Loss | Cancer, Bladder | Osteochondroma | Wieacker-Wolff Syndrome | Lassa Fever | Ichthyosis, X-linked | Erythematotelangiectatic Rosacea | Borjeson-Forssman-Lehmann Syndrome | Bardet-Biedl Syndrome | Malaria, Cerebral | Autosomal Recessive Bestrophinopathy | Cyst | Osteomalacia | McCune-Albright Syndrome | Pyruvate Carboxylase Deficiency Disease | Cellulitis | Angioimmunoblastic T-cell Lymphoma | Overactive Bladder | Esophagitis, Eosinophilic | Neuroblastoma | Granuloma Annulare | Fibromuscular Dysplasia | Otosclerosis | Spinocerebellar Ataxia Type 2 | Goldenhar Syndrome | Spinocerebellar Ataxia Type 21 | Fatty Aldehyde Dehydrogenase Deficiency | Megacystis-microcolon-intestinal Hypoperistalsis Syndrome | Poirier-Bienvenu Neurodevelopmental Syndrome | Chronic Myeloid Leukemia | Ocular Albinism Type 1 | Vascular Cognitive Impairment | Myositis | Hyperglycemia | Sick Sinus Syndrome 1 | Sensory Neuropathy | Giant Cell Arteritis | Optic Neuritis | Glutaric Aciduria Type 1 | Pneumothorax | Joubert Syndrome 2 | Tyrosine Hydroxylase Deficiency | Cancer, Breast | Plasma Cell Leukemia | LMNA-related Congenital Muscular Dystrophy | Epidermal Nevus Syndrome | Oligospermia | Fibrosis | Congenital Torticollis | Leukemia | Osteosclerosis | Anal Fissure | Ischemia | Hydrops Fetalis | Neuronal Ceroid Lipofuscinosis | Mumps | Congenital Hereditary Endothelial Dystrophy Type II | Hyperinsulinemia | Dermatomyositis | Carbonic Anhydrase VA Deficiency | Blomstrand Osteochondrodysplasia | Deafness, Dystonia, And Cerebral Hypomyelination | Mucolipidosis Type IV | Hyperinsulinism-hyperammonemia Syndrome | Dwarfism | Presbyopia | Cocaine-Related Disorders | Pseudoexfoliation Syndrome | Alcoholism | Myelomeningocele | Polycystic Liver | Neuromyelitis Optica | Acute Anterior Uveitis | Otitis Media | Frontometaphyseal Dysplasia | Necrotizing Autoimmune Myopathy | Brooke-Spiegler Syndrome | Burn-McKeown Syndrome | Chronic Beryllium Disease | Bleeding Disorder Due To CalDAG-GEFI Deficiency | CREST Syndrome | Carpenter Syndrome | Sleep Disorder | D-2-Hydroxyglutaric Aciduria | Anxiety Disorders | Mucormycosis | Angiomyolipoma | Hepatoblastoma | Lyme Disease | Delirium | Prolymphocytic Leukemia | Chromosome 8q21.11 Deletion Syndrome | Lichen Sclerosus | C3 Glomerulonephritis | Bacterial Meningitis | Long QT Syndrome Type 2 | Meniere's Disease | Congenital Diaphragmatic Hernia | Walker-Warburg Syndrome | Niemann-Pick Disease, Type C | Analgesia | Albinism | Papulopustular Rosacea | Generalized Epilepsy And Paroxysmal Dyskinesia | Eosinophilia | Creatine Deficiency Syndrome | Congenital Bilateral Absence Of Vas Deferens | Cutaneous Angiosarcoma | Eiken Syndrome | Pure Autonomic Failure | Blau Syndrome | Diabetes Mellitus, Transient Neonatal | WAGR Syndrome | Mitochondrial DNA Depletion Syndrome 13 | Primary Familial Brain Calcification | Dental Caries | Lymphoma, AIDS-related | Mohr-Tranebjaerg Syndrome | Mitochondrial DNA Depletion Syndrome, Myopathic Form | Orthostatic Intolerance | Bicuspid Aortic Valve | Spitzoid Melanoma | Osteoporosis, Postmenopausal | Cystitis, Interstitial | Pseudohypoparathyroidism Type 2 | Amyotrophic Lateral Sclerosis, Juvenile | Neonatal Progeroid Syndrome | Polyomavirus Nephropathy | Glucagonoma | Sleep Apnea | Retinal Dystrophy | Autoimmune Autonomic Ganglionopathy | Rubinstein-Taybi Syndrome | Coenzyme Q10 Deficiency | Sclerosteosis 2 | Endophthalmitis | Hereditary Coproporphyria | Disseminated Superficial Actinic Porokeratosis | Lymphoma Lymphoblastic | Werner's Syndrome | Stuttering | Myopia | N-acetylglutamate Synthase Deficiency | Diabetic Nephropathy | Atrioventricular Septal Defect | Fahr Disease | Congenital Absence Of Vas Deferens | Familial Episodic Pain Syndrome | Multiple Hamartoma Syndrome | Woodhouse-Sakati Syndrome | Progressive Familial Intrahepatic Cholestasis Type 1 | Uveitis | Scleroderma | Hepatitis E | Tyrosinemia | Rhabdomyosarcoma | Pulmonary Capillary Hemangiomatosis | Dystrophy, Cone-rod | Insulinoma | Charcot-Marie-Tooth Disease Type 2T | Spinocerebellar Ataxia Type 27 | Nicotine Addiction | Kohlschutter-Tonz Syndrome | Restless Legs Syndrome | Sleep Apnea, Central | Reflex Epilepsy | T-cell Lymphoma, Subcutaneous Panniculitis-like | Behavioral Variant Of Frontotemporal Dementia | Pyruvate Decarboxylase Deficiency | IMAGe Syndrome | Congenital Ichthyosiform Erythroderma | Lipid Metabolism Disorders | Pulmonary Tuberculosis | Long QT Syndrome Type 1 | Hypoplastic Left Heart Syndrome | Familial Hemiplegic Migraine | Histiocytosis | Retinoblastoma | Lipid Storage Myopathy | DOCK8 Immunodeficiency Syndrome | Hyperthyroidism | Retinopathy Of Prematurity | Pneumoconiosis | Allan-Herndon-Dudley Syndrome | Arteriosclerosis | Pilomatrix Carcinoma | Cutaneous T-cell Lymphoma | Paternal Uniparental Disomy Of Chromosome 14 | Jaundice, Obstructive | Epidermolysis Bullosa Dystrophica | Anorexia Nervosa | GAPO Syndrome | HIBCH Deficiency | Hereditary Mixed Polyposis Syndrome | Myofibromatosis | Charcot-Marie-Tooth Disease, Type 2A | Primary Progressive Nonfluent Aphasia | Treacher Collins Syndrome | Lung Diseases | Sponastrime Dysplasia | Fraser Syndrome | Leishmaniasis, Cutaneous | Gray Platelet Syndrome | Anorectal Fistula | Osteogenesis Imperfecta Type V | Stroke, Ischemic | Chordoid Glioma | Carney Triad | Adenoid Cystic Carcinoma | Spinal And Bulbar Muscular Atrophy | Exostoses | Vertigo | Corneal Dystrophies, Hereditary | Roberts Syndrome | Nemaline Myopathy 8 | Heavy Chain Disease | Sick Sinus Syndrome | Adenylosuccinate Lyase Deficiency | Blepharophimosis Syndrome | Phenylketonuria II | Atopy | Lipodystrophy | Crigler-Najjar Syndrome | Gerodermia Osteodysplastica | Wagner Disease | Anterior Segment Dysgenesis | Arthropathy | Peters-plus Syndrome | Amebiasis | Pseudohypoaldosteronism | Homocystinuria | Leukocyte Adhesion Deficiency Type 1 | Premenstrual Syndrome | Greenberg Dysplasia | Tetanus | Hypoproteinemia, Hypercatabolic | Acrodysostosis | Palmoplantar Keratoderma | Blepharospasm | Micropenis | Congenital Sodium Diarrhea | Neurocysticercosis | Holoprosencephaly | Preaxial Polydactyly | Hypobetalipoproteinemias | Blepharo-cheilo-odontic Syndrome | Hyperferritinemia-cataract Syndrome | Fanconi Syndrome | Osteoporosis | Thanatophoric Dysplasia