Sickle Cell Disease

About the Disease
Sickle Cell Anemia, also known as hemoglobin sc disease, is related to hereditary persistence of fetal hemoglobin-sickle cell disease syndrome and deficiency anemia, and has symptoms including abdominal pain, angina pectoris and chest pain. An important gene associated with Sickle Cell Anemia is HBB (Hemoglobin Subunit Beta), and among its related pathways/superpathways are Golgi-to-ER retrograde transport and Binding and Uptake of Ligands by Scavenger Receptors. The drugs Deferoxamine and Tocopherol have been mentioned in the context of this disorder. Affiliated tissues include Blood, bone marrow and bone, and related phenotypes are chronic hemolytic anemia and recurrent infections

Common Targets
HAMP | HMGCR | KEAP1 | BCAM | NOS3 | CFI | ADAMTS13 | CFP | PRMT5 | BCL11A | ITGA2 | HDAC3 | F2 | GSTT1 | HMOX2 | SELL | HRH2 | CDA | DPP4 | CCR2 | SYK | XDH | AKR1B1 | PDE9A | PKLR | EHMT1 | ZNF644 | EED | Guanylate cyclase (nonspecified subtype) | PGAM5-KEAP1-NRF2 Complex | KLF10 | NF-kappaB (NFkB) | SELP | NMDA receptor | GSTP1 | Integrin alphaIIbbeta3 (fibrinogen gpIIb/IIIa) receptor | WIZ | TRPA1 | CXCL12 | RORA | ABCC8 | P2RY12 | LOC105378010 | FASLG | GSTM1 | Heme Oxygenase (HO) (nonspecified subtype) | JAK3 | F5 | Proteasome Complex | CCR5 | KDM1A | Histone deacetylase (nonspecified subtype) | POLL | CXCR2 | NBEA | G1786 | EDN1 | CYB5R3 | HBB | ZNF410 | Polycomb Repressive Complex 2 | Potassium Channels (nonspecified subtype) | C3 | SLC40A1 | NPEPPS | CD47 | EHMT2 | CCL2 | CD19 | HMOX1 | BRIP1 | HBG1 | GPR158 | Soluble guanylyl cyclase | Invariant T Cell Receptor | HBG2 | BPGM | G2475 | G4780 | MPO | HDAC2 | MTHFR | PPARG | G5243 | THBD | PPARA | CTTN | DNA Methyltransferase (DNMT) (nonspecified subtype) | CYP2C19 | Integrin alphavbeta3 (vitronectin) receptor | TRPV1 | CFB | MSC-AS1 | GNA12 | FFAR4 | DDC | VWF | HDAC1 | G7852

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