Neurotoxicity

About the Disease
Toxic Encephalopathy, also known as neurotoxicity, is related to amyloidosis and neuroblastoma. An important gene associated with Toxic Encephalopathy is H2AC18 (H2A Clustered Histone 18), and among its related pathways/superpathways are Signal Transduction and Akt Signaling. The drugs Abacavir and Lamivudine have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and breast, and related phenotypes are Decreased caspase 3/7 activity and nervous system

Common Targets
PPARA | BIVM-ERCC5 | CFAP36 | MIR4745 | MIR4432 | SLC28A3 | FARS2 | Calcium channel (nonspecified subtype) | NGFR | SLC28A1 | MIR106B | NAT2 | SLC6A2 | CYP17A1 | MIR154 | MIR449B | G142 | POR | RRM1 | XRCC2 | RAD52 | CDA | ACSF3 | PGR | MIR1208 | MUTYH | MIR3117 | CYP1A1 | G9429 | ABCG1 | DCK | MIR140 | Neurotrophic Factor (nonspecified subtype) | MTHFR | PXDC1 | G5243 | ABCC2 | GSTT1 | MIR122 | CYP2C8 | MIR16-1 | EGR2 | BBS12 | SLC19A1 | SCN4A | MIR182 | G4193 | DAPK1 | PLAT | CYP3A5 | MVP | MIR183 | HTR2A | IL17F | CAPN1 | MIR27A | CSF2 | GSTP1 | CYP2C9 | NOX3 | Poly [ADP-ribose] polymerase (nonspecified subtype) | GSTM1 | MIR646 | PARP2 | HTR2C | MIR216A | CYP2B6 | ABCC1 | NADPH Oxidase Complex | ACYP2 | EPHX1 | SOX10 | FGF13 | G596 | DHFR | UMPS | NADPH Oxidase (nonspecified subtype) | SLC29A1 | DPYD | LIG3 | MIR6076 | MIR6128 | G6647 | MIR96 | Superoxide dismutase (SOD) (nonspecified subtype) | MIR5197 | CYP3A4 | CMPK1 | mu-Calpain (calpain 1) | ERCC5 | OPRM1 | MIR5090 | SLC8A3 | NT5C2 | MIR149 | SCN10A | CYP2C19 | ERCC1 | CASP7

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