Silicosis

About the Disease
Silicosis, also known as silicotuberculosis, is related to anthracosis and pneumoconiosis. An important gene associated with Silicosis is FASLG (Fas Ligand), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Isoniazid and Rifapentine have been mentioned in the context of this disorder. Affiliated tissues include lung, bone marrow and skin, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Common Targets
G3725 | G7124 | G7157 | NLRP3 Inflammasome | SPRY1 | G114548 | NLRP1 Inflammasome | TGFB1 | PDE4A | G5728 | PDE4D | TYK2

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Impetigo | Narcolepsy | Hemophagocytic Lymphohistiocytosis | Zygomycosis | Premature Ejaculation | Vaginitis | Amblyopia | Hyperhomocysteinemia | Hypothalamic Obesity | Neovascular Glaucoma | Congenital Ichthyosiform Erythroderma | Dyslipidemia | AIDS | Netherton Syndrome | Metaphyseal Chondrodysplasia, Schmid Type | Schistosomiasis Mansoni | SAPHO Syndrome | Isovaleric Acidemia | Exfoliative Dermatitis | Keratosis, Actinic | Sialoadenitis | Enlarged Vestibular Aqueduct | Globozoospermia | Abetalipoproteinemia | Ghosal Syndrome | Charcot-Marie-Tooth Disease Type 3 | Perivascular Epithelioid Cell Tumor | Fibrosis | Primary Hyperoxaluria Type 1 | Spondylocarpotarsal Synostosis Syndrome | Hemochromatosis | Gray Platelet Syndrome | Stromal Corneal Dystrophy | Photosensitivity | Mixed Connective Tissue Disease | Epidermal Nevus Syndrome | Cranioectodermal Dysplasia | Haim-Munk Syndrome | Amyotrophic Lateral Sclerosis, Juvenile | Neurofibromatosis Type 1 | Hemoglobinopathies | Arts Syndrome 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