Malignant Hyperthermia

About the Disease
Malignant Hyperthermia, also known as anesthesia related hyperthermia, is related to malignant hyperthermia 1 and myopathy, congenital, bailey-bloch, and has symptoms including fever, muscle rigidity and pain, postoperative. An important gene associated with Malignant Hyperthermia is RYR1 (Ryanodine Receptor 1), and among its related pathways/superpathways are Activation of cAMP-Dependent PKA and CREB Pathway. The drugs Caffeine and Halothane have been mentioned in the context of this disorder. Affiliated tissues include skeletal muscle, heart and brain, and related phenotypes are muscle and homeostasis/metabolism

Common Targets
RYR1 | CACNA1S | FKTN | RYR2 | KBTBD13 | ATP2A2 | COL6A1 | LAMA2 | FKRP | TTN | DMD | Ryanodine receptor (nonspecified subtype)

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