Pityriasis Rubra Pilaris

About the Disease
Pityriasis Rubra Pilaris, also known as devergie's disease, is related to familial pityriasis rubra pilaris and psoriasis 13. An important gene associated with Pityriasis Rubra Pilaris is CARD14 (Caspase Recruitment Domain Family Member 14), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Alefacept and Dermatologic Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, thyroid and liver, and related phenotypes are palmoplantar keratoderma and papule

Common Targets
Interleukin 17 (nonspecified subtype) | IL17RA | CARD14 | Interleukin-12 (IL-12) | IL12A | Interleukin 23 complex (IL-23) | IL12B

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