Diffuse Palmoplantar Keratoderma

About the Disease
Diffuse Palmoplantar Keratoderma, also known as diffuse palmoplantar hyperkeratosis, is related to palmoplantar keratoderma, nonepidermolytic and naxos disease. An important gene associated with Diffuse Palmoplantar Keratoderma is DSG1 (Desmoglein 1), and among its related pathways/superpathways are Keratinization and RND3 GTPase cycle. Affiliated tissues include skin, heart and lung, and related phenotype is integument.

Common Targets
CDH12

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