Wolfram Syndrome

About the Disease
Wolfram Syndrome, also known as didmoad syndrome, is related to wolfram syndrome 1 and wolfram syndrome 2, and has symptoms including ataxia, seizures and tremor. An important gene associated with Wolfram Syndrome is WFS1 (Wolframin ER Transmembrane Glycoprotein), and among its related pathways/superpathways are Glucose / Energy Metabolism and Neuroscience. The drugs Acetylcysteine and Iron have been mentioned in the context of this disorder. Affiliated tissues include eye, pituitary and brain, and related phenotypes are diabetes mellitus and sensorineural hearing impairment

Common Targets
G3630 | CDK13 | CISD2 | ND1 | RYR2 | Chaperone (nonspecified subtype) | Glycogen synthase kinase 3 (GSK-3) (nonspecified subtype) | WFS1 | GLP1R | AMP-activated protein kinase (AMPK) | RYR1

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