Granular Corneal Dystrophy

About the Disease
Granular Corneal Dystrophy, also known as familial hereditary corneal degeneration, is related to corneal dystrophy, groenouw type i and corneal dystrophy, reis-bucklers type. An important gene associated with Granular Corneal Dystrophy is TGFBI (Transforming Growth Factor Beta Induced). The drugs Hyaluronic acid and Tetryzoline have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and myeloid, and related phenotypes are Negative genetic interaction between BLM-/- and BLM+/+ and vision/eye

Common Targets
TGFBI

Note: If you'd like to get a target analysis report for Granular Corneal Dystrophy, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Granular Corneal Dystrophy at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Carpenter Syndrome | Sickle Cell Anemia | Spondyloarthritis | Pemphigus Foliaceus | Homocystinuria | Bethlem Myopathy | Chondroma | Ventricular Septal Defect | Platyspondylic Lethal Skeletal Dysplasia, Torrance Type | Mesial Temporal Lobe Epilepsy With Hippocampal Sclerosis | Amelanotic Melanoma | Meesmann Corneal Dystrophy | Hereditary Sensory And Autonomic Neuropathy | Hypospadias | Vitreoretinal Degeneration, Snowflake Type | Arthrogryposis | Glycogen Storage Disease Type 1 | Anorectal Fistula | Prolidase Deficiency | Lymphangiomatosis | Lymphoma Lymphoblastic | Lentigo | Lipoma | Leiomyosarcoma | Basal Cell Nevus Syndrome | DEND Syndrome | Usher Syndrome Type III | Eclampsia | Pachyonychia Congenita | Mitochondrial Encephalomyopathy | Hypermethioninemia | Blomstrand Osteochondrodysplasia | Pearson Syndrome | Atopy | Measles | Tracheal Disorders | Spinocerebellar Ataxia Type 38 | Diabetic Macular Edema | Lymphangioleiomyomatosis | Keratosis, Actinic | Metabolic Syndrome | DNA Ligase IV Deficiency | Skin Papilloma | Charcot-Marie-Tooth Disease Type 4B1 | Alcoholism | Hemophagocytic Lymphohistiocytosis | Polycythemia Vera | Metaphyseal Chondrodysplasia, Schmid Type | Iron Overload | Johanson-Blizzard Syndrome | Dyggve-Melchior-Clausen Disease | Hoyeraal-Hreidarsson Syndrome | Bone Giant Cell Tumor | Cerebrovascular Disorders | Spinocerebellar Ataxia Type 23 | Fuchs Dystrophy | Dystonia Musculorum Deformans | Asperger Syndrome | Lyme Disease | Vascular Cognitive Impairment | Early Infantile Epileptic Encephalopathy | Rhinitis | Enhanced S-cone Syndrome | Wagner Disease | Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive 1 | Hepatitis C, Chronic | NDH Syndrome | Histiocytic Sarcoma | Alagille Syndrome | Charcot-Marie-Tooth Disease Type 2T | Lattice Corneal Dystrophy Type 1 | Optic Nerve Diseases | Idiopathic Multicentric Castleman Disease | Myelomeningocele | Niemann-Pick Disease, Type C | Thrombasthenia | Papulopustular Rosacea | Metachondromatosis | Nutrition Disorders | Osteitis | Osteogenesis Imperfecta Type III | Lymphoma, B-cell | Creatine Deficiency Syndrome Due To AGAT Deficiency | Hartnup Disease | Granular Corneal Dystrophy Type 1 | Neuroendocrine Cancer | Chondrosarcoma | Tylosis With Esophageal Cancer | Isovaleric Acidemia | Hypermetropia | Dent Disease | Congenital Bile Acid Synthesis Defect | Subcortical Band Heterotopia | Snyder-Robinson Syndrome | Leukemia-lymphoma, Adult T-cell | Hereditary Xerocytosis | Endophthalmitis | Auriculocondylar Syndrome | Hypogammaglobulinemia | Tic Disorder | Kabuki Syndrome 2 | Palmoplantar Keratoderma | Pre-eclampsia | Corneal Dystrophy And Perceptive Deafness | Congenital Fiber-type Disproportion Myopathy | Autosomal Recessive Congenital Ichthyosis | Charcot-Marie-Tooth Disease, Type 6 | Scleroderma | KBG Syndrome | Rift Valley Fever | Dental Caries | Cramp Fasciculation Syndrome | Multiple Epiphyseal Dysplasia | Primary Torsion Dystonia | Sulfite Oxidase Deficiency | Reye Syndrome | Hyperlipidemia | Primary Hyperoxaluria | Gastritis, Atrophic | Placenta Previa | Endometriosis | Weill-Marchesani Syndrome | Trachoma | Papilloma | Myopia | Diffuse Intrinsic Pontine Glioma | Charcot-Marie-Tooth Disease Type 4 | Craniolenticulosutural Dysplasia | Spastic Paraplegia Type 7 | Poikiloderma With Neutropenia | Neurofibromatosis | Familial Hypobetalipoproteinemia | Schamberg Disease | Thrombocytopenia | Goldenhar Syndrome | Congenital Dyserythropoietic Anemia | Jaundice, Obstructive | Keratitis-ichthyosis-deafness Syndrome | Smith-Kingsmore Syndrome | Hydronephrosis | Behavioral Variant Of Frontotemporal Dementia | Hemorrhoids | Hypotrichosis, Congenital, With Juvenile Macular Dystrophy | Waardenburg Syndrome Type 2 | ICF Syndrome | Stroke, Hemorrhagic | Insulin Resistance | Vitelliform Macular Dystrophy | Hypertension, Renovascular | Hereditary Hemorrhagic Telangiectasia | Combined Deficiency Of Factor V And Factor VIII | Polyarteritis Nodosa | Phosphoenolpyruvate Carboxykinase Deficiency, Cytosolic | Charcot-Marie-Tooth Disease, Type 1A | Lipid Metabolism Disorders | Harlequin Ichthyosis | Disseminated Superficial Actinic Porokeratosis | Platelet Disorders | Rhabdomyosarcoma | Leukemia | Lymphoma, AIDS-related | Recurrent Respiratory Papillomatosis | Aicardi-Goutieres Syndrome | Prurigo Nodularis | Biotinidase Deficiency | Atelosteogenesis Type 2 | Mucolipidosis Type IV | Migraine | Epidermolysis Bullosa Simplex | Frontotemporal Dementia | Familial Advanced Sleep Phase Syndrome | Encephalopathy, Glycine | Trichuriasis | Generalized Epilepsy And Paroxysmal Dyskinesia | Spinocerebellar Ataxia Type 17 | Acromicric Dysplasia | Cri-du-chat Syndrome | Immunoproliferative Disorders | Lymphedema | Acute Coronary Syndrome | LEOPARD Syndrome | Chitayat Syndrome | Pulmonary Tuberculosis | Myotonic Disorders | Macular Degeneration | Hennekam Lymphangiectasia-lymphedema Syndrome | Pierson Syndrome | Tularemia | Hereditary Hemorrhagic Telangiectasia Type 2 | Transcobalamin Deficiency | Brooke-Spiegler Syndrome | Hypophosphatasia | Sarcoma, Endometrial Stromal | Colon Adenoma | Premature Ejaculation | Arrhythmogenic Right Ventricular Cardiomyopathy | Malignant Fibrous Histiocytoma | Bronchiectasis | Hypogonadism | Inflammatory Joint Disease | Hemoglobinopathies | Nicolaides-Baraitser Syndrome | Perry Syndrome | Duodenal Atresia | Hyperekplexia | Fukuyama Congenital Muscular Dystrophy | Polydactyly | Conjunctivitis, Allergic | Peyronie's Disease | Chiari Malformation Type I | Ataxia-hypogonadism-choroidal Dystrophy Syndrome | Carcinoid Syndrome | Mucolipidosis Type II | Bacterial Meningitis | Myoclonic Epilepsy With Ragged Red Fibers | COACH Syndrome | Generalized Epilepsy With Febrile Seizures Plus | Glycogen Storage Disease Type 5 | Angioimmunoblastic T-cell Lymphoma | Androgen Insensitivity | Diabetes | Communication Disorders | Stroke, Ischemic | Sleep Apnea, Central | Occipital Neuralgia | Pseudohypoparathyroidism Type 1C | Epidermolytic Palmoplantar Keratoderma | Chondrodysplasia Punctata 1, X-linked Recessive | Glomerulonephritis | Progressive Familial Intrahepatic Cholestasis Type 1 | Basal Ganglia Disease, Biotin-responsive | Hypothyroidism | Congenital Torticollis | Lipodystrophy | Maple Syrup Urine Disease | Carpal Tunnel Syndrome | Tyrosinemia Type 1 | Osteopetrosis | Monilethrix | Intestinal Obstruction | Hidradenitis Suppurativa | Deafness, Dystonia, And Cerebral Hypomyelination | Trismus-pseudocamptodactyly Syndrome | Retinitis Pigmentosa 3 | Leukocyte Adhesion Deficiency Type 1 | WAGR Syndrome | Combined Malonic And Methylmalonic Acidemia | Chronic Neutrophilic Leukemia | Cardiofaciocutaneous Syndrome | Meningeal Melanocytoma | Spinocerebellar Ataxia Type 40 | Centronuclear Myopathy | Pontocerebellar Hypoplasia Type 7 | Keratoacanthoma | Hamartoma | Hydrolethalus Syndrome | Spinal Muscular Atrophy | Schizotypal Personality Disorder | Chronic Granulomatous Disease | Congenital Dyserythropoietic Anemia Type 4 | Congenital Generalized Lipodystrophy | Fabry's Disease | Myasthenia | Sarcosinemia | PHARC Syndrome | Pulmonary Veno-occlusive Disease | Chronic Myelomonocytic Leukemia | Osteoarthritis | ADNP Syndrome | Anorexia Nervosa | Adenomyosis | Microvillus Inclusion Disease | Familial Mediterranean Fever | Whipple's Disease | Hemorrhagic Disorders | Cataplexy | Mixed Connective Tissue Disease | Hypopituitarism | Wolfram Syndrome 2 | Thrombocythemia, Essential | Fetal And Neonatal Alloimmune Thrombocytopenia | Choroiditis | GM2-gangliosidosis AB Variant | Chordoma | Vici Syndrome | Glaucoma | Cystinosis | Osteochondrosis | Glioblastoma Multiforme | Lateral Meningocele Syndrome | Esophageal Carcinoma | Adrenoleukodystrophy, X-linked | Coronary Heart Disease | Hemangioblastoma | Porphyria Cutanea Tarda | Language Disorders | Tendinitis | Pleomorphic Xanthoastrocytoma | Acute Leukemia | Multicystic Renal Dysplasia | Asthma, Nocturnal | Pyruvate Dehydrogenase Deficiency | Galactosialidosis | Spinocerebellar Ataxia Type 10 | Traboulsi Syndrome | Cardiomyopathy, Hypertrophic | Hyperhomocysteinemia | Anthrax | Seizures-scoliosis-macrocephaly Syndrome | Osteoporosis, Postmenopausal | Inborn Errors Of Metabolism | Cystitis, Interstitial | Prader-Willi Syndrome | Thrombophlebitis | Crohn's Disease | Gaze Palsy, Familial Horizontal, With Progressive Scoliosis, 2 | Central Retinal Artery Occlusion | Pneumonia, Viral | Common Variable Immunodeficiency | Liver Diseases | MIRAGE Syndrome | Skin Carcinoma | Anti-glomerular Basement Membrane Disease | Brachydactyly | Glutathione Synthetase Deficiency | Congenital Myopathy | Melanoma, Malignant | Sarcoma, Ewing | Purpura | Stomatitis | Pituitary Stalk Interruption Syndrome | Autosomal Recessive Spastic Paraplegia Type 75 | Gastric Atrophy | Congenital Dysfibrinogenemia | Neurofibromatosis-Noonan Syndrome | Intracerebral Hemorrhage | Obesity, Morbid | Atrioventricular Septal Defect | Leukocyte Adhesion Deficiency | Neurotoxicity | Arteriovenous Malformations | Glycogen Storage Disease Type 1b | Stickler Syndrome | Gyrate Atrophy Of The Choroid And Retina | Progressive Encephalopathy-optic Atrophy Syndrome | Aplasia Cutis Congenita | Haim-Munk Syndrome | Neurofibromatosis Type 2 | Charcot-Marie-Tooth Disease Type 2D | Myoclonic Atonic Epilepsy | Omenn Syndrome | Lafora Disease | Renal Hypouricemia | Pituitary Dwarfism | Meningitis | Hypodontia | Neuromyotonia | Werner's Syndrome | Hereditary Pyropoikilocytosis | Erythema Nodosum | Ichthyosis Bullosa Of Siemens | Periventricular Leukomalacia | Craniofacial Dysostosis | Basal Ganglia Disease | Cutis Laxa | Cabezas Syndrome | Sclerosteosis 2 | Astrocytoma | Proopiomelanocortin Deficiency | Agranulocytosis | Arthritis, Psoriatic | Mitochondrial DNA Depletion Syndrome | Thin Basement Membrane Disease | Seasonal Mood Disorder | Pupil Disorders | Chorioretinitis | Optic Atrophy 2 | Colitis, Microscopic | Tyrosine Hydroxylase Deficiency | Cryoglobulinemia | Myofibrillar Myopathy | Dwarfism | Hepatitis E | Chylothorax, Congenital | Anovulation | Usher Syndrome Type II | Holoprosencephaly | Fibromuscular Dysplasia | Agnathia-Otocephaly Complex | Congenital Sodium Diarrhea | 3-methylglutaconic Aciduria | Tetanus | Pemphigus Vulgaris | Hemangioendothelioma | Chanarin-Dorfman Syndrome | Familial Partial Lipodystrophy | Noonan Syndrome-like Disorder With Loose Anagen Hair | Retinal Diseases | Myelodysplasia | Fundus Albipunctatus