Cirrhosis

About the Disease
Liver Cirrhosis, also known as cirrhosis, is related to alcoholic liver cirrhosis and primary biliary cholangitis, and has symptoms including abdominal pain, constipation and diarrhea. An important gene associated with Liver Cirrhosis is FARSB (Phenylalanyl-TRNA Synthetase Subunit Beta), and among its related pathways/superpathways are Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) and Lung fibrosis. The drugs Racivir and Propofol have been mentioned in the context of this disorder. Affiliated tissues include Bone and Blood.

Common Targets
HOXA6 | GPBAR1 | G5599 | IL22 | AVPR1A | SMO | MRGPRX1 | HFE | LRRK2 | HOXA7 | Integrin alpha4beta1 (VLA-4) receptor | RNR1 | Phosphodiesterase IV (PDE4) (nonspecified subtype) | CENPW | F2RL1 | SPINT2 | NR3C2 | IGF2R | IFNL2 | SERPINB3 | CNR2 | GHRL | HSD17B14 | PPARA | Phosphatidylinositol 3-kinase (PI3K) (nonspecified subtype) | THRB | Ribosomal Protein S6 Kinase, 90kDa (nonspecified subtype) | LGALS3 | TRIB1 | COL1A1 | G1029 | HOXA9 | GAS5 | PNPLA3 | AURKB | SOX1 | HLA-DRB1 | G1950 | IFNL3 | ROCK1 | CFD | PDGFRB | Hedgehog Protein (nonspecified subtype) | G598 | LPAR1 | ALDH2 | HLA-DQA1 | G842 | RNF7 | KCND3 | MMP3 | IL4R | DDR2 | RUNX3 | ADIPOQ | Lipoxygenase (nonspecified subtype) | AVPR1B | IKZF1 | CNRIP1 | PIK3CD | MAP3K5 | PIK3CB | ABCB4 | Relaxin receptor (nonspecified subtype) | G2475 | PPARG | HLA-DQB2 | CNR1 | G7124 | HOXA10 | SLC14A1 | Integrin alpha4beta7 (LPAM-1) receptor | G23411 | CEBPA | RASGRF2 | CHIT1 | IL7R | ADORA1 | ADAM17 | NOD2 | G4609 | ADORA2B | CD14 | HTR2B | G1385 | PTGS1 | KCNJ1 | HOXA11 | CCN2 | BMP1 | AFP | G2099 | FLT4 | S1PR2 | TWNK | BGLAP | JUNB | PPARD | PCSK9 | CASP8 | CCR2 | PTCH1 | SOD2 | LIPA | MIR604 | G5595 | ADORA2A | KRT18 | AVPR2 | APOC3 | TGFBR1 | ADRB3 | Tubulin | FLT1 | TM6SF2 | G4170 | GLS | G999 | TGM2 | Histone acetyltransferase (HAT) (nonspecified subtype) | CREB3 | PTPN1 | JUND | ACHE | Guanylate cyclase (nonspecified subtype) | Casein kinase II (CKII) | AKR1B1 | HOXA13 | IL12RB2 | Interleukin-12 (IL-12) | DNMT3B | OXT | TLR2 | G4318 | ADH1B | MAP1LC3B | GCKR | GPAM | PIK3CA | SUSD4 | SOCS3 | MAPK9 | G5743 | COL1A2 | AQP2 | HOXA1 | NR1H4 | G367 | KCNA5 | PCSK7 | G4233 | MERTK | RYR2 | LOC105369710 | VDR | CISH | Interferon alpha/beta Receptor (nonspecified subtype) | SLC10A1 | ADRB1 | FGFR4 | G6PC1 | FOCAD | HOXA2 | EVX1 | HMBS | STAT4 | MBOAT7 | MTARC1 | MTHFR | LEPR | KDR | HSD17B13 | beta-Adrenoceptor (nonspecified subtype) | Caspase (nonspecified subtype) | DDR1 | IL1A | IL10 | AOC1 | CHIA | CD33 | SPTBN1 | AP-1 Transcription Factor Complex | Transforming growth factor beta (nonspecified subtype) | G1956 | ZNF699 | LOXL2 | PDE5A | APOBEC3B | IFNG | TLR9 | CHI3L1 | SERPINH1 | Vasopressin Receptor (nonspecified subtype) | Cytochrome P450 Enzymes (nonspecified subtype) | G1786 | GC | S1PR5 | ROCK2 | SLC14A2 | ARAP3 | DOK1 | G7422 | DNA topoisomerase (nonspecified subtype) | MAPKAPK3 | Histone deacetylase (nonspecified subtype) | G3845 | Complement Complex | Inosine 5'-monophosphate dehydrogenase (IMPDH) (nonspecified subtype) | VHL | SERPINA1 | FAS | GSTP1 | CREBBP | NAMPT | ISG15 | RUNX1 | GSTM1 | TIMP2 | AKR1B10 | CFTR | IL1B | PLA2G2D | TMEM176B | KLF6 | CASP1 | IFNL4 | G3146 | IL21 | BIRC5 | Phospholipase A2, Secretory (sPLA2) (nonspecified subtype) | IL4 | G3569 | Cytochrome P450 4A (nonspecified subtype) | NLRP3 Inflammasome | SGIP1 | GATA3 | GUCY2C | EPHX1 | NR1D1 | CTCFL | Angiotensin receptor (AT) (nonspecified subtype) | ABCB11 | APOE | CCL2 | CREB5 | CRBN | G7015 | CTNNB1 | G114548 | G596 | GLP1R | MIR196A2 | GSPT1 | MAOB | G3576 | TSBP1 | TOR1B | HLA-DQB1 | FRZB | MICA | HOXA3 | SIRT3 | ABL1 | SLC29A1 | OXTR | PIK3CG | RASSF1 | ACER1 | EFNA1 | IL18 | G8878 | KIF1B | IFNAR2 | SLC31A1 | EPAS1 | HOXA4 | Soluble guanylyl cyclase | NF-kappaB (NFkB) | AOC3 | Transcription Factor TCF (nonspecified subtype) | KIR2DS4 | TRPM5 | AURKA | Vasopressin V1 Receptor (nonspecified subtype) | Mitogen-activated protein kinase p38 (MAPK p38) (nonspecified subtype) | KIT | DNA-Directed DNA Polymerase Complex | B9D2 | GCGR | HOXA5 | XBP1 | SIRT6 | SAMM50 | Transforming growth factor (TGF)-beta receptor (nonspecified subtype) | HDAC6 | LPIN1 | PPIA | Phosphodiesterase (nonspecified subtype) | ENPP2 | EDNRA | PLA2G2A | FAP | SPP1 | LDLR | FGFR2 | TGFB1 | G29126 | G595 | AMP-activated protein kinase (AMPK) | CD36 | DEPDC5 | G7099 | RUNX2

Note: If you'd like to get a target analysis report for Cirrhosis, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Cirrhosis at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

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