Gitelman Syndrome

About the Disease
Gitelman Syndrome, also known as familial hypokalemia-hypomagnesemia, is related to pseudohypoaldosteronism, type i, autosomal recessive and chondrocalcinosis, and has symptoms including muscle cramp, polyuria and seizures. An important gene associated with Gitelman Syndrome is SLC12A3 (Solute Carrier Family 12 Member 3), and among its related pathways/superpathways are Transport of inorganic cations/anions and amino acids/oligopeptides and Ion channel transport. The drugs Progesterone and Mifepristone have been mentioned in the context of this disorder. Affiliated tissues include Kidney, heart and skin, and related phenotypes are hypokalemia and failure to thrive

Common Targets
SLC12A3 | TRNF | TRNI | NPHS1

Note: If you'd like to get a target analysis report for Gitelman Syndrome, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Gitelman Syndrome at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

CREST Syndrome | Angioedema | Acute Coronary Syndrome | Congenital Dyserythropoietic Anemia Type 4 | Priapism | Light Chain Amyloidosis | Bleeding Disorder Due To CalDAG-GEFI Deficiency | Myelofibrosis | Occipital Neuralgia | Brachydactyly | Generalized Epilepsy And Paroxysmal Dyskinesia | Pelizaeus-Merzbacher Disease | Left Ventricular Noncompaction | Obsessive-compulsive Disorder | Photosensitivity | Schindler Disease | Hereditary Neuropathy With Liability To Pressure Palsies | Leukoplakia | Hypokalemic Periodic Paralysis | Liebenberg Syndrome | Encephalopathy, Ethylmalonic | Essential Fructosuria | Aldosterone Deficiency | Fuchs Heterochromic Iridocyclitis | 3-methylcrotonyl-CoA Carboxylase Deficiency | Bainbridge-Ropers Syndrome | Gout | Trichuriasis | Ataxia-hypogonadism-choroidal Dystrophy Syndrome | Spondylocostal Dysostosis | Rothmund-Thomson Syndrome | Hemangioendothelioma | Congenital Absence Of Vas Deferens | Osteomyelitis | Dent Disease | Prune Belly Syndrome | Porencephaly | Nemaline Myopathy 8 | Personality Disorders | Gilbert Syndrome | Beta-Propeller Protein-associated Neurodegeneration | Mitochondrial Encephalomyopathy | Proximal Symphalangism | Shock, Cardiogenic | Rubeosis Iridis | Arthropathy | Pituitary Dwarfism | Parkinson's Disease | Inflammatory Myofibroblastic Tumor | Hydrocephalus, Normal Pressure | Bladder Exstrophy | Sleep Apnea, Obstructive | Budd-Chiari Syndrome | Growth Hormone Excess | Hashimoto Thyroiditis | Jacobsen Syndrome | Dysgerminoma | Retinal Vasculitis | Cranioectodermal Dysplasia | Restless Legs Syndrome | Goiter, Nodular | Myelodysplasia | Anuria | Antisynthetase Syndrome | Spinocerebellar Ataxia Type 1 | Familial Glucocorticoid Deficiency | Chondrodysplasia Punctata 2, X-linked Dominant | Congenital Lipoid Adrenal Hyperplasia | Tendinitis | Primary Carnitine Deficiency | Rash | Bruck Syndrome | Myosin Storage Myopathy | Smoldering Myeloma | Ichthyosis Bullosa Of Siemens | Esotropia | Diabetic Nephropathy | Beare-Stevenson Syndrome | Glycogen Storage Disease Type 0, Muscle | Sorsby Fundus Dystrophy | Nager Acrofacial Dysostosis | Familial Mediterranean Fever | Large Granular Lymphocytic Leukemia | Turner's Syndrome | Megacystis-microcolon-intestinal Hypoperistalsis Syndrome | Bone Marrow Necrosis | Osteonecrosis | Schizoaffective Disorder | Stevens-Johnson Syndrome | Spinocerebellar Ataxia Type 15 | Charcot-Marie-Tooth Disease, Type 2 | Arthritis, Psoriatic | Hyperekplexia | Prurigo Nodularis | Persistent Mullerian Duct Syndrome | Oculodentodigital Dysplasia | Ichthyosis Hystrix, Curth-Macklin Type | Anovulation | Ligneous Conjunctivitis | Periodontitis | McKusick Type Metaphyseal Chondrodysplasia | Craniofrontonasal Syndrome | Pityriasis Rubra Pilaris | 3-methylglutaconic Aciduria | Charcot-Marie-Tooth Disease, Type 1A | Thin Basement Membrane Disease | Addison Disease | Overactive Bladder | Sclerosing Cholangitis | Progressive Familial Intrahepatic Cholestasis | Charcot-Marie-Tooth Disease | Basal Ganglia Disease | Retinal Diseases | Congestive Heart Failure | Cardiomyopathy, Dilated, 1L | NGLY1 Deficiency | Relapsing Polychondritis | Chronic Mucocutaneous Candidiasis | Sandhoff Disease | Parkinson Disease 6, Autosomal Recessive Early-onset | Iron Overload | Optic Nerve Diseases | Diffuse Mesangial Sclerosis | Mountain Sickness | Epiphyseal Chondrodysplasia, Miura Type | Myoclonus-dystonia Syndrome | Tetraplegia | Congenital Hereditary Endothelial Dystrophy Type II | Erythropoietic Protoporphyria | Amyloidosis | Spina Bifida | Meningioma, Benign | Ataxia-ocular Apraxia 2 | CEDNIK Syndrome | Cartilage Disorders | Vaginitis | Rhabdomyosarcoma, Alveolar | Persistent Fetal Circulation | Hyperandrogenemia | Dementia | Glycogen Storage Disease Type 3 | T-cell Prolymphocytic Leukemia | Allan-Herndon-Dudley Syndrome | Renal Hypomagnesemia 3 | Cirrhosis | Hepatitis D | Retinal Degeneration | Charcot-Marie-Tooth Disease, Type 2A | Primary Hyperoxaluria Type 1 | Hypotension, Orthostatic | Senior-Loken Syndrome | Sarcoma, Alveolar Soft Part | Rift Valley Fever | Keratoconjunctivitis | Spinocerebellar Ataxia Type 31 | Platyspondylic Lethal Skeletal Dysplasia, Torrance Type | Ureteropelvic Junction Obstruction | Pancytopenia | Muscle Wasting | Asplenia | Syphilis | Epidermolysis Bullosa Simplex, Localized | Vici Syndrome | Familial Partial Lipodystrophy | Waardenburg Syndrome Type 2 | Castleman Disease | IMAGe Syndrome | Hereditary Sensory And Autonomic Neuropathy | Ileitis | Osteosarcoma | Osteoglophonic Dysplasia | Kaposi Sarcoma | Gerodermia Osteodysplastica | Spinocerebellar Ataxia Type 10 | Hyperlipidemia Type V | Hidradenitis Suppurativa | Familial Hyperaldosteronism | Dwarfism | Multiple Myeloma | Plasma Cell Dyscrasia | Adenoma, Pituitary | Skin Papilloma | Pneumonia, Mycoplasma | Enhanced S-cone Syndrome | Hypophosphatemic Rickets With Hypercalciuria, Hereditary | Hyperparathyroidism, Primary | Mitochondrial Disease | Hyperbilirubinemia, Neonatal | Exostoses | Progressive Myoclonic Epilepsy | Schizophrenia, Paranoid | McLeod Syndrome | Hartsfield Syndrome | Charcot-Marie-Tooth Disease Type 3 | PHARC Syndrome | Polycythemia | Genee-Wiedemann Syndrome | Snyder-Robinson Syndrome | Antiphospholipid Syndrome | Autism | Warsaw Breakage Syndrome | Heavy Chain Disease | Majeed Syndrome | Familial Isolated Hyperparathyroidism | Sclerosteosis 2 | Histiocytic Sarcoma | Retinal Coloboma | Crimean-Congo Hemorrhagic Fever | Venous Insufficiency | Keratocystic Odontogenic Tumor | Situs Inversus | Pierson Syndrome | Congenital Central Hypoventilation Syndrome | Mucolipidosis | Strabismus | Craniofacial Dysostosis | Tetanus | Spinal Muscular Atrophy | Encephalopathy, Glycine | Eccrine Porocarcinoma | Impulse Control Disorder | Kallmann Syndrome | Anal Fissure | Hypertrophy | Hemangioma | Greenberg Dysplasia | Myoclonic Atonic Epilepsy | Myositis | Facioscapulohumeral Muscular Dystrophy Type 1 | Pemphigus Foliaceus | Osteogenesis Imperfecta Type II | Fibrillation, Atrial | DEND Syndrome | Smith-Kingsmore Syndrome | Axenfeld-Rieger Syndrome | Barrett Esophagus | Neurofibroma | Frontotemporal Dementia | Mitochondrial DNA Depletion Syndrome 13 | 3-hydroxy-3-methylglutaryl-CoA Synthase Deficiency | Splenomegaly | Enterocolitis, Necrotizing | Craniolenticulosutural Dysplasia | Wolman Disease | Emery-Dreifuss Muscular Dystrophy | Familial Male-limited Precocious Puberty | Carbonic Anhydrase VA Deficiency | Progressive External Ophthalmoplegia | Thrombocythemia, Essential | Acute Chest Syndrome | Intracranial Hypertension | Acne | Birt-Hogg-Dube Syndrome | Pseudoexfoliation Syndrome | Autoimmune Interstitial Lung, Joint, And Kidney Disease | Sick Sinus Syndrome | Herpes Genitalis | Zellweger Syndrome | Whipple's Disease | Hepatitis C, Chronic | Myofibromatosis | Hydrocephalus | Progressive Encephalopathy-optic Atrophy Syndrome | Carcinoid Tumor | Congenital Nephrotic Syndrome | Cutaneous Lupus Erythematosus | Antisocial Personality Disorder | Keratosis, Seborrheic | Apert Syndrome | Cabezas Syndrome | Lymphedema-distichiasis Syndrome | Reticular Dysgenesis | Autism Spectrum Disorders | Kashin-Beck Disease | Meesmann Corneal Dystrophy | Lipid Metabolism Disorders | T-cell Chronic Lymphocytic Leukemia | Brooke-Spiegler Syndrome | Megaloblastic Anemia | Microcephalic Osteodysplastic Primordial Dwarfism, Type I | Anti-NMDA Receptor Encephalitis | Twin-to-twin Transfusion Syndrome | Corneal Dystrophy And Perceptive Deafness | Spondylo-megaepiphyseal-metaphyseal Dysplasia | Cardiomyopathy, Hypertrophic | Trismus-pseudocamptodactyly Syndrome | Fibromuscular Dysplasia | Fanconi Anemia | Erythromelalgia | Osteoarthritis | Leukocyte Adhesion Deficiency Type 1 | Specific Granule Deficiency | Xeroderma Pigmentosum | Phenylketonuria II | Torticollis | Sialoadenitis | Hypogonadism | Veno-occlusive Disease | Metachromatic Leukodystrophy | Primary Erythromelalgia | Bulimia Nervosa | Leri Pleonosteosis | Congenital Bile Acid Synthesis Defect | Distal Spinal Muscular Atrophy | Primary Lateral Sclerosis | Thalassemia, Beta | Cancer, Skin | Hepatitis, Chronic | Bernard-Soulier Syndrome | Giant Cell Arteritis | Pulmonary Stenosis | Communication Disorders | Bronchitis, Chronic | Iron Deficiency Anemia | Glycogen Storage Disease Type 9 | Intellectual Disability, Autosomal Dominant 5 | Hereditary Hemorrhagic Telangiectasia Type 2 | Hypertelorism | Congenital Hereditary Endothelial Dystrophy Type I | Gastritis, Atrophic | Pure Red Cell Aplasia | Amish Infantile Epilepsy Syndrome | Pemphigoid | Burn-McKeown Syndrome | Metabolic Diseases | Gigantism | VACTERL Association | Triphalangeal Thumb-polysyndactyly Syndrome | 3-hydroxyacyl-CoA Dehydrogenase Deficiency | Traboulsi Syndrome | Weill-Marchesani Syndrome | Spinal Muscular Atrophy Type 3 | Ocular Albinism Type 1 | Hyperparathyroidism, Secondary | Congenital Mirror Movements | Ectrodactyly | Lymphangioleiomyomatosis | Coronary Restenosis | Hypermetropia | Goiter | Shwachman-Bodian-Diamond Syndrome | Ameloblastic Carcinoma | Hypohidrotic Ectodermal Dysplasia, X-linked | Anemia | H Syndrome | Autoimmune Hemolytic Anemia | Li-Fraumeni Syndrome | Hemorrhoids | Neurotoxicity | Exotropia | Carcinoma, Transitional Cell | Multiple Sclerosis, Secondary Progressive | Stroke, Hemorrhagic | Neurofibromatosis Type 2 | Chronic Leukemia | Hernia, Inguinal | Sturge-Weber Syndrome | Best Macular Dystrophy | Anorchia | Encephalocele | Lipid Storage Myopathy | Peters-plus Syndrome | Glaucoma, Congenital | Martsolf Syndrome | Congenital Disorders Of Glycosylation Type II | Carcinoid Syndrome | Demyelinating Diseases | Arthritis | Paget's Disease Of The Breast | Congenital Primary Aphakia | Paraganglioma, Carotid Body | Tuberculous Meningitis | Stromal Corneal Dystrophy | Congenital Dyserythropoietic Anemia Type 1 | Genitopatellar Syndrome | Danon Disease | Thrombophlebitis | Ameloblastoma | Seizures-scoliosis-macrocephaly Syndrome | Woodhouse-Sakati Syndrome | Evans Syndrome | Neuromyotonia | Oligoastrocytoma | Cardiac Sarcoidosis | Congenital Hemolytic Anemia | Pineoblastoma | Palsy, Cerebral | Malnutrition | Osteopetrosis | Esophagitis | Mucormycosis | Polymyositis | Malaria | Infertility, Male | Lewy Body Dementia | Knobloch Syndrome | Fahr Disease | Hypersensitivity | Metatropic Dysplasia | Trichothiodystrophy