Familial Juvenile Hyperuricemic Nephropathy

About the Disease
Tubulointerstitial Kidney Disease, Autosomal Dominant, 1, also known as familial juvenile hyperuricemic nephropathy, is related to nephronophthisis and hyperuricemic nephropathy, familial juvenile, 3. An important gene associated with Tubulointerstitial Kidney Disease, Autosomal Dominant, 1 is UMOD (Uromodulin), and among its related pathways/superpathways are "Uricosurics Pathway, Pharmacodynamics" and "Allopurinol Pathway, Pharmacokinetics". Affiliated tissues include kidney, liver and bone, and related phenotypes are renal insufficiency and hyperuricemia

Common Targets
UMOD | HNF1B

Note: If you'd like to get a target analysis report for Familial Juvenile Hyperuricemic Nephropathy, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Familial Juvenile Hyperuricemic Nephropathy at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Pseudohypoparathyroidism Type 1A | Maple Syrup Urine Disease | Adrenomyeloneuropathy | Methylmalonic Aciduria And Homocystinuria, CblC Type | Temporal Lobe Epilepsy | Speech Disorders | Hepatitis E | Stomatitis | Cockayne Syndrome | Antiphospholipid Syndrome | Epithelioid Hemangioma | Anemia | Sclerosing Cholangitis | Hemochromatosis Type 2 | Frontometaphyseal Dysplasia | Rosacea | CDKL5 Deficiency Disorder | Bronchiolitis | Bare Lymphocyte Syndrome | Lymphoma | Oguchi Disease-2 | Acrocallosal Syndrome | Nicotine Addiction | Greenberg Dysplasia | Spinocerebellar Ataxia Type 7 | Klippel-Feil Syndrome | Sickle Cell Anemia | Alzheimer Disease, Late Onset | Genee-Wiedemann Syndrome | Benign Familial Infantile Seizures | Cerebrotendinous Xanthomatosis | Coenzyme Q10 Deficiency | Combined Pituitary Hormone Deficiency | Cardiomyopathy, Dilated, 1L | Thyroid Dyshormonogenesis | Central Pain Syndrome | Osteogenesis Imperfecta Type II | Diarrhea | Vogt-Koyanagi-Harada Syndrome | SAPHO Syndrome | Neuroendocrine Cancer | Charcot-Marie-Tooth Disease | Tangier Disease | Acrodysostosis | Acrodermatitis | Menetrier Disease | Hypolipoproteinemia | Richter's Syndrome | Tylosis With Esophageal Cancer | Infantile Nephropathic Cystinosis | Endometriosis | Spondylolisthesis | Retinopathy, Diabetic | Menkes Disease | Blastomycosis | Osteonecrosis Of The Jaw | Trachoma | Pycnodysostosis | Pontocerebellar Hypoplasia Type 2 | Anorectal Malformations | Erythema Nodosum | Prolidase Deficiency | Rett Syndrome | Sturge-Weber Syndrome | Adenoid Cystic Carcinoma | Vitiligo | Retinopathy Of Prematurity | Mohr-Tranebjaerg Syndrome | Angioimmunoblastic T-cell Lymphoma | Porencephaly | Uveitis | Blepharoconjunctivitis | Hereditary Pyropoikilocytosis | Pyruvate Carboxylase Deficiency Disease | Fetal Akinesia Deformation Sequence | Adenoma, Pituitary | Sulfite Oxidase Deficiency | Benign Hereditary Chorea | Retinal Telangiectasia | KBG Syndrome | Familial Hypobetalipoproteinemia | Hereditary Mixed Polyposis Syndrome | Kearns-Sayre Syndrome | Pilomatrix Carcinoma | Rhabdomyosarcoma | Ataxia-hypogonadism-choroidal Dystrophy Syndrome | Schistosomiasis | Hypersensitivity | IgA Nephropathy | Gastroschisis | Noonan Syndrome | Gardner Syndrome | Pfeiffer Syndrome | Sotos Syndrome | Blau Syndrome | Hypercalcemia | Renal Hypouricemia | Diverticulitis | Chronic Neutrophilic Leukemia | Chordoid Glioma | Carbamoyl Phosphate Synthetase I Deficiency | Urethritis | Enlarged Vestibular Aqueduct | Uremia | Loeys-Dietz Syndrome Type 4 | Hemophagocytic Lymphohistiocytosis | Binge Eating Disorder | Idiopathic Pulmonary Fibrosis | Reticular Dysgenesis | Cat Eye Syndrome | Kabuki Syndrome 2 | Encephalopathy, Hepatic | Congenital Stromal Corneal Dystrophy | Renal Tubular Dysgenesis | Generalized Epilepsy With Febrile Seizures Plus | Tatton-Brown-Rahman Syndrome | Hereditary Elliptocytosis | Acute Lymphocytic Leukemia | Papulopustular Rosacea | Juvenile Xanthogranuloma | Corneal Neovascularization | Ganglioglioma | Schamberg Disease | Platelet Disorders | Progressive Familial Intrahepatic Cholestasis Type 2 | Primary Carnitine Deficiency | Graft-versus-host Disease | Distal Myopathy 2 | Osteogenesis Imperfecta Type V | Neurogenic Bladder | Lymphoma, AIDS-related | Nephritis, Interstitial | Peritonitis | Waardenburg Syndrome | Glycogen Storage Disease Type 6 | Zygomycosis | Primary Erythromelalgia | Shwachman-Bodian-Diamond Syndrome | Familial Isolated Hyperparathyroidism | Hereditary Spherocytosis | Lymphoproliferative Disease, X-linked | Encephalitis, Tick-borne | Amyotrophic Lateral Sclerosis-parkinsonism-dementia Complex | Dengue Hemorrhagic Fever | Periventricular Nodular Heterotopia | Smith-Magenis Syndrome | Long QT Syndrome Type 1 | Disseminated Intravascular Coagulation | Early Infantile Epileptic Encephalopathy 4 | Macrophage Activation Syndrome | Alstrom Syndrome | Isovaleric Acidemia | Fibromyalgia | Neonatal Progeroid Syndrome | Vascular Cognitive Impairment | Anorchia | Urolithiasis | Hypervalinemia | Hermansky-Pudlak Syndrome | Optic Atrophy 2 | 17-beta-hydroxysteroid Dehydrogenase X Deficiency | Veno-occlusive Disease | Leri Pleonosteosis | Thyroiditis | McCune-Albright Syndrome | Neuroectodermal Tumors, Primitive | Eclampsia | Cornelia De Lange Syndrome | Intracranial Hypertension | Hypertensive Nephropathy | Spinocerebellar Ataxia Type 23 | Hypothalamic Obesity | Multiple Sclerosis | Myasthenia | Tay-Sachs Disease | Polyarteritis Nodosa | Still Disease | Seborrheic Dermatitis | Cousin Syndrome | Arthritis | Ameloblastoma | Leber Congenital Amaurosis | Common Cold | Hypertension, Portal | Colitis | GM2-gangliosidosis AB Variant | Kashin-Beck Disease | Retinal Dystrophy | Hyperparathyroidism | Hemorrhage | Pure Red Cell Aplasia | Adenomatoid Tumor | Herpes Genitalis | Tetraplegia | Autosomal Recessive Bestrophinopathy | Asthma, Exercise-induced | Paroxysmal Nocturnal Hemoglobinuria | Angioedema | Juvenile Polyposis | Neuromyotonia | Primary Hyperoxaluria Type 1 | Perry Syndrome | Cerebral Amyloid Angiopathy | Chiari Malformation Type I | Idiopathic Multicentric Castleman Disease | Hydrocephalus, Normal Pressure | Iron Deficiency Anemia | T-cell Leukemia | Non-epidermolytic Palmoplantar Keratoderma | Blue Rubber Bleb Nevus Syndrome | Myeloid Leukemia | Neurofibroma | Incontinentia Pigmenti | Hyperlipidemia | Isobutyryl-CoA Dehydrogenase Deficiency | Coronary Restenosis | Duane Retraction Syndrome | Hyper IgE Syndrome | Microcephalic Primordial Dwarfism | Hyperparathyroidism, Primary | Corticobasal Syndrome | Pulmonary Capillary Hemangiomatosis | Carbohydrate Metabolism Disorders | Liddle Syndrome | Osteogenesis Imperfecta Type VI | Mitochondrial Disease | Hypohidrotic Ectodermal Dysplasia, X-linked | Interstitial Lung Diseases | Multiple Sulfatase Deficiency | Lung Diseases | Primary Biliary Cholangitis | Thyrotoxic Periodic Paralysis | Rhabdomyosarcoma, Embryonal | Polymicrogyria | Tyrosine Hydroxylase Deficiency | Sensorineural Hearing Loss | Lichen Sclerosus | Hypoglycemia | Ligneous Conjunctivitis | Muckle-Wells Syndrome | Spondylocarpotarsal Synostosis Syndrome | Iron Overload | Pancytopenia | Parkinson Disease 6, Autosomal Recessive Early-onset | Plasmacytoma | Pulmonary Tuberculosis | Spinal Muscular Atrophy | Rotor Syndrome | Usher Syndrome Type IIC | Desbuquois Syndrome | Osteoarthritis | Congenital Mirror Movements | Esotropia | McKusick Type Metaphyseal Chondrodysplasia | Congenital Dyserythropoietic Anemia | Chondrodysplasia Punctata | Peyronie's Disease | Hepatitis A | Scleritis | Hypokalemic Periodic Paralysis | Macrophagic Myofasciitis | Cutaneous Lupus Erythematosus | Scleroderma | Prune Belly Syndrome | Persistent Truncus Arteriosus | Tumoral Calcinosis | Myelitis, Transverse | Oculocutaneous Albinism | Spitz Nevus | Dwarfism | Ventricular Septal Defect | Cantu Syndrome | Multiple Hamartoma Syndrome | Cardiofaciocutaneous Syndrome | Cancer, Kidney | Exfoliative Dermatitis | Leprosy | Cancer, Breast | Split Hand-foot Malformation | Peeling Skin Syndrome Type B | Angiodysplasia | Trichothiodystrophy | Homocystinuria | Mitochondrial Encephalomyopathy | Twin-to-twin Transfusion Syndrome | Craniopharyngioma | Epilepsy Of Infancy With Migrating Focal Seizures | Supravalvular Aortic Stenosis | Metachromatic Leukodystrophy | Craniofacial Dysostosis | McLeod Syndrome | Best Macular Dystrophy | Pneumococcal Meningitis | Amish Infantile Epilepsy Syndrome | Gallstones | Epidermolysis Bullosa Simplex, Localized | Lymphoma Lymphoblastic | Cohen Syndrome | Autoimmune Autonomic Ganglionopathy | Progressive Encephalopathy-optic Atrophy Syndrome | Waardenburg Syndrome Type 2A | Purpura | Usher Syndrome | Huntington's Disease | Whipple's Disease | Hemimegalencephaly | Brenner Tumor | Proteasome-associated Autoinflammatory Syndrome 2 | Hyperostosis | Congenital Hereditary Endothelial Dystrophy Type I | Amblyopia | Milk Allergy | Swine Influenza | Pleomorphic Xanthoastrocytoma | Leri-Weill Dyschondrosteosis | Scapuloperoneal Myopathy, X-linked Dominant | Patent Foramen Ovale | Pierre Robin Syndrome | Congenital Hereditary Endothelial Dystrophy Type II | Spinocerebellar Ataxia Type 17 | Gastritis, Atrophic | Alexander Disease | Porphyria Cutanea Tarda | Globozoospermia | Anti-NMDA Receptor Encephalitis | Chronic Myeloid Leukemia | Mountain Sickness | Bietti Crystalline Dystrophy | Cholangitis | Sarcosinemia | VACTERL Association | Gastritis | Hyperlipidemia, Familial Combined | Retinal Coloboma | Familial Glucocorticoid Deficiency | Niemann-Pick Disease, Type B | Bulimia Nervosa | MELAS Syndrome | Meesmann Corneal Dystrophy | Ectodermal Dysplasia | Coffin-Siris Syndrome | Liver Failure | Absence Epilepsy | Thalassemia, Beta | Triphalangeal Thumb-polysyndactyly Syndrome | Chanarin-Dorfman Syndrome | Mesothelioma, Malignant | Neutrophilia | Personality Disorders | Glaucoma | Syndactyly | Joubert Syndrome | Progressive Myoclonic Epilepsy | Angiomyolipoma | Raine Syndrome | Rheumatoid Arthritis | Osteomalacia | Multisystemic Smooth Muscle Dysfunction Syndrome | Tonsillitis | Dysgerminoma | Mycosis Fungoides | Familial Advanced Sleep Phase Syndrome | Muscle Wasting | Amelanotic Melanoma | Periodic Limb Movement Disorder | Molybdenum Cofactor Deficiency | Spinocerebellar Ataxia Type 28 | Autosomal Recessive Spastic Paraplegia Type 35 | Short-chain Acyl-CoA Dehydrogenase Deficiency | Multicentric Carpotarsal Osteolysis Syndrome | Pantothenate Kinase-associated Neurodegeneration | Hereditary Inclusion Body Myopathy | 3-hydroxyacyl-CoA Dehydrogenase Deficiency | Thromboembolism | Acute Kidney Injury | Hyperekplexia | Li-Fraumeni Syndrome | Early Infantile Epileptic Encephalopathy 1 | Melanoma, Malignant | Aplastic Anemia | CHARGE Syndrome | Hemangioma | Melanoma, Uveal | Mitochondrial DNA Depletion Syndrome, Encephalomyopathic Form | Very Long-chain Acyl-CoA Dehydrogenase Deficiency | Gigantism | Sarcoma, Endometrial Stromal | X-linked Creatine Transporter Deficiency | Neurofibromatosis Type 2 | Cardiac Sarcoidosis | Multiple Sclerosis, Relapsing-remitting | Spinocerebellar Ataxia Type 10 | Fuchs Dystrophy | Glycogen Storage Disease Type 1b | Niemann-Pick Disease, Type C | Aspartylglycosaminuria | Focal Dermal Hypoplasia | Tetanus | Schistosomiasis Mansoni | B-cell Prolymphocytic Leukemia