Disease

Thrombosis

About the Disease
Complement Hyperactivation, Angiopathic Thrombosis, and Protein-Losing Enteropathy, also known as chaple, is related to blood group, cromer system and protein-losing enteropathy. An important gene associated with Complement Hyperactivation, Angiopathic Thrombosis, and Protein-Losing Enteropathy is CD55 (CD55 Molecule (Cromer Blood Group)). The drugs Dabigatran and Norethisterone have been mentioned in the context of this disorder. Affiliated tissues include liver, whole blood and endothelial, and related phenotypes are thrombocytosis and hepatomegaly

Common Targets
Integrin alphavbeta3 (vitronectin) receptor | G4780 | CHST15 | EPCAM | F2RL1 | PROC | Heat shock protein 90 (nonspecified subtype) | Integrin alpha4beta1 (VLA-4) receptor | ITPR2 | THBS1 | KLK7 | Serine/threonine-protein kinase (PAK) (nonspecified subtype) | PPARA | Prostanoid Receptor (nonspecified subtype) | Diacylglycerol Acyltransferase (DGAT) (nonspecified subtype) | Prostaglandin EP Receptor (nonspecified subtype) | VWF | PF4 | PREP | Tyrosine-Protein Kinases Src (nonspecified subtype) | F9 | PADI4 | KCNA3 | P2RY1 | cAMP Phosphodiesterase (nonspecified subtype) | DUSP3 | XYLB | Protein kinase C (nonspecified subtype) | RAC1 | GPR119 | SLC9A1 | Protein Kinase B (PKB/Akt) (nonspecified subtype) | Phosphatidylinositol 3-kinase (PI3K) (nonspecified subtype) | ASNS | L-type voltage-dependent calcium channel complex | ADRA1A | P2RX1 | NGFR | CYSLTR1 | Calcium channel (nonspecified subtype) | AXL | ITPR3 | LGALS3 | FKBP1A | TRPM8 | KMT2C | G59272 | ST14 | G2475 | PTPRS | F13A1 | EPHX2 | FFAR1 | ORAI1 | MAOA | KNG1 | MIR23A | G1950 | HTR1A | PLA2G4A | PPARG | PTGER3 | Phosphodiesterase 1 (PDE1) (nonspecified subtype) | CNR1 | Cyclophilins (nonspecified subtype) | Alpha-2 Adrenergic receptors (nonspecified subtype) | ADRA2B | SLC6A2 | SPHK2 | CDK5/p25 | TYR | Lipoxygenase (nonspecified subtype) | P2Y purinoceptor (nonspecified subtype) | CHEK1 | Mitogen-Activated Protein Kinase (MAP Kinase)-Activated Protein Kinase (nonspecified subtype) | F11R | G842 | SELL | TRPV1 | P2RY2 | PTGIR | PIK3CD | HRH2 | G142 | MAP3K5 | RHCE | ALOX12 | HMGCR | BMX | Phospholipase A2 (nonspecified subtype) | PIK3CB | CDK5 | PAR Receptor (nonspecified subtype) | Calcium release-activated channel (CRAC) | APLNR | VKORC1 | HDAC1 | ICAM1 | PTGS1 | G23411 | GP1BA | Chymotrypsin (nonspecified subtype) | BCR | ADORA1 | NOD2 | GABA(A) receptor | P2RX3 | ITGA2B | PROCR | HSD11B1 | CALM1 | TNFSF11 | Integrin Receptor (nonspecified subtype) | DYRK1A | F3 | ADAM17 | ACHE | CSNK2A1 | P2RY4 | cGMP Phosphdiesterase (PDE) (nonspecified subtype) | GNAQ | G protein-Coupled Inwardly-Rectifying Potassium Channel (GIRK) (nonspecified subtype) | CCN2 | DPP4 | ABCA1 | CCR2 | S1PR4 | PPARD | G5743 | ADORA2A | Acetylcholine Receptors (Nicotinic) (nAChR) (nonspecified subtype) | Tubulin | CACNA1C | Phospholipase C (nonspecified subtype) | PIK3CA | AVPR2 | APOH | SYK | F10 | NTRK1 | FLT1 | PCSK9 | Reverse transcriptase (Telomerase) | G3630 | Alcohol Dehydrogenase (nonspecified subtype) | TGFBR1 | Tyrosine Kinase (nonspecified subtype) | Gap junction Connexin ( (nonspecified subtype) | ZFP36L2 | YWHAZ | AKR1B1 | G5243 | PTPN1 | XDH | Guanylate cyclase (nonspecified subtype) | ADRA2A | F2 | P2RY6 | TGM2 | VCAM1 | BCHE | MTHFR | LIPA | G4318 | SERPINC1 | FGA | MASP2 | SELP | ITGB2 | GSK3B | Integrin alpha5beta1 (VLA-5) receptor | PIK3C2A | Adenylate Cyclase (nonspecified subtype) | TET2 | Myosin Class II (nonspecified subtype) | P2RY11 | TMPRSS11D | CES1 | NR1H4 | Integrin alphavbeta5 receptor | SERPINE1 | PDPN | CLEC1B | SLC44A2 | G836 | GJA8 | G581 | TMPRSS2 | NOS3 | Mitogen-Activated Protein Kinase (nonspecified subtype) | G1956 | Integrin alphaIIbbeta3 (fibrinogen gpIIb/IIIa) receptor | OPRD1 | PIK3C2B | PTGER4 | IL10 | KCNJ3 | CPB1 | KDR | KCNA5 | GUSB | K(ATP) Channel (nonspecified subtype) | PLG | P2RX4 | MERTK | 15-Lipoxygenase (nonspecified subtype) | TEK | PLAT | PTGDR | IL-6 receptor | Vascular endothelial growth factor receptor (VEGFR) (nonspecified subtype) | SLC6A4 | CYP3A5 | MYH2 | MPIG6B | UHRF1 | IgE Receptors (nonspecified subtype) | SUMO1 | ADRB1 | FASN | GNRHR | PTGDR2 | Phospholipase A2, Cytosolic (nonspecified subtype) | CDK1/Cyclin B | Trypsin (nonspecified subtype) | TCF7 | PDE5A | ADIPOR1 | AKR1C3 | beta-Adrenoceptor (nonspecified subtype) | P2RY12 | MBL2 | Elastase (nonspecified subtype) | IL1B | ABCC8 | Cysteine Protease (nonspecified subtype) | G7422 | NEDD9 | TNFRSF11A | CPB2 | Prostanoid TP receptor (nonspecified subtype) | Serine protease (nonspecified subtype) | HTR2A | Carboxypeptidase N | F5 | ACKR3 | AP-1 Transcription Factor Complex | SELPLG | G3569 | Immunoglobulin E (IgE) | KCNJ5 | GUCY1A1 | TRPA1 | Class III phosphatidylinositol 3-kinase (PI3-kinase) sub-complex | NOS2 | NMDA receptor | TSPAN15 | PDE3B | Kallikrein (nonspecified subtype) | FASLG | ADRA1D | PDE2A | Dopamine receptor (nonspecified subtype) | CDK2/Cyclin A | HRH1 | PIK3C3 | P2X Receptor (nonspecified subtype) | MPL | FCN1 | CYP2C9 | HSD11B2 | Sterol O-acyltransferase (ACAT) (nonspecified subtype) | L-Type calcium channel (nonspecified subtype) | Janus Kinase (nonspecified subtype) | AGTR1 | TXNRD1 | TYRO3 | GAA | Carboxypeptidase B (nonspecified subtype) | Leukotriene B4 receptor (LTB4-R) (nonspecified subtype) | NOX3 | HTR1B | Tryptase (nonspecified subtype) | Vasopressin Receptor (nonspecified subtype) | S1PR5 | Integrin alpha2beta3 Receptor | FGF1 | PON1 | Integrin alphavbeta6 receptor | 5-Hydroxytryptamine Receptor 2 (5-HT2) (nonspecified subtype) | Histone deacetylase (nonspecified subtype) | FCGR2A | JAK2 | ADRB2 | Muscarinic Acetylcholine Receptor (mAChR) (nonspecified subtype) | Gastric H+/K+-ATPase | Proteasome Complex | ZNF568 | G7015 | SERPINF2 | ITGB3 | Cyclooxygenase (COX) (nonspecified subtype) | alpha1-Adrenoceptor (nonspecified subtype) | Cannabinoid receptor (nonspecified subtype) | UGT1A1 | NLRP3 Inflammasome | ADIPOR2 | Adenosine receptor (nonspecified subtype) | Inosine 5'-monophosphate dehydrogenase (IMPDH) (nonspecified subtype) | NAT8B | NOX1 | APOE | Coagulation Factor XIII | PARP2 | PROS1 | HPSE | TIGIT | PLAU | AKR1B10 | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7 (nonspecified protein) | CD47 | Inositol 1,4,5-Trisphosphate Receptor (InsP3R) (nonspecified subtype) | G114548 | F2RL3 | STING1 | NF-kappaB (NFkB) | F11 | G3576 | KLKB1 | GP6 | CYP4F2 | Large Conductance BK(Ca) Potassium Channel (Maxi K+ Channel) (nonspecified subtype) | NADPH Oxidase Complex | CRBN | Gap Junction Protein (nonspecified subtype) | Cyclin A (nonspecified subtype) | CCL2 | HLA-DQB1 | Nitric oxide synthase (NOS) (nonspecified subtype) | Intrinsic Tenase Complex | CTSB | F2R | ALOX5 | PDIA3 | HSD17B1 | Angiotensin receptor (AT) (nonspecified subtype) | NQO1 | GJD2 | Sphingolipid delta(4)-desaturase (nonspecified subtype) | Potassium Channels (nonspecified subtype) | Integrin alpha1beta1 (VLA-1) receptor | Vascular endothelial growth factors (VEGF) (nonspecified subtype) | F7 | Endothelin receptor (nonspecified subtype) | ADRA1B | TBXA2R | MAOB | ABO | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3 (PDE3) (nonspecified subtype) | ABCC4 | SUV39H1 | CDK1 | ABL1 | alpha-Amylase (nonspecified subtype) | TFPI | PIK3CG | FGG | ABCC3 | NADPH Oxidase (nonspecified subtype) | Integrin alphavbeta8 Receptor | HMOX1 | ANPEP | PTPRC | Soluble guanylyl cyclase | CDC42 | DEGS2 | DYRK2 | DEGS1 | SLC29A1 | FGF2 | REN | ATF5 | G5347 | Integrin alpha2beta1 (VLA-2) receptor | G6774 | PRKG1 | PTGFR | PTAFR | ODC1 | PI3 | Mitogen-activated protein kinase p38 (MAPK p38) (nonspecified subtype) | PGK1 | MPO | G6714 | PDE4D | RHOA | THBD | SENP1 | HTR1D | G7124 | HIF1A | Phosphodiesterase (nonspecified subtype) | PDE3A | PPT1 | DNA-Dependent Protein Kinase (DNA-PK) | ALOX15 | HTR7 | AMP-activated protein kinase (AMPK) | F8 | TRPM3 | ENPP2 | BTK | SELE | F12 | MAP3K3 | RPS6KA1 | CYBA | RIPK2 | AVPR1A | G7157 | APEH | TBXAS1 | OPRM1 | 5-Hydroxytryptamine Receptor 3 (5-HT3 receptor) (nonspecified subtype) | LDLR | CGAS | KCNJ11 | MIR6886 | STXBP5 | LPAR5 | Fibrinogen | Phosphodiesterase IV (PDE4) (nonspecified subtype) | CDK2 | KRT37 | HLA-DRB1 | Protein farnesyltransferase | CD36 | CNR2 | KCNH2 | ACE | GPR35 | Cyclin B (nonspecified subtype) | CETP | PMM2 | LRRK2 | CYP2C19 | ELANE

疾病靶点研报
Thrombosis

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