Polydactyly

About the Disease
Polydactyly, also known as non-syndromic polydactyly, is related to short-rib thoracic dysplasia 3 with or without polydactyly and short-rib thoracic dysplasia 6 with or without polydactyly. An important gene associated with Polydactyly is CC2D2A (Coiled-Coil And C2 Domain Containing 2A), and among its related pathways/superpathways are Organelle biogenesis and maintenance and Signaling by Hedgehog. The drugs Clonidine and Adrenergic alpha-Agonists have been mentioned in the context of this disorder. Affiliated tissues include bone, heart and kidney, and related phenotypes are growth/size/body region and nervous system

Common Targets
GLI3

Note: If you'd like to get a target analysis report for Polydactyly, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Polydactyly at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Acrodysostosis | Temtamy Preaxial Brachydactyly Syndrome | Mucolipidosis Type IV | Charcot-Marie-Tooth Disease, Type 1A | Colitis, Microscopic | Pituitary Stalk Interruption Syndrome | Sarcoma | Congenital Nystagmus | Glutaric Aciduria Type 2 | Blepharitis | Focal Dermal Hypoplasia | Hypotension, Orthostatic | Vestibular Disease | Chordoma | Progressive Osseous Heteroplasia | Giant Axonal Neuropathy | Schistosomiasis Mansoni | Scabies | Kaposiform Hemangioendothelioma | Lichen Sclerosus | Dementia | Craniometaphyseal Dysplasia | Panuveitis | Rolandic Epilepsy | Trimethylaminuria | Chorioretinitis | Postpoliomyelitis Syndrome | ACTH-independent Macronodular Adrenal Hyperplasia | Dystonia | Gerodermia Osteodysplastica | Spondylocostal Dysostosis | Measles | Triple A Syndrome | Gerstmann-Straussler-Scheinker Syndrome | Connective Tissue Disorders | Basal Ganglia Cerebrovascular Disease | Inflammatory Joint Disease | Hidradenitis Suppurativa | Leukoplakia, Oral | Epidermolysis Bullosa Simplex With Mottled Pigmentation | Multisystemic Smooth Muscle Dysfunction Syndrome | Congenital Generalized Lipodystrophy | Wilson's Disease | Spitzoid Melanoma | Hepatitis | Congenital Adrenal Hyperplasia | Succinic Semialdehyde Dehydrogenase Deficiency | Epidermolysis Bullosa | Fibrodysplasia Ossificans Progressiva | Blood Protein Disorders | Congenital Torticollis | Chondroma | Cysticercosis | Addison Disease | Li-Fraumeni Syndrome | Ataxia-hypogonadism-choroidal Dystrophy Syndrome | Autonomic Nervous System Disorders | Autoimmune Polyendocrine Syndrome | Cervical Dystonia | Incontinentia Pigmenti | Glycogen Storage Disease Type 9 | Waardenburg Syndrome Type 2 | Exfoliative Dermatitis | B-cell Chronic Lymphocytic Leukemia | Parkinson Disease 6, Autosomal Recessive Early-onset | Coronary Restenosis | Bone Marrow Necrosis | Anorectal Fistula | Fanconi Anemia | Anosmia, Congenital | Glycogen Storage Disease Type 1a | Chronic Idiopathic Myelofibrosis | Amelanotic Melanoma | Chronic Inflammatory Demyelinating Polyneuropathy | Cancer, Kidney | Meckel-Gruber Syndrome | Malaria | Auriculocondylar Syndrome | Chronic Kidney Disease | Genitopatellar Syndrome | Reflex Epilepsy | Spinocerebellar Ataxia Type 17 | Common Cold | Cancer, Colon | Noonan Syndrome | Brenner Tumor | Hepatitis E | Patent Ductus Arteriosus | Tatton-Brown-Rahman Syndrome | Cantu Syndrome | Nephrotic Syndrome Type 1 | Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive 1 | Lymphangioleiomyomatosis | Cystitis, Interstitial | Neurotoxicity | Retinal Vasculitis | Herpes Genitalis | Alopecia | Methemoglobinemia | Crouzon Syndrome With Acanthosis Nigricans | Gastritis | ADNP Syndrome | Huntington's Disease-like 2 | Oligoasthenoteratozoospermia | Osteogenesis Imperfecta Type VI | Hyperlipidemia | Glycogen Storage Disease Type 1b | Calcium Pyrophosphate Deposition Disease | Biotinidase Deficiency | Cholera | Encephalitis, Tick-borne | Precocious Puberty | Castleman Disease | Mitochondrial DNA Depletion Syndrome | Behavioral Variant Of Frontotemporal Dementia | Parkinsonism | Renpenning Syndrome | Hyperekplexia | Greig Cephalopolysyndactyly Syndrome | Perry Syndrome | Diffuse Intrinsic Pontine Glioma | Cancer, Bladder | T-cell Chronic Lymphocytic Leukemia | Polycystic Liver | Peters-plus Syndrome | Congenital Primary Aphakia | Hypertension, Renovascular | Anxiety Disorders | Neonatal Progeroid Syndrome | Moyamoya Disease | Encephalopathy | COACH Syndrome | Optic Neuropathy, Anterior Ischemic | Facioscapulohumeral Muscular Dystrophy | Paroxysmal Nocturnal Hemoglobinuria | Infantile Liver Failure Syndrome 1 | Hemorrhoids | Binge Eating Disorder | Disseminated Intravascular Coagulation | Long QT Syndrome Type 2 | Hyperammonemia | Methylmalonic Acidemia | Bullous Pemphigoid | Tibial Muscular Dystrophy | Keratosis | Ichthyosis Bullosa Of Siemens | Leber Congenital Amaurosis | Niemann-Pick Disease, Type A | Urea Cycle Disorder | Mitochondrial DNA Depletion Syndrome, Myopathic Form | Netherton Syndrome | Diabetes Mellitus, Transient Neonatal | Knobloch Syndrome | Hepatitis C, Chronic | Craniofrontonasal Syndrome | Neural Tube Defect | Pupil Disorders | Clouston Hidrotic Ectodermal Dysplasia | Spinocerebellar Ataxia Type 1 | Diffuse Palmoplantar Keratoderma | Proteus Syndrome | Prediabetes | Vitamin D Deficiency | Oculocutaneous Albinism Type 1 | Cerebral Amyloid Angiopathy | Kearns-Sayre Syndrome | Walker-Warburg Syndrome | Usher Syndrome Type III | Gaucher Disease | Angioedema, Hereditary | Keratoconjunctivitis | Primary Progressive Nonfluent Aphasia | Pyoderma Gangrenosum | Sjogren Syndrome | Angelman Syndrome | Sensory Ataxic Neuropathy, Dysarthria, And Ophthalmoparesis | Palsy, Cerebral | Rhabdomyosarcoma, Embryonal | Pemphigus Foliaceus | Spondylo-megaepiphyseal-metaphyseal Dysplasia | Chondrodysplasia Punctata 2, X-linked Dominant | Antiphospholipid Syndrome | Sickle Cell Anemia | Kabuki Syndrome | LRBA Deficiency | AIDS Dementia Complex | Leukocyte Adhesion Deficiency Type 1 | Irritable Bowel Syndrome | Prolactinoma | Varices | Arthropathy | Congenital Stationary Night Blindness | Hypotrichosis, Congenital, With Juvenile Macular Dystrophy | Epidermolysis Bullosa Simplex, Generalized | Sepiapterin Reductase Deficiency | Trichothiodystrophy | Goiter, Nodular | Becker Muscular Dystrophy | Familial Dysautonomia | Osteonecrosis Of The Jaw | Emery-Dreifuss Muscular Dystrophy | LEOPARD Syndrome | Arteriovenous Malformations | Palmoplantar Keratoderma | Intestinal Tuberculosis | Corneal Ulcer | Hypodontia | Stargardt Disease | Mucolipidosis Type II | Insulin Resistance | Long-chain 3-hydroxyacyl-coenzyme A Dehydrogenase Deficiency | Platyspondylic Lethal Skeletal Dysplasia, Torrance Type | Tyrosinemia | Hypereosinophilic Syndrome | Intestinal Pseudo-obstruction | Sialidosis Type I | Neutrophilia | Familial Hypertrophic Cardiomyopathy | Twin-to-twin Transfusion Syndrome | McLeod Syndrome | Meningeal Melanocytoma | Phenylketonuria | Mesial Temporal Lobe Epilepsy With Hippocampal Sclerosis | D-2-Hydroxyglutaric Aciduria | Carbonic Anhydrase VA Deficiency | Hypolipoproteinemia | CDKL5 Deficiency Disorder | Williams Syndrome | Familial Partial Lipodystrophy | Prolymphocytic Leukemia | CEDNIK Syndrome | Heavy Chain Disease | Jaundice, Obstructive | Pseudohypoparathyroidism Type 1A | Thrombotic Microangiopathy | Oguchi Disease-2 | Geleophysic Dysplasia | Pulmonary Sclerosing Hemangioma | X-linked Myotubular Myopathy | Best Macular Dystrophy | Exocrine Pancreatic Insufficiency | Liver Failure, Acute Infantile | Feingold Syndrome | Cerebellofaciodental Syndrome | Endometriosis | Hemochromatosis Type 1 | Epithelioid Hemangioma | Autosomal Recessive Spastic Paraplegia Type 75 | Seasonal Mood Disorder | Renal Hypouricemia | Sponastrime Dysplasia | Renal Tubular Acidosis | Rosacea | LMNA-related Congenital Muscular Dystrophy | Chronic Myelomonocytic Leukemia | Benign Hereditary Chorea | Infantile Refsum Disease | Carpenter Syndrome | Polycythemia | Usher Syndrome Type I | Primary Lateral Sclerosis | Asphyxia Neonatorum | Osteochondroma | Hypermethioninemia | Compartment Syndrome | Meningioma | Pelvic Inflammatory Disease | Pleural Tuberculosis | Cryptorchidism | Lymphangiomatosis | Ganglioglioma | Still Disease | Glutaric Aciduria Type 3 | Nicolaides-Baraitser Syndrome | Periodic Limb Movement Disorder | Krabbe Disease | Panniculitis | Spinocerebellar Ataxia Type 31 | Rheumatoid Arthritis | Senior-Loken Syndrome | Craniopharyngioma | Lymphedema-distichiasis Syndrome | Retinitis | Glomerulonephritis, Membranous | Lathosterolosis | Infertility, Male | Alexander Disease | Acne Vulgaris | Fucosidosis | Atopy | Alzheimer Disease, Late Onset | Polymyositis | Warsaw Breakage Syndrome | Mumps | Sarcoma, Endometrial Stromal | Gallstones | 3-M Syndrome | Ectodermal Dysplasia | Beta-Propeller Protein-associated Neurodegeneration | Acromegaly | Otitis Media | Histiocytosis | Tumoral Calcinosis | Crisponi Syndrome | Pituitary Dwarfism | Adenylosuccinate Lyase Deficiency | Stromal Corneal Dystrophy | Retinitis Pigmentosa | Hyperprolactinemia | Growth Hormone Excess | Benign Familial Pemphigus | Porokeratosis | Hypersomnia | PHARC Syndrome | Erythromelalgia | Medium-chain Acyl-CoA Dehydrogenase Deficiency | Dysplastic Nevus | Bipolar Disorder | Subacute Sclerosing Panencephalitis | Epidermal Nevus Syndrome | Sleep Disorder | Neurofibroma, Plexiform | Spinocerebellar Ataxia Type 2 | Polymyalgia Rheumatica | Paroxysmal Kinesigenic Dyskinesia | Liebenberg Syndrome | FG Syndrome | Acute Chest Syndrome | Papilloma | Colorectal Adenoma | Hemolytic Uremic Syndrome, Atypical | Epilepsy Of Infancy With Migrating Focal Seizures | Odonto-onycho-dermal Dysplasia | Stuttering | Waardenburg Syndrome Type 4A | Pelizaeus-Merzbacher Disease | Pseudohermaphroditism | Spinocerebellar Ataxia Type 13 | Colitis, Lymphocytic | Giant Cell Arteritis | Central Pain Syndrome | Duane Retraction Syndrome | Primary Hyperoxaluria Type 3 | Guanidinoacetate Methyltransferase Deficiency | Fascioliasis | Retinal Diseases | Hypertension, Pulmonary | Systemic Lupus Erythematosus | Atopic Dermatitis | Autonomic Neuropathy | Neuropathy | T-cell Leukemia | Hypertelorism | Barrett Esophagus | Chromosome 9q34.3 Deletion Syndrome | Myofibrillar Myopathy | Coma | Diabetic Neuropathy | Cutaneous Lupus Erythematosus | Choroiditis | Leukemia-lymphoma, Adult T-cell | Retinal Telangiectasia | Colitis, Collagenous | Hyperuricemic Nephropathy, Familial Juvenile | Primary Ovarian Insufficiency | Inflammatory Myofibroblastic Tumor | Pneumonia, Bacterial | Localized Scleroderma | Kawasaki Disease | GAPO Syndrome | Hypertension, Portal | Werner's Syndrome | Relapsing Polychondritis | Blepharo-cheilo-odontic Syndrome | Thrombosis | Dowling-Degos Disease | Galactosialidosis | Bone Giant Cell Tumor | Carney Triad | Salla Disease | Motion Sickness | Schizophrenia, Paranoid | Ghosal Syndrome | Hemangioma | Chronic Beryllium Disease | Silver-Russell Syndrome | Osteogenesis Imperfecta Type V | Cystitis | Charcot-Marie-Tooth Disease, Type 2C | Epicondylitis | Autosomal Recessive Congenital Ichthyosis | Language Disorders | Cardiomyopathy, Restrictive | Waardenburg Syndrome Type 2E | Osteoporosis-pseudoglioma Syndrome | Schaaf-Yang Syndrome | Mast Cell Leukemia | Adrenomyeloneuropathy | Pure Red Cell Aplasia | Stroke, Hemorrhagic