Acute Lung Injury

About the Disease
Adult Respiratory Distress Syndrome, also known as acute respiratory distress syndrome, is related to critical covid-19 and pulmonary edema, and has symptoms including apnea, cheyne-stokes respiration and coughing. An important gene associated with Adult Respiratory Distress Syndrome is CXCL8 (C-X-C Motif Chemokine Ligand 8), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Iron and Ibuprofen have been mentioned in the context of this disorder. Affiliated tissues include Lung, and related phenotypes are respiratory failure and tachypnea

Common Targets
SLC27A2 | Heat shock protein 90 (nonspecified subtype) | Integrin alpha4beta1 (VLA-4) receptor | H4C16 | MYD88 | PF4 | TYK2 | Phosphatidylinositol 3-kinase (PI3K) (nonspecified subtype) | Protein Kinase B (PKB/Akt) (nonspecified subtype) | IKBKB | CYSLTR1 | PDGFRB | P2RX1 | DIO2 | NEU1 | Nuclear factor of activated T-cells (nonspecified subtype) | Chemokine CXC receptor (nonspecified subtype) | G1950 | G1432 | PPARG | PRKCA | TRPV4 | SUFU | MAP3K5 | NR3C1 | KEAP1 | ICAM1 | HMGCR | BCR | SFTPB | Chymotrypsin (nonspecified subtype) | G9429 | PDE10A | Histone H3 (nonspecified subtype) | CD14 | FPR1 | F3 | DCUN1D1 | SCARB1 | G5743 | alpha-Adrenoceptor (nonspecified subtype) | KCNK2 | EIF2AK2 | Neurotrophic Factor (nonspecified subtype) | CCR2 | Tubulin | CIRBP | FGFR1 | SLC22A6 | TRAF6 | F2 | ANGPT2 | G3630 | PGAM5-KEAP1-NRF2 Complex | SERPINC1 | ACKR1 | VDR | TAS2R46 | SELP | G3480 | Adenylate Cyclase (nonspecified subtype) | IRAK4 | FBXO3 | NR1H4 | GADD45A | IL10 | Epithelial Sodium Channel (ENaC) | SLC22A8 | G4193 | TRPC6 | PYCARD | PTGDR2 | Interferon alpha/beta Receptor (nonspecified subtype) | PTP4A3 | PRTN3 | IL1B | CALCA | Trypsin (nonspecified subtype) | G7422 | G3569 | MBL2 | Elastase (nonspecified subtype) | Serine protease (nonspecified subtype) | Caspase (nonspecified subtype) | NOS2 | NMDA receptor | PDE2A | PDGFRA | CCR1 | CFTR | NOX3 | FPR2 | JAK2 | UBE2M | Complement Complex | CCR5 | VHL | BDKRB1 | DCLK1 | JAK3 | NAMPT | G3082 | FAS | JAK1 | NF-kappaB (NFkB) | MIF | G3576 | MIR92A1 | STING1 | ALOX5 | NADPH Oxidase Complex | G3146 | Nitric oxide synthase (NOS) (nonspecified subtype) | FBXO48 | MIR92A2 | IRAK1 | TNFRSF1A | KIT | ABL1 | alpha-Amylase (nonspecified subtype) | TGFB1 | G7124 | NADPH Oxidase (nonspecified subtype) | SLC26A4 | Integrin alphavbeta8 Receptor | SERPING1 | LTA4H | POLR2E | GRIN2B | G7099 | PRDX6 | PI3 | MPO | RHOA | THBD | GPR182 | ARF6 | LY96 | HIF1A | TLR4/MD-2 complex | AMP-activated protein kinase (AMPK) | MDM4 | SELE | PPIA | Protein Phosphatase 2B | Monoamine oxidase (MAO) (nonspecified subtype) | CGAS | Phosphodiesterase IV (PDE4) (nonspecified subtype) | CSF1R | GYPA | BDKRB2 | ELANE | G4780

Note: If you'd like to get a target analysis report for Acute Lung Injury, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Acute Lung Injury at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Pityriasis Rubra Pilaris | Kashin-Beck Disease | Cryptorchidism | Niemann-Pick Disease, Type B | Renal-hepatic-pancreatic Dysplasia | Familial Male-limited Precocious Puberty | Kabuki Syndrome 2 | Hoyeraal-Hreidarsson Syndrome | Familial Advanced Sleep Phase Syndrome | Familial Retinal Arterial Macroaneurysm | Papillorenal Syndrome | Pearson Syndrome | Seasonal Mood Disorder | Myocarditis | Acute Leukemia | Infertility | Idiopathic Pulmonary Fibrosis | Phenylketonuria | Poirier-Bienvenu Neurodevelopmental Syndrome | Spinocerebellar Ataxia Type 8 | Acral Lentiginous Melanoma | T-cell Prolymphocytic Leukemia | 3-methylglutaconic Aciduria Type IV | Familial Glucocorticoid Deficiency | Scleroderma, Diffuse | Dentinogenesis Imperfecta | Multiple System Atrophy | Skin Carcinoma | Diabetes Insipidus, Neurogenic | Gynecomastia | Homocystinuria | Fuchs Dystrophy | Chylomicron Retention Disease | Adrenoleukodystrophy, X-linked | Unverricht-Lundborg Syndrome | Eczema | Japanese Encephalitis | Anterior Segment Dysgenesis | Ocular Hypertension | Autosomal Recessive Spastic Paraplegia Type 75 | Vici Syndrome | Cornelia De Lange Syndrome | Hypopigmentation | Leigh Syndrome | Adenomyosis | Agnathia-Otocephaly Complex | Huntington's Disease | Sick Sinus Syndrome 1 | X-linked Sideroblastic Anemia | Adrenal Insufficiency | Bronchiectasis | Spinocerebellar Ataxia Type 20 | Dysequilibrium Syndrome | Blepharoconjunctivitis | Ligneous Conjunctivitis | Charcot-Marie-Tooth Disease Type 2T | Acute Myeloid Leukemia | Myelofibrosis | Hyperoxaluria | Hyperprolactinemia | Multiple Sclerosis | Polyomavirus Nephropathy | Orotic Aciduria | Inflammatory Bowel Disease | Blau Syndrome | Polydactyly | D-2-Hydroxyglutaric Aciduria | Bruck Syndrome | Fibrosis | Empyema | Choreoathetosis, Hypothyroidism, And Neonatal Respiratory Distress | Osteogenesis Imperfecta Type I | Cardiospondylocarpofacial Syndrome | Neuroectodermal Tumors, Primitive | Hypertrophy | Otopalatodigital Syndrome Type 2 | Anthrax | Nephroblastoma | Roberts Syndrome | Malignant Fibrous Histiocytoma | Hypohidrotic Ectodermal Dysplasia | Netherton Syndrome | Megalencephaly | Acrocallosal Syndrome | Atelosteogenesis Type 2 | Sensory Neuropathy | Hashimoto Thyroiditis | Apparent Mineralocorticoid Excess Syndrome | Craniosynostosis | Alazami Syndrome | Sickle Cell Anemia | Chanarin-Dorfman Syndrome | Eiken Syndrome | Dysmorphophobia | Congenital Primary Aphakia | Biotinidase Deficiency | Light Chain Amyloidosis | Alveolar Capillary Dysplasia | Colitis | Delayed Sleep Phase Syndrome | Familial Hypertrophic Cardiomyopathy | Lafora Disease | Carcinoma, Small Cell | Split Hand-foot Malformation | Schwannoma | Platelet Disorders | Juvenile Myelomonocytic Leukemia | Seizures | L-2-Hydroxyglutaric Aciduria | Anorexia Nervosa | Extramammary Paget's Disease | Spinal Muscular Atrophy Type 2 | Waardenburg Syndrome Type 2 | LRBA Deficiency | Hemangioma | Arthritis, Gouty | Veno-occlusive Disease | Nemaline Myopathy | Endocarditis | Pigment Dispersion Syndrome | Niemann-Pick Disease, Type C | Neovascular Glaucoma | Carcinoma, Transitional Cell | Van Der Knaap Disease | Hypotonia-cystinuria Syndrome | Choriocarcinoma | Hyperuricemia | Astigmatism | Epilepsy, Generalized | Autoimmune Polyendocrine Syndrome | Paracoccidioidomycosis | Spinocerebellar Ataxia Type 3 | Acromegaly | Hypotension, Orthostatic | Duodenal Atresia | Robinow Syndrome | Chloridorrhea, Congenital | Cheilitis | Strabismus | ACTH-independent Macronodular Adrenal Hyperplasia | ADNP Syndrome | Ovarian Hyperstimulation Syndrome | Stromal Corneal Dystrophy | Atopy | Melanoma, Malignant | Imerslund-Grasbeck Syndrome | Mastitis | Kaposiform Hemangioendothelioma | Xeroderma Pigmentosum | Kawasaki Disease | X-linked Creatine Transporter Deficiency | Lichen Planus | Pelvic Inflammatory Disease | Charcot-Marie-Tooth Disease, Type 2C | Transthyretin-related Amyloidosis | Hepatitis B, Chronic | Polycythemia | Esophageal Adenocarcinoma | Nevus | Macular Degeneration | Huntington's Disease-like 2 | Hemosiderosis | Nephrosclerosis | Epidermolytic Ichthyosis, Annular | Glycogen Storage Disease Type 6 | Raynaud Phenomenon | Generalized Epilepsy And Paroxysmal Dyskinesia | Mumps | Multiple Hamartoma Syndrome | Major Depression | Hyperandrogenemia | Primary Sclerosing Cholangitis | Goiter | C3 Glomerulonephritis | Stevens-Johnson Syndrome | Diastrophic Dysplasia | Thalassemia | Leprosy | Cardiomyopathy, Dilated, 1L | Creatine Deficiency Syndrome Due To AGAT Deficiency | Corneal Dystrophies, Hereditary | Adult Polyglucosan Body Disease | Gaucher Disease | Pleural Tuberculosis | Spinal And Bulbar Muscular Atrophy | Tic Disorder | Obesity, Morbid | Epidermolysis Bullosa Simplex, Dowling-Meara Type | Hereditary Pyropoikilocytosis | Intestinal Obstruction | Focal Dermal Hypoplasia | Best Macular Dystrophy | CEDNIK Syndrome | Persistent Truncus Arteriosus | Paraganglioma | Adenoma, Pleomorphic | Colitis, Lymphocytic | Systemic Mastocytosis | Cerebral Amyloid Angiopathy | Rhabdomyosarcoma, Alveolar | Neurodevelopmental Disorder With Central Hypotonia And Dysmorphic Facies | Epidermolysis Bullosa Acquisita | Acute Motor Axonal Neuropathy | Periventricular Nodular Heterotopia | Papillon-Lefevre Syndrome | Chromosome 5q Deletion Syndrome | Small Lymphocytic Lymphoma | Oligoastrocytoma | Multicentric Carpotarsal Osteolysis Syndrome | Guttate Psoriasis | Hereditary Folate Malabsorption | Cranioectodermal Dysplasia | Familial Hypobetalipoproteinemia | Adrenomyeloneuropathy | Gardner Syndrome | Rhabdomyosarcoma, Embryonal | Central Core Disease | Hypophosphatasia | Tyrosinemia Type 2 | Glomerulonephritis, Membranous | Hyperammonemia | Angioedema | Paraplegia | Cousin Syndrome | Acute Lung Injury | Macrophage Activation Syndrome | Cardiac Sarcoidosis | Fraser Syndrome | Hypertension, Essential | Congenital Stationary Night Blindness | Reflex Epilepsy | Pitt-Hopkins Syndrome | Encephalopathy, Glycine | Achromatopsia | Exocrine Pancreatic Insufficiency | Rheumatic Heart Disease | Sarcoidosis | Premature Ejaculation | 3C Syndrome | Trachoma | Porokeratosis | Cancer, Lung | Primary Biliary Cholangitis | Corneal Ulcer | Dupuytren Disease | Congenital Disorders Of Glycosylation | Monilethrix | Esophagitis | Esophageal Carcinoma | Palsy, Cerebral | Chronic Idiopathic Myelofibrosis | Pupil Disorders | Heroin Dependence | Hypertension | B-cell Prolymphocytic Leukemia | Stroke, Ischemic | Bloom Syndrome | Hereditary Coproporphyria | Infantile Refsum Disease | Aldosteronism | Endometriosis | Syndactyly | Aicardi-Goutieres Syndrome | Acute Anterior Uveitis | Alpha-thalassemia Myelodysplasia Syndrome | Glutaric Aciduria Type 2 | Tendinitis | Okihiro Syndrome | Pure Red Cell Aplasia | Alexander Disease | Macular Corneal Dystrophy | Cushing Syndrome | Pain | McKusick Type Metaphyseal Chondrodysplasia | Temtamy Preaxial Brachydactyly Syndrome | Crigler-Najjar Syndrome | Thin Basement Membrane Disease | Hyperkalemic Periodic Paralysis | Sarcoma, Ewing | Nephronophthisis | Bipolar Disorder | Cancer, Kidney | Peritonitis | Congenital Dysfibrinogenemia | Protein C Deficiency | Acute Generalized Exanthematous Pustulosis | Splenomegaly | Erythema Nodosum | Sleep Apnea, Obstructive | Pineoblastoma | Histiocytic Sarcoma | Ehlers-Danlos Syndrome With Progressive Kyphoscoliosis, Myopathy, And Hearing Loss | Dental Caries | Pemphigus Vulgaris | Ollier Disease | Shprintzen-Goldberg Syndrome | Urethritis | Leri-Weill Dyschondrosteosis | Parkinson Disease 6, Autosomal Recessive Early-onset | DEND Syndrome | Focal Segmental Glomerulosclerosis | Schistosomiasis Mansoni | Anal Fissure | Mitochondrial Encephalomyopathy | Lateral Meningocele Syndrome | Asphyxia Neonatorum | Sarcoidosis, Pulmonary | Pneumococcal Meningitis | Myoclonic Epilepsy With Ragged Red Fibers | Pierson Syndrome | Ventricular Septal Defect | Congenital Absence Of Vas Deferens | Xeroderma Pigmentosum Variant Type | Vitiligo | Microtia | Scapuloperoneal Spinal Muscular Atrophy | Gerodermia Osteodysplastica | Pemphigoid | Motor Neuron Diseases | Marinesco-Sjogren Syndrome | Smith-Kingsmore Syndrome | Vulvovaginitis | Spinocerebellar Ataxia Type 17 | Hepatitis | Diarrhea | Torticollis | Traboulsi Syndrome | Basal Ganglia Disease, Biotin-responsive | Fabry's Disease | Pelizaeus-Merzbacher Disease | Benign Hereditary Chorea | Lassa Fever | Beta-Propeller Protein-associated Neurodegeneration | Granular Corneal Dystrophy | Periodontitis | Measles | Hypospadias | Cryptosporidiosis | Autonomic Nervous System Disorders | Renal Tubular Acidosis | Apert Syndrome | Mabry Syndrome | Hypokalemic Periodic Paralysis | Spina Bifida | Spinocerebellar Ataxia Type 21 | Behcet's Disease | Congenital Lipoid Adrenal Hyperplasia | Asthma | Progressive Familial Intrahepatic Cholestasis Type 1 | Chorea-acanthocytosis | Congenital Muscular Dystrophy | Spasticity | Arrhythmogenic Right Ventricular Cardiomyopathy | Desbuquois Syndrome | Retinal Coloboma | Spinal Muscular Atrophy Type 3 | Multiple Sclerosis, Relapsing-remitting | Congenital Torticollis | Metabolic Syndrome | Teratozoospermia | Thanatophoric Dysplasia Type 1 | Keratoconjunctivitis | Rett Syndrome | Sclerosteosis | Cenani-Lenz Syndactyly Syndrome | Pheochromocytoma | Mitochondrial DNA Depletion Syndrome 13 | Osteonecrosis | Enterocolitis, Necrotizing | Familial Isolated Hyperparathyroidism | Antisocial Personality Disorder | Charcot-Marie-Tooth Disease Type 4E | Spondylometaphyseal Dysplasia | Hemangioblastoma | Giant Cell Glioblastoma | Glutaric Aciduria Type 1 | Pendred Syndrome | Hyperhomocysteinemia | Photosensitivity | Disseminated Intravascular Coagulation | LMNA-related Congenital Muscular Dystrophy | Amyotrophic Lateral Sclerosis | Seminoma | Multicystic Renal Dysplasia | Cockayne Syndrome | Neurofibromatosis | Aceruloplasminemia | Epidermolysis Bullosa Simplex | Primary Lateral Sclerosis | Retinal Detachment | Angiomyolipoma | Blepharophimosis Syndrome | Cirrhosis | Gingivitis | Leukoencephalopathy, Progressive Multifocal | Reticular Dysgenesis | Amelogenesis Imperfecta | Omenn Syndrome | Urofacial Syndrome | Alagille Syndrome