Li-Fraumeni Syndrome

About the Disease
Li-Fraumeni Syndrome 2, also known as lfs2, is related to bone osteosarcoma and li-fraumeni syndrome 1. An important gene associated with Li-Fraumeni Syndrome 2 is CHEK2 (Checkpoint Kinase 2). The drugs Benzocaine and Tannic acid have been mentioned in the context of this disorder. Affiliated tissues include breast, bone and brain, and related phenotypes are glioma and meningioma

Common Targets
G999 | MSH3 | G3630 | G842 | LATS1 | CHEK1 | HAUS1 | PMS2 | CAPNS2 | MSH4 | TSC2 | RASGEF1A | CHRNA7 | RAD17 | G4193 | STK11 | REV1 | IQGAP2 | RAD54B | DLC1 | PDE5A | G7157 | PRSS1 | AKT2 | POLQ | BLM | G472 | MLH3 | TDG | MMS19 | PNKP | XRCC1 | FANCA | SDHD | CHEK2 | PALB2 | Voltage-Gated Calcium Channel alpha-2/delta (nonspecified subtype) | CRLF1 | AMP-activated protein kinase (AMPK) | BMPR1A | CDK7 | DCLRE1C | RBPJL | BRCA2 | MDM4 | G1956 | RECQL4 | SLX4

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