Crohn's Disease

About the Disease
Crohn's Disease, also known as crohn disease, is related to inflammatory bowel disease and inflammatory bowel disease 1, and has symptoms including abdominal pain, constipation and diarrhea. An important gene associated with Crohn's Disease is NOD2 (Nucleotide Binding Oligomerization Domain Containing 2), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Hydrocortisone and Hydrocortisone succinate have been mentioned in the context of this disorder. Affiliated tissues include Bone and Adipose, and related phenotypes are no effect and no effect

Common Targets
FFAR4 | CATSPER3 | IL1RN | TEKT5 | CXCL9 | PPP1R15A | BRD7 | Protein Phosphatase 2A | TACR3 | TLR5 | TNFRSF11B | HEATR3 | NPHS1 | PMM2 | GPR35 | TRIM3 | C1orf141 | LOC105379570 | BABAM2 | MALT1 | PTPN2 | LRRK2 | CCDC26 | OR1N2 | CSF1R | MUSK | ADCY7 | IL6ST | SCN10A | RALYL | TNFRSF1B | CSF3 | Integrin alpha4beta1 (VLA-4) receptor | Phosphodiesterase IV (PDE4) (nonspecified subtype) | CD24 | CSK | F2RL1 | ZBTB38 | PTGES | Integrin alphavbeta3 (vitronectin) receptor | ELANE | TRAF1 | CD3 Complex (T Cell Receptor Complex) | LOC105379648 | CFB | Tyrosine-Protein Kinases Src (nonspecified subtype) | OPRM1 | CDC42BPB | IL-15 receptor | TRAF3IP2-AS1 | TACR2 | OPRK1 | TNFSF8 | CNR2 | Glucosidase (nonspecified subtype) | PWWP3A | CCDC91 | ECM1 | EPHB2 | PDE4B | GHSR | LOC105379652 | SLC7A9 | RPS6KA2 | IL37 | TNFRSF25 | PPARA | DNAI2 | HORMAD2 | IL23A | MUC19 | LINC00824 | CD27 | Protein Kinase B (PKB/Akt) (nonspecified subtype) | TNFSF14 | CD6 | TBC1D5 | IFNB1 | IL2RA | G7157 | LOC105379658 | CCR6 | G4780 | MIF-AS1 | Serine/Threonine Kinase (nonspecified subtype) | GATD3 | SORBS2 | LOC105370548 | HLA-B | TNPO3 | TYK2 | FKBP1A | Interleukin-1 (nonspecified subtype) | HLA-DRB1 | CDC37 | HP | SBNO2 | DIS3L2 | HDAC8 | ANXA3 | RARA | CALD1 | MUC22 | TUBD1 | MCU | CFI | IL17RA | IFNGR1 | GREB1 | LTA | NFATC1 | G6PC2 | ROCK1 | G1432 | ADRA2B | JMJD7 | HLA-DQA1 | STAT6 | SH2B1 | DNAH3 | MUC16 | IRGM | ERAP2 | AMOTL1 | G7124 | TUFM | IL6-AS1 | MAP2K1 | G598 | TPMT | CYB561A3 | MYO9B | ZYX | Interleukin 21 receptor complex | DUOX2 | Somatostatin receptor (nonspecified subtype) | DDR2 | G842 | VPS41 | LAMB1 | LCK | KPNA7 | LY75-CD302 | INTS11 | ADGRF5 | RUNX3 | IKZF1 | CPLANE1 | TRPM8 | PHTF1 | OAS2 | GH1 | TJP3 | GAL3ST3 | PTPRZ1 | CTSS | ZNF407 | LOC105369160 | ZFP36L1 | SLC39A11 | MLN | G2475 | PIK3CD | Estrogen receptor (nonspecified subtype) | DHODH | IL10RA | MCCC2 | PPARG | CCDC85B | OR2G6 | G4851 | CLEC4A | BMP2 | DAP | SYNPO2 | KEAP1 | MROH3P | TCF19 | MYO10 | GPC5-AS1 | PPP3R2 | ADCY3 | ZEB2 | MAPK11 | CGNL1 | DYRK4 | GPR18 | CNTNAP5 | KRT72 | SLC6A2 | LRRK1 | HDAC7 | CDKAL1 | ICAM1 | PLCL2 | PDE10A | GM-CSF Receptor (GM-CSF-R) | TSPAN14 | TRPV6 | DLG5 | CPA6 | Integrin alpha4beta7 (LPAM-1) receptor | KRT4 | TG | MICALCL | RPUSD2 | Protein Tyrosine Phosphatase (PTP) (nonspecified subtype) | THBS3 | EED | PROCR | ADORA1 | PLCL1 | QRICH1 | PPP3CC | SP140 | HTR2B | TBX21 | TCF4 | CDT1 | TNFSF11 | CKAP4 | XIAP | ADAM17 | WWOX | CD44 | NOD2 | LNX1 | PACS1 | BTNL2 | ADORA2B | TRPV1 | ARIH2 | LOC105373703 | CARD9 | TJP1 | MLXIPL | ZNF300 | HSD11B1 | IL12RB1 | DLG1 | MORC4 | S1PR4 | MAP3K8 | IL34 | IL17REL | TUBA4A | NAV1 | ATP5IF1 | PTDSS2 | HLA-A | IL-2 receptor | KCNJ1 | LOC105371082 | CD86 | NR4A1 | TNFSF10 | POU5F1 | TSBP1-AS1 | GUCY1A2 | LOC105447645 | KDELR3 | AFP | DSG3 | MAP3K14 | LOC105369326 | LINC02964 | MCF2L | ALPK1 | CD40 | KCNN4 | DUSP16 | OR1L1 | NAT1 | G9429 | THEMIS | DPP4 | ATG16L1 | TIRAP | MAPK12 | alpha-Adrenoceptor (nonspecified subtype) | FHIT | NR1I2 | CDH15 | ZNF597 | LY75 | EPHB4 | NR5A2 | SOD2 | UBE2L3 | KBTBD11 | Raf kinase (nonspecified subtype) | SYK | CARS2 | LPXN | G3605 | Integrin alphaEbeta7 receptor | NR3C1 | PGAM5-KEAP1-NRF2 Complex | FOSL2-AS1 | NFKBIA | IL17RD | G999 | ACHE | PHLDB1 | ADORA2A | TGFBR1 | GPX1 | G5595 | KLHL29 | LACC1 | NCF4 | FNBP1 | PIWIL4-AS1 | TIAM1 | NUDT1 | TRAPPC9 | NAV2 | TOPORS | GSTT1 | PTPN1 | Histone acetyltransferase (HAT) (nonspecified subtype) | Voltage-Gated Sodium Channel Complex | ITGB2 | Integrin alpha5beta1 (VLA-5) receptor | BBS12 | G4170 | SMAD7 | PBX2 | FBXO3 | NKD1 | IGDCC4 | MIR21 | FCGR3A | HHIPL1 | KLRK1 | TSC22D4 | ATXN2L | G3630 | LOC105377989 | HLA-DQA2 | IFNGR2 | LRPAP1 | TET2 | FIBP | HLA-DRA | PIK3CA | CLEC2D | G5743 | DNMT3B | VSTM4 | RIT1 | TDRD1 | AVEN | IL12RB2 | Interleukin-12 (IL-12) | TLR2 | G4318 | ROBO4 | G581 | SLC16A1 | MVK | ZAP70 | TAS1R1 | SFMBT1 | DLK1 | SLC22A23 | IL11 | NEDD4 | CLDN12 | MAP3K13 | MAPKAPK2 | PXDN | IL27 | DNAH1 | GCKR | ADAMTSL1 | EPHA3 | LOXL1-AS1 | CRPPA | FKBP5 | MAP1LC3B | G836 | TTC33 | RAPGEF4 | ACO2 | Mitogen-Activated Protein Kinase (nonspecified subtype) | PIKFYVE | UBASH3A | NR1H4 | CCL11 | METTL21A | DOCK5 | G5243 | DENND1B | TIE1 | G2309 | OPRD1 | Interferon (nonspecified subtype) | ERMAP | SOCS3 | LOXL1 | ASPSCR1 | LOC105374211 | HSPA6 | TTTY14 | LINC01387 | Sodium channel (nonspecified subtype) | BACH2 | FOSL2 | ZGPAT | PTGER4 | UBAC2 | SPDL1 | TAGAP-AS1 | HIVEP1 | IL-6 receptor | HELT | VDR | SIGIRR | S100A8 | TIMMDC1 | QARS1 | IL1R1 | AHNAK | CLDN10 | NPY4R | CCNY | ACVR1 | KRT12 | DLG4 | ARHGEF3 | Interferon alpha/beta Receptor (nonspecified subtype) | DHPS | CDKN2A-DT | RAF1 | TNP1 | JAZF1 | FGFR4 | LOC105378120 | POSTN | CIBAR2 | WFS1 | GPC5 | RAB38 | BCL2A1 | IL11RA | GRK4 | C3orf84 | CTLA4 | Glycogen synthase kinase 3 (GSK-3) (nonspecified subtype) | SMAD2 | TNFAIP3 | GPATCH8 | ANKRD55 | PTGDR2 | NPIPB8 | VMP1 | VNN1 | KIAA0586 | HNRNPUL1 | TMX1 | Toll-Like Receptor (nonspecified subtype) | MAGI3 | BCL2L11 | RC3H2 | LILRA3 | STAT4 | ITLN1 | FASN | HDAC4 | IL17F | IL2 | DNAH12 | PNP | LOC105369736 | PRKDC | PREX1 | ESYT1 | NOL10 | G9734 | IL10 | CTNND1 | SST | MAML2 | SELPLG | CDON | IL1A | FGD5 | G1956 | IL18RAP | STK17B | LOC105378327 | PA2G4 | LOC285626 | Polycomb Repressive Complex 2 | BLK | FBXO38 | GHR | PPP5C | CCR9 | R3HDML | LINC02210-CRHR1 | CD80 | EPHA4 | RGS14 | IKZF3 | SYMPK | PDE1B | KLRC4-KLRK1 | CSF2 | F5 | FASLG | PRUNE2 | TEX41 | EPHA2 | SFTPD | PDE5A | OR10R2 | PDE2A | PRKCB | OGA | KIR2DL1 | G196 | CRHR1 | ELF1 | ROR1 | TRPM4 | CLDN2 | IFNG | DAG1 | BTG4 | TPPP | TRPM2 | MAP2K2 | SCN9A | SLC22A4 | KCNH3 | GLOD4 | PDGFRA | DHX32 | EP400 | NMDA receptor | G7422 | ANO9 | NFKBIZ | Janus Kinase (nonspecified subtype) | ZNF365 | GGA2 | OAZ1 | LOC101928354 | MDFIC | CYP26B1 | RNASE3 | TRAIP | NOS2 | PTPN22 | GDF6 | MEFV | S1PR5 | ROCK2 | ERGIC1 | IL12A | TRPA1 | SLC2A14 | Ikzf1 | IL5RA | MLNR | VHL | CDHR1 | HINT3 | Histone deacetylase (nonspecified subtype) | NOX3 | ERAP1 | IL1B | NKX2-3 | FHIP1B | LINC01430 | LOC105372112 | INSC | LINC03040 | RNASET2 | IL1RL2 | CLEC10A | ADAP1 | Cyclooxygenase (COX) (nonspecified subtype) | FCGR2A | PDE11A | FAM98A | HK2 | MIR146A | TACR1 | CRISPLD2 | ZBTB26 | CCR5 | PUSL1 | CXCL10 | RASSF3 | BSN | GSTP1 | CLCA2 | ZNF77 | KIR2DL2 | SLC10A2 | PPP3CB | OSM | PLAU | GSTM1 | PGLYRP2 | FAS | SRSF1 | EPHA5 | PPL | CREBBP | SNAPC1 | G3569 | DEFA5 | PPP3R1 | SLC16A3 | SLC30A9 | Proteasome Complex | SERPINA12 | CNBD1 | SMAD3 | INAVA | GSN | LTBR | CCDC89 | GLP2R | CLDN4 | TTLL5 | SECISBP2 | UGT1A1 | FAM174C | TMEM45A | IL4 | DCHS2 | SLC50A1 | MIF | FUT10 | PKP1 | SLCO3A1 | TNFSF15 | NASP | GCNT3 | PARD3 | IL21 | TGM6 | AGER | SYPL1 | CRB1 | POLR2C | MAGI1 | BIRC5 | STING1 | NLRP3 Inflammasome | Intrinsic Tenase Complex | PCBD2 | EGLN1 | OSMR | HNF4A | F11 | DMBT1 | FTO | P2RX7 | CMKLR1 | KLKB1 | CFAP73 | SLC22A5 | NELL1 | FUT2 | APOE | JAK3 | LINC01882 | ERI1 | OTOP2 | Nitric oxide synthase (NOS) (nonspecified subtype) | IL6R | JAK2 | SNAPC4 | CACNA1E | JAK1 | CRBN | CHORDC1 | UBE3D | TNFRSF8 | KRR1 | MRGPRX2 | CTNNB1 | DEFB1 | DRD3 | F2R | ALOX5 | SLC34A2 | ACSS3 | SOAT2 | G3576 | CALCOCO2 | HLA-C | PARK7 | G114548 | IL13 | OR52I1 | EPRS1 | NID2 | HCG22 | G3439 | TMBIM1 | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3 (PDE3) (nonspecified subtype) | MADCAM1 | KSR1 | WDFY1 | ITGAL | LINC00598 | Vascular endothelial growth factors (VEGF) (nonspecified subtype) | TNFRSF1A | FERMT1 | G596 | ZNF721 | MIR196A2 | C10orf55 | PARD6G | OR1M1 | SLC6A3 | NLRX1 | RIPK1 | GSPT1 | SLC11A1 | S1PR1 | PNKD | USH1C | PIK3CG | TMCO6 | CD19 | LOC105370032 | TLR7 | ABCA3 | NDFIP1 | MICA | PITX1-AS1 | CRP | CSF2RB | DTX1 | MAP1LC3A | TMPRSS3 | NF-kappaB (NFkB) | FLII | DOCK7 | PTPRC | ZFP90 | Rho kinase (ROCK) (nonspecified subtype) | TRAF3IP2 | IL18 | LGALS1 | PLCH1 | DPP9 | EXOC3L4 | CD302 | IRS1 | DUOX1 | IL23R | MST1 | GPR65 | MYRF | ARFGAP2 | RSPO3 | SCN5A | TFR2 | KLHDC8B | MMP1 | PGLYRP4 | HMOX1 | RASGRP4 | NUBP1 | DAGLB | GRIN2B | LINC02571 | TXK | G5133 | AOC3 | LOC107986022 | IL22RA1 | TNFRSF9 | PTAFR | PTGER2 | Interleukin 23 complex (IL-23) | KIT | G6774 | MUC6 | PRELP | FUT3 | GALC | LOC100996583 | ATG16L2 | LAMB2P1 | G6714 | Mitogen-activated protein kinase p38 (MAPK p38) (nonspecified subtype) | RARS2 | ADAM30 | PTPN6 | ZNF831 | IL2RB | G6647 | LINC02341 | FAM151A | THADA | NFKB1 | RPS6KA5 | IL-23 receptor complex | FRRS1 | TLR1 | DPH5 | ULK1 | PLOD3 | ZMIZ1 | GRIN3B | Defensin (nonspecified subtype) | AHRR | ADRA2C | SRRD | PDE4D | BANK1 | IL21R | STK40 | WDR75 | HDAC6 | CD226 | CHRNA5 | RORC | CHD9 | ANXA2 | G3620 | SCARNA5 | LPIN1 | NICN1 | POLD1 | RIPK2 | IL12B | LOC105377135 | FAP | CARD8 | ADAMTS12 | GNA12 | CAT | HCK | TGFB1 | NEB | TLR8 | Protein Phosphatase 2B | DQX1 | IRF1-AS1 | USP13 | CRTC3 | AMP-activated protein kinase (AMPK) | USP4 | IPMK | LOC102723878 | MACROD2 | G7099 | OR52N1 | SKAP2 | GPATCH1 | HIF1A | OR51L1 | IDO2 | CD3G | SLC2A13 | NPY4R2 | ADAM10 | CHST11 | TLR3 | LOC101927745 | CX3CL1 | Interleukin 17 (nonspecified subtype) | LRP6 | IL33 | SLC39A8 | CXCR5 | PUS10 | KIR3DL2 | TNFAIP8 | CNTN5

Note: If you'd like to get a target analysis report for Crohn's Disease, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Crohn's Disease at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

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