Primary Progressive Aphasia

About the Disease
Frontotemporal Lobar Degeneration with Tdp43 Inclusions, Grn-Related, also known as primary progressive aphasia, is related to progressive non-fluent aphasia and aphasia, and has symptoms including personality changes, agitation and memory loss. An important gene associated with Frontotemporal Lobar Degeneration with Tdp43 Inclusions, Grn-Related is GRN (Granulin Precursor), and among its related pathways/superpathways are Neuroscience and Copper homeostasis. The drugs Memantine and Citalopram have been mentioned in the context of this disorder. Affiliated tissues include brain, bone marrow and eye, and related phenotypes are hallucinations and cerebral cortical atrophy

Common Targets
TARDBP | PSEN2 | DCTN1 | APP | GRN | APOE | G8878 | PRNP

Note: If you'd like to get a target analysis report for Primary Progressive Aphasia, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Primary Progressive Aphasia at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Lennox-Gastaut Syndrome | Familial Advanced Sleep Phase Syndrome | Williams Syndrome | Endometriosis | Dysequilibrium Syndrome | Actinomycetoma | Hemophilia | Anterior Segment Dysgenesis | Chronic Myeloid Leukemia | Inflammatory Myopathy | Frank-ter Haar Syndrome | Hypoglycemia | Senior-Loken Syndrome | Creatine Deficiency Syndrome | Craniofacial Dysostosis | Thyroiditis | Gastric Atrophy | Metatropic Dysplasia | Disseminated Intravascular Coagulation | Congenital Nystagmus | Congenital Hereditary Endothelial Dystrophy Type II | Auriculocondylar Syndrome | Paroxysmal Nocturnal Hemoglobinuria | Prune Belly Syndrome | Fabry's Disease | Methylmalonic Aciduria And Homocystinuria, CblC Type | Onchocerciasis | Anodontia | Seizures-scoliosis-macrocephaly Syndrome | Basal Ganglia Cerebrovascular Disease | Chylothorax, Congenital | Pontocerebellar Hypoplasia Type 7 | Synpolydactyly | Thymoma, Malignant | Multiple Sulfatase Deficiency | Tenosynovial Giant Cell Tumor | Fibrodysplasia Ossificans Progressiva | Nicotine Addiction | Genee-Wiedemann Syndrome | Charcot-Marie-Tooth Disease Type 2E | Hypertriglyceridemia | Sarcomatoid Carcinoma Of The Lung | Schwartz-Jampel-Aberfeld Syndrome | Oculocutaneous Albinism Type 4 | Nephrocalcinosis | Coronary Restenosis | Hypercalcemia | Hypophosphatasia | Hyperhomocysteinemia | Chondrodysplasia Punctata 1, X-linked Recessive | Colitis, Collagenous | Seasonal Mood Disorder | Filariasis | Juvenile Myoclonic Epilepsy | Benign Recurrent Intrahepatic Cholestasis 1 | Congenital Afibrinogenemia | Rhizomelic Chondrodysplasia Punctata | Trismus-pseudocamptodactyly Syndrome | Major Depression | Melanoma, Malignant | Tyrosinemia | Greig Cephalopolysyndactyly Syndrome | Osteoporosis-pseudoglioma Syndrome | Contact Dermatitis | Neurofibrosarcoma | Hemolytic Uremic Syndrome | Pseudohypoparathyroidism Type 1B | H Syndrome | Cantu Syndrome | Benign Hereditary Chorea | Malignant Peripheral Nerve Sheath Tumor | Mycosis Fungoides | Cardiac Arrest | Chronic Myelomonocytic Leukemia | Schizophrenia | Spinocerebellar Ataxia Type 27 | Fuchs Heterochromic Iridocyclitis | Autosomal Recessive Congenital Ichthyosis | Primary Torsion Dystonia | Gastrointestinal Disorders | Encephalopathy, Glycine | Alpha-1 Antitrypsin Deficiency | Torticollis | Werner's Syndrome | Fowler's Syndrome | Maternally Inherited Diabetes And Deafness | Clouston Hidrotic Ectodermal Dysplasia | Exfoliative Dermatitis | Spitzoid Melanoma | Turner's Syndrome | Gout | Sarcoma, Endometrial Stromal | Raine Syndrome | Lipid Metabolism Disorders | IMAGe Syndrome | Epidermolysis Bullosa Dystrophica | Angioedema, Hereditary | Dystonia-parkinsonism, X-linked | Anencephaly | Absence Epilepsy | Myoclonus-dystonia Syndrome | Renal Tubular Acidosis | Vitreoretinal Degeneration, Snowflake Type | Infantile Spasm | Analgesia | Japanese Encephalitis | Herpes Genitalis | Stickler Syndrome | Adenoma, Pleomorphic | Trichotillomania | 3-M Syndrome | Frontotemporal Dementia With Amyotrophic Lateral Sclerosis | Adult Polyglucosan Body Disease | Pemphigus Vulgaris | Myopia | Glomerulonephritis, Membranoproliferative | Charcot-Marie-Tooth Disease | Plasma Cell Dyscrasia | Progressive External Ophthalmoplegia | Osteogenesis Imperfecta Type IV | Stomatitis | Congenital Generalized Lipodystrophy | Acute Anterior Uveitis | Cole-Carpenter Syndrome | Tracheal Disorders | Sleep Apnea, Obstructive | CEDNIK Syndrome | Spinocerebellar Ataxia Type 10 | Pseudoexfoliation Syndrome | Optic Nerve Hypoplasia, Bilateral | Meleda Disease | Stromal Corneal Dystrophy | Limb Girdle Muscular Dystrophy | HUPRA Syndrome | Epidermolysis Bullosa Simplex, Localized | Dementia, Vascular | Dupuytren Disease | Spinocerebellar Ataxia Type 20 | Choroiditis | Conjunctivitis, Allergic | Chitayat Syndrome | Fontaine Progeroid Syndrome | Esotropia | Prediabetes | Hyperkalemic Periodic Paralysis | Transthyretin-related Amyloidosis | Diabetic Nephropathy | Thrombasthenia | Sensory Ataxic Neuropathy, Dysarthria, And Ophthalmoparesis | Xeroderma Pigmentosum | Exostoses | Leishmaniasis, Visceral | Subacute Sclerosing Panencephalitis | Central Core Disease | Delayed Sleep Phase Syndrome | Early Infantile Epileptic Encephalopathy 13 | Dysthymia | Schwannoma | Combined Deficiency Of Factor V And Factor VIII | Tangier Disease | Chudley-McCullough Syndrome | Myhre Syndrome | Duodenal Atresia | Ectrodactyly | Recurrent Respiratory Papillomatosis | Hypercholesterolemia, Familial | Knobloch Syndrome | Pyruvate Carboxylase Deficiency Disease | Congestive Heart Failure | Pneumonia, Mycoplasma | Thyroid Dyshormonogenesis | Hemolytic Uremic Syndrome, Atypical | Kleine-Levin Syndrome | Endometrial Hyperplasia | Galloway-Mowat Syndrome | Keratosis, Seborrheic | Epidermodysplasia Verruciformis | Pineoblastoma | Endocarditis | Thyrotoxic Periodic Paralysis | Protein C Deficiency | Familial Hyperaldosteronism | Klinefelter Syndrome | Personality Disorders | Microtia | Syndactyly | D-2-Hydroxyglutaric Aciduria | Smith-Magenis Syndrome | Cavitary Optic Disc Anomalies | Orthostatic Intolerance | Hypermethioninemia | Eosinophilic Asthma | Carcinoma, Small Cell | Cerebral Amyloid Angiopathy | Follicular Dendritic Cell Sarcoma | Fundus Albipunctatus | Palmoplantar Keratoderma | Trigonocephaly | Blepharitis | Vogt-Koyanagi-Harada Syndrome | Cannabis Abuse | Cenani-Lenz Syndactyly Syndrome | Gnathodiaphyseal Dysplasia | Optic Nerve Diseases | Spinocerebellar Ataxia Type 1 | LRBA Deficiency | Giant Axonal Neuropathy | Bronchitis, Chronic | Cheilitis | HIBCH Deficiency | Peritonitis | Alcoholism | Asthma | Focal Segmental Glomerulosclerosis | Hyperuricemia | Cancer, Breast | Birk-Barel Syndrome | Scapuloperoneal Spinal Muscular Atrophy | Allan-Herndon-Dudley Syndrome | Spinocerebellar Ataxia Type 16 | Microcephalic Primordial Dwarfism | Hypertension, Essential | Autosomal Recessive Spastic Paraplegia Type 54 | Johanson-Blizzard Syndrome | Chorioretinitis | Wolfram Syndrome 2 | Non-Langerhans Cell Histiocytosis | Chediak-Higashi Syndrome | Sporadic Inclusion Body Myositis | Otopalatodigital Syndrome Type 2 | Protein S Deficiency | WAGR Syndrome | Episodic Ataxia Type 2 | Nephropathy | Aneurysm, Abdominal Aortic | Progressive Familial Intrahepatic Cholestasis Type 2 | Polymicrogyria | Atelosteogenesis Type 2 | Macular Degeneration | Skin Papilloma | Mabry Syndrome | Scleroderma, Diffuse | Lipid Storage Diseases | Congenital Dyserythropoietic Anemia Type 4 | Sclerosteosis 2 | Lupus Erythematosus | IgA Deficiency | Familial Exudative Vitreoretinopathy | Cranial Nerve Disease | Joubert Syndrome 2 | Antisynthetase Syndrome | Retinitis Pigmentosa | Progressive Encephalopathy-optic Atrophy Syndrome | Glioblastoma Multiforme | Ehlers-Danlos Syndrome | Arts Syndrome | Coma | Varices | Atopic Dermatitis | Amyotrophic Lateral Sclerosis-parkinsonism-dementia Complex | Chronic Granulomatous Disease, X-linked | Spinocerebellar Ataxia Type 17 | Trichorhinophalangeal Syndrome | Carcinoma, Squamous Cell | Leukodystrophies | Lathosterolosis | Chromosome 16p11.2 Deletion Syndrome | Central Retinal Artery Occlusion | Renal-hepatic-pancreatic Dysplasia | Hennekam Lymphangiectasia-lymphedema Syndrome | Hypoparathyroidism | Intermittent Claudication | Spinal And Bulbar Muscular Atrophy | Scapuloperoneal Myopathy, X-linked Dominant | Acrodermatitis Enteropathica | Keratocystic Odontogenic Tumor | Walker-Warburg Syndrome | Hypomyelination With Atrophy Of Basal Ganglia And Cerebellum | Rheumatic Heart Disease | Vasculitis | DICER1 Syndrome | Primary Progressive Aphasia | Parkinsonism | Skin Fragility-woolly Hair Syndrome | Sturge-Weber Syndrome | Pure Autonomic Failure | Androgenic Alopecia | Retinal Dystrophy, Early-onset Severe | Carbonic Anhydrase VA Deficiency | Pulmonary Tuberculosis | Aneurysm, Thoracic Aortic | Bare Lymphocyte Syndrome | Olmsted Syndrome | Ileitis | Eating Disorder | IgA Nephropathy | Infantile Nephropathic Cystinosis | Diabetes | Congenital Mirror Movements | Non-epidermolytic Palmoplantar Keratoderma | Cellulitis | Rhabdomyosarcoma | Still Disease | Leber Congenital Amaurosis | Fanconi Anemia | Cousin Syndrome | Pneumonia, Bacterial | Rhabdoid Tumor | Hypervalinemia | T-cell Prolymphocytic Leukemia | Glycogen Storage Disease Type 5 | Hypertensive Retinopathy | Brugada Syndrome 1 | Juvenile Xanthogranuloma | Wilson's Disease | Antiphospholipid Syndrome | Diffuse Palmoplantar Keratoderma | Stroke | Mucolipidosis | Pelizaeus-Merzbacher Disease | Hepatic Steatosis | Familial Isolated Hyperparathyroidism | Spinal Muscular Atrophy | Keratosis | Aicardi-Goutieres Syndrome | Polycystic Liver | Patent Ductus Arteriosus | C3 Glomerulopathy | Mixed Connective Tissue Disease | Congenital Dysfibrinogenemia | Growth Hormone Excess | Alveolar Capillary Dysplasia | Exocrine Pancreatic Insufficiency | Sickle Cell Disease | Cryoglobulinemia | Adrenal Insufficiency | Zimmermann-Laband Syndrome | Conduct Disorder | Arteriosclerosis | Tricho-hepato-enteric Syndrome | Polymyalgia Rheumatica | Liddle Syndrome | Babesiosis | Methemoglobinemia | Ganglioneuroma | Hypohidrotic Ectodermal Dysplasia, X-linked | Heterotopic Ossification | Neutropenia | Muscle Wasting | Osteopetrosis | Sweet Syndrome | Hyperinsulinism-hyperammonemia Syndrome | B-cell Prolymphocytic Leukemia | Arthritis, Reactive | Hypopigmentation | Polycythemia Vera | Focal Cortical Dysplasia Type 2 | Cardiofaciocutaneous Syndrome | Cancer, Skin | Esophageal Motility Disorders | Hypothyroidism | Cholestasis, Intrahepatic | Encephalopathy, Hepatic | Relapsing Polychondritis | Tyrosinemia Type 2 | Intestinal Tuberculosis | Thanatophoric Dysplasia Type 1 | Nephrotic Syndrome Type 1 | Hepatitis, Autoimmune | Rickets | Epiphyseal Chondrodysplasia, Miura Type | Alazami Syndrome | Chondroma | Bietti Crystalline Dystrophy | Oculodentodigital Dysplasia | Gitelman Syndrome | Plasmacytoma | Bacterial Meningitis | Guttate Psoriasis | Tatton-Brown-Rahman Syndrome | CHARGE Syndrome | Dysplastic Nevus | Deafness, Dystonia, And Cerebral Hypomyelination | Duane Retraction Syndrome | Epidermolysis Bullosa | Phosphoenolpyruvate Carboxykinase Deficiency, Cytosolic | Christianson Syndrome | CHOPS Syndrome | Macrophage Activation Syndrome | Lymphedema | Craniometaphyseal Dysplasia | Muir-Torre Syndrome | Multiple Congenital Anomalies-hypotonia-seizures Syndrome 2 | Wolff-Parkinson-White Syndrome | Charcot-Marie-Tooth Disease Type 2T | Kashin-Beck Disease | Stargardt Disease | Sleep Disorder | Triphalangeal Thumb-polysyndactyly Syndrome | GAPO Syndrome