Aldosteronism

About the Disease
Conn's Syndrome, also known as cushing syndrome, is related to ectopic cushing syndrome and acth-secreting pituitary adenoma, and has symptoms including cushingoid facies An important gene associated with Conn's Syndrome is USP8 (Ubiquitin Specific Peptidase 8), and among its related pathways/superpathways are Metabolism and Disease. The drugs Bromocriptine and Metformin have been mentioned in the context of this disorder. Affiliated tissues include pituitary, adrenal gland and adrenal cortex, and related phenotypes are increased circulating cortisol level and paradoxical increased cortisol secretion on dexamethasone suppression test

Common Targets
NF-kappaB (NFkB) | SLC12A2 | HSD17B2 | NR3C2 | CYP7A1 | CYP17A1 | KCND3 | ESR2 | NEDD4L | KCNA5 | WNK1 | NR3C1 | KCNJ5 | 17-beta-Hydroxysteroid dehydrogenase (nonspecified subtype) | CYP19A1 | ARMC5 | PRKACA | HSD3B1 | CYP11B2 | REN | HSD3B2 | SLC12A1

Note: If you'd like to get a target analysis report for Aldosteronism, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Aldosteronism at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Pierson Syndrome | Nail Disorder, Nonsyndromic Congenital | Lipid Storage Myopathy | Retinal Dystrophy | Gestational Trophoblastic Disease | Osteitis | Onchocerciasis | Seasonal Mood Disorder | Thyroiditis, Autoimmune | Juvenile Xanthogranuloma | Schizophrenia | Microcephaly | Eosinophilic Asthma | Tuberculous Meningitis | Short-chain Acyl-CoA Dehydrogenase Deficiency | Hemorrhoids | Supravalvular Aortic Stenosis | Thanatophoric Dysplasia Type 1 | Tularemia | Nail-Patella Syndrome | Hemorrhagic Disorders | Charcot-Marie-Tooth Disease, Type 2 | Gyrate Atrophy Of The Choroid And Retina | Sarcoma, Alveolar Soft Part | Jalili Syndrome | Oral Lichen Planus | Megalencephaly | Varices | Cancer, Prostate | Fuchs Dystrophy | Galloway-Mowat Syndrome | Keratoacanthoma | Hyperuricemia | Primary Pigmented Nodular Adrenocortical Disease | Zygomycosis | Raine Syndrome | Mucolipidosis | Retinal Detachment | Primary Sclerosing Cholangitis | Congenital Dyserythropoietic Anemia Type 4 | Hereditary Multiple Exostoses | Fibromyalgia | Carcinoma, Signet Ring Cell | Major Depression | Agranulocytosis | 3C Syndrome | Pityriasis Rubra Pilaris | Creatine Deficiency Syndrome Due To AGAT Deficiency | Primrose Syndrome | Spinocerebellar Ataxia Type 3 | Seminoma | Microphthalmia | Urolithiasis | Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive 2 | Diffuse Intrinsic Pontine Glioma | Cyst | Cantu Syndrome | Porphyria | Diabetic Neuropathy | Myeloid Leukemia | Turner's Syndrome | Waardenburg Syndrome Type 4A | Moyamoya Disease | Sleep Disorder | Hypermethioninemia | Hypodontia | Rickets | Thrombosis | Hyperinsulinemic Hypoglycemia | Neurodermatitis | Chromosome 17q21.31 Deletion Syndrome | Autosomal Recessive Spastic Paraplegia Type 54 | Diabetes | Periventricular Nodular Heterotopia | Duane Retraction Syndrome | Bursitis | Chordoid Glioma | Spondylolisthesis | Cholestasis | Hemochromatosis Type 2 | Corneal Edema | Sepiapterin Reductase Deficiency | Pulverulent Zonular Cataract | Blepharo-cheilo-odontic Syndrome | Huntington's Disease | Obesity | Abetalipoproteinemia | Schwannoma | Leishmaniasis, Visceral | Epithelioid Hemangioma | Meconium Ileus | Charcot-Marie-Tooth Disease Axonal Type 2N | Hepatitis B, Chronic | Adrenal Insufficiency | Spinocerebellar Ataxia Type 2 | Amebiasis | Non-epidermolytic Palmoplantar Keratoderma | Glutaric Aciduria Type 2 | Cerebellar Ataxia, Cayman Type | Macrophagic Myofasciitis | Histiocytosis | Dysequilibrium Syndrome | Vogt-Koyanagi-Harada Syndrome | Lymphedema | Osteomalacia | Situs Inversus | Amenorrhea | Gastroenteritis, Eosinophilic | Choriocarcinoma | Haim-Munk Syndrome | Thyroid Dysgenesis | Neutrophilia | Fibrosis | Beckwith-Wiedemann Syndrome | Lassa Fever | Heart Septal Defects | Cellulitis | Argininosuccinic Aciduria | Familial Digital Arthropathy-brachydactyly | Frank-ter Haar Syndrome | Cold-induced Sweating Syndrome | Infantile Refsum Disease | Joubert Syndrome 2 | Urticaria | Early Infantile Epileptic Encephalopathy 1 | Heterotopic Ossification | Rubinstein-Taybi Syndrome | Perry Syndrome | Hypolipoproteinemia | COACH Syndrome | Proctitis | Central Retinal Artery Occlusion | Congenital Disorders Of Glycosylation | Platyspondylic Lethal Skeletal Dysplasia, Torrance Type | Hemimegalencephaly | Osteogenesis Imperfecta Type V | Osteogenesis Imperfecta Type IV | Muscular Dystrophy | Ornithine Transcarbamylase Deficiency | Basal Ganglia Disease, Biotin-responsive | Pure Red Cell Aplasia | Coffin-Siris Syndrome | Pituitary Dwarfism | Chudley-McCullough Syndrome | Muir-Torre Syndrome | Hydrolethalus Syndrome | Glioma | Osteopathia Striata With Cranial Sclerosis | Ocular Hypertension | Coma | Pneumoconiosis | Blepharospasm | Otopalatodigital Syndrome Type 2 | Cone Dystrophy | Anosmia, Congenital | Fatty Aldehyde Dehydrogenase Deficiency | AIDS | Diffuse Palmoplantar Keratoderma | Retinitis Pigmentosa 3 | Primary Ovarian Insufficiency | Blepharophimosis Syndrome | Oligospermia | Sclerosteosis 2 | Neural Tube Defect | Skin Papilloma | Diabetes Gestational | Analgesia | Mastitis | Benign Hereditary Chorea | Dermatitis Herpetiformis | Guanidinoacetate Methyltransferase Deficiency | 3-hydroxy-3-methylglutaryl-CoA Synthase Deficiency | Spinocerebellar Ataxia Type 21 | Aldosterone Deficiency | Cerebellofaciodental Syndrome | Mitochondrial DNA Depletion Syndrome | Adenosine Deaminase 2 Deficiency | Schindler Disease | Gastrointestinal Disorders | Oligoastrocytoma | Prader-Willi Syndrome | Coffin-Lowry Syndrome | Tremor | Acute Kidney Injury | Purpura, Thrombotic Thrombocytopenic | Infantile Nephropathic Cystinosis | Hypersomnia | Optic Neuropathy | Menkes Disease | Dysmorphophobia | Epithelial-myoepithelial Carcinoma | Cystitis | Sponastrime Dysplasia | Familial Exudative Vitreoretinopathy | Juvenile Hyaline Fibromatosis | Panniculitis | Progressive External Ophthalmoplegia | Pleurisy | Ollier Disease | Ichthyosis Hystrix, Curth-Macklin Type | Chronic Neutrophilic Leukemia | Non-Langerhans Cell Histiocytosis | Renal Medullary Carcinoma | Gastroschisis | Thrombophilia | Diabetes Type 1 | Lysosomal Acid Lipase Deficiency | Ocular Surface Squamous Neoplasia | Peeling Skin Syndrome Type B | Aldosteronism | Gangliosidosis | Cholelithiasis | Brachydactyly | Hereditary Elliptocytosis | Congenital Disorders Of Glycosylation Type II | Varicocele | Addison Disease | Scleroderma | Placenta Previa | HANAC Syndrome | Oligodendroglioma | Peritonitis | Alveolar Capillary Dysplasia | Bronchitis | Pemphigus | Familial Mediterranean Fever | Intracerebral Hemorrhage | Frontotemporal Dementia With Amyotrophic Lateral Sclerosis | Diabetic Encephalopathy | Cryptorchidism | Liddle Syndrome | Otosclerosis | Malaria | Spinocerebellar Ataxia Type 31 | Pyruvate Dehydrogenase Deficiency | Hepatopulmonary Syndrome | Pre-eclampsia | Geleophysic Dysplasia | Basan Syndrome | Amelogenesis Imperfecta | Osteonecrosis Of The Jaw | Congenital Absence Of Vas Deferens | Mannosidase Deficiency Diseases | Polyneuropathy | Double Outlet Right Ventricle | Ataxia-hypogonadism-choroidal Dystrophy Syndrome | Cri-du-chat Syndrome | Transthyretin-related Amyloidosis | Schnyder Crystalline Corneal Dystrophy | Papillorenal Syndrome | Gliosarcoma | Birt-Hogg-Dube Syndrome | Lymphopenia | Neurodegeneration Due To Cerebral Folate Transport Deficiency | Pyruvate Decarboxylase Deficiency | Sjogren Syndrome | Familial Hypobetalipoproteinemia | Prolidase Deficiency | Norrie Disease | Polycythemia | Holt-Oram Syndrome | Tendinitis | Pouchitis | Acromegaly | Phosphoglycerate Dehydrogenase Deficiency | Autism | D-2-Hydroxyglutaric Aciduria | Toxoplasmosis | Thalassemia | Neonatal Progeroid Syndrome | Feingold Syndrome | Trichuriasis | Antisocial Personality Disorder | Familial Male-limited Precocious Puberty | Temporal Lobe Epilepsy | Spastic Paraplegia Type 7 | Vertigo | Bicuspid Aortic Valve | Hemolytic Uremic Syndrome, Atypical | Corneal Neovascularization | Strabismus | Thromboembolism | Fragile X Syndrome | Neurofibroma, Plexiform | Angioedema, Acquired | Hyperglycemia | Carbohydrate Metabolism Disorders | Pigment Dispersion Syndrome | Glioblastoma Multiforme | Pneumococcal Meningitis | Chorioretinitis | Neurocutaneous Syndromes | Pulmonary Vein Stenosis | Cartilage Disorders | Still Disease | Venous Insufficiency | NGLY1 Deficiency | Multicentric Carpotarsal Osteolysis Syndrome | Sarcoidosis | Alkaptonuria | Polyarteritis Nodosa | Osteoporosis, Postmenopausal | Multiple Epiphyseal Dysplasia | Retinopathy, Diabetic | Clouston Hidrotic Ectodermal Dysplasia | Pyruvate Carboxylase Deficiency Disease | Lattice Corneal Dystrophy | Empyema | Coronary Restenosis | Pseudohypoparathyroidism Type 1A | Hypohidrotic Ectodermal Dysplasia | Progressive Osseous Heteroplasia | Succinic Semialdehyde Dehydrogenase Deficiency | Allergic Contact Dermatitis | Congenital Lipoid Adrenal Hyperplasia | Cat Eye Syndrome | Hepatitis C, Chronic | Ichthyosis Bullosa Of Siemens | Vestibular Disease | Ischemia | Spinocerebellar Ataxia Type 15 | Alopecia Areata | Syncope | Blomstrand Osteochondrodysplasia | Kabuki Syndrome | Keratosis | Choreoathetosis, Hypothyroidism, And Neonatal Respiratory Distress | Charcot-Marie-Tooth Disease Type 2E | Chondrosarcoma | Hemolytic Anemia | Leukocyte Adhesion Deficiency Type 1 | Porencephaly | Von Hippel-Lindau Disease | Tietze Syndrome | Anorchia | Juvenile Myelomonocytic Leukemia | Trachoma | Maternally Inherited Diabetes And Deafness | Ectopia Lentis, Isolated, Autosomal Recessive | Influenza | Tetraplegia | Myoclonic Epilepsy With Ragged Red Fibers | Hypotrichosis, Congenital, With Juvenile Macular Dystrophy | Duchenne Muscular Dystrophy | Sleep Apnea, Central | Goiter | Primary Carnitine Deficiency | Encephalitis | Stroke, Hemorrhagic | Blastomycosis | Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive 1 | Multiple Sclerosis, Secondary Progressive | Meningioma | Tylosis With Esophageal Cancer | Nance-Horan Syndrome | Epidermolysis Bullosa Simplex, Dowling-Meara Type | Aceruloplasminemia | Triphalangeal Thumb-polysyndactyly Syndrome | Multiple Sclerosis, Primary Progressive | Alpha-mannosidosis | Giant Axonal Neuropathy | Thin Basement Membrane Disease | Pituitary Disorders | Granular Corneal Dystrophy Type 1 | Potocki-Shaffer Syndrome | Hypertension, Essential | Osteopetrosis | Multiple Congenital Anomalies-hypotonia-seizures Syndrome 2 | Behcet's Disease | Hypereosinophilic Syndrome | Chromosome 9q34.3 Deletion Syndrome | Nanophthalmos | Rothmund-Thomson Syndrome | Hypercalciuria | Nutrition Disorders | Mitochondrial Encephalomyopathy | Spinocerebellar Ataxia Type 6 | Gynecomastia | Autosomal Recessive Bestrophinopathy | Diverticulitis | Parkinson Disease 6, Autosomal Recessive Early-onset | Hairy Cell Leukemia | Epilepsy, Generalized | Neutropenia | Pierpont Syndrome | Paroxysmal Kinesigenic Dyskinesia | Rash | Hashimoto Thyroiditis | Depression | Azoospermia | Metabolic Syndrome | Esotropia | Aspergillosis | Adenoid Cystic Carcinoma | Congenital Sodium Diarrhea | Huntington's Disease-like 2 | Acromesomelic Dysplasia | Fibronectin Glomerulopathy | Senior-Loken Syndrome | Asthma, Nocturnal