Primary Biliary Cholangitis

About the Disease
Primary Biliary Cholangitis, also known as primary biliary cirrhosis, is related to gastrointestinal system disease and non-alcoholic fatty liver disease. An important gene associated with Primary Biliary Cholangitis is PBC2 (Biliary Cirrhosis, Primary, 2), and among its related pathways/superpathways are miRNAs involved in DNA damage response and Cell differentiation - expanded index. The drugs Abatacept and Meropenem have been mentioned in the context of this disorder. Affiliated tissues include Umbilical Cord, liver and bone, and related phenotypes are cirrhosis and biliary cirrhosis

Common Targets
PUS10 | RPS6KA4 | GPBAR1 | CLCNKA | IL21-AS1 | TTC27 | LOC105372988 | SLC22A1 | CD3 Complex (T Cell Receptor Complex) | FUNDC2 | HORMAD2 | PDE4B | TNPO3 | PPARA | CYP7A1 | HLA-B | TMEM39A | G4780 | UBE2A | OR52B2 | TYK2 | TRAF3 | FAM110D | PNPLA3 | LOC105377551 | CD58 | KCNH5 | HLA-DRB1 | TPMT | HLA-DQA1 | LYVE1 | RUNX3 | CTSS | BMX | DLAT | BRD4 | SIGLEC8 | PIK3CD | EPS8L1 | PPARG | CTNNA2 | CTSL | PLCL2 | CLN3 | CASP10 | CSF3R | G7124 | PLCL1 | PRKRIP1 | NOTCH4 | SCNN1D | NOX4 | SEZ6L | S1PR4 | HSD11B1 | IQCN | NUDT15 | GABA(A) receptor | ZNF614 | HLA-A | CD40 | ZSCAN5B | UBE2L3 | PPARD | ELP1 | G3605 | SERPINA7 | MMEL1 | LACC1 | G4137 | CD244 | SHC1 | NR3C1 | CCDC113 | ACHE | ULK4 | DCHS1 | G3480 | GIPR | HLA-DRA | FCRL3 | OBSL1 | ITGA11 | IL12RB2 | G3630 | Interleukin-12 (IL-12) | SLC22A23 | LILRA1 | EPG5 | USP2 | GCKR | DENND1B | PIK3CA | SYNGR1 | ELMO1 | ZGPAT | NR1H4 | ADORA3 | TIMMDC1 | C1orf94 | G4233 | CCNY | MS4A1 | VDR | CXCR3 | Vascular endothelial growth factor receptor (VEGFR) (nonspecified subtype) | HIVEP2 | CTLA4 | NADSYN1 | LINC02513 | WHAMM | STAT4 | ARID3A | LOC285626 | CHIA | CD80 | IL10 | OR8G5 | IKZF3 | ELF1 | PRKCB | BTG4 | CLEC16A | TLR9 | MED4 | IL16 | Integrin alphavbeta6 receptor | S1PR5 | IL12A | PAPPA | APOA1 | NOX1 | ZNF865 | CXCL10 | SLC10A2 | IL12A-AS1 | CREBBP | SPIB | HLA-DPB1 | TNFSF15 | LINC01100 | HNF4A | CLDN14 | CTSB | OR52W1 | Integrin alphavbeta1 | ABCB11 | SH2B3 | TRIM32 | SRSF12 | FER1L6 | JAK1 | JAK2 | MANBA | Vascular endothelial growth factors (VEGF) (nonspecified subtype) | CTNNB1 | ZNF683 | TNFRSF1A | GLP1R | ACACA | HLA-DQB1 | EXOC3L4 | TEAD1 | FGF2 | PIK3CG | PPARGC1A | USP37 | MRGPRX4 | GPR65 | PER3 | HECW2 | RELN | Interleukin 23 complex (IL-23) | CAPSL | LOC105379031 | NF-kappaB (NFkB) | G6774 | UMAD1 | CMA1 | ZMIZ1 | RAD51B | G6647 | NFKB1 | DKK2 | IL21R | GCGR | ZNF292 | FCRL4 | TNFSF4 | LOC105377139 | Phosphodiesterase (nonspecified subtype) | POLD1 | IL12B | URM1 | BTK | FGFR2 | NCOR1 | CX3CL1 | LOC101927745

Note: If you'd like to get a target analysis report for Primary Biliary Cholangitis, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Primary Biliary Cholangitis at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Vitreoretinopathy, Proliferative | Yellow Fever | Corticobasal Syndrome | Esophageal Carcinoma | Schwannomatosis | Inflammatory Myopathy | Photosensitivity | Hyperglycemia | Uveitis, Anterior | Pulmonary Capillary Hemangiomatosis | Bipolar Disorder | Polymyositis | Cantu Syndrome | Waardenburg Syndrome Type 4 | Tracheal Disorders | Infertility | Acute Myeloid Leukemia | Open-angle Glaucoma | Temtamy Preaxial Brachydactyly Syndrome | Carney Triad | Familial Advanced Sleep Phase Syndrome | Stickler Syndrome | Blepharospasm | Hypereosinophilic Syndrome | Angiosarcoma Of The Breast | Fibromuscular Dysplasia | Angina Pectoris | Sotos Syndrome | Impetigo | Spondylosis | Autonomic Nervous System Disorders | Specific Granule Deficiency | Frontotemporal Dementia With Amyotrophic Lateral Sclerosis | Hemangioma | Corneal Neovascularization | Muscle Wasting | Pulmonary Stenosis | Hyperostosis | Spinal And Bulbar Muscular Atrophy | Asperger Syndrome | Fanconi Anemia | Combined Deficiency Of Factor V And Factor VIII | Multiple Sclerosis, Relapsing-remitting | Pterygium | Aldosterone Deficiency | Hyperprolactinemia | Liver Failure | Cardiospondylocarpofacial Syndrome | Pneumococcal Meningitis | Perry Syndrome | Cranial Nerve Disease | Senior-Loken Syndrome | Non-Hodgkin Lymphoma | Branchiootorenal Syndrome | Hypoparathyroidism | Erectile Dysfunction | Myosin Storage Myopathy | Von Willebrand Disease | Joubert Syndrome 2 | Esophageal Motility Disorders | Epidermolysis Bullosa | Treacher Collins Syndrome | Multiple Sulfatase Deficiency | Dystrophy, Cone-rod | Prurigo Nodularis | Anosmia, Congenital | Dysequilibrium Syndrome | Hyperekplexia | Osteogenesis Imperfecta | Poirier-Bienvenu Neurodevelopmental Syndrome | Pemphigoid | Gastroenteritis | X-linked Charcot-Marie-Tooth Disease | Prune Belly Syndrome | Microcephaly, Seizures, And Developmental Delay | Cryopyrin-associated Periodic Syndromes | Synovitis | Phenylketonuria | Cirrhosis | Pfeiffer Syndrome | Hoyeraal-Hreidarsson Syndrome | Lymphoma Lymphoblastic | Fibrosis | AIDS Dementia Complex | Carcinoid Syndrome | Intestinal Obstruction | Keratoconjunctivitis | Microcephaly | Isobutyryl-CoA Dehydrogenase Deficiency | Thalassemia | Renal Oncocytoma | Thrombosis | Hydrops Fetalis | Carcinoma, Signet Ring Cell | Hypophosphatemic Rickets, Autosomal Recessive, 1 | Cutaneous Mastocytosis | Impulse Control Disorder | Charcot-Marie-Tooth Disease Type 2T | Pantothenate Kinase-associated Neurodegeneration | Insulinoma | Down Syndrome | Sick Sinus Syndrome | Genee-Wiedemann Syndrome | Swine Influenza | Plasma Cell Leukemia | Antenatal Bartter Syndrome Type 1 | Microcephalic Osteodysplastic Primordial Dwarfism, Type I | Alzheimer Disease, Late Onset | Medulloblastoma | Ileitis | Cholangitis | Borjeson-Forssman-Lehmann Syndrome | Hypersensitivity | Osmotic Demyelination Syndrome | Aspergillosis | Coronary Heart Disease | Skin Papilloma | Keratocystic Odontogenic Tumor | Camurati-Engelmann Disease | Diabetes | GLUT1 Deficiency Syndrome | Aceruloplasminemia | Gaucher Disease | Central Pain Syndrome | Primary Aldosteronism | 3-hydroxy-3-methylglutaric Aciduria | Carcinoma, Transitional Cell | Parvovirus B19 Infection | Orotic Aciduria | Hypertension, Portal | Retinal Coloboma | Cellulitis | Osteonecrosis | Werner's Syndrome | Angioimmunoblastic T-cell Lymphoma | Tuberculosis | Schistosomiasis Mansoni | Optic Neuropathy | Glutaric Aciduria Type 2 | Metanephric Adenoma | AIDS | Dyggve-Melchior-Clausen Disease | Beckwith-Wiedemann Syndrome | Erythrokeratodermia Variabilis | Congenital Lipoid Adrenal Hyperplasia | Congenital Fiber-type Disproportion Myopathy | Metabolic Syndrome | Lymphopenia | Vici Syndrome | Liddle Syndrome | Peripheral T-cell Lymphoma | Niemann-Pick Disease, Type B | Paronychia | Galloway-Mowat Syndrome | Myelitis, Transverse | Otitis Externa | Infantile Nephropathic Cystinosis | Primary Cutaneous Amyloidosis | Erythropoietic Protoporphyria | Juvenile Polyposis | Arteriovenous Malformations | Trichorhinophalangeal Syndrome | Intestinal Tuberculosis | Thyroid Hormone Resistance | Antithrombin III Deficiency | Connective Tissue Disorders | Triphalangeal Thumb-polysyndactyly Syndrome | Seasonal Mood Disorder | Wagner Disease | Hypotrichosis, Congenital, With Juvenile Macular Dystrophy | Dyskeratosis Congenita | Obesity, Morbid | Mastitis | Pulmonary Vein Stenosis | Nutrition Disorders | Vitamin B12 Deficiency | Partington Syndrome | Metaphyseal Chondrodysplasia, Schmid Type | ADNP Syndrome | Fascioliasis | Dent Disease | Endometrial Hyperplasia | Leiomyosarcoma | Hypercalciuria | Mood Disorder | Colorectal Adenoma | Fabry's Disease | Hernia, Inguinal | Acrodysostosis | Glioma | Schizoaffective Disorder | Pyruvate Carboxylase Deficiency Disease | Panuveitis | Argininosuccinic Aciduria | Shprintzen-Goldberg Syndrome | Infantile Liver Failure Syndrome 1 | Williams Syndrome | Rett Syndrome | Neovascular Glaucoma | Acute Lung Injury | LRBA Deficiency | Allergic Contact Dermatitis | McLeod Syndrome | Genitopatellar Syndrome | Paracoccidioidomycosis | Prolactinoma | Pelizaeus-Merzbacher Disease | Glycogen Storage Disease Type 5 | Aicardi-Goutieres Syndrome | Epidermolysis Bullosa Simplex | Cardiomyopathy, Peripartum | Waardenburg Syndrome | Sulfite Oxidase Deficiency | Glomerulonephritis | Noonan Syndrome-like Disorder With Loose Anagen Hair | Neurodegeneration With Brain Iron Accumulation | Krabbe Disease | Cousin Syndrome | Osteopetrosis | Sarcoidosis | Nail-Patella Syndrome | Hepatorenal Syndrome | Ophthalmia, Sympathetic | Cerebral Amyloid Angiopathy | Pyelonephritis | Dysferlinopathy | Thrombotic Microangiopathy | Phosphoglycerate Dehydrogenase Deficiency | Porphyria, Variegate | Auriculocondylar Syndrome | Shock, Cardiogenic | Microvillus Inclusion Disease | Sialidosis | Multiple Sclerosis, Secondary Progressive | Pigment Dispersion Syndrome | Hypodontia | Charcot-Marie-Tooth Disease Type 4D | Bladder Exstrophy | Epithelioid Hemangioma | Huntington's Disease | Marfan Syndrome | Hyperferritinemia-cataract Syndrome | High Molecular Weight Kininogen Deficiency | Transient Bullous Dermolysis Of The Newborn | Pleurisy | Basal Ganglia Cerebrovascular Disease | Fundus Albipunctatus | Acute Motor Axonal Neuropathy | Retinopathy, Diabetic | Ehlers-Danlos Syndrome | Thrombocythemia, Essential | Pneumonia, Viral | Adenocarcinoma | Spinocerebellar Ataxia Type 13 | Spinocerebellar Ataxia Type 1 | Cancer, Colon | Vertebrobasilar Insufficiency | Neural Tube Defect | Birk-Barel Syndrome | Wolman Disease | Avian Influenza | NDH Syndrome | Malonyl-CoA Decarboxylase Deficiency | Mucormycosis | Congenital Hereditary Endothelial Dystrophy Type II | VACTERL Association | Restless Legs Syndrome | Keratopathy | Multiple Mitochondrial Dysfunctions Syndrome Type 1 | Rift Valley Fever | Cleidocranial Dysplasia | Non-bullous Congenital Ichthyosiform Erythroderma | Juvenile Myoclonic Epilepsy | Colitis | Early Infantile Epileptic Encephalopathy 1 | Fowler's Syndrome | Malaria, Cerebral | Benign Familial Neonatal Convulsions | Carotid Artery Disease | T-cell Leukemia | Behavioral Variant Of Frontotemporal Dementia | Duchenne Muscular Dystrophy | Autism | DNA Ligase IV Deficiency | Amyotrophic Lateral Sclerosis, Juvenile | Retinitis Pigmentosa | Hypotrichosis Simplex | Schwannoma | Peeling Skin Syndrome, Acral Type | Chylomicron Retention Disease | Tinea Versicolor | Fibrodysplasia Ossificans Progressiva | Leukemia | Autosomal Recessive Spastic Paraplegia Type 75 | Familial Glucocorticoid Deficiency | Spondylo-ocular Syndrome | Amish Infantile Epilepsy Syndrome | Androgen Insensitivity | Adenoma, Pituitary | Erdheim-Chester Disease | Osteosclerosis | Nicolaides-Baraitser Syndrome | Situs Inversus | Hemangioendothelioma | Cold-induced Sweating Syndrome | Conduct Disorder | Christianson Syndrome | Oligoastrocytoma | Cornelia De Lange Syndrome | Microcephalic Osteodysplastic Primordial Dwarfism, Type II | Brenner Tumor | Stromal Corneal Dystrophy | Pain | Best Macular Dystrophy | Tremor | Shwachman-Bodian-Diamond Syndrome | Spermatocele | Creutzfeldt-Jakob Disease | Cone Dystrophy | Melanoma, Uveal | Fetal Akinesia Deformation Sequence | Meniere's Disease | Charcot-Marie-Tooth Disease, Type 1A | Trichothiodystrophy | Cutis Laxa | Anxiety Disorders | Osteogenesis Imperfecta Type IV | Migraine | Glycogen Storage Disease Type 0, Muscle | Sensory Neuropathy | Acne | Chromosome 17q21.31 Deletion Syndrome | Leukoplakia, Oral | Cancer, Breast | Pontocerebellar Hypoplasia Type 7 | Retinopathy Of Prematurity | Biotinidase Deficiency | Lymphoproliferative Disease, X-linked | Neurofibromatosis Type 2 | Rhabdomyosarcoma | Glycogen Storage Disease | Proctitis | Thyrotoxic Periodic Paralysis | Tularemia | Menetrier Disease | 3-methylglutaconic Aciduria Type IV | Antley-Bixler Syndrome | Mitochondrial DNA Depletion Syndrome, Myopathic Form | Charcot-Marie-Tooth Disease, Type 6 | T-cell Chronic Lymphocytic Leukemia | Scoliosis | Alkaptonuria | Hydrolethalus Syndrome | Congenital Poikiloderma | Polycythemia | Ectopia Lentis, Isolated, Autosomal Recessive | Hypophosphatemic Rickets With Hypercalciuria, Hereditary | Peripheral Neuropathy | Cholecystitis | Pure Red Cell Aplasia | Congenital Generalized Lipodystrophy | Waardenburg Syndrome Type 4A | Androgenic Alopecia | Compartment Syndrome | Retinal Diseases | Osteoarthritis | Hemochromatosis Type 2 | Paternal Uniparental Disomy Of Chromosome 14 | Uremic Pruritus | Distal Spinal Muscular Atrophy | Non-Langerhans Cell Histiocytosis | Mitochondrial DNA Depletion Syndrome | Familial Hemiplegic Migraine | Fibromyalgia | Hypoproteinemia, Hypercatabolic | Glaucomatocyclitic Crisis | Hyperinsulinemia | Primary Erythromelalgia | Irritable Bowel Syndrome | Dengue Hemorrhagic Fever | Saethre-Chotzen Syndrome | Osteogenesis Imperfecta Type I | Primary Torsion Dystonia | Thrombophlebitis | Oculocutaneous Albinism Type 1 | Hereditary Neuropathy With Liability To Pressure Palsies | Spinocerebellar Ataxia Type 16 | Cholelithiasis | Spinocerebellar Ataxia Type 38 | Epidermolysis Bullosa Simplex, Generalized | Keratoacanthoma | Uveitis | Dominant Optic Atrophy | Barakat Syndrome | Primary Familial Brain Calcification | Liver Diseases | DRESS Syndrome | Pneumoconiosis | Lathosterolosis | Chondroma