Ebstein Anomaly

About the Disease
Ebstein Anomaly, also known as ebstein's anomaly, is related to cardiomyopathy, dilated, 1e and interatrial communication. An important gene associated with Ebstein Anomaly is CDK8 (Cyclin Dependent Kinase 8), and among its related pathways/superpathways are Cardiac conduction and Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases. Affiliated tissues include heart, liver and bone marrow, and related phenotypes are respiratory insufficiency and fatigue

Common Targets
EPHB4 | ZNF534 | NKX2-5 | SMARCA4 | JUP | TBX5 | MYH6 | TTN | TCAP | CORIN | MYH7 | BMPR2

Note: If you'd like to get a target analysis report for Ebstein Anomaly, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Ebstein Anomaly at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Parkinson's Disease | Cryptosporidiosis | Poretti-Boltshauser Syndrome | Glutaric Aciduria Type 2 | Cartilage Disorders | Congenital Poikiloderma | Von Hippel-Lindau Disease | Noonan Syndrome-like Disorder With Loose Anagen Hair | Maternally Inherited Diabetes And Deafness | Androgenic Alopecia | Motion Sickness | Seminoma | Basal Cell Nevus Syndrome | Cataplexy | Hydrocephalus, Normal Pressure | Malignant Fibrous Histiocytoma | Cancer, Prostate | Malignant Peripheral Nerve Sheath Tumor | Fibromyalgia | Intermittent Explosive Disorder | Hyperostosis | Anterior Segment Dysgenesis | Crigler-Najjar Syndrome | Lactose Intolerance | Corneal Dystrophy | Hemangioendothelioma | Panic Disorder | Spinocerebellar Ataxia Type 38 | Choriocarcinoma | Pityriasis Rubra Pilaris | Chromosome 17q21.31 Deletion Syndrome | Macular Corneal Dystrophy Type 1 | Cutaneous Mastocytosis | Goldenhar Syndrome | Glioma | Pernicious Anemia | Eating Disorder | Pendred Syndrome | Osteoporosis, Postmenopausal | Megalencephaly | Hypotrichosis Simplex | Optic Neuropathy | Galactosialidosis | Leukocyte Adhesion Deficiency | Early Infantile Epileptic Encephalopathy 13 | Carcinoid Syndrome | Proopiomelanocortin Deficiency | Myopathy | Charcot-Marie-Tooth Disease Axonal Type 2N | Autoimmune Polyendocrinopathy Syndrome Type I | Postpoliomyelitis Syndrome | Leber Hereditary Optic Neuropathy | Craniofrontonasal Syndrome | Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive 2 | Cerebrovascular Disorders | Congenital Disorders Of Glycosylation Type II | Sarcoidosis | Iron Deficiency Anemia | Trichotillomania | Adenosine Deaminase Deficiency | Encephalopathy, Hepatic | Esophageal Adenocarcinoma | Obesity | Left Ventricular Noncompaction | Atrial Septal Defect | Poirier-Bienvenu Neurodevelopmental Syndrome | Lymphomatoid Granulomatosis | Genitopatellar Syndrome | Osteopetrosis | GAPO Syndrome | Spondylosis | Pneumonia, Bacterial | Extramammary Paget's Disease | Thrombotic Microangiopathy | Adrenomyeloneuropathy | Glutathione Synthetase Deficiency | Hypopituitarism | Benign Familial Neonatal Convulsions | Very Long-chain Acyl-CoA Dehydrogenase Deficiency | Spondylometaphyseal Dysplasia | Jacobsen Syndrome | Gangliosidosis | Glycogen Storage Disease Type 1b | Cheilitis | Progressive Osseous Heteroplasia | Keratitis | Meckel-Gruber Syndrome | Chorea | Tylosis With Esophageal Cancer | Lymphangioleiomyomatosis | Charcot-Marie-Tooth Disease Type 4E | Retinitis | Bruck Syndrome | Bardet-Biedl Syndrome | Gingivitis | Geleophysic Dysplasia | Medium-chain Acyl-CoA Dehydrogenase Deficiency | Fibronectin Glomerulopathy | Vitamin K Deficiency | Glycogen Storage Disease Type 1 | Plasmacytoma | Lymphedema-distichiasis Syndrome | McKusick Type Metaphyseal Chondrodysplasia | Non-Langerhans Cell Histiocytosis | Sclerosteosis | Tuberculous Meningitis | Glomerulonephritis, Membranous | Hashimoto Thyroiditis | Glycogen Storage Disease Type 6 | Membranous Nephropathy | Cardiofaciocutaneous Syndrome | Lichen Sclerosus | Corneal Dystrophy And Perceptive Deafness | Corneal Edema | Cohen Syndrome | Mood Disorder | Rubinstein-Taybi Syndrome | Clouston Hidrotic Ectodermal Dysplasia | Autoimmune Autonomic Ganglionopathy | NDH Syndrome | Discoid Lupus Erythematosus | Ollier Disease | Cranioectodermal Dysplasia | Hairy Cell Leukemia | High Molecular Weight Kininogen Deficiency | Seizures-scoliosis-macrocephaly Syndrome | Pancytopenia | Monilethrix | Veno-occlusive Disease | Primary Torsion Dystonia | Esophageal Carcinoma | Cyst | Leri-Weill Dyschondrosteosis | Combined Pituitary Hormone Deficiency | Menetrier Disease | Overactive Bladder | Enterocolitis, Necrotizing | Fatty Aldehyde Dehydrogenase Deficiency | Pigment Dispersion Syndrome | Malonyl-CoA Decarboxylase Deficiency | Brachydactyly | Hereditary Mixed Polyposis Syndrome | Alazami Syndrome | Cushing Syndrome | Smoldering Myeloma | Cholelithiasis | Cluster Headache | Glutaric Aciduria Type 3 | Spinocerebellar Ataxia Type 31 | Diffuse Intrinsic Pontine Glioma | Atelosteogenesis Type 2 | Idiopathic Pulmonary Fibrosis | Glaucomatocyclitic Crisis | Charcot-Marie-Tooth Disease Type 2E | 3-methylglutaconic Aciduria Type I | Colitis | Cervicitis | Hereditary Multiple Exostoses | Sitosterolemia | Triple A Syndrome | Encephalitis | Restless Legs Syndrome | Absence Epilepsy | Neovascular Glaucoma | Hereditary Pyropoikilocytosis | Pituitary Dwarfism | Lipid Metabolism Disorders | Blomstrand Osteochondrodysplasia | Binge Eating Disorder | Periventricular Nodular Heterotopia | Dysmorphophobia | Pseudohypoparathyroidism Type 1C | Bronchitis | Multiple Sclerosis, Secondary Progressive | Prolymphocytic Leukemia | Non-proliferative Diabetic Retinopathy | Persistent Hyperplastic Primary Vitreous | Hereditary Elliptocytosis | Waardenburg Syndrome Type 2A | Niemann-Pick Disease, Type B | Aldosterone Deficiency | Fanconi Anemia | Odonto-onycho-dermal Dysplasia | Keratosis, Actinic | Congenital Adrenal Hyperplasia | Spondyloperipheral Dysplasia | Retinal Vasculitis | Acute Kidney Injury | Multiple Sulfatase Deficiency | Chronic Granulomatous Disease, X-linked | Osteoglophonic Dysplasia | Urticaria | Chronic Thromboembolic Pulmonary Hypertension | Hermansky-Pudlak Syndrome | Tatton-Brown-Rahman Syndrome | Mitochondrial DNA Depletion Syndrome, Myopathic Form | Sengers Syndrome | Endophthalmitis | Insulinoma | Rhabdomyosarcoma, Alveolar | Blepharophimosis Syndrome | Neuroma | Neurodermatitis | Spinocerebellar Ataxia Type 23 | Anti-glomerular Basement Membrane Disease | Neuromyotonia | Pseudoexfoliation Syndrome | LRBA Deficiency | Dowling-Degos Disease | Necrobiosis Lipoidica | Porokeratosis | Language Disorders | Aicardi-Goutieres Syndrome | Heart Failure | Multiple Myeloma | Chondrosarcoma | Aneurysm, Abdominal Aortic | Exfoliative Dermatitis | Tyrosinemia Type 1 | Hypohidrotic Ectodermal Dysplasia, X-linked | Papilloma | Autoimmune Interstitial Lung, Joint, And Kidney Disease | Hypertriglyceridemia | Stuve-Wiedemann Syndrome | Spitz Nevus | Hyperuricemic Nephropathy, Familial Juvenile | Hyperlipidemia Type V | Keratoconjunctivitis | Brachial Plexus Neuropathy | Blood Protein Disorders | Lysosomal Acid Lipase Deficiency | Fibrosarcoma | Heart Block | Dysgerminoma | Frontotemporal Dementia | Conjunctivitis | Mastitis | Progressive Familial Intrahepatic Cholestasis | Benign Recurrent Intrahepatic Cholestasis 1 | Spinal And Bulbar Muscular Atrophy | Lesch-Nyhan Syndrome | Giant Cell Glioblastoma | Aspergillosis | Hydrocephalus | Myelomeningocele | Ehlers-Danlos Syndrome | Ovarian Hyperstimulation Syndrome | Gardner Syndrome | Onchocerciasis | Frank-ter Haar Syndrome | Primary Progressive Aphasia | Glycogen Storage Disease | Sarcomatoid Carcinoma Of The Lung | Lathosterolosis | Celiac Disease | Achromatopsia | Lateral Meningocele Syndrome | Malnutrition | Venous Insufficiency | Double Outlet Right Ventricle | 3-methylglutaconic Aciduria Type IV | Congenital Sodium Diarrhea | Congenital Aniridia | Whipple's Disease | Sarcoidosis, Pulmonary | Low Tension Glaucoma | B-cell Chronic Lymphocytic Leukemia | Renal Tubular Acidosis | Oculocutaneous Albinism Type 2 | Glioblastoma | Congenital Nephrotic Syndrome | Porencephaly | Neuromuscular Disorders | Schizotypal Personality Disorder | Congenital Heart Defects | Vascular Cognitive Impairment | Hereditary Coproporphyria | Familial Hyperaldosteronism | Pathological Gambling | Focal Dermal Hypoplasia | Thyroid Dysgenesis | Arthritis, Reactive | Sarcoma, Endometrial Stromal | Antisynthetase Syndrome | Multicentric Carpotarsal Osteolysis Syndrome | Facioscapulohumeral Muscular Dystrophy Type 2 | Patent Ductus Arteriosus | POEMS Syndrome | Stiff-man Syndrome | Trichorhinophalangeal Syndrome | Smith-Kingsmore Syndrome | Diabetes Insipidus, Nephrogenic | Papulopustular Rosacea | Chudley-McCullough Syndrome | Spondylo-ocular Syndrome | Glutaric Aciduria Type 1 | Acute Chest Syndrome | Melanocytic Nevus | Argininosuccinic Aciduria | Schizophrenia, Paranoid | Campomelic Dysplasia | Arteriovenous Malformations | Neurofibromatosis Type 2 | Congenital Absence Of Vas Deferens | Hypertension, Renovascular | Malaria, Cerebral | Reflex Epilepsy | Glaucoma | Loeys-Dietz Syndrome Type 4 | Motor Neuron Diseases | Retinal Degeneration | Macrophagic Myofasciitis | Klippel-Feil Syndrome | Gastritis, Atrophic | Moyamoya Disease | Episodic Ataxia | Glomerulonephritis | Angiosarcoma | Scapuloperoneal Myopathy, X-linked Dominant | Osmotic Demyelination Syndrome | Spinocerebellar Ataxia Type 20 | Albinism | Cockayne Syndrome | Hypertension, Essential | Alopecia Areata | Ichthyosis | Hypersomnia | Tietze Syndrome | Thyrotoxic Periodic Paralysis | Tendinopathy | Cryptococcal Meningitis | Diastrophic Dysplasia | Chromosome 16p11.2 Deletion Syndrome | Lupus Erythematosus | Netherton Syndrome | Asplenia | Congenital Dyserythropoietic Anemia Type 1 | Schizencephaly | Borjeson-Forssman-Lehmann Syndrome | Asphyxia Neonatorum | Hypertension, Pulmonary | Primary Familial Brain Calcification | Danon Disease | Dysthymia | Myocarditis | Unverricht-Lundborg Syndrome | Hyperthermia, Malignant | Carcinoma, Merkel Cell | Hypobetalipoproteinemias | Hypothyroidism | Meningioma | Alpers Syndrome | Cholecystitis | Rothmund-Thomson Syndrome | Pneumonia, Viral | Hepatitis, Chronic | Gestational Trophoblastic Disease | Leukoplakia | Non-Hodgkin Lymphoma | Raine Syndrome | Carbonic Anhydrase VA Deficiency | Adenosine Deaminase 2 Deficiency | Cat Eye Syndrome | Thin Basement Membrane Disease | Bone Giant Cell Tumor | Autoimmune Polyendocrine Syndrome | Otitis Media | Actinomycetoma | Nephrotic Syndrome Type 1 | Osteogenesis Imperfecta | Pancreatitis, Chronic | Ileitis | Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive 1 | Chitayat Syndrome | Phenylketonuria | Jawad Syndrome | Fanconi Syndrome | Optic Neuritis | Pontocerebellar Hypoplasia Type 2 | Meningeal Melanocytoma | Epidermal Nevus Syndrome | Choreoathetosis, Hypothyroidism, And Neonatal Respiratory Distress | Urofacial Syndrome | Osteoporosis-pseudoglioma Syndrome | Seasonal Mood Disorder | Pulmonary Alveolar Proteinosis | Dengue Shock Syndrome | Oculocutaneous Albinism Type 1 | Cancer, Skin | Hemimegalencephaly | Scleroderma, Diffuse | Systemic Mastocytosis | Saul-Wilson Syndrome | Microcephaly, Seizures, And Developmental Delay | Melnick-Needles Syndrome | Cherubism | Hereditary Spherocytosis | Paronychia | Mucolipidosis Type III | Histoplasmosis