Disease

Ebstein Anomaly

About the Disease
Ebstein Anomaly, also known as ebstein's anomaly, is related to cardiomyopathy, dilated, 1e and interatrial communication. An important gene associated with Ebstein Anomaly is CDK8 (Cyclin Dependent Kinase 8), and among its related pathways/superpathways are Cardiac conduction and Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases. Affiliated tissues include heart, liver and bone marrow, and related phenotypes are respiratory insufficiency and fatigue

Common Targets
EPHB4 | ZNF534 | NKX2-5 | SMARCA4 | JUP | TBX5 | MYH6 | TTN | TCAP | CORIN | MYH7 | BMPR2

疾病靶点研报
Ebstein anomaly

Note: If you'd like to get a target analysis report for Ebstein Anomaly, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Ebstein Anomaly at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.tech.

Other Diseases

Polycystic Liver | Peeling Skin Syndrome, Acral Type | Congenital Muscular Dystrophy | Cocaine-Related Disorders | Primary Cutaneous Amyloidosis | Combined Pituitary Hormone Deficiency | Riboflavin Transporter Deficiency Neuronopathy | Jaundice, Obstructive | Prolidase Deficiency | Congenital Sodium Diarrhea | Osteopetrosis | Encephalopathy, Glycine | Coronary Heart Disease | Okihiro Syndrome | Mitochondrial DNA Depletion Syndrome | Perivascular Epithelioid Cell Tumor | 3-methylglutaconic Aciduria | Ataxia-hypogonadism-choroidal Dystrophy Syndrome | Acromicric Dysplasia | Primary Torsion Dystonia | Neuromuscular Disorders | Sensorineural Hearing Loss | Spitz Nevus | Osteosarcoma | Glycogen Storage Disease Type 1a | Tracheal Disorders | Bronchitis, Chronic | Congenital Aniridia | Spinal Cord Diseases | Diabetic Encephalopathy | Thanatophoric Dysplasia Type 1 | Cancer, Brain | Retinitis Pigmentosa 3 | ICF Syndrome | Mitochondrial Cytopathy | Infantile Neuroaxonal Dystrophy | Paternal Uniparental Disomy Of Chromosome 14 | Distal Myopathy 2 | B-cell Prolymphocytic Leukemia | Gastritis | Retinopathy Of Prematurity | Pulmonary Tuberculosis | Hypospadias | Coronary Restenosis | Clouston Hidrotic Ectodermal Dysplasia | Chediak-Higashi Syndrome | Hyperkeratosis | Meleda Disease | Partington Syndrome | Cri-du-chat Syndrome | Tenosynovial Giant Cell Tumor | Tay-Sachs Disease | Asphyxia Neonatorum | Batten Disease | Uremic Pruritus | Familial Male-limited Precocious Puberty | Microcephaly, Seizures, And Developmental Delay | GNE Myopathy | Spinal Muscular Atrophy | Diffuse Palmoplantar Keratoderma | Pemphigus Foliaceus | Pneumonia, Mycoplasma | Primrose Syndrome | Panic Disorder | Acute Chest Syndrome | Portal Vein Thrombosis | Lymphoproliferative Disorders | Schizophrenia | Hypermetropia | Waardenburg Syndrome Type 2 | Discoid Lupus Erythematosus | Purpura | Thyroiditis | Iron Overload | Thrombophlebitis | Crisponi Syndrome | Coma | Micro Syndrome | Corneal Dystrophies, Hereditary | Woodhouse-Sakati Syndrome | Ghosal Syndrome | Renal Dysplasia | Blau Syndrome | Keratocystic Odontogenic Tumor | Stargardt Disease | Schistosomiasis Mansoni | Primary Progressive Nonfluent Aphasia | Sclerosing Cholangitis | Macrodactyly | Hyperostosis | Chromosome 17q21.31 Deletion Syndrome | Chorioretinitis | Basal Ganglia Cerebrovascular Disease | Lipoma | Pathological Gambling | Spinocerebellar Ataxia Type 1 | Adenomyosis | Stuttering | Schizophrenia, Paranoid | Leukemia | Rolandic Epilepsy | Fowler's Syndrome | Schizencephaly | Craniofrontonasal Syndrome | Plasma Cell Dyscrasia | Proximal Symphalangism | Spinocerebellar Ataxia Type 13 | X-linked Creatine Transporter Deficiency | Mucolipidosis Type III | Lipodystrophy | Diabetes Mellitus, Transient Neonatal | Pyruvate Kinase Deficiency | Alzheimer Disease, Late Onset | Conn Syndrome | Ependymoma | Spinocerebellar Ataxia Type 27 | Neutropenia | Birk-Barel Syndrome | Pancreatitis, Chronic | Miyoshi Myopathy | Neurofibroma | Subcortical Band Heterotopia | Platelet Disorders | Nemaline Myopathy | Gaze Palsy, Familial Horizontal, With Progressive Scoliosis, 2 | Lafora Disease | Noonan Syndrome-like Disorder With Loose Anagen Hair | Angioedema, Hereditary | Swine Influenza | Lymphoproliferative Disease, X-linked | Pulmonary Stenosis | Mitochondrial DNA Depletion Syndrome, Myopathic Form | Prurigo Nodularis | Hyperbilirubinemia, Neonatal | Sleep Apnea | Neural Tube Defect | Chronic Kidney Disease | Eosinophilia | Trichorhinophalangeal Syndrome | Mitochondrial DNA Depletion Syndrome, Encephalomyopathic Form | Cyclic Vomiting Syndrome | Aldosteronism | Atrioventricular Septal Defect | Hypokalemia | Glaucoma, Congenital | Paget's Disease Of The Breast | Nail Disorder, Nonsyndromic Congenital | Angina Pectoris | Epidermolysis Bullosa | Pouchitis | Lupus Erythematosus | Fetal Akinesia Deformation Sequence | Prune Belly Syndrome | Cole-Carpenter Syndrome | Hemolytic Uremic Syndrome, Atypical | VACTERL Association | Oligoastrocytoma | 3-methylglutaconic Aciduria Type IV | Camurati-Engelmann Disease | Measles | Dysplastic Nevus | Disseminated Intravascular Coagulation | Hypoparathyroidism | Distal Myopathy | Venous Insufficiency | Early Infantile Epileptic Encephalopathy 1 | Dowling-Degos Disease | Paraganglioma | Mucolipidosis Type IV | Trismus-pseudocamptodactyly Syndrome | Glomerulonephritis, Membranous | Rett Syndrome | Neuroblastoma | FG Syndrome | Pigment Dispersion Syndrome | Tuberculosis | Atelosteogenesis Type 2 | Epithelioid Hemangioma | Erythropoietic Protoporphyria | Sickle Cell Disease | Granular Corneal Dystrophy | Postaxial Polydactyly | Toxoplasmosis | Heterotopic Ossification | Episodic Ataxia Type 1 | Pterygium | Diabetes Insipidus, Neurogenic | Hyperthyroidism | Osteochondroma | Leishmaniasis, Cutaneous | Autism Spectrum Disorders | Gastric Atrophy | Giant Cell Glioblastoma | Thin Basement Membrane Disease | Waardenburg Syndrome Type 4A | Gallstones | Sclerocornea | Imerslund-Grasbeck Syndrome | Binge Eating Disorder | Arthritis, Psoriatic | Chronic Thromboembolic Pulmonary Hypertension | Androgenic Alopecia | Hypertension, Renovascular | Smith-Lemli-Opitz Syndrome | Hemochromatosis Type 1 | Hypertriglyceridemia | Epidermolytic Hyperkeratosis | Focal Cortical Dysplasia Type 2 | Wagner Disease | Neurofibromatosis | Dominant Optic Atrophy | Benign Recurrent Intrahepatic Cholestasis 1 | Microphthalmia, Syndromic 7 | Acne | Colitis, Collagenous | Mast Cell Leukemia | 3C Syndrome | Lymphoma, Primary Cutaneous Anaplastic Large Cell | Hyperinsulinemic Hypoglycemia | Aspartylglycosaminuria | Hyperparathyroidism-jaw Tumor Syndrome | Schindler Disease | Neuropathy | Glaucoma | Esophageal Carcinoma | Mesothelioma, Malignant | Hypothalamic Obesity | Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive 2 | Papilledema | Choroiditis | Acute Anterior Uveitis | Meningioma, Benign | Cholecystitis | Hypoglycemia | Primary Biliary Cholangitis | Early Infantile Epileptic Encephalopathy 4 | Nephroblastoma | Carcinoma, Signet Ring Cell | Hypermethioninemia | Chorea-acanthocytosis | Sitosterolemia | Postpartum Depression | Megaloblastic Anemia | Medium-chain Acyl-CoA Dehydrogenase Deficiency | ADNP Syndrome | Angiosarcoma | Juvenile Hyaline Fibromatosis | High Molecular Weight Kininogen Deficiency | Stromal Corneal Dystrophy | Craniofacial Dysostosis | Meconium Ileus | Hypophosphatemic Rickets, Autosomal Recessive, 1 | Hereditary Elliptocytosis | Spastic Paraplegia Type 7 | Aplasia Cutis Congenita | Chromosome 5q Deletion Syndrome | Charcot-Marie-Tooth Disease Type 4E | Blastoma, Pleuropulmonary | Prolymphocytic Leukemia | Congenital Hereditary Endothelial Dystrophy Type II | Motor Neuron Diseases | Syphilis | Hypopigmentation | Gastrointestinal Disorders | Pituitary Stalk Interruption Syndrome | Gynecomastia | Leber Hereditary Optic Neuropathy | Cystinosis | Patent Foramen Ovale | Pierpont Syndrome | Diabetes Insipidus, Nephrogenic | Nail-Patella Syndrome | Congenital Nystagmus | Cholestasis | Gangliosidosis | Chromosome 9q34.3 Deletion Syndrome | Obesity, Morbid | Nemaline Myopathy 8 | Fatty Aldehyde Dehydrogenase Deficiency | Inflammatory Myofibroblastic Tumor | Autoimmune Autonomic Ganglionopathy | Rubeosis Iridis | PASLI Disease | Inflammatory Myopathy | Obsessive-compulsive Disorder | Autoimmune Interstitial Lung, Joint, And Kidney Disease | Rotor Syndrome | Kaposiform Hemangioendothelioma | Progressive Osseous Heteroplasia | Cancer, Colon | Tatton-Brown-Rahman Syndrome | Myopathy | Congenital Absence Of Vas Deferens | COACH Syndrome | Insulinoma | Goiter, Nodular | Congenital Dyserythropoietic Anemia Type 4 | Infertility, Male | Carpenter Syndrome | Sialoadenitis | Familial Hyperaldosteronism | Mevalonate Kinase Deficiency | Congestive Heart Failure | Alpha-1 Antitrypsin Deficiency | Varicocele | Polycythemia Vera | Tinea Versicolor | Iron Deficiency Anemia | Urethritis | Optic Atrophy 2 | Odonto-onycho-dermal Dysplasia | Gout | Myoclonus-dystonia Syndrome | Dubin-Johnson Syndrome | Pernicious Anemia | Corneal Dystrophy And Perceptive Deafness | Joubert Syndrome | Retinal Detachment | Cerebrotendinous Xanthomatosis | Adrenal Insufficiency | Multicentric Carpotarsal Osteolysis Syndrome | Actinomycetoma | Hyperparathyroidism | Arthrogryposis | Coloboma | Hepatorenal Syndrome | Hidradenitis | Avellino Corneal Dystrophy | Pyruvate Carboxylase Deficiency Disease | Chorea | Klippel-Feil Syndrome | Fanconi Syndrome | Transcobalamin Deficiency | Hyperkalemic Periodic Paralysis | Schwannomatosis | Carbamoyl Phosphate Synthetase I Deficiency | Cushing Syndrome | Barakat Syndrome | Vitamin K Deficiency | Lattice Corneal Dystrophy | Neurodegeneration With Brain Iron Accumulation | Kashin-Beck Disease | Trichothiodystrophy | Purpura, Thrombotic Thrombocytopenic | Neurofibromatosis Type 2 | Phenylketonuria | Wolcott-Rallison Syndrome | Congenital Tufting Enteropathy | Epidermolysis Bullosa Simplex | Kabuki Syndrome | Rhinitis | Metabolic Diseases | Angiodysplasia | Steel Syndrome | Sturge-Weber Syndrome | Microcephalic Osteodysplastic Primordial Dwarfism, Type I | Goldenhar Syndrome | Hepatitis, Alcoholic | Spinal Muscular Atrophy Type 2 | Genee-Wiedemann Syndrome | Sarcoidosis, Pulmonary | Autosomal Recessive Bestrophinopathy | H Syndrome | Multiple Sulfatase Deficiency | Primary Sclerosing Cholangitis | Carpal Tunnel Syndrome | Dermatofibrosarcoma | Lung Diseases | Polymicrogyria | Fibromuscular Dysplasia | Currarino Syndrome | Fetal And Neonatal Alloimmune Thrombocytopenia | Sleep Apnea, Obstructive | Neurotoxicity | Glioma | Dementia | Benign Familial Pemphigus | Cutaneous Lupus Erythematosus | Gitelman Syndrome | Autoimmune Disease | Gyrate Atrophy Of The Choroid And Retina | Familial Partial Lipodystrophy | Cysticercosis | Amelogenesis Imperfecta | Erectile Dysfunction | Galactosialidosis | Sick Sinus Syndrome 1 | Hypertelorism | Erysipelas | Stroke, Hemorrhagic | Cranioectodermal Dysplasia | Teratozoospermia | Hypercholesterolemia | Joubert Syndrome 2 | Synpolydactyly | Skin Fragility-woolly Hair Syndrome | Meesmann Corneal Dystrophy | Priapism | Ornithine Transcarbamylase Deficiency | Osteoporosis-pseudoglioma Syndrome