Primary Progressive Aphasia

About the Disease
Frontotemporal Lobar Degeneration with Tdp43 Inclusions, Grn-Related, also known as primary progressive aphasia, is related to progressive non-fluent aphasia and aphasia, and has symptoms including personality changes, agitation and memory loss. An important gene associated with Frontotemporal Lobar Degeneration with Tdp43 Inclusions, Grn-Related is GRN (Granulin Precursor), and among its related pathways/superpathways are Neuroscience and Copper homeostasis. The drugs Memantine and Citalopram have been mentioned in the context of this disorder. Affiliated tissues include brain, bone marrow and eye, and related phenotypes are hallucinations and cerebral cortical atrophy

Common Targets
TARDBP | PSEN2 | DCTN1 | APP | GRN | APOE | G8878 | PRNP

Note: If you'd like to get a target analysis report for Primary Progressive Aphasia, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Primary Progressive Aphasia at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Bone Marrow Necrosis | Blastoma, Pleuropulmonary | Cancer, Breast | Feingold Syndrome | Wagner Disease | Pain | Aspergillosis | Fibronectin Glomerulopathy | Auriculocondylar Syndrome | Mood Disorder | Cardiomyopathy, Hypertrophic | Focal Dermal Hypoplasia | Lupus Erythematosus | Congenital Heart Defects | Lathosterolosis | Recurrent Respiratory Papillomatosis | Viral Meningitis | Gyrate Atrophy Of The Choroid And Retina | Sensory Neuropathy | Hypohidrotic Ectodermal Dysplasia | Menkes Disease | Neurocysticercosis | Mandibuloacral Dysplasia With Type A Lipodystrophy | Purpura, Thrombotic Thrombocytopenic | Apert Syndrome | Pulmonary Sclerosing Hemangioma | Mycosis Fungoides | Diverticulitis | Alopecia Areata | Pseudohermaphroditism | Vascular Calcification | Encephalopathy, Hepatic | 3-hydroxy-3-methylglutaric Aciduria | Micropenis | Frank-ter Haar Syndrome | Marinesco-Sjogren Syndrome | Holoprosencephaly | Oral Lichen Planus | Usher Syndrome Type IIC | Meniere's Disease | Chordoma | Phosphoglycerate Dehydrogenase Deficiency | Atopic Dermatitis | Hydrops Fetalis | Meningioma | Multiple Sclerosis, Chronic Progressive | Sickle Cell Disease | Corneal Dystrophy And Perceptive Deafness | Bronchitis | Acute Generalized Exanthematous Pustulosis | Megacystis-microcolon-intestinal Hypoperistalsis Syndrome | Primary Biliary Cholangitis | Anorectal Fistula | HUPRA Syndrome | Pierpont Syndrome | Onchocerciasis | Dowling-Degos Disease | Raine Syndrome | Netherton Syndrome | Pseudohypoparathyroidism Type 1B | Glycogen Storage Disease Type 0, Muscle | Erectile Dysfunction | Ectopia Lentis, Isolated, Autosomal Recessive | Vitamin K Deficiency | Renal Failure | Syphilis | Nephropathy | Vitamin A Deficiency | Reflex Epilepsy | Pitt-Hopkins Syndrome | Hemorrhoids | Hepatic Steatosis | Optic Atrophy 2 | Keratocystic Odontogenic Tumor | Multiple Hamartoma Syndrome | Unverricht-Lundborg Syndrome | Retinopathy, Diabetic | Crouzon Syndrome With Acanthosis Nigricans | Neutrophilia | Ichthyosis Hystrix, Curth-Macklin Type | Motor Neuron Diseases | Ophthalmia, Sympathetic | Sengers Syndrome | Erythropoietic Protoporphyria | AIDS | Palmoplantar Keratoderma | Hemangioblastoma | Paroxysmal Nocturnal Hemoglobinuria | Treacher Collins Syndrome | Oculocutaneous Albinism Type 1 | Aicardi-Goutieres Syndrome | Polyarteritis Nodosa | Blepharitis | Osteitis | Tangier Disease | Pyelonephritis | Bacterial Meningitis | Delirium | Nance-Horan Syndrome | Huntington's Disease-like 2 | Contact Dermatitis | Atopy | Limb Girdle Muscular Dystrophy | Familial Hypertrophic Cardiomyopathy | Carcinoid Syndrome | Maternally Inherited Diabetes And Deafness | Central Retinal Artery Occlusion | Tatton-Brown-Rahman Syndrome | Arthritis, Reactive | Congenital Sodium Diarrhea | Patent Ductus Arteriosus | Glaucoma, Congenital | PASLI Disease | Duchenne Muscular Dystrophy | Peeling Skin Syndrome Type B | Glycogen Storage Disease Type 1 | Sensorineural Hearing Loss | Myelitis | Harlequin Ichthyosis | Varicocele | Cluster Headache | Trimethylaminuria | Ophthalmoplegia | Kearns-Sayre Syndrome | Phosphoenolpyruvate Carboxykinase Deficiency, Cytosolic | Leukoencephalopathy, Progressive Multifocal | Dementia, Vascular | Tyrosinemia Type 1 | Phenylketonuria II | Peutz-Jeghers Syndrome | Bronchitis, Chronic | Liver Failure | Liver Failure, Acute Infantile | Allan-Herndon-Dudley Syndrome | Cancer, Prostate | Trigonocephaly | Hypotrichosis | Acromicric Dysplasia | Mitochondrial DNA Depletion Syndrome, Hepatocerebral Form | Hereditary Spastic Paraplegia | Thrombosis | Temporal Lobe Epilepsy | Macrodactyly | Carcinoma, Squamous Cell | DRESS Syndrome | Alpha-mannosidosis | Progressive Encephalopathy-optic Atrophy Syndrome | Hypocalcemia | Hypercalciuria | Polymyositis | Coronary Heart Disease | Mohr-Tranebjaerg Syndrome | Cherubism | Spondyloarthritis | Neuroblastoma | Amyloidosis | Dysthymia | Polycystic Ovary Syndrome | Asthma | Anuria | Succinic Semialdehyde Dehydrogenase Deficiency | Pleomorphic Xanthoastrocytoma | Splenomegaly | Osteopetrosis | Hyperlipidemia Type V | Sclerocornea | Miyoshi Myopathy | Adenocarcinoma | Cole-Carpenter Syndrome | Ectodermal Dysplasia | Primary Torsion Dystonia | Lymphoproliferative Disorders | POEMS Syndrome | Hartsfield Syndrome | Hypersensitivity Pneumonitis | Swine Influenza | Hemophilia | Facioscapulohumeral Muscular Dystrophy Type 1 | Glutaric Aciduria Type 1 | DEND Syndrome | Carcinoma, Signet Ring Cell | AIDS Dementia Complex | Kabuki Syndrome 2 | Fuchs Heterochromic Iridocyclitis | Wolfram Syndrome 2 | Weill-Marchesani Syndrome | Chronic Thromboembolic Pulmonary Hypertension | Osteoporosis-pseudoglioma Syndrome | Congenital Primary Aphakia | Diabetic Macular Edema | Mountain Sickness | Charcot-Marie-Tooth Disease, Type 1A | Primary Carnitine Deficiency | FG Syndrome | Hypospadias | Lyme Disease | Transcobalamin Deficiency | Malnutrition | Spondyloepiphyseal Dysplasia Tarda, X-linked | Cancer, Kidney | Major Depression | Methemoglobinemia Type IV | Neuromuscular Disorders | Combined Pituitary Hormone Deficiency | Tuberculosis | Pyloric Stenosis, Infantile Hypertrophic | Histoplasmosis | 3-methylcrotonyl-CoA Carboxylase Deficiency | Hemolytic Anemia | Pulmonary Stenosis | Spinocerebellar Ataxia Type 2 | Diffuse Intrinsic Pontine Glioma | Leber Congenital Amaurosis | Hyperkeratosis | Encephalitis, Tick-borne | Infertility | Cancer, Lung | Benign Recurrent Intrahepatic Cholestasis 1 | Antiphospholipid Syndrome | Cutaneous T-cell Lymphoma | GM2-gangliosidosis AB Variant | Granuloma Annulare | Inflammatory Joint Disease | Epidermolysis Bullosa | Autosomal Recessive Spastic Paraplegia Type 75 | Wolcott-Rallison Syndrome | Fabry's Disease | Asphyxia Neonatorum | HANAC Syndrome | Wiskott-Aldrich Syndrome | DOCK8 Immunodeficiency Syndrome | Mitochondrial Disease | Cousin Syndrome | Meesmann Corneal Dystrophy | Adenomyosis | Carpenter Syndrome | Antley-Bixler Syndrome | Metaphyseal Chondrodysplasia, Schmid Type | Keratitis-ichthyosis-deafness Syndrome | Autoimmune Autonomic Ganglionopathy | Androgen Insensitivity | Porokeratosis | Scleroderma, Diffuse | Giant Axonal Neuropathy | Hypercholesterolemia | Bicuspid Aortic Valve | Hyperinsulinemic Hypoglycemia | Acrodysostosis | Leukemia-lymphoma, Adult T-cell | Fowler's Syndrome | Meleda Disease | Snyder-Robinson Syndrome | Microphthalmia, Syndromic 7 | Acute Kidney Injury | Olmsted Syndrome | Leiomyosarcoma | Liver Diseases | Myelofibrosis | Reticular Dysgenesis | Obesity | Pilomatrix Carcinoma | Myasthenia Gravis | Lattice Corneal Dystrophy | Lassa Fever | Kabuki Syndrome | CREST Syndrome | Carney-Stratakis Syndrome | Sarcoma, Endometrial Stromal | Early Infantile Epileptic Encephalopathy | Familial Dysautonomia | Pseudoachondroplasia | Colitis | Transient Bullous Dermolysis Of The Newborn | Esophagitis, Eosinophilic | Paget's Disease Of The Breast | Astrocytoma | GAPO Syndrome | Iron Deficiency Anemia | Jawad Syndrome | Epithelioid Hemangioma | Proximal Symphalangism | Metachromatic Leukodystrophy | Achondrogenesis | Stroke, Hemorrhagic | Glycogen Storage Disease | Milk Allergy | Asthma, Nocturnal | Vestibular Disease | Intermittent Claudication | Cerebellofaciodental Syndrome | Cutaneous Angiosarcoma | Polycystic Kidney, Autosomal Recessive | Angina Pectoris | Cardiac Arrest | Porphyria, Acute Intermittent | Aplasia Cutis Congenita | Gerodermia Osteodysplastica | Chronic Neutrophilic Leukemia | Panniculitis | Meningococcal Infections | Graves Disease | Charcot-Marie-Tooth Disease Type 4D | Conn Syndrome | Colitis, Collagenous | Azoospermia | Retinoschisis | Congenital Hereditary Endothelial Dystrophy Type II | Cushing Syndrome | Mosaic Variegated Aneuploidy Syndrome 2 | Thrombocythemia, Essential | Acute Anterior Uveitis | Carpal Tunnel Syndrome | Charcot-Marie-Tooth Disease Type 4E | Hyperprolactinemia | Hereditary Pyropoikilocytosis | Celiac Disease | Glaucoma | Hypothalamic Obesity | Infantile Liver Failure Syndrome 1 | Gigantism | Erythromelalgia | Norrie Disease | Situs Inversus | Autoimmune Polyendocrinopathy Syndrome Type I | Pericarditis | Lipid Storage Diseases | DNA Ligase IV Deficiency | Toxoplasmosis | 3-hydroxyacyl-CoA Dehydrogenase Deficiency | Skin Fragility-woolly Hair Syndrome | Infantile Neuroaxonal Dystrophy | Hartnup Disease | Renal Dysplasia | Early Infantile Epileptic Encephalopathy 28 | Mitochondrial Myopathy | Prolidase Deficiency | Neovascular Glaucoma | Paronychia | Ulcerative Colitis | Heterotopic Ossification | Fetal And Neonatal Alloimmune Thrombocytopenia | Hypoparathyroidism | Tyrosinemia | Ornithine Transcarbamylase Deficiency | Agammaglobulinemia | SAPHO Syndrome | Poretti-Boltshauser Syndrome | Presbycusis | Hypersomnia | Granular Corneal Dystrophy Type 1 | Corneal Ulcer | Schwartz-Jampel-Aberfeld Syndrome | Long QT Syndrome Type 1 | Hypogammaglobulinemia | Zollinger-Ellison Syndrome | Fibrosis | Alzheimer Disease, Late Onset | Myoclonus-dystonia Syndrome | Temtamy Preaxial Brachydactyly Syndrome | Choroiditis | 3-methylglutaconic Aciduria | Encephalopathy | Brugada Syndrome 1 | Geleophysic Dysplasia | Juvenile Xanthogranuloma | Tyrosinemia Type 2 | Leri Pleonosteosis | Lymphoma Lymphoblastic | CHOPS Syndrome | Pseudo-pseudohypoparathyroidism | Tuberculous Meningitis | Bruck Syndrome | Hereditary Neuropathy With Liability To Pressure Palsies | Schuurs-Hoeijmakers Syndrome | Chitayat Syndrome | Eiken Syndrome | Multiple Mitochondrial Dysfunctions Syndrome Type 1 | Fanconi Anemia | Salla Disease | Optic Neuropathy, Anterior Ischemic | Spondylo-megaepiphyseal-metaphyseal Dysplasia | Borderline Personality Disorder | Proopiomelanocortin Deficiency | Charcot-Marie-Tooth Disease Type 4B1 | Colon Adenoma | Enhanced S-cone Syndrome | Fetal Alcohol Syndrome | Usher Syndrome | Malaria, Cerebral | Hereditary Elliptocytosis | Aspartylglycosaminuria | 3-methylglutaconic Aciduria Type IV | Dyggve-Melchior-Clausen Disease | Chiari Malformation Type I | Peripheral Neuropathy | Hyperparathyroidism-jaw Tumor Syndrome | Smith-Lemli-Opitz Syndrome | Osteopathia Striata With Cranial Sclerosis | Cabezas Syndrome | Duane Retraction Syndrome