Alexander Disease

About the Disease
Alexander Disease, also known as alexander's disease, is related to leukodystrophy and multiple system atrophy 1, and has symptoms including muscle spasticity and seizures. An important gene associated with Alexander Disease is GFAP (Glial Fibrillary Acidic Protein), and among its related pathways/superpathways are Signaling by Receptor Tyrosine Kinases and Neuroscience. The drug Metronidazole has been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and eye, and related phenotypes are macrocephaly and intellectual disability

Common Targets
GFAP | MALAT1 | HDAC6 | THRA | MALT1 | THRB

Note: If you'd like to get a target analysis report for Alexander Disease, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Alexander Disease at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.tech.

Other Diseases

Choroiditis | Torticollis | Axenfeld-Rieger Syndrome | Diarrhea | Menetrier Disease | Familial Exudative Vitreoretinopathy | Chondrodysplasia Punctata 1, X-linked Recessive | Angioedema, Hereditary | B-cell Prolymphocytic Leukemia | Arthritis, Reactive | Mycosis Fungoides | Autoimmune Hemolytic Anemia | Bulimia Nervosa | 3-methylglutaconic Aciduria | Non-proliferative Diabetic Retinopathy | Patent Foramen Ovale | Ataxia-ocular Apraxia 2 | Hyperbilirubinemia, Neonatal | Retinal Coloboma | Esophagitis, Eosinophilic | Pancreatitis, Chronic | Familial Hypobetalipoproteinemia | Cholangitis | Kabuki Syndrome 2 | Amish Infantile Epilepsy Syndrome | Uveitis | Carcinoma, Merkel Cell | Vasculitis | Leukocyte Adhesion Deficiency Type 1 | Apraxia | 3C Syndrome | Primary Erythromelalgia | Temtamy Preaxial Brachydactyly Syndrome | Basal Ganglia Disease | Nager Acrofacial Dysostosis | Noonan Syndrome-like Disorder With Loose Anagen Hair | Autoimmune Autonomic Ganglionopathy | Hyperoxaluria | Eccrine Porocarcinoma | Still Disease | IgA Nephropathy | Schizencephaly | Constipation | Reflex Epilepsy | Benign Familial Neonatal Convulsions | Glycogen Storage Disease Type 0 | Frank-ter Haar Syndrome | Hyperacusis | Neuroma | AIDS Dementia Complex | Mixed Connective Tissue Disease | Lipid Storage Myopathy | Infectious Diarrhea | Episodic Ataxia Type 2 | Periodontitis | Ellis-Van Creveld Syndrome | Fowler's Syndrome | Endometritis | Metatropic Dysplasia | Kallmann Syndrome | Familial Episodic Pain Syndrome | Headache | Liebenberg Syndrome | Ependymoma | Delayed Sleep Phase Syndrome | Hereditary Multiple Exostoses | Optic Neuritis | Mucolipidosis | Dengue Shock Syndrome | Withdrawal Syndrome | Megalencephaly | ACTH-independent Macronodular Adrenal Hyperplasia | Colitis, Microscopic | Anti-glomerular Basement Membrane Disease | Hyperglycemia | Greenberg Dysplasia | Arthropathy | Methemoglobinemia | Melnick-Needles Syndrome | Infantile Neuroaxonal Dystrophy | Cancer, Prostate | Acute Myeloid Leukemia | Portal Vein Thrombosis | Sclerocornea | Sialidosis Type I | Chromosome 9q34.3 Deletion Syndrome | Waardenburg Syndrome Type 4 | Myeloid Leukemia | Progressive External Ophthalmoplegia | Liver Failure, Acute Infantile | Encephalopathy | Corticobasal Syndrome | Autosomal Recessive Spastic Paraplegia Type 35 | Schizoaffective Disorder | Pneumothorax | Allergic Contact Dermatitis | Takayasu's Arteritis | Light Chain Amyloidosis | Myelitis | Primrose Syndrome | Cerebrotendinous Xanthomatosis | Carcinoma, Transitional Cell | Osteosarcoma | Peters-plus Syndrome | Waardenburg Syndrome Type 2 | Sleep Apnea, Central | Strabismus | Superficial Spreading Melanoma | Choriocarcinoma | Smith-Lemli-Opitz Syndrome | Cellulitis | Autosomal Recessive Congenital Ichthyosis | NGLY1 Deficiency | Androgen Insensitivity | Blue Rubber Bleb Nevus Syndrome | Otosclerosis | Holoprosencephaly | Brugada Syndrome 1 | Insulinoma | Chitayat Syndrome | Pseudohermaphroditism | Hereditary Xerocytosis | Spinocerebellar Ataxia Type 16 | Encephalopathy, Hepatic | Cramp Fasciculation Syndrome | Kaposiform Hemangioendothelioma | Crohn's Disease | Hypoglycemia | Charcot-Marie-Tooth Disease, Type 2A | PHARC Syndrome | Glycogen Storage Disease Type 1b | Nemaline Myopathy 10 | Blastomycosis | Hypercalcemia | Syndactyly | Erythropoietic Protoporphyria | Diabetes Type 2 | Primary Hyperoxaluria | Hypoproteinemia, Hypercatabolic | Hypermetropia | Diamond-Blackfan Anemia | Eiken Syndrome | Cannabis Abuse | Platelet Disorders | Infantile Spasm | Sarcomatoid Carcinoma Of The Lung | AIDS | Hypotrichosis | Thromboembolism | Sick Sinus Syndrome 1 | Dementia, Vascular | Glycogen Storage Disease Type 0, Muscle | Waardenburg Syndrome Type 4A | Multiple Epiphyseal Dysplasia | NDH Syndrome | Trichothiodystrophy | Macrophagic Myofasciitis | Hyperthyroidism | Sandhoff Disease | Glomerulonephritis, Membranoproliferative | Chondrodysplasia Punctata | Pemphigoid | Coloboma | Richter's Syndrome | Otitis Externa | Primary Hyperoxaluria Type 3 | Vitamin K Deficiency | Heterotaxy | Mitochondrial DNA Depletion Syndrome 13 | Retinal Vasculitis | Granular Corneal Dystrophy Type 1 | Necrobiosis Lipoidica | Cholestasis | Crimean-Congo Hemorrhagic Fever | Fukuyama Congenital Muscular Dystrophy | Keratopathy | Pain | Neurotoxicity | Acute Motor Axonal Neuropathy | Cryptosporidiosis | Cholera | Wolfram Syndrome | Cyst | Wilson's Disease | Hypersensitivity | Sensory Neuropathy | Diabetes Insipidus | 5-oxoprolinase Deficiency | Anemia | Thymoma, Malignant | Splenomegaly | 3-methylglutaconic Aciduria Type IV | Autoimmune Polyendocrine Syndrome | GAPO Syndrome | Schizophrenia, Paranoid | Gestational Trophoblastic Disease | Non-Langerhans Cell Histiocytosis | Cardiac Arrest | Angiosarcoma Of The Breast | D-2-Hydroxyglutaric Aciduria | Craniolenticulosutural Dysplasia | Krabbe Disease | Omenn Syndrome | Familial Mediterranean Fever | Hypothalamic Obesity | Oguchi Disease-2 | Pancytopenia | Trigonocephaly | Niemann-Pick Disease, Type B | N-acetylglutamate Synthase Deficiency | Schwartz-Jampel-Aberfeld Syndrome | Stomatitis | Cat Eye Syndrome | Congenital Ichthyosiform Erythroderma | Multicentric Carpotarsal Osteolysis Syndrome | Ectopia Lentis, Isolated, Autosomal Recessive | Tyrosinemia Type 2 | Myelomeningocele | Long QT Syndrome Type 1 | Premenstrual Syndrome | Meconium Ileus | Familial Hyperaldosteronism | Lymphoma, B-cell | Smoldering Myeloma | Synovitis | Epidermolysis Bullosa Simplex, Localized | Osteochondroma | Heimler Syndrome | Clouston Hidrotic Ectodermal Dysplasia | Diabetic Nephropathy | Gardner Syndrome | Budd-Chiari Syndrome | Motion Sickness | WAGR Syndrome | Hypophosphatasia | Spinocerebellar Ataxia Type 40 | Pachyonychia Congenita | Schistosomiasis | Carey-Fineman-Ziter Syndrome | Cockayne Syndrome | Granuloma Annulare | Hyperparathyroidism-jaw Tumor Syndrome | Sotos Syndrome | Oculocutaneous Albinism | Mitochondrial Myopathy | Metaphyseal Chondrodysplasia, Schmid Type | Prader-Willi Syndrome | Panniculitis | Diabetes Type 1 | Histoplasmosis | Nanophthalmos | Progressive Familial Intrahepatic Cholestasis Type 1 | Trismus-pseudocamptodactyly Syndrome | Multiple Sclerosis, Primary Progressive | Congenital Aniridia | Cantu Syndrome | Urethritis | Communication Disorders | Fibrodysplasia Ossificans Progressiva | Asthma, Exercise-induced | Gaze Palsy, Familial Horizontal, With Progressive Scoliosis, 2 | Primary Progressive Nonfluent Aphasia | Thrombasthenia | Potocki-Shaffer Syndrome | Primary Pigmented Nodular Adrenocortical Disease | Autonomic Neuropathy | Lactose Intolerance | Ganglioglioma | Retinoblastoma | Pupil Disorders | Myasthenia Gravis | Urticaria | Cerebellofaciodental Syndrome | Adenoma, Pleomorphic | Corneal Neovascularization | Niemann-Pick Disease, Type A | Tic Disorder | Incontinentia Pigmenti | Neurodevelopmental Disorder With Central Hypotonia And Dysmorphic Facies | Rhabdomyosarcoma, Alveolar | Multiple Sclerosis, Relapsing-remitting | Rheumatic Heart Disease | Congenital Nystagmus | Histiocytic Sarcoma | Diabetes Insipidus, Neurogenic | Veno-occlusive Disease | Parkinson's Disease | Dysferlinopathy | Chromosome 16p11.2 Deletion Syndrome | Osteopathia Striata With Cranial Sclerosis | Spinocerebellar Ataxia Type 14 | Chronic Granulomatous Disease, X-linked | Feingold Syndrome | Spinocerebellar Ataxia Type 10 | Spitzoid Melanoma | Kawasaki Disease | Myasthenia | Hypotrichosis Simplex | Benign Familial Infantile Seizures | Hypermethioninemia | POEMS Syndrome | Tyrosinemia Type 1 | Hereditary Hemorrhagic Telangiectasia Type 2 | Carcinoma, Signet Ring Cell | Cluster Headache | Glycogen Storage Disease | Neurofibroma, Plexiform | Dominant Optic Atrophy | Glaucomatocyclitic Crisis | Adrenomyeloneuropathy | Carcinoma, Squamous Cell | Reticular Dysgenesis | Castleman Disease | Schaaf-Yang Syndrome | Hodgkin Lymphoma | Mesial Temporal Lobe Epilepsy With Hippocampal Sclerosis | Plasmacytoma | Common Variable Immunodeficiency | Muir-Torre Syndrome | Chronic Leukemia | Fontaine Progeroid Syndrome | Desbuquois Syndrome | Bacterial Meningitis | Dermatitis Herpetiformis | Turner's Syndrome | Panuveitis | Asthma, Nocturnal | Polyomavirus Nephropathy | Leukodystrophies | Sorsby Fundus Dystrophy | Neurofibrosarcoma | Heart Block | Methylmalonic Acidemia | Colorectal Adenoma | Klippel-Feil Syndrome | Adenomyosis | Familial Partial Lipodystrophy | Cherubism | Exfoliative Dermatitis | Paroxysmal Nocturnal Hemoglobinuria | Hypoalbuminemia | Marshall-Smith Syndrome | Nevus | Behcet's Disease | Coffin-Lowry Syndrome | Erdheim-Chester Disease | Meniere's Disease | Hydrolethalus Syndrome | Absence Epilepsy | Overactive Bladder | Maternally Inherited Diabetes And Deafness | Acute Lymphocytic Leukemia | Asperger Syndrome | IMAGe Syndrome | Huntington's Disease-like 2 | Corneal Dystrophy | Medulloblastoma | Familial Isolated Hyperparathyroidism | Alstrom Syndrome | Vitamin D Deficiency | Pseudomyxoma Peritonei | Oligodendroglioma | Juvenile Myoclonic Epilepsy | Colitis | Thrombocythemia, Essential | Chondromyxoid Fibroma | Sweet Syndrome | Osteochondrosis | Antiphospholipid Syndrome | TARP Syndrome | Histiocytosis | Hyperkeratosis | Congenital Heart Block | Cri-du-chat Syndrome | Angioedema | Thrombophlebitis | Spinocerebellar Ataxia Type 8 | Keratosis, Actinic | Facioscapulohumeral Muscular Dystrophy Type 1 | Osteonecrosis | Persistent Truncus Arteriosus | Cholesteryl Ester Storage Disease | Bare Lymphocyte Syndrome | Argininosuccinic Aciduria | Pyruvate Dehydrogenase Deficiency | Facioscapulohumeral Muscular Dystrophy Type 2 | Hypertensive Nephropathy | T-cell Lymphoma, Subcutaneous Panniculitis-like | Large Granular Lymphocytic Leukemia | Parvovirus B19 Infection | Adenylosuccinate Lyase Deficiency | Neurodegeneration With Brain Iron Accumulation | Nijmegen Breakage Syndrome | Fraser Syndrome | Fascioliasis | Hereditary Sensory And Autonomic Neuropathy | Scapuloperoneal Myopathy, X-linked Dominant | Cardiofaciocutaneous Syndrome | Ocular Albinism Type 1 | Leukoencephalopathy, Progressive Multifocal