Disease

Cohen Syndrome

About the Disease
Cohen Syndrome, also known as pepper syndrome, is related to granulocytopenia and neutropenia. An important gene associated with Cohen Syndrome is VPS13B (Vacuolar Protein Sorting 13 Homolog B), and among its related pathways/superpathways is Autophagy pathway. The drugs Carboplatin and Picropodophyllin have been mentioned in the context of this disorder. Affiliated tissues include eye, bone and tongue, and related phenotypes are myopia and intellectual disability

Common Targets
VPS13B | BICD2 | STAG1

疾病靶点研报
Cohen Syndrome

Note: If you'd like to get a target analysis report for Cohen Syndrome, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Cohen Syndrome at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Optic Neuropathy, Anterior Ischemic | Lipid Storage Diseases | Creatine Deficiency Syndrome Due To AGAT Deficiency | Atelosteogenesis Type 1 | Arthritis | Light Chain Amyloidosis | Neurodegeneration With Brain Iron Accumulation | Metabolic Diseases | Inflammatory Bowel Disease | Cervicitis | Acrocallosal Syndrome | Hypothalamic Obesity | Spondylo-megaepiphyseal-metaphyseal Dysplasia | Geleophysic Dysplasia | Calcium Pyrophosphate Deposition Disease | Mannosidase Deficiency Diseases | Progressive Familial Intrahepatic Cholestasis | Lysosomal Acid Lipase Deficiency | Heimler Syndrome | Keratosis, Seborrheic | Steel Syndrome | Herpes Genitalis | Nail-Patella Syndrome | Coloboma | Tendinopathy | Alzheimer Disease, Late Onset | Vestibular Disease | Pregnancy, Ectopic | Echinococcosis | Rett Syndrome | Isovaleric Acidemia | Xeroderma Pigmentosum | Miyoshi Myopathy | Crohn's Disease | Sensory Neuropathy | McLeod Syndrome | Atopic Dermatitis | Hypertension, Portal | Hypoplastic Left Heart Syndrome | Takotsubo Cardiomyopathy | 3-methylcrotonyl-CoA Carboxylase Deficiency | Polycystic Liver | Familial Hyperaldosteronism | Fetal Akinesia Deformation Sequence | Ligneous Conjunctivitis | Viral Meningitis | Absence Epilepsy | Myopathy | 3-hydroxy-3-methylglutaric Aciduria | Paroxysmal Nocturnal Hemoglobinuria | Myelofibrosis | Shock, Cardiogenic | Familial Pheochromocytoma-paraganglioma | Monilethrix | Martsolf Syndrome | Williams Syndrome | Charcot-Marie-Tooth Disease, Type 2 | Chudley-McCullough Syndrome | Anorchia | Anti-NMDA Receptor Encephalitis | Eczema | Kleine-Levin Syndrome | Familial Cerebral Amyloid Angiopathy | Paronychia | Bacterial Meningitis | Onchocerciasis | Imerslund-Grasbeck Syndrome | Pyloric Stenosis, Infantile Hypertrophic | Peyronie's Disease | Fuchs Dystrophy | Hemochromatosis | Hyperuricemia | Charcot-Marie-Tooth Disease Axonal Type 2N | Polycystic Kidney, Autosomal Recessive | Aicardi-Goutieres Syndrome | Metachromatic Leukodystrophy | Necrotizing Autoimmune Myopathy | Pseudohypoparathyroidism Type 1B | Tinea | Crigler-Najjar Syndrome | Adenosine Deaminase Deficiency | Cryoglobulinemia | Pseudohermaphroditism | Focal Segmental Glomerulosclerosis | Ocular Surface Squamous Neoplasia | Thrombocytopenia | Spondylolisthesis | Hereditary Hemorrhagic Telangiectasia | Pontocerebellar Hypoplasia Type 2 | Pierpont Syndrome | Mycosis Fungoides | Neutropenia | Iron Overload | Alopecia Areata | Delayed Sleep Phase Syndrome | Granular Corneal Dystrophy | Epithelial-myoepithelial Carcinoma | Antiphospholipid Syndrome | Nager Acrofacial Dysostosis | Carey-Fineman-Ziter Syndrome | Erythropoietic Protoporphyria | Diabetic Nephropathy | Primary Hyperoxaluria Type 3 | Alpha-1 Antitrypsin Deficiency | Senior-Loken Syndrome | High Molecular Weight Kininogen Deficiency | Osteosclerosis | Tyrosine Hydroxylase Deficiency | Liebenberg Syndrome | Stroke | Astrocytoma | Corneal Neovascularization | Wilson's Disease | Pulmonary Alveolar Proteinosis | Congenital Bilateral Absence Of Vas Deferens | Hemangioendothelioma | Parkinson's Disease | Subcortical Band Heterotopia | Primary Biliary Cholangitis | Congenital Myasthenic Syndrome | Cushing Syndrome | Tangier Disease | T-cell Leukemia | TARP Syndrome | Apparent Mineralocorticoid Excess Syndrome | Hypophosphatemic Rickets With Hypercalciuria, Hereditary | Epidermolytic Palmoplantar Keratoderma | Riboflavin Transporter Deficiency Neuronopathy | Myoclonus | Panniculitis | Hepatoblastoma | Neurodegeneration Due To Cerebral Folate Transport Deficiency | Leri Pleonosteosis | Tetanus | Limb Girdle Muscular Dystrophy | Meningococcal Infections | Tietze Syndrome | Craniofrontonasal Syndrome | Non-bullous Congenital Ichthyosiform Erythroderma | Ovarian Hyperstimulation Syndrome | Smith-Kingsmore Syndrome | Alexander Disease | Gangliosidosis | Microcephalic Primordial Dwarfism | Carpenter Syndrome | Fetal And Neonatal Alloimmune Thrombocytopenia | Hypertension, Renal | Common Variable Immunodeficiency | Familial Digital Arthropathy-brachydactyly | Early Infantile Epileptic Encephalopathy 1 | Li-Fraumeni Syndrome | Rotor Syndrome | Non-proliferative Diabetic Retinopathy | Charcot-Marie-Tooth Disease | 6-pyruvoyl-tetrahydropterin Synthase Deficiency | Silicosis | Alpha-mannosidosis | Large Granular Lymphocytic Leukemia | Interstitial Lung Diseases | 3-methylglutaconic Aciduria Type I | Persistent Mullerian Duct Syndrome | Wagner Disease | Pancreatitis | Lymphoproliferative Disorders | Kaposiform Hemangioendothelioma | Nephroblastoma | Tremor | Leigh Syndrome | Alagille Syndrome | Charcot-Marie-Tooth Disease Type 2T | Glioblastoma | Ependymoma | Nail Disorder, Nonsyndromic Congenital | Glutaric Aciduria Type 2 | Gerstmann-Straussler-Scheinker Syndrome | Gastritis, Atrophic | Osteoporosis-pseudoglioma Syndrome | HANAC Syndrome | Bainbridge-Ropers Syndrome | Salla Disease | Communication Disorders | Farber Disease | Angiodysplasia | Nijmegen Breakage Syndrome | Hyperthermia, Malignant | Angioedema, Acquired | Tibial Muscular Dystrophy | Paraplegia | Multiple Sclerosis | Desmosterolosis | Celiac Disease | Chronic Periodontitis | Lichen Sclerosus | Measles | Endocarditis | Neurogenic Bladder | Paraganglioma, Carotid Body | Fragile X Syndrome | Turner's Syndrome | Spondylometaphyseal Dysplasia | Tetraplegia | Renal Hypomagnesemia 3 | Gray Platelet Syndrome | Becker Muscular Dystrophy | Microcephalic Osteodysplastic Primordial Dwarfism, Type II | Dysgerminoma | Parapsoriasis | Tyrosinemia | Autoimmune Polyendocrine Syndrome | Neural Tube Defect | Myopia | Lipodystrophy | Amblyopia | Plasma Cell Leukemia | Hemolytic Uremic Syndrome, Atypical | Atrial Septal Defect | Zimmermann-Laband Syndrome | Low Tension Glaucoma | Chorea-acanthocytosis | Angiosarcoma Of The Breast | Basal Ganglia Cerebrovascular Disease | Schizophrenia | Spinocerebellar Ataxia Type 31 | Vulvovaginitis | Non-Langerhans Cell Histiocytosis | Amyotrophic Lateral Sclerosis, Juvenile | Pyruvate Decarboxylase Deficiency | Crisponi Syndrome | Frontotemporal Dementia With Amyotrophic Lateral Sclerosis | Diabetic Neuropathy | Benign Familial Neonatal Convulsions | Retinopathy, Diabetic | Pseudohypoparathyroidism Type 2 | Hemangioma | Anorectal Fistula | Otitis Externa | Malaria | Proopiomelanocortin Deficiency | Aspergillosis | Postpartum Depression | Conjunctivitis | Oculocutaneous Albinism Type 2 | Hypokalemic Periodic Paralysis | Arthritis, Reactive | Empyema | Enhanced S-cone Syndrome | Myocarditis | Hypogonadism | Pyruvate Dehydrogenase Deficiency | Basal Ganglia Disease | Charcot-Marie-Tooth Disease Type 4E | Roberts Syndrome | Gastritis | Chylothorax, Congenital | Waardenburg Syndrome Type 2A | Extramammary Paget's Disease | Cat Eye Syndrome | Myasthenia Gravis | Acute Myeloid Leukemia | Primrose Syndrome | Mountain Sickness | Waardenburg Syndrome Type 4A | Androgen Insensitivity | Granuloma Annulare | 3C Syndrome | Duodenal Atresia | Temporal Lobe Epilepsy | Congestive Heart Failure | Ophthalmoplegia | Juvenile Myoclonic Epilepsy | Arteriosclerosis | Skin Carcinoma | Hypokalemia | Rhabdomyosarcoma | Spinocerebellar Ataxia Type 40 | Dowling-Degos Disease | McKusick Type Metaphyseal Chondrodysplasia | Periventricular Nodular Heterotopia | Potocki-Shaffer Syndrome | Rhinitis | Biotinidase Deficiency | Optic Atrophy 2 | Early Infantile Epileptic Encephalopathy 28 | Vaginitis | Erythematotelangiectatic Rosacea | Thymoma, Malignant | Pseudoachondroplasia | Seizures-scoliosis-macrocephaly Syndrome | Epilepsy Of Infancy With Migrating Focal Seizures | Histiocytosis | Juvenile Xanthogranuloma | Mosaic Variegated Aneuploidy Syndrome 2 | Diabetes Mellitus, Transient Neonatal | Hypotrichosis | Hyperphenylalaninemia | Trismus-pseudocamptodactyly Syndrome | Autonomic Neuropathy | Metabolic Syndrome | Androgenic Alopecia | Kallmann Syndrome | Melnick-Needles Syndrome | 3-methylglutaconic Aciduria Type IV | Posterior Polar Cataract | 17-beta-hydroxysteroid Dehydrogenase X Deficiency | Spondylocarpotarsal Synostosis Syndrome | Corneal Dystrophy | Medium-chain Acyl-CoA Dehydrogenase Deficiency | Meningioma | Poikiloderma With Neutropenia | Esophageal Carcinoma | Agranulocytosis | Veno-occlusive Disease | Pontocerebellar Hypoplasia Type 7 | Alstrom Syndrome | Adenoma, Villous | Urolithiasis | Acute Anterior Uveitis | Addison Disease | Moyamoya Disease | Congenital Hereditary Endothelial Dystrophy Type II | Focal Facial Dermal Dysplasia | Pyoderma Gangrenosum | Granular Corneal Dystrophy Type 1 | Adenoma, Pituitary | Adenomatoid Tumor | Multicystic Renal Dysplasia | Melanoma, Malignant | Acromegaly | Bone Giant Cell Tumor | Lattice Corneal Dystrophy Type 1 | Proctitis | Cancer, Kidney | Lentigo | Neonatal Progeroid Syndrome | Methemoglobinemia Type IV | Spasticity | Cancer, Prostate | IgA Deficiency | Osteogenesis Imperfecta | Dominant Optic Atrophy | Glycogen Storage Disease Type 1b | Sclerosteosis | Hyperparathyroidism, Secondary | Progressive Encephalopathy-optic Atrophy Syndrome | Achondrogenesis | Varicocele | Hepatitis, Chronic | Blue Rubber Bleb Nevus Syndrome | Lassa Fever | Peeling Skin Syndrome, Acral Type | Enlarged Vestibular Aqueduct | Spinal Cord Diseases | Keratoacanthoma | Olmsted Syndrome | Rhizomelic Chondrodysplasia Punctata | Congenital Adrenal Hyperplasia | Familial Dysautonomia | Primary Aldosteronism | Schistosomiasis | C3 Glomerulopathy | Facioscapulohumeral Muscular Dystrophy | Noonan Syndrome-like Disorder With Loose Anagen Hair | Orotic Aciduria | Familial Advanced Sleep Phase Syndrome | Spondyloarthritis | Glycogen Storage Disease | Niemann-Pick Disease, Type C | Cold-induced Sweating Syndrome | Gangliosidosis, GM1 | Mabry Syndrome | Lymphangioma | Keratitis-ichthyosis-deafness Syndrome | Fanconi Syndrome | Gnathodiaphyseal Dysplasia | Dyskeratosis Congenita | Eosinophilia | Urea Cycle Disorder | Niemann-Pick Disease, Type A | HELLP Syndrome | Acne | Juvenile Polyposis | Wolfram Syndrome 2 | Dermatitis | Cranial Nerve Disease | Charcot-Marie-Tooth Disease Type 4D | CEDNIK Syndrome | Pineoblastoma | Macrodactyly | Epidermolysis Bullosa Acquisita | Pulmonary Sclerosing Hemangioma | Japanese Encephalitis | Bladder Exstrophy | Growth Hormone Excess | GATA2 Deficiency | Autism | Canavan Disease | Krabbe Disease | Megaloblastic Anemia | Progressive Familial Intrahepatic Cholestasis Type 2 | Cluster Headache