Growth Hormone Excess

About the Disease
Acromegaly, also known as gigantism, is related to pituitary adenoma 1, multiple types and pituitary tumors, and has symptoms including endocrine system signs and symptoms An important gene associated with Acromegaly is AIP (Aryl Hydrocarbon Receptor Interacting Protein), and among its related pathways/superpathways are GPCR downstream signalling and Class A/1 (Rhodopsin-like receptors). The drugs Somatostatin and Liraglutide have been mentioned in the context of this disorder. Affiliated tissues include limb, pituitary and bone, and related phenotypes are hyperhidrosis and macroglossia

Common Targets
SSTR2 | GHSR | DRD2 | GHR | SSTR5 | GHRHR | AIP

Note: If you'd like to get a target analysis report for Growth Hormone Excess, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Growth Hormone Excess at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Familial Episodic Pain Syndrome | Dysthymia | Anti-glomerular Basement Membrane Disease | Multifocal Motor Neuropathy | Chronic Thromboembolic Pulmonary Hypertension | Dentinogenesis Imperfecta | Glycogen Storage Disease Type 9 | Hereditary Xerocytosis | Fetal Akinesia Deformation Sequence | Myelomeningocele | Meniere's Disease | Lymphedema-distichiasis Syndrome | Pseudohypoparathyroidism Type 1C | Gangliosidosis, GM1 | Hypertension, Portal | Myotonia | Schwannoma | Duchenne Muscular Dystrophy | Granular Corneal Dystrophy Type 1 | Ornithine Transcarbamylase Deficiency | Neutrophilia | Tardive Dyskinesia | AIDS | Leukocyte Adhesion Deficiency | Essential Fructosuria | Seizures-scoliosis-macrocephaly Syndrome | Uveitis, Anterior | Osteoporosis, Postmenopausal | Cherubism | Hypereosinophilic Syndrome | Nail Disorder, Nonsyndromic Congenital | Spondyloperipheral Dysplasia | Mixed Connective Tissue Disease | Occipital Neuralgia | Sickle Cell Disease | Persistent Hyperplastic Primary Vitreous | 3-methylglutaconic Aciduria | Klinefelter Syndrome | Lipid Storage Myopathy | Ocular Albinism Type 1 | Wiedemann-Steiner Syndrome | Schwannomatosis | Cold-induced Sweating Syndrome | Intracerebral Hemorrhage | Ovarian Sex Cord-stromal Tumor | Angioedema, Acquired | Seminoma | Muscle Wasting | Glutaric Aciduria Type 3 | Angiomyolipoma | Multiple Sclerosis, Relapsing-remitting | Cousin Syndrome | Spitz Nevus | DOCK8 Immunodeficiency Syndrome | Stroke, Ischemic | Myoclonus | Tonsillitis | POEMS Syndrome | VACTERL/VATER Association | Cryptorchidism | Papillon-Lefevre Syndrome | Schizoaffective Disorder | IgA Nephropathy | Cartilage Disorders | NDH Syndrome | Strabismus | Epicondylitis | Pulmonary Sclerosing Hemangioma | Conjunctivitis | Zellweger Syndrome | ICF Syndrome | Basal Cell Nevus Syndrome | Crimean-Congo Hemorrhagic Fever | Pituitary Disorders | Lymphoma, Mantle Cell | Adenosine Deaminase 2 Deficiency | Chronic Enteropathy Associated With SLCO2A1 Gene | Disseminated Intravascular Coagulation | Dystonia-parkinsonism, X-linked | Myoclonic Atonic Epilepsy | Zygomycosis | Nephrotic Syndrome Type 1 | Molybdenum Cofactor Deficiency | Cholera | Autoimmune Polyendocrinopathy Syndrome Type I | Myositis, Focal | Hypertension, Renovascular | Localized Scleroderma | Colitis, Lymphocytic | Hyperlipidemia Type V | Autonomic Neuropathy | Charcot-Marie-Tooth Disease Type 3 | Hypothyroidism | Necrotizing Autoimmune Myopathy | Cholestasis | Common Cold | Split Hand-foot Malformation | Early Infantile Epileptic Encephalopathy | X-linked Creatine Transporter Deficiency | Chronic Granulomatous Disease | Encephalopathy, Ethylmalonic | Spinocerebellar Ataxia Type 1 | Epidermolytic Hyperkeratosis | Hereditary Hemorrhagic Telangiectasia Type 2 | Azoospermia | Dengue Hemorrhagic Fever | Spondylolisthesis | Blastomycosis | Thrombocytopenia | Paronychia | Vertebrobasilar Insufficiency | Influenza | Diabetic Encephalopathy | Oculocutaneous Albinism Type 1 | Otitis Externa | Sporadic Inclusion Body Myositis | Chondrodysplasia Punctata | Alopecia | Liver Failure | Carbamoyl Phosphate Synthetase I Deficiency | Neurotoxicity | Ichthyosis Hystrix, Curth-Macklin Type | Lattice Corneal Dystrophy | Saethre-Chotzen Syndrome | Congenital Central Hypoventilation Syndrome | Optic Neuropathy | Becker Muscular Dystrophy | Neurofibroma, Plexiform | Familial Glucocorticoid Deficiency | Angioimmunoblastic T-cell Lymphoma | Dyskeratosis Congenita | Lymphopenia | Neovascular Glaucoma | Corneal Dystrophy | Spinocerebellar Ataxia Type 8 | Ataxia-ocular Apraxia 2 | Osteitis | Behavioral Variant Of Frontotemporal Dementia | Succinic Semialdehyde Dehydrogenase Deficiency | Megacystis-microcolon-intestinal Hypoperistalsis Syndrome | Glycogen Storage Disease Type 3 | Greig Cephalopolysyndactyly Syndrome | Acute Lymphocytic Leukemia | AIDS Dementia Complex | Stuve-Wiedemann Syndrome | Sandhoff Disease | Pure Red Cell Aplasia | Wolcott-Rallison Syndrome | Cholelithiasis | Non-Hodgkin Lymphoma | Carey-Fineman-Ziter Syndrome | Jaundice, Obstructive | Microphthalmia, Syndromic 7 | Non-bullous Congenital Ichthyosiform Erythroderma | Pleomorphic Xanthoastrocytoma | Maple Syrup Urine Disease | HELLP Syndrome | Delirium | Hemochromatosis Type 2 | Sialoadenitis | Multiple Sulfatase Deficiency | Dermatitis Herpetiformis | Fuchs Heterochromic Iridocyclitis | Alazami Syndrome | Cerebral Cavernous Malformations | Osteochondroma | Oculodentodigital Dysplasia | Gaze Palsy, Familial Horizontal, With Progressive Scoliosis, 2 | Nevus | Hyperuricemic Nephropathy, Familial Juvenile | Pericarditis | Lichen Sclerosus | Hereditary Neuropathy With Liability To Pressure Palsies | Anal Fissure | Mast Cell Leukemia | Dysmorphophobia | Pulmonary Veno-occlusive Disease | Chromosome 5q Deletion Syndrome | Mitochondrial DNA Depletion Syndrome, Myopathic Form | Snyder-Robinson Syndrome | Graves Disease | Charcot-Marie-Tooth Disease Type 2T | Charcot-Marie-Tooth Disease Type 2D | Persistent Mullerian Duct Syndrome | Bartsocas-Papas Syndrome | Avian Influenza | Congenital Nystagmus | Lymphoma | Lymphangiomatosis | Congenital Bile Acid Synthesis Defect | Ligneous Conjunctivitis | Prolymphocytic Leukemia | Sickle Cell Anemia | B-cell Chronic Lymphocytic Leukemia | Borjeson-Forssman-Lehmann Syndrome | Congenital Generalized Lipodystrophy | Neurodegeneration Due To Cerebral Folate Transport Deficiency | MELAS Syndrome | Pfeiffer Syndrome | Preaxial Polydactyly | Creatine Deficiency Syndrome | Idiopathic Pulmonary Fibrosis | Insulinoma | FG Syndrome | Congenital Stromal Corneal Dystrophy | Diamond-Blackfan Anemia | Congenital Stationary Night Blindness | Polyneuropathy | Anorectal Malformations | Nemaline Myopathy | Melanoma, Uveal | Pemphigus Vulgaris | Noonan Syndrome | Schamberg Disease | Pyruvate Kinase Deficiency | Congenital Disorders Of Glycosylation Type II | Thyroid Dyshormonogenesis | Patent Foramen Ovale | Endometriosis | Endometrial Hyperplasia | Esophageal Motility Disorders | Hepatic Adenomatosis | Meningioma | Johanson-Blizzard Syndrome | Tietze Syndrome | Granular Corneal Dystrophy | Fetal Alcohol Syndrome | Scleroderma | Aarskog-Scott Syndrome | Autoimmune Disease | Agranulocytosis | Neurodegeneration With Brain Iron Accumulation | Galactosialidosis | Arrhythmogenic Right Ventricular Cardiomyopathy | Osteosclerosis | Recurrent Respiratory Papillomatosis | Osteogenesis Imperfecta Type VI | Panuveitis | Hepatitis | Primary Hyperoxaluria Type 3 | Pontocerebellar Hypoplasia | Temporal Lobe Epilepsy | Osteogenesis Imperfecta Type IV | Cancer, Colon | ADNP Syndrome | Lesch-Nyhan Syndrome | Tuberculous Meningitis | Chondromyxoid Fibroma | Coronary Artery Disease | Presbyopia | Leri Pleonosteosis | Hyperparathyroidism, Primary | Infertility | Spondyloepiphyseal Dysplasia Tarda, X-linked | Bruck Syndrome | Burn-McKeown Syndrome | Mitochondrial Disease | Renal-hepatic-pancreatic Dysplasia | Anxiety Disorders | Cushing Syndrome | Poikiloderma With Neutropenia | Hypocalcemia | VEXAS Syndrome | Ureteropelvic Junction Obstruction | Fahr Disease | Neurodevelopmental Disorders | Familial Hypertrophic Cardiomyopathy | Greenberg Dysplasia | Methylmalonic Acidemia | Macrophage Activation Syndrome | Astrocytoma | Dystrophy, Cone-rod | Perry Syndrome | Porphyria | Spitzoid Melanoma | Relapsing Polychondritis | Jalili Syndrome | Seasonal Mood Disorder | Paternal Uniparental Disomy Of Chromosome 14 | Atelosteogenesis Type 1 | Follicular Dendritic Cell Sarcoma | Hartsfield Syndrome | Hypogonadism | Hypobetalipoproteinemias | Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive 1 | Liddle Syndrome | Small Lymphocytic Lymphoma | Hydronephrosis | Spinocerebellar Ataxia Type 2 | Ophthalmoplegia | Endocarditis | Hidradenitis | Glutaric Aciduria Type 2 | Birk-Barel Syndrome | Scapuloperoneal Myopathy, X-linked Dominant | Corneal Ulcer | Early Infantile Epileptic Encephalopathy 4 | Leukodystrophies | Dysequilibrium Syndrome | Asphyxia Neonatorum | Congenital Adrenal Hyperplasia | Charcot-Marie-Tooth Disease, Type 1A | Hashimoto Thyroiditis | Arteriovenous Malformations | Globozoospermia | Joubert Syndrome | Corneal Edema | Abetalipoproteinemia | Anti-NMDA Receptor Encephalitis | Gastroenteritis, Eosinophilic | Infantile Nephropathic Cystinosis | Hereditary Coproporphyria | Spinocerebellar Ataxia Type 10 | Sezary Syndrome | Retinitis Pigmentosa 3 | Raine Syndrome | Hepatic Veno-occlusive Disease | Spinocerebellar Ataxia Type 7 | Vitamin K Deficiency | Sepiapterin Reductase Deficiency | Ectopia Lentis, Isolated, Autosomal Recessive | Acute Anterior Uveitis | Cerebellar Ataxia, Cayman Type | Hemorrhage | Milk Allergy | Osteomyelitis | Triphalangeal Thumb-polysyndactyly Syndrome | Language Disorders | Tinea Versicolor | Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia | Malaria | Barakat Syndrome | Waardenburg Syndrome Type 2 | Progressive Familial Intrahepatic Cholestasis Type 2 | Charcot-Marie-Tooth Disease Axonal Type 2N | Familial Pheochromocytoma-paraganglioma | Focal Segmental Glomerulosclerosis | Methemoglobinemia | Pancreatitis | Eclampsia | Systemic Mastocytosis | Klippel-Feil Syndrome | Encephalopathy, Hepatic | Congenital Hemolytic Anemia | Hyperparathyroidism-jaw Tumor Syndrome | Holoprosencephaly | Babesiosis | Syphilis | Carotid Artery Disease | Gastroschisis | Opisthorchiasis | Periodontitis | Epidermolytic Ichthyosis, Annular | Mitochondrial Myopathy | Histiocytosis | Congenital Myasthenic Syndrome | Menetrier Disease | Spondylocostal Dysostosis | Gigantism | Nephropathy | Epidermolysis Bullosa Simplex, Localized | Exostoses | Yellow Fever | Hypoalbuminemia | Kaposiform Hemangioendothelioma | Peripheral T-cell Lymphoma | Tularemia | Anovulation | Blepharo-cheilo-odontic Syndrome | Cenani-Lenz Syndactyly Syndrome | Waardenburg Syndrome Type 2E | Schistosomiasis | Craniofacial Dysostosis | Sarcoma, Ewing | Pityriasis Rubra Pilaris | Common Variable Immunodeficiency | Immunoproliferative Disorders | Carney-Stratakis Syndrome | Autoimmune Interstitial Lung, Joint, And Kidney Disease | Beckwith-Wiedemann Syndrome | Leukocyte Adhesion Deficiency Type 1 | Splenomegaly | Thyroiditis, Autoimmune | Guillain-Barre Syndrome | Mood Disorder | Schaaf-Yang Syndrome | Pelvic Inflammatory Disease | Medulloblastoma | Epidermolysis Bullosa | Congenital Adrenal Hyperplasia 1 | Craniolenticulosutural Dysplasia | Renal Dysplasia | Neurogenic Bladder | Wolff-Parkinson-White Syndrome | Dyslexia | Pyruvate Decarboxylase Deficiency | Porphyria Cutanea Tarda | Bone Marrow Necrosis | KBG Syndrome | Cerebrovascular Disorders