Polydactyly

About the Disease
Polydactyly, also known as non-syndromic polydactyly, is related to short-rib thoracic dysplasia 3 with or without polydactyly and short-rib thoracic dysplasia 6 with or without polydactyly. An important gene associated with Polydactyly is CC2D2A (Coiled-Coil And C2 Domain Containing 2A), and among its related pathways/superpathways are Organelle biogenesis and maintenance and Signaling by Hedgehog. The drugs Clonidine and Adrenergic alpha-Agonists have been mentioned in the context of this disorder. Affiliated tissues include bone, heart and kidney, and related phenotypes are growth/size/body region and nervous system

Common Targets
GLI3

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