Pyoderma Gangrenosum

About the Disease
Pyoderma Gangrenosum, also known as phagedenic pyoderma, is related to pyogenic sterile arthritis, pyoderma gangrenosum, and acne and neutrophilic dermatosis, acute febrile. An important gene associated with Pyoderma Gangrenosum is PSTPIP1 (Proline-Serine-Threonine Phosphatase Interacting Protein 1), and among its related pathways/superpathways are MIF Mediated Glucocorticoid Regulation and Integrin Pathway. The drugs Mitogens and Endothelial Growth Factors have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and myeloid, and related phenotypes are fever and skin ulcer

Common Targets
CD6 | C5 | IL17RA | HSD17B4 | PROCR | GYPC | S1PR4 | ARPC2 | SYN3 | USP15 | MAPKAPK2 | IL1B | UBAC2 | IL1A | S1PR5 | CD47 | G7124 | PNKD | NDFIP1 | PSTPIP1 | Interleukin 17 (nonspecified subtype)

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