Beta-Propeller Protein-associated Neurodegeneration

About the Disease
Neurodegeneration with Brain Iron Accumulation 5, also known as beta-propeller protein-associated neurodegeneration, is related to parkinsonism and neurodegeneration with brain iron accumulation 6, and has symptoms including muscle rigidity, paraparesis, spastic and tremor. An important gene associated with Neurodegeneration with Brain Iron Accumulation 5 is WDR45 (WD Repeat Domain 45), and among its related pathways/superpathways are Selective autophagy and Autophagy. The drug Iron has been mentioned in the context of this disorder. Affiliated tissues include brain, globus pallidus and lung, and related phenotypes are intellectual disability and sleep disturbance

Common Targets
WDR45

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