Disease

Syndactyly

About the Disease
Chromosome 2q35 Duplication Syndrome, also known as syndactyly, is related to syndactyly, type iii and syndactyly, type iv. An important gene associated with Chromosome 2q35 Duplication Syndrome is CUP2Q35 (Syndactyly, Type I), and among its related pathways/superpathways are Endochondral ossification and Head and neck squamous cell carcinoma. The drugs Clonidine and Adrenergic alpha-Agonists have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and eye, and related phenotypes are finger syndactyly and toe syndactyly

Common Targets
NECTIN4 | HOXD13 | CKAP2L | BHLHA9 | TTC30B | GJA1 | LRP4

疾病靶点研报
Syndactyly

Note: If you'd like to get a target analysis report for Syndactyly, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Syndactyly at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Bipolar Disorder | Supravalvular Aortic Stenosis | Hemophagocytic Lymphohistiocytosis | Cutaneous Mastocytosis | Giant Cell Glioblastoma | Retinopathy, Diabetic | Anti-NMDA Receptor Encephalitis | PHARC Syndrome | Osteitis | Smoldering Myeloma | Very Long-chain Acyl-CoA Dehydrogenase Deficiency | Osteoporosis-pseudoglioma Syndrome | Mannosidase Deficiency Diseases | Hemolytic Uremic Syndrome, Atypical | Pulmonary Veno-occlusive Disease | Spinocerebellar Ataxia Type 23 | Infantile Nephropathic Cystinosis | Acute Chest Syndrome | Otosclerosis | Basal Cell Nevus Syndrome | Pigment Dispersion Syndrome | Aldosterone Deficiency | Triple A Syndrome | Dermatitis | Amebiasis | Beta-Propeller Protein-associated Neurodegeneration | Hyperuricemic Nephropathy, Familial Juvenile | Pityriasis Rubra Pilaris | Saethre-Chotzen Syndrome | Hypophosphatemic Rickets, Autosomal Recessive, 1 | Amyotrophic Lateral Sclerosis | Hypokalemia | Pulmonary Alveolar Proteinosis | Otitis Externa | Retinitis | Schizophrenia | Polycystic Kidney, Autosomal Recessive | Neutropenia | Cherubism | Filariasis | Hypertension, Renal | Vertigo | Astrocytoma | Micropenis | Polyomavirus Nephropathy | Subacute Sclerosing Panencephalitis | Nephroblastoma | Withdrawal Syndrome | Camurati-Engelmann Disease | Wiskott-Aldrich Syndrome | Congenital Bilateral Absence Of Vas Deferens | Leukoplakia | Atopic Dermatitis | Meleda Disease | Major Depression | Colitis, Microscopic | Congenital Nephrotic Syndrome | Gliosarcoma | Papillorenal Syndrome | Nance-Horan Syndrome | Marinesco-Sjogren Syndrome | Walker-Warburg Syndrome | Vitamin D Deficiency | Waardenburg Syndrome Type 4A | Cardiospondylocarpofacial Syndrome | Androgenic Alopecia | Liddle Syndrome | Porphyria | Uterine Leiomyoma | Ghosal Syndrome | Ganglioneuroma | Glaucoma | Spinal Muscular Atrophy Type 2 | Hemochromatosis Type 1 | Nephrosclerosis | Schaaf-Yang Syndrome | Trichuriasis | Schuurs-Hoeijmakers Syndrome | Progressive Familial Intrahepatic Cholestasis | Glycogen Storage Disease Type 3 | Wolfram Syndrome | Down Syndrome | Benign Hereditary Chorea | Carbonic Anhydrase VA Deficiency | Kearns-Sayre Syndrome | Palmoplantar Keratoderma | Light Chain Amyloidosis | Chylothorax, Congenital | Osteochondrosis | Sleep Apnea, Central | Salla Disease | Ependymoma | Coenzyme Q10 Deficiency | Pilomatrix Carcinoma | Familial Mediterranean Fever | Episodic Ataxia | Relapsing Polychondritis | Charcot-Marie-Tooth Disease, Type 6 | Alagille Syndrome | Blau Syndrome | Intestinal Obstruction | Trichotillomania | Multiple Congenital Anomalies-hypotonia-seizures Syndrome 2 | Malaria | Pelvic Inflammatory Disease | Tendinitis | Mitochondrial DNA Depletion Syndrome, Hepatocerebral Form | Fuchs Heterochromic Iridocyclitis | 5-oxoprolinase Deficiency | Meconium Ileus | Hyperhomocysteinemia | Myopathy | Prediabetes | Raine Syndrome | Epidermolytic Palmoplantar Keratoderma | Familial Digital Arthropathy-brachydactyly | Dysmorphophobia | Christianson Syndrome | Muir-Torre Syndrome | Chronic Inflammatory Demyelinating Polyneuropathy | Posterior Polar Cataract | Dyggve-Melchior-Clausen Disease | Vaginitis | Dowling-Degos Disease | Early Infantile Epileptic Encephalopathy 28 | Schwannomatosis | Fuchs Dystrophy | Xeroderma Pigmentosum | Multiple System Atrophy | Leukoplakia, Oral | Sensorineural Hearing Loss | Microtia | Central Core Disease | Azoospermia | Adenocarcinoma | Cranial Nerve Disease | Motor Neuron Diseases | Meningococcal Meningitis | Panic Disorder | Opisthorchiasis | Episodic Ataxia Type 2 | Lamellar Ichthyosis | Pathological Gambling | Gray Platelet Syndrome | Astrocytoma, Anaplastic | Renal Hypomagnesemia 3 | Obsessive-compulsive Disorder | Methemoglobinemia Type IV | Lymphoma, Mantle Cell | Multiple Mitochondrial Dysfunctions Syndrome Type 1 | Infantile Spasm | Porencephaly | Myotonia | Oral Lichen Planus | Niemann-Pick Disease, Type B | Anuria | Benign Familial Infantile Seizures | Pulmonary Capillary Hemangiomatosis | Haim-Munk Syndrome | Hypoparathyroidism | DiGeorge Syndrome | Keratosis, Seborrheic | Xeroderma Pigmentosum Variant Type | Atrioventricular Septal Defect | Galactosemia | Arthritis | Atrial Septal Defect | Anosmia, Congenital | Gastrointestinal Disorders | Retinal Dystrophy | Leprosy | Tuberculosis | Familial Hemiplegic Migraine | AIDS | Chromosome 17q21.31 Deletion Syndrome | Chromosome 16p11.2 Deletion Syndrome | Panniculitis | Campomelic Dysplasia | Kohlschutter-Tonz Syndrome | Hyperferritinemia-cataract Syndrome | Behcet's Disease | Hypersensitivity Pneumonitis | Clouston Hidrotic Ectodermal Dysplasia | Paternal Uniparental Disomy Of Chromosome 14 | Pseudohypoparathyroidism Type 2 | Craniofrontonasal Syndrome | Torticollis | Tangier Disease | Leishmaniasis, Visceral | Lung Diseases | Progressive Osseous Heteroplasia | Pain | Creatine Deficiency Syndrome | Trimethylaminuria | Familial Male-limited Precocious Puberty | Osteogenesis Imperfecta Type I | Noonan Syndrome-like Disorder With Loose Anagen Hair | Congenital Disorders Of Glycosylation Type II | Schindler Disease | Von Hippel-Lindau Disease | Sezary Syndrome | Epilepsy, Generalized | Synovitis | Pierson Syndrome | Bethlem Myopathy | Hypertension, Essential | Carcinoma In Situ | Diverticulitis | Keratitis | Schizophrenia, Paranoid | Actinomycetoma | Pendred Syndrome | Basal Ganglia Disease | Biotinidase Deficiency | Endocarditis | Diabetes Mellitus, Transient Neonatal | Spondyloperipheral Dysplasia | Cat Eye Syndrome | Ectodermal Dysplasia | Tinea | Sandhoff Disease | Porphyria, Variegate | Sick Sinus Syndrome | Inflammatory Myopathy | KBG Syndrome | Amyotrophic Lateral Sclerosis, Juvenile | Rheumatic Heart Disease | Maple Syrup Urine Disease | Peripheral Neuropathy | Schistosomiasis Mansoni | Scapuloperoneal Myopathy, X-linked Dominant | Chondrodysplasia Punctata 2, X-linked Dominant | Diastrophic Dysplasia | Menkes Disease | Vici Syndrome | Atelosteogenesis Type 2 | Multiple Sclerosis, Secondary Progressive | Charcot-Marie-Tooth Disease, Type 2 | Takotsubo Cardiomyopathy | Familial Thoracic Aortic Aneurysm | Prune Belly Syndrome | Menetrier Disease | Spinal Muscular Atrophy | Cerebrovascular Disorders | Hereditary Hemorrhagic Telangiectasia | Syncope | Microphthalmia, Syndromic 7 | Duane Retraction Syndrome | Trachoma | Infectious Diarrhea | Sotos Syndrome | Oculocutaneous Albinism Type 1 | Dengue Hemorrhagic Fever | Camptocormia | Loeys-Dietz Syndrome Type 4 | Rift Valley Fever | Creatine Deficiency Syndrome Due To AGAT Deficiency | Lymphoma, Primary Cutaneous Anaplastic Large Cell | Ulcerative Colitis | Stroke | Erythropoietic Protoporphyria | Polydactyly | Skin Carcinoma | Papilloma | Sialidosis | Osteogenesis Imperfecta | Tylosis With Esophageal Cancer | Cold-induced Sweating Syndrome | Congenital Torticollis | Parvovirus B19 Infection | Bacterial Meningitis | Congenital Muscular Dystrophy | Mast Cell Leukemia | Arterial Tortuosity Syndrome | Congenital Adrenal Hyperplasia | Usher Syndrome Type III | Pituitary Dwarfism | Hyperlipidemia Type V | Dysfibrinogenemia | Whipple's Disease | Metabolic Diseases | Hereditary Elliptocytosis | Glutaric Aciduria Type 1 | Acromesomelic Dysplasia | Hyperandrogenemia | Perivascular Epithelioid Cell Tumor | Blood Protein Disorders | Congenital Myasthenic Syndrome | Hypoalbuminemia | Pycnodysostosis | Ichthyosis, X-linked | Fowler's Syndrome | Polyarteritis Nodosa | Milk Allergy | Fibrosis | Lipid Storage Myopathy | Prostatitis | Multicentric Carpotarsal Osteolysis Syndrome | Huntington's Disease-like 2 | Hepatic Adenomatosis | Hyperinsulinemic Hypoglycemia | Oguchi Disease-2 | Ligneous Conjunctivitis | Congenital Poikiloderma | Metanephric Adenoma | Pterygium | Blastomycosis | Lateral Meningocele Syndrome | Sickle Cell Anemia | Myosin Storage Myopathy | Hypothyroidism | Ureteropelvic Junction Obstruction | Meesmann Corneal Dystrophy | Graves Disease | Fragile X Syndrome | GAPO Syndrome | Histiocytic Sarcoma | Alopecia | Craniofacial Dysostosis | Liebenberg Syndrome | Bruck Syndrome | Senior-Loken Syndrome | Hypogonadism | Hypertensive Retinopathy | Coffin-Lowry Syndrome | Hyperbilirubinemia, Neonatal | Isovaleric Acidemia | Chromosome 8q21.11 Deletion Syndrome | Synpolydactyly | Sensory Ataxic Neuropathy, Dysarthria, And Ophthalmoparesis | Lymphedema-distichiasis Syndrome | Multiple Sulfatase Deficiency | Polycystic Kidney, Autosomal Dominant | Norrie Disease | Charcot-Marie-Tooth Disease, Type 2A | Richter's Syndrome | Lichen Planus | Familial Retinal Arterial Macroaneurysm | Megaloblastic Anemia | Carney-Stratakis Syndrome | LRBA Deficiency | Sweet Syndrome | Waardenburg Syndrome Type 4 | Arteriosclerosis | Heavy Chain Disease | Microphthalmia | Cartilage Disorders | Spondylometaphyseal Dysplasia | Language Disorders | Pleurisy | Autosomal Recessive Congenital Ichthyosis | Glutaric Aciduria Type 3 | Seborrheic Dermatitis | Vascular Calcification | Behavioral Variant Of Frontotemporal Dementia | Apert Syndrome | Congenital Nystagmus | Unverricht-Lundborg Syndrome | Multicystic Renal Dysplasia | Thyroiditis | Retinal Coloboma | Renal Tubular Dysgenesis | Ebstein Anomaly | Leukocyte Adhesion Deficiency | Disseminated Intravascular Coagulation | Paronychia | Trismus-pseudocamptodactyly Syndrome | Scabies | Bladder Exstrophy | Wiedemann-Steiner Syndrome | Urticaria | Reflex Epilepsy | Kaposi Sarcoma | Hypermethioninemia | Malnutrition | Neuronal Ceroid Lipofuscinosis | Cri-du-chat Syndrome | Presbycusis | Osteonecrosis Of The Jaw | Spinocerebellar Ataxia Type 3 | Cohen Syndrome | Encephalitis, Tick-borne | Orthostatic Intolerance | Cryopyrin-associated Periodic Syndromes | Lichen Sclerosus | Giant Axonal Neuropathy | Autosomal Recessive Bestrophinopathy | Fontaine Progeroid Syndrome | Schnyder Crystalline Corneal Dystrophy | Hyperammonemia | Hyperuricemia | DRESS Syndrome | Glutaric Aciduria Type 2 | Congenital Diaphragmatic Hernia | 3-hydroxy-3-methylglutaric Aciduria | Metaphyseal Chondrodysplasia, Schmid Type | Pneumonia, Bacterial | Hemochromatosis Type 2 | Keratosis | Low Phospholipid Associated Cholelithiasis