Disease

Primary Progressive Aphasia

About the Disease
Frontotemporal Lobar Degeneration with Tdp43 Inclusions, Grn-Related, also known as primary progressive aphasia, is related to progressive non-fluent aphasia and aphasia, and has symptoms including personality changes, agitation and memory loss. An important gene associated with Frontotemporal Lobar Degeneration with Tdp43 Inclusions, Grn-Related is GRN (Granulin Precursor), and among its related pathways/superpathways are Neuroscience and Copper homeostasis. The drugs Memantine and Citalopram have been mentioned in the context of this disorder. Affiliated tissues include brain, bone marrow and eye, and related phenotypes are hallucinations and cerebral cortical atrophy

Common Targets
TARDBP | PSEN2 | DCTN1 | APP | GRN | APOE | G8878 | PRNP

疾病靶点研报
Primary Progressive Aphasia

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