Disease

X-linked Adrenoleukodystrophy, ALD

About the Disease
Adrenoleukodystrophy, also known as x-linked adrenoleukodystrophy, is related to peroxisomal acyl-coa oxidase deficiency and neonatal adrenoleukodystrophy, and has symptoms including exanthema, pruritus and hidebound skin. An important gene associated with Adrenoleukodystrophy is ABCD1 (ATP Binding Cassette Subfamily D Member 1), and among its related pathways/superpathways are Fatty acid metabolism and Peroxisomal lipid metabolism. The drugs Pramipexole and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include adrenal cortex, adrenal gland and spinal cord, and related phenotypes are intellectual disability and gait disturbance

Common Targets
PPARG | THRB | KEAP1 | ME1 | HMGCR | CD1A | NR1H3 | ABCD2 | CD1D | NF-kappaB (NFkB) | CD1B | ELOVL1 | CYP4F2 | Mitochondrial pyruvate carrier complex (MPC) | MAOB | AMP-activated protein kinase (AMPK) | ABCD1 | G4780 | CD1E | G2475

疾病靶点研报
X-linked Adrenoleukodystrophy, ALD

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